Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for April, 2013

ApoList – April 2013

Posted by cris on April 30, 2013

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Non-apoptotic cell death
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Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
Laurence Lamy, Vu N. Ngo, N.C. Tolga Emre, Arthur L. Shaffer, Yandan Yang, Erming Tian, Vinod Nair, Michael J. Kruhlak, Adriana Zingone, Ola Landgren, Louis M. Staudt
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00073-1

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species
Francisco J. Roca, Lalita Ramakrishnan
http://www.cell.com/abstract/S0092-8674(13)00344-9

Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroptosis
Jian Zou, Taro Kawai, Tetsuo Tsuchida, Tatsuya Kozaki, Hiroki Tanaka, Kyung-Sue Shin, Himanshu Kumar, Shizuo Akira
http://www.cell.com/immunity/abstract/S1074-7613(13)00154-4

Alternative Germ Cell Death Pathway in Drosophila Involves HtrA2/Omi, Lysosomes, and a Caspase-9 Counterpart
Keren Yacobi-Sharon, Yuval Namdar, Eli Arama
http://www.cell.com/developmental-cell/abstract/S1534-5807(13)00095-6

Dimers of mitochondrial ATP synthase form the permeability transition pore
Valentina Giorgio, Sophia von Stockum, Manuela Antoniel, Astrid Fabbro, Federico Fogolari, Michael Forte, Gary D. Glick, Valeria Petronilli, Mario Zoratti, Ildikó Szabó, Giovanna Lippe, and Paolo Bernardi
http://www.pnas.org/content/110/15/5887.abstract.html?etoc

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Bcl-2 family proteins
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Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation
R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu and L Zhang
http://www.nature.com/cdd/journal/v20/n5/abs/cdd20134a.html

BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins
Levi J. Beverly, Lauren A. Howell, Maria Hernandez Corbacho, Lavona Casson, Jerry E. Chipuk and Leah J. Siskind
http://www.biochemj.org/bj/452/bj4520111.htm

BNIP3 acts as transcriptional repressor of death receptor-5 expression and prevents TRAIL-induced cell death in gliomas
T R Burton, E S Henson, M B Azad, M Brown, D D Eisenstat and S B Gibson
http://www.nature.com/cddis/journal/v4/n4/abs/cddis2013100a.html

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death
C Moran, A Sanz-Rodriguez, A Jimenez-Pacheco, J Martinez-Villareal, R C McKiernan, E M Jimenez-Mateos, C Mooney, I Woods, J H M Prehn, D C Henshall and T Engel
http://www.nature.com/cddis/journal/v4/n4/abs/cddis2013136a.html

Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors
Sabine Pietkiewicz, Dennis Sohn, Roland P. Piekorz, Susanne Grether-Beck, Wilfried Budach, Kanaga Sabapathy, Reiner U. Jänicke
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061438

pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737
J Bertin-Ciftci, B Barré, J Le Pen, L Maillet, C Couriaud, P Juin and F Braun
http://www.nature.com/cdd/journal/v20/n5/abs/cdd20136a.html

Reconstitution of the Anti-Apoptotic Bcl-2 Protein into Lipid Membranes and Biophysical Evidence for Its Detergent-Driven Association with the Pro-Apoptotic Bax Protein
Marcus Wallgren, Martin Lidman, Anders Pedersen, Kristoffer Brännström, B. Göran Karlsson, Gerhard Gröbner
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061452

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Caspases and phagocytosis
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Caspase-1 activation is protective against hepatocyte cell death by up-regulating beclin1 and mitochondrial autophagy in the setting of redox stress
Qian Sun, Wentao Gao, Patricia Loughran, Rick Shapiro, Jie Fan, Timothy R. Billiar, and Melanie J. Scott
http://www.jbc.org/cgi/content/abstract/M112.426791v1

Proteolytic Processing of Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9
Qi Hu, Di Wu, Wen Chen, Zhen Yan, and Yigong Shi
http://www.jbc.org/cgi/content/abstract/M112.441568v1

Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy
Issam Arrouss, Fariba Nemati, Fernando Roncal, Marie Wislez, Karim Dorgham, David Vallerand, Nathalie Rabbe, Narjesse Karboul, Françoise Carlotti, Jeronimo Bravo, Dominique Mazier, Didier Decaudin, Angelita Rebollo
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060816

