Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for April, 2013

ApoList – April 2013

Posted by cris on April 30, 2013

Non-apoptotic cell death

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
Laurence Lamy, Vu N. Ngo, N.C. Tolga Emre, Arthur L. Shaffer, Yandan Yang, Erming Tian, Vinod Nair, Michael J. Kruhlak, Adriana Zingone, Ola Landgren, Louis M. Staudt

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species
Francisco J. Roca, Lalita Ramakrishnan

Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroptosis
Jian Zou, Taro Kawai, Tetsuo Tsuchida, Tatsuya Kozaki, Hiroki Tanaka, Kyung-Sue Shin, Himanshu Kumar, Shizuo Akira

Alternative Germ Cell Death Pathway in Drosophila Involves HtrA2/Omi, Lysosomes, and a Caspase-9 Counterpart
Keren Yacobi-Sharon, Yuval Namdar, Eli Arama

Dimers of mitochondrial ATP synthase form the permeability transition pore
Valentina Giorgio, Sophia von Stockum, Manuela Antoniel, Astrid Fabbro, Federico Fogolari, Michael Forte, Gary D. Glick, Valeria Petronilli, Mario Zoratti, Ildikó Szabó, Giovanna Lippe, and Paolo Bernardi

Bcl-2 family proteins

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation
R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu and L Zhang

BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins
Levi J. Beverly, Lauren A. Howell, Maria Hernandez Corbacho, Lavona Casson, Jerry E. Chipuk and Leah J. Siskind

BNIP3 acts as transcriptional repressor of death receptor-5 expression and prevents TRAIL-induced cell death in gliomas
T R Burton, E S Henson, M B Azad, M Brown, D D Eisenstat and S B Gibson

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death
C Moran, A Sanz-Rodriguez, A Jimenez-Pacheco, J Martinez-Villareal, R C McKiernan, E M Jimenez-Mateos, C Mooney, I Woods, J H M Prehn, D C Henshall and T Engel

Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors
Sabine Pietkiewicz, Dennis Sohn, Roland P. Piekorz, Susanne Grether-Beck, Wilfried Budach, Kanaga Sabapathy, Reiner U. Jänicke

pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737
J Bertin-Ciftci, B Barré, J Le Pen, L Maillet, C Couriaud, P Juin and F Braun

Reconstitution of the Anti-Apoptotic Bcl-2 Protein into Lipid Membranes and Biophysical Evidence for Its Detergent-Driven Association with the Pro-Apoptotic Bax Protein
Marcus Wallgren, Martin Lidman, Anders Pedersen, Kristoffer Brännström, B. Göran Karlsson, Gerhard Gröbner

Caspases and phagocytosis

Caspase-1 activation is protective against hepatocyte cell death by up-regulating beclin1 and mitochondrial autophagy in the setting of redox stress
Qian Sun, Wentao Gao, Patricia Loughran, Rick Shapiro, Jie Fan, Timothy R. Billiar, and Melanie J. Scott

Proteolytic Processing of Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9
Qi Hu, Di Wu, Wen Chen, Zhen Yan, and Yigong Shi

Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy
Issam Arrouss, Fariba Nemati, Fernando Roncal, Marie Wislez, Karim Dorgham, David Vallerand, Nathalie Rabbe, Narjesse Karboul, Françoise Carlotti, Jeronimo Bravo, Dominique Mazier, Didier Decaudin, Angelita Rebollo

A Novel Cell Lysis Approach Reveals That Caspase-2 Rapidly Translocates from the Nucleus to the Cytoplasm in Response to Apoptotic Stimuli
Alexander A. Tinnikov, Herbert H. Samuels

Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis
Erika Segear Johnson, Kelly R. Lindblom, Alexander Robeson, Robert D. Stevens, Olga R. Ilkayeva, Christopher B. Newgard, Sally Kornbluth, and Joshua L. Andersen

Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response
M H M Melis, K L Simpson, S J Dovedi, A Welman, M MacFarlane, C Dive, J Honeychurch and T M Illidge

Proteasomal regulation of caspase-8 in cancer cell apoptosis
Michael V. Fiandalo, Steven R. Schwarze & Natasha Kyprianou

