ApoList – April 2013

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Non-apoptotic cell death
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Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
Laurence Lamy, Vu N. Ngo, N.C. Tolga Emre, Arthur L. Shaffer, Yandan Yang, Erming Tian, Vinod Nair, Michael J. Kruhlak, Adriana Zingone, Ola Landgren, Louis M. Staudt
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00073-1

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species
Francisco J. Roca, Lalita Ramakrishnan
http://www.cell.com/abstract/S0092-8674(13)00344-9

Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroptosis
Jian Zou, Taro Kawai, Tetsuo Tsuchida, Tatsuya Kozaki, Hiroki Tanaka, Kyung-Sue Shin, Himanshu Kumar, Shizuo Akira
http://www.cell.com/immunity/abstract/S1074-7613(13)00154-4

Alternative Germ Cell Death Pathway in Drosophila Involves HtrA2/Omi, Lysosomes, and a Caspase-9 Counterpart
Keren Yacobi-Sharon, Yuval Namdar, Eli Arama
http://www.cell.com/developmental-cell/abstract/S1534-5807(13)00095-6

Dimers of mitochondrial ATP synthase form the permeability transition pore
Valentina Giorgio, Sophia von Stockum, Manuela Antoniel, Astrid Fabbro, Federico Fogolari, Michael Forte, Gary D. Glick, Valeria Petronilli, Mario Zoratti, Ildikó Szabó, Giovanna Lippe, and Paolo Bernardi
http://www.pnas.org/content/110/15/5887.abstract.html?etoc

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Bcl-2 family proteins
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Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation
R Peng, J-S Tong, H Li, B Yue, F Zou, J Yu and L Zhang
http://www.nature.com/cdd/journal/v20/n5/abs/cdd20134a.html

BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins
Levi J. Beverly, Lauren A. Howell, Maria Hernandez Corbacho, Lavona Casson, Jerry E. Chipuk and Leah J. Siskind
http://www.biochemj.org/bj/452/bj4520111.htm

BNIP3 acts as transcriptional repressor of death receptor-5 expression and prevents TRAIL-induced cell death in gliomas
T R Burton, E S Henson, M B Azad, M Brown, D D Eisenstat and S B Gibson
http://www.nature.com/cddis/journal/v4/n4/abs/cddis2013100a.html

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death
C Moran, A Sanz-Rodriguez, A Jimenez-Pacheco, J Martinez-Villareal, R C McKiernan, E M Jimenez-Mateos, C Mooney, I Woods, J H M Prehn, D C Henshall and T Engel
http://www.nature.com/cddis/journal/v4/n4/abs/cddis2013136a.html

Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors
Sabine Pietkiewicz, Dennis Sohn, Roland P. Piekorz, Susanne Grether-Beck, Wilfried Budach, Kanaga Sabapathy, Reiner U. Jänicke
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061438

pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737
J Bertin-Ciftci, B Barré, J Le Pen, L Maillet, C Couriaud, P Juin and F Braun
http://www.nature.com/cdd/journal/v20/n5/abs/cdd20136a.html

Reconstitution of the Anti-Apoptotic Bcl-2 Protein into Lipid Membranes and Biophysical Evidence for Its Detergent-Driven Association with the Pro-Apoptotic Bax Protein
Marcus Wallgren, Martin Lidman, Anders Pedersen, Kristoffer Brännström, B. Göran Karlsson, Gerhard Gröbner
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061452

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Caspases and phagocytosis
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Caspase-1 activation is protective against hepatocyte cell death by up-regulating beclin1 and mitochondrial autophagy in the setting of redox stress
Qian Sun, Wentao Gao, Patricia Loughran, Rick Shapiro, Jie Fan, Timothy R. Billiar, and Melanie J. Scott
http://www.jbc.org/cgi/content/abstract/M112.426791v1

Proteolytic Processing of Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9
Qi Hu, Di Wu, Wen Chen, Zhen Yan, and Yigong Shi
http://www.jbc.org/cgi/content/abstract/M112.441568v1

Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy
Issam Arrouss, Fariba Nemati, Fernando Roncal, Marie Wislez, Karim Dorgham, David Vallerand, Nathalie Rabbe, Narjesse Karboul, Françoise Carlotti, Jeronimo Bravo, Dominique Mazier, Didier Decaudin, Angelita Rebollo
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060816

A Novel Cell Lysis Approach Reveals That Caspase-2 Rapidly Translocates from the Nucleus to the Cytoplasm in Response to Apoptotic Stimuli
Alexander A. Tinnikov, Herbert H. Samuels
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061085

Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis
Erika Segear Johnson, Kelly R. Lindblom, Alexander Robeson, Robert D. Stevens, Olga R. Ilkayeva, Christopher B. Newgard, Sally Kornbluth, and Joshua L. Andersen
http://www.jbc.org/cgi/content/abstract/M112.437210v1

Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response
M H M Melis, K L Simpson, S J Dovedi, A Welman, M MacFarlane, C Dive, J Honeychurch and T M Illidge
http://www.nature.com/cdd/journal/v20/n5/abs/cdd20138a.html

Proteasomal regulation of caspase-8 in cancer cell apoptosis
Michael V. Fiandalo, Steven R. Schwarze & Natasha Kyprianou
http://link.springer.com/article/10.1007/s10495-013-0821-y

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
Amelia E. Hochreiter-Hufford, Chang Sup Lee, Jason M. Kinchen, Jennifer D. Sokolowski, Sanja Arandjelovic, Jarrod A. Call, Alexander L. Klibanov, Zhen Yan, James W. Mandell & Kodi S. Ravichandran
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12135.html

Innate recognition of apoptotic cells: novel apoptotic cell-associated molecular patterns revealed by crossreactivity of anti-LPS antibodies
I Tennant, J D Pound, L A Marr, J J L P Willems, S Petrova, C A Ford, M Paterson, A Devitt and C D Gregory
http://www.nature.com/cdd/journal/v20/n5/abs/cdd2012165a.html

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Miscellaneous
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OTUB1 modulates c-IAP1 stability to regulate signalling pathways
Tatiana Goncharov, Kyle Niessen, Maria Cristina de Almagro, Anita Izrael-Tomasevic, Anna V Fedorova, Eugene Varfolomeev, David Arnott, Kurt Deshayes, Donald S Kirkpatrick and Domagoj Vucic
http://www.nature.com/emboj/journal/v32/n8/full/emboj201362a.html

Cytochrome c causes pore formation in cardiolipin-containing membranes
Chris L. Bergstrom, Paul A. Beales, Yang Lv, T. Kyle Vanderlick, and John T. Groves
http://www.pnas.org/content/110/16/6269.abstract.html?etoc

Genes of the Mitochondrial Apoptotic Pathway in Mytilus galloprovincialis
Noelia Estévez-Calvar, Alejandro Romero, Antonio Figueras, Beatriz Novoa
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061502

Apoptosis-like cell death pathways in the unicellular parasite Toxoplasma gondii following treatment with apoptosis inducers and chemotherapeutic agents: a proof-of-concept study
Ayu Dewi Ni Nyoman & Carsten G. K. Lüder
http://link.springer.com/article/10.1007/s10495-013-0832-8

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Reviews
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New directions in ER stress-induced cell death
Susan E. Logue, Patricia Cleary, Svetlana Saveljeva & Afshin Samali
http://link.springer.com/article/10.1007/s10495-013-0818-6

CD95 in cancer: tool or target?
Martin-Villalba, Llorens-Bobadilla, and Wollny
http://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(13)00042-7

Programming cancer cells for high expression levels of Mcl1
Franziska Ertel, Mai Nguyen, Anne Roulston and Gordon C Shore
http://www.nature.com/embor/journal/v14/n4/full/embor201320a.html

Shaping organisms with apoptosis
M Suzanne and H Steller
http://www.nature.com/cdd/journal/v20/n5/abs/cdd201311a.html

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Comments
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Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You
Richard G. Carroll, Seamus J. Martin
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00135-9

Cell biology: Death brings new life to muscle
Shannon F. Yu, Mary K. Baylies
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12097.html

FAS-Dependent Apoptosis Is Immunogenic
http://cancerdiscovery.aacrjournals.org/content/3/4/OF12.abstract.html

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