A Novel Cell Lysis Approach Reveals That Caspase-2 Rapidly Translocates from the Nucleus to the Cytoplasm in Response to Apoptotic Stimuli
Alexander A. Tinnikov, Herbert H. Samuels
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061085

Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis
Erika Segear Johnson, Kelly R. Lindblom, Alexander Robeson, Robert D. Stevens, Olga R. Ilkayeva, Christopher B. Newgard, Sally Kornbluth, and Joshua L. Andersen
http://www.jbc.org/cgi/content/abstract/M112.437210v1

Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response
M H M Melis, K L Simpson, S J Dovedi, A Welman, M MacFarlane, C Dive, J Honeychurch and T M Illidge
http://www.nature.com/cdd/journal/v20/n5/abs/cdd20138a.html

Proteasomal regulation of caspase-8 in cancer cell apoptosis
Michael V. Fiandalo, Steven R. Schwarze & Natasha Kyprianou
http://link.springer.com/article/10.1007/s10495-013-0821-y

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
Amelia E. Hochreiter-Hufford, Chang Sup Lee, Jason M. Kinchen, Jennifer D. Sokolowski, Sanja Arandjelovic, Jarrod A. Call, Alexander L. Klibanov, Zhen Yan, James W. Mandell & Kodi S. Ravichandran
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12135.html

Innate recognition of apoptotic cells: novel apoptotic cell-associated molecular patterns revealed by crossreactivity of anti-LPS antibodies
I Tennant, J D Pound, L A Marr, J J L P Willems, S Petrova, C A Ford, M Paterson, A Devitt and C D Gregory
http://www.nature.com/cdd/journal/v20/n5/abs/cdd2012165a.html

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Miscellaneous
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OTUB1 modulates c-IAP1 stability to regulate signalling pathways
Tatiana Goncharov, Kyle Niessen, Maria Cristina de Almagro, Anita Izrael-Tomasevic, Anna V Fedorova, Eugene Varfolomeev, David Arnott, Kurt Deshayes, Donald S Kirkpatrick and Domagoj Vucic
http://www.nature.com/emboj/journal/v32/n8/full/emboj201362a.html

Cytochrome c causes pore formation in cardiolipin-containing membranes
Chris L. Bergstrom, Paul A. Beales, Yang Lv, T. Kyle Vanderlick, and John T. Groves
http://www.pnas.org/content/110/16/6269.abstract.html?etoc

Genes of the Mitochondrial Apoptotic Pathway in Mytilus galloprovincialis
Noelia Estévez-Calvar, Alejandro Romero, Antonio Figueras, Beatriz Novoa
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061502

Apoptosis-like cell death pathways in the unicellular parasite Toxoplasma gondii following treatment with apoptosis inducers and chemotherapeutic agents: a proof-of-concept study
Ayu Dewi Ni Nyoman & Carsten G. K. Lüder
http://link.springer.com/article/10.1007/s10495-013-0832-8

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Reviews
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New directions in ER stress-induced cell death
Susan E. Logue, Patricia Cleary, Svetlana Saveljeva & Afshin Samali
http://link.springer.com/article/10.1007/s10495-013-0818-6

CD95 in cancer: tool or target?
Martin-Villalba, Llorens-Bobadilla, and Wollny
http://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(13)00042-7

Programming cancer cells for high expression levels of Mcl1
Franziska Ertel, Mai Nguyen, Anne Roulston and Gordon C Shore
http://www.nature.com/embor/journal/v14/n4/full/embor201320a.html

Shaping organisms with apoptosis
M Suzanne and H Steller
http://www.nature.com/cdd/journal/v20/n5/abs/cdd201311a.html

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Comments
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Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You
Richard G. Carroll, Seamus J. Martin
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00135-9

Cell biology: Death brings new life to muscle
Shannon F. Yu, Mary K. Baylies
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12097.html

FAS-Dependent Apoptosis Is Immunogenic
http://cancerdiscovery.aacrjournals.org/content/3/4/OF12.abstract.html

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ApoList – March 2013

Posted by cris on April 2, 2013

 

