ApoList – June 2013


Bcl-2 family proteins

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
Xi Wang, Madhavi Bathina, John Lynch, Brian Koss, Christopher Calabrese, Sharon Frase, John D. Schuetz, Jerold E. Rehg, and Joseph T. Opferman

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure
Robert L. Thomas, David J. Roberts, Dieter A. Kubli, Youngil Lee, Melissa N. Quinsay, Jarvis B. Owens, Kimberlee M. Fischer, Mark A. Sussman, Shigeki Miyamoto, and Åsa B. Gustafsson

The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm−/− mice
S Biswas, Q Shi, A Wernick, A Aiello and S S Zinkel

tBid undergoes multiple conformational changes at the membrane required for Bax activation
Aisha Shamas-Din, Scott Bindner, Weijia Zhu, Yehudit Zaltsman, Clinton Campbell, Atan Gross, Brian Leber, David W. Andrews, and Cécile Fradin

Control of Cellular Bcl-xL Levels by Deamidation-Regulated Degradation
So Hee Dho, Benjamin E. Deverman, Carlo Lapid, Scott R. Manson, Lu Gan, Jacob J. Riehm, Rajeev Aurora, Ki-Sun Kwon, Steven J. Weintraub

MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R
J Gong, J-P Zhang, B Li, C Zeng, K You, M-X Chen, Y Yuan and S-M Zhuang

BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR
Clémentine Aguirre, Tim ten Brink, Olivier Walker, Florence Guillière, Dany Davesne, Isabelle Krimm

AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts
Diana M. González-Gironès, Cristina Moncunill-Massaguer, Daniel Iglesias-Serret, Ana M. Cosialls, Alba Pérez-Perarnau, Claudia M. Palmeri, Camila Rubio-Patiño, Andreas Villunger, Gabriel Pons & Joan Gil

Consequences of the combined loss of BOK and BAK or BOK and BAX
F Ke, P Bouillet, T Kaufmann, A Strasser, J Kerr and A K Voss

Three-dimensional structure of Bax-mediated pores in membrane bilayers
X-P Xu, D Zhai, E Kim, M Swift, J C Reed, N Volkmann and D Hanein

Death receptors

Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors
T Bagci-Onder, A Agarwal, D Flusberg, S Wanningen, P Sorger and K Shah

Structural And Biophysical Characterization Of The Interactions Between The Death Domain Of Fas Receptor And Calmodulin
Timothy F. Fernandez, Alexandra B. Samal, Gregory J. Bedwell, Yabing Chen, and Jamil S. Saad

Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex
Jillian F. Wise, Zuzana Berkova, Rohit Mathur, Haifeng Zhu, Frank K. Braun, Rong-Hua Tao, Anita L. Sabichi, Xue Ao, Hoyoung Maeng, and Felipe Samaniego


Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles
A.N. Böing, J. Stap, C.M. Hau, G.B. Afink, C. Ris-Stalpers, E.A. Reits, A. Sturk, C.J.F. van Noorden, R. Nieuwland

Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation
M Amir, E Zhao, L Fontana, H Rosenberg, K Tanaka, G Gao and M J Czaja

Bioluminescence imaging of caspase-3 activity in mouse liver
Qiuxia Fu, Xiangguo Duan, Shaoduo Yan, Licui Wang, Yong Zhou, Shuaizheng Jia, Juan Du, Xiaohui Wang, Yuhua Zhang & Linsheng Zhan


Cell death proteomics database: consolidating proteomics data on cell death.
Arntzen MØ, Bull VH, Thiede B.

The Indirect Activation Model of Mitochondrial Outer Membrane Permeabilisation (MOMP) Initiation requires a Trade-off between Robustness in Absence, and Sensitivity in Presence of Stress
Andreas U Lindner,   Jochen HM Prehn and   Heinrich J Huber

Rotenone induces neuronal death by microglial phagocytosis of neurons
Julius V. Emmrich, Tamara C. Hornik, Jonas J. Neher and Guy C. Brown


Developmentally Programmed Cell Death in Drosophila
Donna Denton, May T. Aung-Htut, Sharad Kumar

Decoding and unlocking the BCL-2 dependency of cancer cells
Philippe Juin, Olivier Geneste, Fabien Gautier, Stéphane Depil & Mario Campone

Central roles of apoptotic proteins in mitochondrial function
S M Kilbride and J H M Prehn

Mature neurons: equipped for survival
A J Kole, R P Annis and M Deshmukh

Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation
K Kono, K Mimura and R Kiessling

Crosstalk between apoptosis, necrosis and autophagy
Vassiliki Nikoletopoulou, Maria Markaki, Konstantinos Palikaras, Nektarios Tavernarakis

Cell death by cornification
Leopold Eckhart, Saskia Lippens, Erwin Tschachler, Wim Declercq

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family
K Azijli, B Weyhenmeyer, G J Peters, S de Jong and F A E Kruyt

Previews / other

Bid-ding for mercy: twisted killer in action
A Egle, D Asslaber, A Villunger and J Pinon-Hofbauer

The dark side of TRAIL signaling
S Fulda

Adaptation to Starvation: Translating a Matter of Life or Death
Brendan D. Manning

Extracellular Adenosine Induces p53-Dependent Cell Death

Cell death: A2B via p53

What Makes You Can Also Break You, Part II: Mitochondrial Permeability Transition Pore Formation by Dimers of the F1FO ATP-Synthase?
Gyorgy Szabadkai and Christos Chinopoulos

Vital dyes and virtual deaths
M Husmann

Apoptosis Methods
Edited by Seamus J. Martin and Conor M. Henry


– Measuring apoptosis by microscopy and flow cytometry
Conor M. Henry, Emilie Hollville, Seamus J. Martin
– Isolation, characterisation and reconstitution of cell death signalling complexes
Michelle A. Hughes, Claudia Langlais, Kelvin Cain, Marion MacFarlane
– In vivo assessment of specific cytotoxic T lymphocyte killing
T. Clemente, M.R. Dominguez, N.J. Vieira, M.M. Rodrigues, G.P. Amarante-Mendes
– Evaluation of pyroptosis in macrophages using cytosolic delivery of purified flagellin
Silvia L. Lage, Gustavo P. Amarante-Mendes, Karina R. Bortoluci
– Determination of apoptotic and necrotic cell death in vitro and in vivo
Tom Vanden Berghe, Sasker Grootjans, Vera Goossens, Yves Dondelinger, Dmitri V. Krysko, Nozomi Takahashi, Peter Vandenabeele
– Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines
Claudia Manzl, Florian Baumgartner, Lukas Peintner, Fabian Schuler, Andreas Villunger
– Flow cytometry based assays for the measurement of apoptosis-associated mitochondrial membrane depolarisation and cytochrome c release
Melinda E. Christensen, Elisa S. Jansen, Washington Sanchez, Nigel J. Waterhouse
– BAK/BAX activation and cytochrome c release assays using isolated mitochondria
Thibaud T. Renault, Konstantinos V. Floros, Jerry E. Chipuk
– BH3 profiling in whole cells by fluorimeter or FACS
Jeremy Ryan, Anthony Letai
– Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions
Markus Rehm, Jochen H.M. Prehn
– Methods for detection and analysis of apoptosis signaling in the C. elegans germline
Benjamin Lant, W. Brent Derry


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