Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for June, 2013

MetaboList – May 2013

Posted by cris on June 3, 2013

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Cancer metabolism
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The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
Alfred Csibi, Sarah-Maria Fendt, Chenggang Li, George Poulogiannis, Andrew Y. Choo, Douglas J. Chapski, Seung Min Jeong, Jamie M. Dempsey, Andrey Parkhitko, Tasha Morrison, Elizabeth P. Henske, Marcia C. Haigis, Lewis C. Cantley, Gregory Stephanopoulos, Jane Yu, John Blenis
http://www.cell.com/abstract/S0092-8674(13)00465-0

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
Joanna Kaplon, Liang Zheng, Katrin Meissl, Barbara Chaneton, Vitaly A. Selivanov, Gillian Mackay, Sjoerd H. van der Burg, Elizabeth M. E. Verdegaal, Marta Cascante, Tomer Shlomi, Eyal Gottlieb, Daniel S. Peeper
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12154.html

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
Fang Wang, Jeremy Travins, Byron DeLaBarre, Virginie Penard-Lacronique, Stefanie Schalm, Erica Hansen, Kimberly Straley, Andrew Kernytsky, Wei Liu, Camelia Gliser, Hua Yang, Stefan Gross, Erin Artin, Veronique Saada, Elena Mylonas, Cyril Quivoron, Janeta Popovici-Muller, Jeffrey O. Saunders, Francesco G. Salituro, Shunqi Yan, Stuart Murray, Wentao Wei, Yi Gao, Lenny Dang, Marion Dorsch, Sam Agresta, David P. Schenkein, Scott A. Biller, Shinsan M. Su, Stephane de Botton, Katharine E. Yen
http://www.sciencemag.org/content/340/6132/622.abstract

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
Dan Rohle, Janeta Popovici-Muller, Nicolaos Palaskas, Sevin Turcan, Christian Grommes, Carl Campos, Jennifer Tsoi, Owen Clark, Barbara Oldrini, Evangelia Komisopoulou, Kaiko Kunii, Alicia Pedraza, Stefanie Schalm, Lee Silverman, Alexandra Miller, Fang Wang, Hua Yang, Yue Chen, Andrew Kernytsky, Marc K. Rosenblum, Wei Liu, Scott A. Biller, Shinsan M. Su, Cameron W. Brennan, Timothy A. Chan, Thomas G. Graeber, Katharine E. Yen, and Ingo K. Mellinghoff
http://www.sciencemag.org/content/340/6132/626.abstract

Expression and phosphorylation of the AS160_v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma
Cheng JC, McBrayer SK, Coarfa C, Dalva-Aydemir S, Gunaratne PH, Carpten JD, Keats JK, Rosen ST, Shanmugam M
http://www.cancerandmetabolism.com/content/1/1/14/abstract

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Starvation / hypoxia / ischemia
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The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation
Gabriel Leprivier, Marc Remke, Barak Rotblat, Adrian Dubuc, Abigail-Rachele F. Mateo, Marcel Kool, Sameer Agnihotri, Amal El-Naggar, Bin Yu, Syam Prakash Somasekharan, Brandon Faubert, Gaëlle Bridon, Cristina E. Tognon, Joan Mathers, Ryan Thomas, Amy Li, Adi Barokas, Brian Kwok, Mary Bowden, Stephanie Smith, Xiaochong Wu, Andrey Korshunov, Thomas Hielscher, Paul A. Northcott, Jason D. Galpin, Christopher A. Ahern, Ye Wang, Martin G. McCabe, V. Peter Collins, Russell G. Jones, Michael Pollak, Olivier Delattre, Martin E. Gleave, Eric Jan, Stefan M. Pfister, Christopher G. Proud, W. Brent Derry, Michael D. Taylor, Poul H. Sorensen
http://www.cell.com/abstract/S0092-8674(13)00532-1

Extracellular Adenosine Sensing-A Metabolic Cell Death Priming Mechanism Downstream of p53
Jaclyn S. Long, Diane Crighton, James O’Prey, Gillian MacKay, Liang Zheng, Timothy M. Palmer, Eyal Gottlieb, Kevin M. Ryan
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00220-7

Adaptive changes in the neuronal proteome: mitochondrial energy production, endoplasmic reticulum stress, and ribosomal dysfunction in the cellular response to metabolic stress
Abigail G Herrmann, Ruth F Deighton, Thierry Le Bihan, Mailis C McCulloch, James L Searcy, Lorraine E Kerr and James McCulloch
http://www.nature.com/jcbfm/journal/v33/n5/full/jcbfm2012204a.html