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Bcl-2 family proteins
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Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming
Barbara Schellenberg, Pengbo Wang, James A. Keeble, Ricardo Rodriguez-Enriquez, Scott Walker, Thomas W. Owens, Fiona Foster, Jolanta Tanianis-Hughes, Keith Brennan, Charles H. Streuli, Andrew P. Gilmore
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00034-8

Direct activation of full-length proapoptotic BAK
Elizaveta S. Leshchiner, Craig R. Braun, Gregory H. Bird, and Loren D. Walensky
http://www.pnas.org/content/110/11/E986.abstract.html?etoc

Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma
Lei He, Kristine Torres-Lockhart, Nicole Forster, Saranya Ramakrishnan, Patricia Greninger, Mathew J. Garnett, Ultan McDermott, Stephen M. Rothenberg, Cyril H. Benes, and Leif W. Ellisen
http://cancerdiscovery.aacrjournals.org/content/3/3/324.abstract.html

Behavior of Solvent-Exposed Hydrophobic Groove in the Anti-Apoptotic Bcl-XL Protein: Clues for Its Ability to Bind Diverse BH3 Ligands from MD Simulations
Dilraj Lama, Vivek Modi, Ramasubbu Sankararamakrishnan
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054397

Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells
Sudjit Luanpitpong, Pithi Chanvorachote, Christian Stehlik, William Tse, Patrick S. Callery, Liying Wang, and Yon Rojanasakul
http://www.molbiolcell.org/content/24/6/858.abstract?etoc

Sirtuin-3 modulates Bak- and Bax-dependent apoptosis
Manish Verma, Nataly Shulga, and John G. Pastorino
http://jcs.biologists.org/content/126/1/274.abstract.html

ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia
Cassandra J. Vandenberg and Suzanne Cory
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/121/12/2285

PUMA and BIM Are Required for Oncogene Inactivation–Induced Apoptosis
Gregory R. Bean, Yogesh Tengarai Ganesan, Yiyu Dong, Shugaku Takeda, Han Liu, Po M. Chan, Yafen Huang, Lewis A. Chodosh, Gerard P. Zambetti, James J.-D. Hsieh, and Emily H.-Y. Cheng
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/268/ra20

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Death receptor pathway
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The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion
Antonio García Blesa, Mikolaj Klossowicz, Carmen López Osuna, Mario Martínez Florensa, Bernard Malissen, Francisco J. García Cózar, Arkadiusz Miazek and Enrique Aguado
http://www.biochemj.org/bj/450/bj4500511.htm

TNFα induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway
F Marques-Fernandez, L Planells-Ferrer, R Gozzelino, K MO Galenkamp, S Reix, N Llecha-Cano, J Lopez-Soriano, V J Yuste, R S Moubarak and J X Comella
http://www.nature.com/cddis/journal/v4/n2/abs/cddis201325a.html

mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Liqun Zhao, Ping Yue, Fadlo R. Khuri, and Shi-Yong Sun
http://cancerres.aacrjournals.org/content/73/6/1946.abstract.html

Novel phosphorylation and ubiquitination sites regulate ROS-dependent degradation of anti-apoptotic c-FLIP protein
Rachel Wilkie-Grantham, Shu-Ichi Matsuzawa, and John C. Reed
http://www.jbc.org/cgi/content/abstract/M112.431320v1

FcμR (Toso/Faim3) is not an inhibitor of Fas-mediated cell death in mouse T and B cells
Rika Ouchida, Hiromi Mori, Hiroshi Ohno, and Ji-Yang Wang
http://bloodjournal.hematologylibrary.org/cgi/content/full/121/12/2368

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IAPs and caspases
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Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis
J Beaudouin, C Liesche, S Aschenbrenner, M Hörner and R Eils
http://www.nature.com/cdd/journal/v20/n4/abs/cdd2012156a.html

Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase
Yoshio Nakatani, Torsten Kleffmann, Katrin Linke, Stephen M. Condon, Mark G. Hinds and Catherine L. Day
http://www.biochemj.org/bj/450/bj4500629.htm

New types of metacaspases in phytoplankton reveal diverse origins of cell death proteases
C J Choi and J A Berges
http://www.nature.com/cddis/journal/v4/n2/abs/cddis201321a.html

