ApoList – July 2013

Bcl-2 family proteins

Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK
A Geissler, F Haun, D O Frank, K Wieland, M M Simon, M Idzko, R J Davis, U Maurer and C Borner

The p53–PUMA axis suppresses iPSC generation
Yanxin Li, Haizhong Feng, Haihui Gu, Dale W. Lewis, Youzhong Yuan, Lei Zhang, Hui Yu, Peng Zhang, Haizi Cheng, Weimin Miao, Weiping Yuan, Shi-Yuan Cheng, Susanne M. Gollin and Tao Cheng

Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS
Hirokazu Hara, Tatsuya Takeda, Nozomi Yamamoto, Keisuke Furuya, Kazuya Hirose, Tetsuro Kamiya and Tetsuo Adachi

A pre-miR-149 genetic variation affects miR-149 maturation and its ability to regulate Puma in apoptosis
Su-Ling Ding, Jian-Xun Wang, Jian-Qin Jiao, Xin Tu, Qing Wang, Fang Liu, Qian Li, Jie Gao, Qun-Yong Zhou, Dong-Feng Gu, and Pei-Feng Li

Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer
François Vaillant, Delphine Merino, Lily Lee, Kelsey Breslin, Bhupinder Pal, Matthew E. Ritchie, Gordon K. Smyth, Michael Christie, Louisa J. Phillipson, Christopher J. Burns, G. Bruce Mann, Jane E. Visvader, Geoffrey J. Lindeman

Mcl-1 antagonizes Bax/Bak to promote effector CD4+ and CD8+ T-cell responses
P Tripathi, B Koss, J T Opferman and D A Hildeman

A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis
Hongmei Li, Kambiz N. Alavian, Emma Lazrove, Nabil Mehta, Adrienne Jones, Ping Zhang, Pawel Licznerski, Morven Graham, Takuma Uo, Junhua Guo, Christoph Rahner, Ronald S. Duman, Richard S. Morrison & Elizabeth A. Jonas

The BCL-2 family member bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage
Jacqualyn J. Schulman, Forrest A. Wright, Thomas Kaufmann, and Richard J.
H. Wojcikiewicz

Death receptor pathway

RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex
B A Abhari, S Cristofanon, R Kappler, D von Schweinitz, R Humphreys and S Fulda

Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways
M van Dijk, A Halpin-McCormick, T Sessler, A Samali and E Szegezdi

Membrane versus Soluble Isoforms of TNF-α Exert Opposing Effects on Tumor Growth and Survival of Tumor-Associated Myeloid Cells
Shidrokh Ardestani, Bin Li, Desirae L. Deskins, Huiyun Wu, Pierre P. Massion, and Pampee P. Young

Targeting Transmembrane TNF-α Suppresses Breast Cancer Growth
Mingxia Yu, Xiaoxi Zhou, Lin Niu, Guohong Lin, Jin Huang, Wenjing Zhou, Hui Gan, Jing Wang, Xiaodan Jiang, Bingjiao Yin, and Zhuoya Li

TRAIL-induced miR-146a expression suppresses CXCR4-mediated human breast cancer migration
Dongsheng Wang, Dan Liu, Jing Gao, Min Liu, Shilian Liu, Minghong Jiang, Yanxin Liu and Dexian Zheng

Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes
Vladimira Horova, Nada Hradilova, Iva Jelinkova, Michal Koc, Jan Svadlenka, Jan Brazina, Martin Klima, Josef Slavik, Alena Hyrslova Vaculova and Ladislav Andera

Lymphotoxin  induces apoptosis, necroptosis and inflammatory signals with the same potency as TNF
Nima Etemadi, Jessica K. Holien, Diep Chau, Grant Dewson, James M. Murphy, Warren S. Alexander, Michael W. Parker, John Silke and Ueli Nachbur

Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes
Deborah A. Flusberg, Jérémie Roux, Sabrina L. Spencer, and Peter K. Sorger

Caspases and downstream / metacaspases / IAPs

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells
Jun Suzuki, Daniel P. Denning, Eiichi Imanishi, H. Robert Horvitz, Shigekazu Nagata

Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution
M. Eugenia Delgado, Magnus Olsson, Frank A. Lincoln, Boris Zhivotovsky, Markus Rehm

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
Damgaard RB, Fiil BK, Speckmann C, Yabal M, Stadt UZ, Bekker-Jensen S, Jost PJ, Ehl S, Mailand N, Gyrd-Hansen M.