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
Amelia E. Hochreiter-Hufford, Chang Sup Lee, Jason M. Kinchen, Jennifer D. Sokolowski, Sanja Arandjelovic, Jarrod A. Call, Alexander L. Klibanov, Zhen Yan, James W. Mandell & Kodi S. Ravichandran

Innate recognition of apoptotic cells: novel apoptotic cell-associated molecular patterns revealed by crossreactivity of anti-LPS antibodies
I Tennant, J D Pound, L A Marr, J J L P Willems, S Petrova, C A Ford, M Paterson, A Devitt and C D Gregory


OTUB1 modulates c-IAP1 stability to regulate signalling pathways
Tatiana Goncharov, Kyle Niessen, Maria Cristina de Almagro, Anita Izrael-Tomasevic, Anna V Fedorova, Eugene Varfolomeev, David Arnott, Kurt Deshayes, Donald S Kirkpatrick and Domagoj Vucic

Cytochrome c causes pore formation in cardiolipin-containing membranes
Chris L. Bergstrom, Paul A. Beales, Yang Lv, T. Kyle Vanderlick, and John T. Groves

Genes of the Mitochondrial Apoptotic Pathway in Mytilus galloprovincialis
Noelia Estévez-Calvar, Alejandro Romero, Antonio Figueras, Beatriz Novoa

Apoptosis-like cell death pathways in the unicellular parasite Toxoplasma gondii following treatment with apoptosis inducers and chemotherapeutic agents: a proof-of-concept study
Ayu Dewi Ni Nyoman & Carsten G. K. Lüder


New directions in ER stress-induced cell death
Susan E. Logue, Patricia Cleary, Svetlana Saveljeva & Afshin Samali

CD95 in cancer: tool or target?
Martin-Villalba, Llorens-Bobadilla, and Wollny

Programming cancer cells for high expression levels of Mcl1
Franziska Ertel, Mai Nguyen, Anne Roulston and Gordon C Shore

Shaping organisms with apoptosis
M Suzanne and H Steller


Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You
Richard G. Carroll, Seamus J. Martin

Cell biology: Death brings new life to muscle
Shannon F. Yu, Mary K. Baylies

FAS-Dependent Apoptosis Is Immunogenic


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ApoList – March 2013

Posted by cris on April 2, 2013


Bcl-2 family proteins

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming
Barbara Schellenberg, Pengbo Wang, James A. Keeble, Ricardo Rodriguez-Enriquez, Scott Walker, Thomas W. Owens, Fiona Foster, Jolanta Tanianis-Hughes, Keith Brennan, Charles H. Streuli, Andrew P. Gilmore

Direct activation of full-length proapoptotic BAK
Elizaveta S. Leshchiner, Craig R. Braun, Gregory H. Bird, and Loren D. Walensky

Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma
Lei He, Kristine Torres-Lockhart, Nicole Forster, Saranya Ramakrishnan, Patricia Greninger, Mathew J. Garnett, Ultan McDermott, Stephen M. Rothenberg, Cyril H. Benes, and Leif W. Ellisen

Behavior of Solvent-Exposed Hydrophobic Groove in the Anti-Apoptotic Bcl-XL Protein: Clues for Its Ability to Bind Diverse BH3 Ligands from MD Simulations
Dilraj Lama, Vivek Modi, Ramasubbu Sankararamakrishnan

Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells
Sudjit Luanpitpong, Pithi Chanvorachote, Christian Stehlik, William Tse, Patrick S. Callery, Liying Wang, and Yon Rojanasakul

Sirtuin-3 modulates Bak- and Bax-dependent apoptosis
Manish Verma, Nataly Shulga, and John G. Pastorino

ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia
Cassandra J. Vandenberg and Suzanne Cory

PUMA and BIM Are Required for Oncogene Inactivation–Induced Apoptosis
Gregory R. Bean, Yogesh Tengarai Ganesan, Yiyu Dong, Shugaku Takeda, Han Liu, Po M. Chan, Yafen Huang, Lewis A. Chodosh, Gerard P. Zambetti, James J.-D. Hsieh, and Emily H.-Y. Cheng

Death receptor pathway

The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion
Antonio García Blesa, Mikolaj Klossowicz, Carmen López Osuna, Mario Martínez Florensa, Bernard Malissen, Francisco J. García Cózar, Arkadiusz Miazek and Enrique Aguado

