ApoList – April 2013

Non-apoptotic cell death

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
Laurence Lamy, Vu N. Ngo, N.C. Tolga Emre, Arthur L. Shaffer, Yandan Yang, Erming Tian, Vinod Nair, Michael J. Kruhlak, Adriana Zingone, Ola Landgren, Louis M. Staudt

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species
Francisco J. Roca, Lalita Ramakrishnan

Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroptosis
Jian Zou, Taro Kawai, Tetsuo Tsuchida, Tatsuya Kozaki, Hiroki Tanaka, Kyung-Sue Shin, Himanshu Kumar, Shizuo Akira

Alternative Germ Cell Death Pathway in Drosophila Involves HtrA2/Omi, Lysosomes, and a Caspase-9 Counterpart
Keren Yacobi-Sharon, Yuval Namdar, Eli Arama

Dimers of mitochondrial ATP synthase form the permeability transition pore
Valentina Giorgio, Sophia von Stockum, Manuela Antoniel, Astrid Fabbro, Federico Fogolari, Michael Forte, Gary D. Glick, Valeria Petronilli, Mario Zoratti, Ildikó Szabó, Giovanna Lippe, and Paolo Bernardi

Bcl-2 family proteins

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation
R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu and L Zhang

BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins
Levi J. Beverly, Lauren A. Howell, Maria Hernandez Corbacho, Lavona Casson, Jerry E. Chipuk and Leah J. Siskind

BNIP3 acts as transcriptional repressor of death receptor-5 expression and prevents TRAIL-induced cell death in gliomas
T R Burton, E S Henson, M B Azad, M Brown, D D Eisenstat and S B Gibson

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death
C Moran, A Sanz-Rodriguez, A Jimenez-Pacheco, J Martinez-Villareal, R C McKiernan, E M Jimenez-Mateos, C Mooney, I Woods, J H M Prehn, D C Henshall and T Engel

Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors
Sabine Pietkiewicz, Dennis Sohn, Roland P. Piekorz, Susanne Grether-Beck, Wilfried Budach, Kanaga Sabapathy, Reiner U. Jänicke

pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737
J Bertin-Ciftci, B Barré, J Le Pen, L Maillet, C Couriaud, P Juin and F Braun

Reconstitution of the Anti-Apoptotic Bcl-2 Protein into Lipid Membranes and Biophysical Evidence for Its Detergent-Driven Association with the Pro-Apoptotic Bax Protein
Marcus Wallgren, Martin Lidman, Anders Pedersen, Kristoffer Brännström, B. Göran Karlsson, Gerhard Gröbner

Caspases and phagocytosis

Caspase-1 activation is protective against hepatocyte cell death by up-regulating beclin1 and mitochondrial autophagy in the setting of redox stress
Qian Sun, Wentao Gao, Patricia Loughran, Rick Shapiro, Jie Fan, Timothy R. Billiar, and Melanie J. Scott

Proteolytic Processing of Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9
Qi Hu, Di Wu, Wen Chen, Zhen Yan, and Yigong Shi

Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy
Issam Arrouss, Fariba Nemati, Fernando Roncal, Marie Wislez, Karim Dorgham, David Vallerand, Nathalie Rabbe, Narjesse Karboul, Françoise Carlotti, Jeronimo Bravo, Dominique Mazier, Didier Decaudin, Angelita Rebollo

A Novel Cell Lysis Approach Reveals That Caspase-2 Rapidly Translocates from the Nucleus to the Cytoplasm in Response to Apoptotic Stimuli
Alexander A. Tinnikov, Herbert H. Samuels

Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis
Erika Segear Johnson, Kelly R. Lindblom, Alexander Robeson, Robert D. Stevens, Olga R. Ilkayeva, Christopher B. Newgard, Sally Kornbluth, and Joshua L. Andersen

Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response
M H M Melis, K L Simpson, S J Dovedi, A Welman, M MacFarlane, C Dive, J Honeychurch and T M Illidge

Proteasomal regulation of caspase-8 in cancer cell apoptosis
Michael V. Fiandalo, Steven R. Schwarze & Natasha Kyprianou

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
Amelia E. Hochreiter-Hufford, Chang Sup Lee, Jason M. Kinchen, Jennifer D. Sokolowski, Sanja Arandjelovic, Jarrod A. Call, Alexander L. Klibanov, Zhen Yan, James W. Mandell & Kodi S. Ravichandran

Innate recognition of apoptotic cells: novel apoptotic cell-associated molecular patterns revealed by crossreactivity of anti-LPS antibodies
I Tennant, J D Pound, L A Marr, J J L P Willems, S Petrova, C A Ford, M Paterson, A Devitt and C D Gregory


OTUB1 modulates c-IAP1 stability to regulate signalling pathways
Tatiana Goncharov, Kyle Niessen, Maria Cristina de Almagro, Anita Izrael-Tomasevic, Anna V Fedorova, Eugene Varfolomeev, David Arnott, Kurt Deshayes, Donald S Kirkpatrick and Domagoj Vucic

Cytochrome c causes pore formation in cardiolipin-containing membranes
Chris L. Bergstrom, Paul A. Beales, Yang Lv, T. Kyle Vanderlick, and John T. Groves

Genes of the Mitochondrial Apoptotic Pathway in Mytilus galloprovincialis
Noelia Estévez-Calvar, Alejandro Romero, Antonio Figueras, Beatriz Novoa

Apoptosis-like cell death pathways in the unicellular parasite Toxoplasma gondii following treatment with apoptosis inducers and chemotherapeutic agents: a proof-of-concept study
Ayu Dewi Ni Nyoman & Carsten G. K. Lüder


New directions in ER stress-induced cell death
Susan E. Logue, Patricia Cleary, Svetlana Saveljeva & Afshin Samali

CD95 in cancer: tool or target?
Martin-Villalba, Llorens-Bobadilla, and Wollny

Programming cancer cells for high expression levels of Mcl1
Franziska Ertel, Mai Nguyen, Anne Roulston and Gordon C Shore

Shaping organisms with apoptosis
M Suzanne and H Steller


Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You
Richard G. Carroll, Seamus J. Martin

Cell biology: Death brings new life to muscle
Shannon F. Yu, Mary K. Baylies

FAS-Dependent Apoptosis Is Immunogenic