Role of caspase-1 in regulation of triglyceride metabolism
Maya E. Kotas, Michael J. Jurczak, Charles Annicelli, Matthew P. Gillum, Gary W. Cline, Gerald I. Shulman, and Ruslan Medzhitov
http://www.pnas.org/content/110/12/4810.abstract.html?etoc

The E. coli Effector Protein NleF Is a Caspase Inhibitor
Sonja Blasche, Mario Mörtl, Holger Steuber, Gabriella Siszler, Shahista Nisa, Frank Schwarz, Inna Lavrik, Thomas M. A. Gronewold, Klaus Maskos, Michael S. Donnenberg, Dirk Ullmann, Peter Uetz, Manfred Kögl
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058937

Apoptotic microtubules delimit an active caspase free area in the cellular cortex during the execution phase of apoptosis
M Oropesa-Ávila, A Fernández-Vega, M de la Mata, J G Maraver, M D Cordero, D Cotán, M de Miguel, C P Calero, M V Paz, A D Pavón, M A Sánchez, A P Zaderenko, P Ybot-González and J A Sánchez-Alcázar
http://www.nature.com/cddis/journal/v4/n3/abs/cddis201358a.html

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Miscellaneous
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Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage
F J Bock, G Krumschnabel, C Manzl, L Peintner, M C Tanzer, N Hermann-Kleiter, G Baier, L Llacuna, J Yelamos and A Villunger
http://www.nature.com/cddis/journal/v4/n2/abs/cddis201325a.html

Myosin phosphatase is inactivated by caspase-3 cleavage and phosphorylation of myosin phosphatase targeting subunit 1 during apoptosis
Takahiro Iwasaki, Takeshi Katayama, Kazuhiro Kohama, Yaeta Endo, and Tatsuya Sawasaki
http://www.molbiolcell.org/content/24/6/748.abstract?etoc

Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins, SMAC, HtrA2 and ARTS
Jung-bin Kim, So Youn Kim, Byeongmo Kim, Hunjin Lee, Insook Kim, Jeanho Yun, Yejin Jo, Taeheun Oh, Yongsam Jo, Hee-Don Chae, and Deug Y. Shin
http://www.jbc.org/cgi/content/abstract/M112.436113v1

Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium
Mei Shi, Tian Zhang, Lei Sun, Yan Luo, De-Hua Liu, Shu-Tao Xie, Xiao-Yan Song, Guo-Fan Wang, Xiu-Lan Chen, Bai-Cheng Zhou & Yu-Zhong Zhang
http://link.springer.com/article/10.1007/s10495-012-0786-2

Live fluorescence and transmission-through-dye microscopic study of actinomycin D-induced apoptosis and apoptotic volume decrease
Neda R. Kasim, Kate?ina Kuželová, Aleš Holoubek & Michael A. Model
http://link.springer.com/article/10.1007/s10495-013-0804-z

Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in Caenorhabditis elegans
Daniel P. Denning, Victoria Hatch, H. Robert Horvitz
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003341

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Comments
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ABT-199 Clinical Trial Suspended (Updated)
http://pipeline.corante.com/archives/2013/02/15/abt199_clinical_trial_suspended_updated.php

BCL-2–Selective Inhibitors Spare Platelets
http://cancerdiscovery.aacrjournals.org/content/3/3/247.1.abstract.html

BIM, PUMA, and the Achilles’ Heel of Oncogene Addiction
Anne Roulston, William J. Muller, and Gordon C. Shore
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/268/pe12

BAX Mitochondrial Translocation Is Constitutive and Dynamic
http://cancerdiscovery.aacrjournals.org/content/3/3/250.2.abstract.html

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Reviews
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Getting away with murder: how does the BCL-2 family of proteins kill with immunity?
Thibaud T. Renault, Jerry E. Chipuk
http://onlinelibrary.wiley.com/doi/10.1111/nyas.12045/abstract

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics
L Y Dimberg, C K Anderson, R Camidge, K Behbakht, A Thorburn and H L Ford
http://www.nature.com/onc/journal/v32/n11/abs/onc2012164a.html

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