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.
Sagulenko V, Thygesen SJ, Sester DP, Idris A, Cridland JA, Vajjhala PR, Roberts TL, Schroder K, Vince JE, Hill JM, Silke J, Stacey KJ.

Caspase-2 Short Isoform Interacts with Membrane-Associated Cytoskeleton Proteins to Inhibit Apoptosis
Chunhua Han, Ran Zhao, John Kroger, Meihua Qu, Altaf A. Wani, Qi-En Wang

Biochemical evidence of key residues for the activation and autoprocessing of tomato type II metacaspase
Shuai Wen, Qiu-Min Ma, Ya-Li Zhang, Ji-Ping Yang, Guang-Hua Zhao, Da-Qi Fu, Yun-Bo Luo, Gui-Qin Qu

Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage
Jiao Zhang, Xin Wang, Wenjing Cui, Wenwen Wang, Huamei Zhang, Lu Liu, Zicheng Zhang, Zheng Li, Guoguang Ying, Ning Zhang and Binghui Li

Caspase Activity Is Required for Engulfment of Apoptotic Cells
Boris Shklyar, Flonia Levy-Adam, Ketty Mishnaevski, and Estee Kurant

Non apoptotic cell death

GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death
M A Jacquin, J Chiche, B Zunino, M Bénéteau, O Meynet, L A Pradelli, S Marchetti, A Cornille, M Carles and J-E Ricci

Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury
Andreas Linkermann, Jan Hinrich Bräsen, Maurice Darding, Mi Kyung Jin, Ana B. Sanz, Jan-Ole Heller, Federica De Zen, Ricardo Weinlich, Alberto Ortiz, Henning Walczak, Joel M. Weinberg, Douglas R. Green, Ulrich Kunzendorf, and Stefan Krautwald

Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia
S J Kim and Jianrong Li


An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways
Takashi Hirose, H. Robert Horvitz

Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c
Reiko Ban-Ishihara, Takaya Ishihara, Narie Sasaki, Katsuyoshi Mihara, and Naotada Ishihara


Paracrine control of tissue regeneration and cell proliferation by Caspase-3
K Boland, L Flanagan and J HM Prehn

Rejuvenating Bi(d)ology
S S Zinkel, X M Yin and A Gross

Anoikis molecular pathways and its role in cancer progression
Paolo Paoli, Elisa Giannoni, Paola Chiarugi

ER stress-induced cell death mechanisms
Renata Sano, John C. Reed

Previews / comments

Another twist in the on and off affair between cell suicide and inflammation
D L Vaux

Antiinflammatory effects of apoptotic cells
Peter M. Henson, Donna L. Bratton

Guarding effector T-cell survival: all for one, Mcl-1 for all?
E Ottina, M Pellegrini and A Villunger

BCL-2: A New Therapeutic Target in Estrogen Receptor-Positive Breast Cancer?
Lesley-Ann Martin, Mitch Dowsett

XiAP-ping Castration-Resistant Prostate Cancer
The XAF1-XIAP pathway provides a mechanistic link and a path for personalized prostate cancer therapy.

Whence the “Eat Me” Signal?
An enzyme involved in the flipping of phospholipids in dying cells’ surfaces to mark the cells for removal is identified.


Cold Spring Harbor Laboratory Cell Death Meeting Oct 8-12 2013: Abstract Deadline Extended to August 11