Tumor Environmental Factors Glucose Deprivation and Lactic Acidosis Induce Mitotic Chromosomal Instability – An Implication in Aneuploid Human Tumors
Chunyan Dai, Feifei Sun, Chunpeng Zhu, Xun Hu
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063054

The Pro-Survival Role of Autophagy Depends on Bcl-2 Under Nutrition Stress Conditions
Hai-Dong Xu, Dan Wu, Jin-Hua Gu, Jian-Bin Ge, Jun-Chao Wu, Rong Han, Zhong-Qin Liang, Zheng-Hong Qin
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063232

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism
Luke Gammon, Adrian Biddle, Hannah K. Heywood, Anne C. Johannessen, Ian C. Mackenzie
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062493

HIF-1α promotes cap-dependent translation of selective mRNAs by upregulating eIF4E1 in breast cancer cells under hypoxia conditions
Tingfang Yi, Evangelos Papadopoulos, and Gerhard Wagner
http://www.jbc.org/cgi/content/abstract/M113.471466v1

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Amino acids / mTOR / TSC / Rheb / AMPK
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A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
Liron Bar-Peled, Lynne Chantranupong, Andrew D. Cherniack, Walter W. Chen, Kathleen A. Ottina, Brian C. Grabiner, Eric D. Spear, Scott L. Carter, Matthew Meyerson, and David M. Sabatini
http://www.sciencemag.org/content/340/6136/1100.abstract

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso, Shawn M. Davidson, Rengin G. Soydaner-Azeloglu, Seth J. Parker, Jurre J. Kamphorst, Sean Hackett, Elda Grabocka, Michel Nofal, Jeffrey A. Drebin, Craig B. Thompson, Joshua D. Rabinowitz, Christian M. Metallo, Matthew G. Vander Heiden & Dafna Bar-Sagi
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12138.html

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1
Nicolas Panchaud, Marie-Pierre Péli-Gulli, and Claudio De Virgilio
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/277/ra42

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status
Su Melser, Etienne Hébert Chatelain, Julie Lavie, Walid Mahfouf, Caroline Jose, Emilie Obre, Susan Goorden, Muriel Priault, Ype Elgersma, Hamid Reza Rezvani, Rodrigue Rossignol, Giovanni Bénard
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00118-6

Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4
Takahide Matsui and Mitsunori Fukuda
http://www.nature.com/embor/journal/v14/n5/abs/embor201332a.html

mTOR kinase structure, mechanism and regulation
Haijuan Yang, Derek G. Rudge, Joseph D. Koos, Bhamini Vaidialingam, Hyo J. Yang & Nikola P. Pavletich
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12122.html

Deregulated G1–S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2
Gabriel M. Gordon, Tianyi Zhang, Jiong Zhao, and Wei Du
http://jcs.biologists.org/content/126/9/2004.abstract.html

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
Anni I. Nieminen, Vilja M. Eskelinen, Heidi M. Haikala, Topi A. Tervonen, Yan Yan, Johanna I. Partanen, and Juha Klefström
http://www.pnas.org/content/110/20/E1839.abstract.html?etoc

Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity
Teresa Rubio, Santiago Vernia, and Pascual Sanz
http://www.molbiolcell.org/content/24/11/1801.abstract?etoc

Inhibition of AMPK Catabolic Action by GSK3
Tsukasa Suzuki, Dave Bridges, Daisuke Nakada, Georgios Skiniotis, Sean J. Morrison, Jiandie D. Lin, Alan R. Saltiel, Ken Inoki
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00250-5

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Anti-metabolic drugs and treatments
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Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose
Miwa, H; Shikami, M; Goto, M; Mizuno, S; Takahashi, M; Tsunekawa-Imai,
N; Ishikawa, T; Mizutani, M; Horio, T; Gotou, M; Yamamoto, H;
Wakabayashi, M; Watarai, M; Hanamura, I; Imamura, A; Mihara, H; Nitta, M
http://www.spandidos-publications.com/or/29/5/2053

Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells.
Liu H, Kurtoglu M, Cao Y, Xi H, Kumar R, Axten JM, Lampidis TJ.
http://link.springer.com/article/10.1007%2Fs00280-013-2193-y

ABT-263 Enhances Sensitivity to Metformin and 2-Deoxyglucose in Pediatric Glioma by Promoting Apoptotic Cell Death
Jane Levesley, Lynette Steele, Claire Taylor, Priyank Sinha, Sean E. Lawler
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0064051