TNFα induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway
F Marques-Fernandez, L Planells-Ferrer, R Gozzelino, K MO Galenkamp, S Reix, N Llecha-Cano, J Lopez-Soriano, V J Yuste, R S Moubarak and J X Comella

mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Liqun Zhao, Ping Yue, Fadlo R. Khuri, and Shi-Yong Sun

Novel phosphorylation and ubiquitination sites regulate ROS-dependent degradation of anti-apoptotic c-FLIP protein
Rachel Wilkie-Grantham, Shu-Ichi Matsuzawa, and John C. Reed

FcμR (Toso/Faim3) is not an inhibitor of Fas-mediated cell death in mouse T and B cells
Rika Ouchida, Hiromi Mori, Hiroshi Ohno, and Ji-Yang Wang

IAPs and caspases

Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis
J Beaudouin, C Liesche, S Aschenbrenner, M Hörner and R Eils

Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase
Yoshio Nakatani, Torsten Kleffmann, Katrin Linke, Stephen M. Condon, Mark G. Hinds and Catherine L. Day

New types of metacaspases in phytoplankton reveal diverse origins of cell death proteases
C J Choi and J A Berges

Role of caspase-1 in regulation of triglyceride metabolism
Maya E. Kotas, Michael J. Jurczak, Charles Annicelli, Matthew P. Gillum, Gary W. Cline, Gerald I. Shulman, and Ruslan Medzhitov

The E. coli Effector Protein NleF Is a Caspase Inhibitor
Sonja Blasche, Mario Mörtl, Holger Steuber, Gabriella Siszler, Shahista Nisa, Frank Schwarz, Inna Lavrik, Thomas M. A. Gronewold, Klaus Maskos, Michael S. Donnenberg, Dirk Ullmann, Peter Uetz, Manfred Kögl

Apoptotic microtubules delimit an active caspase free area in the cellular cortex during the execution phase of apoptosis
M Oropesa-Ávila, A Fernández-Vega, M de la Mata, J G Maraver, M D Cordero, D Cotán, M de Miguel, C P Calero, M V Paz, A D Pavón, M A Sánchez, A P Zaderenko, P Ybot-González and J A Sánchez-Alcázar


Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage
F J Bock, G Krumschnabel, C Manzl, L Peintner, M C Tanzer, N Hermann-Kleiter, G Baier, L Llacuna, J Yelamos and A Villunger

Myosin phosphatase is inactivated by caspase-3 cleavage and phosphorylation of myosin phosphatase targeting subunit 1 during apoptosis
Takahiro Iwasaki, Takeshi Katayama, Kazuhiro Kohama, Yaeta Endo, and Tatsuya Sawasaki

Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins, SMAC, HtrA2 and ARTS
Jung-bin Kim, So Youn Kim, Byeongmo Kim, Hunjin Lee, Insook Kim, Jeanho Yun, Yejin Jo, Taeheun Oh, Yongsam Jo, Hee-Don Chae, and Deug Y. Shin

Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium
Mei Shi, Tian Zhang, Lei Sun, Yan Luo, De-Hua Liu, Shu-Tao Xie, Xiao-Yan Song, Guo-Fan Wang, Xiu-Lan Chen, Bai-Cheng Zhou & Yu-Zhong Zhang

Live fluorescence and transmission-through-dye microscopic study of actinomycin D-induced apoptosis and apoptotic volume decrease
Neda R. Kasim, Kate?ina Kuželová, Aleš Holoubek & Michael A. Model

Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in Caenorhabditis elegans
Daniel P. Denning, Victoria Hatch, H. Robert Horvitz


ABT-199 Clinical Trial Suspended (Updated)

BCL-2–Selective Inhibitors Spare Platelets

BIM, PUMA, and the Achilles’ Heel of Oncogene Addiction
Anne Roulston, William J. Muller, and Gordon C. Shore

BAX Mitochondrial Translocation Is Constitutive and Dynamic


Getting away with murder: how does the BCL-2 family of proteins kill with immunity?
Thibaud T. Renault, Jerry E. Chipuk

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics
L Y Dimberg, C K Anderson, R Camidge, K Behbakht, A Thorburn and H L Ford


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