Adipocytes Cause Leukemia Cell Resistance to L-Asparaginase via Release of Glutamine
Ehsan A. Ehsanipour, Xia Sheng, James W. Behan, Xingchao Wang, Anna Butturini, Vassilios I. Avramis, and Steven D. Mittelman
http://cancerres.aacrjournals.org/content/73/10/2998.abstract.html

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Lipids
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An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Kevin J. Williams, Joseph P. Argus, Yue Zhu, Moses Q. Wilks, Beth N. Marbois, Autumn G. York, Yoko Kidani, Alexandra L. Pourzia, David Akhavan, Dominique N. Lisiero, Evangelia Komisopoulou, Amy H. Henkin, Horacio Soto, Brian T. Chamberlain, Laurent Vergnes, Michael E. Jung, Jorge Z. Torres, Linda M. Liau, Heather R. Christofk, Robert M. Prins, Paul S. Mischel, Karen Reue, Thomas G. Graeber, and Steven J. Bensinger
http://cancerres.aacrjournals.org/content/73/9/2850.abstract.html

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
Regina M. Young, Daniel Ackerman, Zachary L. Quinn, Anthony Mancuso, Michaela Gruber, Liping Liu, Dionysios N. Giannoukos, Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, Brian Keith, and M. Celeste Simon
http://genesdev.cshlp.org/content/27/10/1115.abstract.html

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
Jurre J. Kamphorst, Justin R. Cross, Jing Fan, Elisa de Stanchina, Robin Mathew, Eileen P. White, Craig B. Thompson, and Joshua D. Rabinowitz
http://www.pnas.org/content/110/22/8882.abstract.html?etoc

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Miscellaneous
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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Jaeseok Han, Sung Hoon Back, Junguk Hur, Yu-Hsuan Lin, Robert Gildersleeve, Jixiu Shan, Celvie L. Yuan, Dawid Krokowski, Shiyu Wang, Maria Hatzoglou, Michael S. Kilberg, Maureen A. Sartor and Randal J. Kaufman
http://www.nature.com/ncb/journal/v15/n5/full/ncb2738.html

Protein-Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation
Ahmed Bettaieb, Jesse Bakke, Naoto Nagata, Kosuke Matsuo, Yannan Xi, Siming Liu, Daniel AbouBechara, Ramzi Melhem, Kimber Stanhope, Bethany Cummings, James Graham, Andrew Bremer, Sheng Zhang, Costas A. Lyssiotis, Zhong-Yin Zhang, Lewis C. Cantley, Peter J. Havel, and Fawaz G. Haj
http://www.jbc.org/cgi/content/abstract/M112.441469v1

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Reviews
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Regulation of mTORC1 and its impact on gene expression at a glance
Mathieu Laplante and David M. Sabatini
http://jcs.biologists.org/content/126/8/1713.full.html

The Emerging “Hallmarks” of Metabolic Reprogramming and Immune Evasion: Distinct or Linked?
Irina Kareva and Philip Hahnfeldt
http://cancerres.aacrjournals.org/content/73/9/2737.abstract.html?etoc

Antagonism between FOXO and MYC Regulates Cellular Powerhouse
Barrie Peck, Emma C. Ferber, and Almut Schulze
http://www.frontiersin.org/molecular_and_cellular_oncology/10.3389/fonc.2013.00096/full

A Tale of Metabolites: The Cross-Talk between Chromatin and Energy Metabolism
Barbara Martinez-Pastor, Claudia Cosentino, and Raul Mostoslavsky
http://cancerdiscovery.aacrjournals.org/content/3/5/497.abstract.html

AMPK: A Contextual Oncogene or Tumor Suppressor?
Jiyong Liang and Gordon B. Mills
http://cancerres.aacrjournals.org/content/73/10/2929.abstract.html

miRNAs link metabolic reprogramming to oncogenesis
Maria Hatziapostolou, Christos Polytarchou, and Dimitrios Iliopoulos
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(13)00049-0

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Comments
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mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis
Gwen R. Buel, Sang Gyun Kim, John Blenis
http://www.sciencedirect.com/science/article/pii/S1550413113001617

GATORs Take a Bite Out of mTOR
Reuben J. Shaw
http://www.sciencemag.org/content/340/6136/1056.short

Silencing a Metabolic Oncogene
Jiyeon Kim and Ralph J. DeBerardinis
http://www.sciencemag.org/content/340/6132/558.short

Adenosine: Essential for Life but Licensed to Kill
Vivian Gama, Mohanish Deshmukh
http://www.sciencedirect.com/science/article/pii/S1097276513003250

Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors
Christopher J. Pirozzi, Zachary J. Reitman, Hai Yan
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00188-8

Metabolism: Glutamine connections
http://www.nature.com/nrc/journal/v13/n5/full/nrc3515.html

Surviving Glutamine Deprivation
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/273/ec100

mTORC1 Stimulates Glutamine Metabolism
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/276/ec112

Oncogenic BRAF Triggers Metabolic Reprogramming in Melanoma
http://cancerdiscovery.aacrjournals.org/content/3/5/OF15.abstract.html

SIRT4 Controls the Cellular Metabolic Response to DNA Damage
http://cancerdiscovery.aacrjournals.org/content/3/5/480.1.abstract.html

KRAS Reprograms Glutamine Metabolism in Pancreatic Cancer
http://cancerdiscovery.aacrjournals.org/content/3/5/483.1.abstract.html

The PP2A Subunit B55α Controls Adaption to Glutamine Deprivation
http://cancerdiscovery.aacrjournals.org/content/3/5/OF16.abstract.html

Primed to Die. By inducing a low-affinity adenosine receptor, p53 poises cells for death in response to stresses that increase extracellular adenosine.
http://app.aaas-science.org/e/er?s=1906&lid=30415&elq=1ed54e8643fd451b977862b4f4ff0d35

Metabolism: Putting energy into mitophagy
http://www.nature.com/nrm/journal/v14/n6/full/nrm3586.html

Therapeutics: Targeting an oncometabolite
http://www.nature.com/nrc/journal/v13/n6/full/nrc3531.html

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ApoList – May 2013

Posted by cris on June 2, 2013

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Bcl-2 family proteins
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BID-induced structural changes in BAK promote apoptosis
Tudor Moldoveanu, Christy R Grace, Fabien Llambi, Amanda Nourse, Patrick Fitzgerald, Kalle Gehring, Richard W Kriwacki & Douglas R Green
http://www.nature.com/nsmb/journal/v20/n5/full/nsmb.2563.html

Intracellular localization of the BCL-2 family member BOK and functional implications
N Echeverry, D Bachmann, F Ke, A Strasser, H U Simon and T Kaufmann
http://www.nature.com/cdd/journal/v20/n6/abs/cdd201310a.html

Deacetylation of p53 induces autophagy by suppressing Bmf expression.
Contreras AU, Mebratu Y, Delgado M, Montano G, Hu CA, Ryter SW, Choi AM, Lin Y, Xiang J, Chand H, Tesfaigzi Y.
http://jcb.rupress.org/content/201/3/427.long

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa
Liz J. Valente, Daniel H.D. Gray, Ewa M. Michalak, Josefina Pinon-Hofbauer, Alex Egle, Clare L. Scott, Ana Janic, Andreas Strasser
http://www.cell.com/cell-reports/abstract/S2211-1247(13)00228-3

Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation
I Garcia, A J Crowther, V Gama, C Ryan Miller, M Deshmukh and T R Gershon
http://www.nature.com/onc/journal/v32/n18/abs/onc2012248a.html

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
Anni I. Nieminen, Vilja M. Eskelinen, Heidi M. Haikala, Topi A. Tervonen, Yan Yan, Johanna I. Partanen, and Juha Klefström
http://www.pnas.org/content/110/20/E1839.abstract.html?etoc

An Interaction between Bcl-xL and VDAC Promotes Mitochondrial Ca2+ Uptake
Huiya Huang, Xiangxin Hu, Colins O. Eno, Guoping Zhao, Chi Li, and Carl White
http://www.jbc.org/cgi/content/abstract/M112.448290v1

The BH3-Only SNARE BNip1 Mediates Photoreceptor Apoptosis in Response to Vesicular Fusion Defects
Yuko Nishiwaki, Asuka Yoshizawa, Yutaka Kojima, Eri Oguri, Shohei Nakamura, Shohei Suzuki, Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Toshiaki Mochizuki, Ichiro Masai
http://www.pnas.org/content/110/22/8882.abstract.html?etoc

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Caspases and IAPs
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Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
Nathan D. Thomsen, James T. Koerber, and James A. Wells
http://www.pnas.org/content/110/21/8477.abstract.html?etoc

A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart
Junmei Ye, Miriam Llorian, Maria Cardona, Anthony Rongvaux, Rana S. Moubarak, Joan X. Comella, Rhonda Bassel-Duby, Richard A. Flavell, Eric N. Olson, Christopher W. J. Smith, and Daniel Sanchis
http://jcs.biologists.org/content/126/7/1682.abstract.html

Caspase-3 Is Involved in the Signalling in Erythroid Differentiation by Targeting Late Progenitors
Daniela Boehm, Christelle Mazurier, Marie-Catherine Giarratana, Dhouha Darghouth, Anne-Marie Faussat, Laurence Harmand, Luc Douay
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062303

MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells
Y Xie, L A Tobin, J Camps, D Wangsa, J Yang, M Rao, E Witasp, K S Awad, N Yoo, T Ried and K F Kwong
http://www.nature.com/onc/journal/v32/n19/full/onc2012258a.html

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning
Corey L. Cusack, Vijay Swahari, W. Hampton Henley, J. Michael Ramsey and Mohanish Deshmukh
http://www.nature.com/ncomms/journal/v4/n5/abs/ncomms2910.html

XIAP regulation of cyclin D1 expression and cancer cell anchorage-independent growth via Its E3 ligase-mediated protein phosphatase 2A/C-Jun axis
Zipeng Cao, Ruowen Zhang, Jingxia Li, Haishan Huang, Dongyun Zhang, Jingjie Zhang, Jimin Gao, Jingyuan Chen, and Chuanshu Huang
http://www.jbc.org/cgi/content/abstract/M112.448365v1

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Miscellaneous
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Extracellular Adenosine Sensing-A Metabolic Cell Death Priming Mechanism Downstream of p53
Jaclyn S. Long, Diane Crighton, James O’Prey, Gillian MacKay, Liang Zheng, Timothy M. Palmer, Eyal Gottlieb, Kevin M. Ryan
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00220-7

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation
Gabriel Leprivier, Marc Remke, Barak Rotblat, Adrian Dubuc, Abigail-Rachele F. Mateo, Marcel Kool, Sameer Agnihotri, Amal El-Naggar, Bin Yu, Syam Prakash Somasekharan, Brandon Faubert, Gaëlle Bridon, Cristina E. Tognon, Joan Mathers, Ryan Thomas, Amy Li, Adi Barokas, Brian Kwok, Mary Bowden, Stephanie Smith, Xiaochong Wu, Andrey Korshunov, Thomas Hielscher, Paul A. Northcott, Jason D. Galpin, Christopher A. Ahern, Ye Wang, Martin G. McCabe, V. Peter Collins, Russell G. Jones, Michael Pollak, Olivier Delattre, Martin E. Gleave, Eric Jan, Stefan M. Pfister, Christopher G. Proud, W. Brent Derry, Michael D. Taylor, Poul H. Sorensen
http://www.cell.com/abstract/S0092-8674(13)00532-1

Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2
Maurício F. M. Machado, Marcelo F. Marcondes, Maria A. Juliano, Karen McLuskey, Jeremy C. Mottram, Catherine X. Moss, Luiz Juliano and Vitor Oliveira
http://onlinelibrary.wiley.com/doi/10.1111/febs.12248/abstract

An apoptosis-independent role of SMAC in tumor suppression
W Qiu, H Liu, A Sebastini, Q Sun, H Wang, L Zhang and J Yu
http://www.nature.com/onc/journal/v32/n19/abs/onc2012265a.html

The retinoblastoma protein induces apoptosis directly at the mitochondria
Keren I. Hilgendorf, Elizaveta S. Leshchiner, Simona Nedelcu, Mindy A. Maynard, Eliezer Calo, Alessandra Ianari, Loren D. Walensky, and Jacqueline A. Lees
Genes Dev. 2013; 27: 1003-1015
http://genesdev.cshlp.org/content/27/9/1003.abstract.html

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Reviews / Comments
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Central roles of apoptotic proteins in mitochondrial function
S M Kilbride and J H M Prehn
http://www.nature.com/onc/journal/v32/n22/abs/onc2012348a.html

Lysosomal cell death at a glance
Sonja Aits and Marja Jäättelä
http://jcs.biologists.org/content/126/9/1905.abstract.html

Adenosine: Essential for Life but Licensed to Kill
Vivian Gama, Mohanish Deshmukh
http://www.sciencedirect.com/science/article/pii/S1097276513003250

Multiple Myeloma Cells Require Caspase-10
http://cancerdiscovery.aacrjournals.org/content/3/5/482.2.abstract.html

Targeting death receptors: is this trail still hot?
Rajen Mody
http://www.thetp.org/article/view/1617/2594

Apoptosis: Direct action
http://www.nature.com/nrc/journal/v13/n6/full/nrc3544.html

Tumor Suppression by p53: Is Apoptosis Important or Not?
Hestia Mellert, Joaquín M. Espinosa
http://www.cell.com/cell-reports/abstract/S2211-1247(13)00228-3

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Dedicated to the memory of Enrique Pérez Payá (1962-2013)

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