Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for March, 2013

ApoList – February 2013

Posted by cris on March 18, 2013

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Death receptors
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Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells
Sean P. Cullen, Conor M. Henry, Conor J. Kearney, Susan E. Logue, Maria Feoktistova, Graham A. Tynan, Ed C. Lavelle, Martin Leverkus, Seamus J. Martin
http://www.sciencedirect.com/science/article/pii/S1097276513000890

Fas expression by tumor stroma is required for cancer eradication
Joanna J. Listopad, Thomas Kammertoens, Kathleen Anders, Bjoern Silkenstedt, Gerald Willimsky, Karin Schmidt, Anja A. Kuehl, Christoph Loddenkemper, and Thomas Blankenstein
http://www.pnas.org/content/110/6/2276.abstract.html?etoc

Fas signaling promotes motility and metastasis through epithelial–mesenchymal transition in gastrointestinal cancer
H X Zheng, Y D Cai, Y D Wang, X B Cui, T T Xie, W J Li, L Peng, Y Zhang, Z Q Wang, J Wang and B Jiang
http://www.nature.com/onc/journal/v32/n9/abs/onc2012126a.html

TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis
Syam Prakash Somasekharan, Michal Koc, Alexandre Morizot, Olivier Micheau, Poul H. B. Sorensen, Olivier Gaide, Ladislav Andera & Jean-Claude Martinou
http://link.springer.com/article/10.1007/s10495-012-0782-6

Antagonism of Inhibitor of Apoptosis Proteins Increases Bone Metastasis via Unexpected Osteoclast Activation
Chang Yang, Jennifer L. Davis, Rong Zeng, Paras Vora, Xinming Su, Lynne I. Collins, Suwanna Vangveravong, Robert H. Mach, David Piwnica-Worms, Katherine N. Weilbaecher, Roberta Faccio, and Deborah Veis Novack
http://cancerdiscovery.aacrjournals.org/content/3/2/212.abstract.html

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Bcl-2 family proteins
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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Andrew J Souers, Joel D Leverson, Erwin R Boghaert, Scott L Ackler, Nathaniel D Catron, Jun Chen, Brian D Dayton, Hong Ding, Sari H Enschede, Wayne J Fairbrother, David C S Huang, Sarah G Hymowitz, Sha Jin, Seong Lin Khaw, Peter J Kovar, Lloyd T Lam, Jackie Lee, Heather L Maecker, Kennan C Marsh, Kylie D Mason, Michael J Mitten, Paul M Nimmer, Anatol Oleksijew, Chang H Park, Cheol-Min Park, Darren C Phillips, Andrew W Roberts, Deepak Sampath, John F Seymour, Morey L Smith, Gerard M Sullivan, Stephen K Tahir, Chris Tse, Michael D Wendt, Yu Xiao, John C Xue, Haichao Zhang, Rod A Humerickhouse, Saul H Rosenberg and Steven W Elmore
http://www.nature.com/nm/journal/v19/n2/full/nm.3048.html

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Ariele Viacava Follis, Jerry E Chipuk, John C Fisher, Mi-Kyung Yun, Christy R Grace, Amanda Nourse, Katherine Baran, Li Ou, Lie Min, Stephen W White, Douglas R Green, Richard W Kriwacki
http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.1166.html

Mechanistic Differences in the Membrane Activity of Bax and Bcl-xL Correlate with Their Opposing Roles in Apoptosis
Stephanie Bleicken, Corinna Wagner, Ana J. García-Sáez
http://www.cell.com/biophysj/abstract/S0006-3495%2812%2905121-1#

Bak apoptotic function is not directly regulated by phosphorylation
V H Tran, R Bartolo, D Westphal, A Alsop, G Dewson and R M Kluck
http://www.nature.com/cddis/journal/v4/n1/abs/cddis2012191a.html

NF-κB activation fails to protect cells to TNFα-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w
Elisenda Casanelles, Raffaella Gozzelino, Fernando Marqués-Fernández, Victoria Iglesias-Guimarais, Mercè Garcia-Belinchón, María Sánchez-Osuna, Carme Solé, Rana S. Moubarak, Joan X. Comella, Victor J. Yuste
http://www.sciencedirect.com/science/article/pii/S0167488913000293

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease
Kylie D. Mason, Ann Lin, Lorraine Robb, Emma C. Josefsson, Katya J. Henley, Daniel H. D. Gray, Benjamin T. Kile, Andrew W. Roberts, Andreas Strasser, David C. S. Huang, Paul Waring, and Lorraine A. O’Reilly
http://www.pnas.org/content/110/7/2599.abstract.html?etoc

Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Mohamed Rahmani, Mandy Mayo Aust, Elisa Attkisson, David C. Williams, Jr, Andrea Ferreira-Gonzalez, and Steven Grant
http://cancerres.aacrjournals.org/content/73/4/1340.abstract.html

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
Eleni D. Lagadinou, Alexander Sach … Michael W. Becker, Craig T. Jordan
http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2812%2900755-2

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cell Sensitive to Tyrosine Kinase Inhibition
Daniel J. Goff, Angela Court Recart … John C. Reed and Catriona H.M. Jamieson
http://www.cell.com/cell-stem-cell/abstract/S1934-5909(12)00716-3

Mcl-1 is essential for the survival of plasma cells
Victor Peperzak, Ingela Vikström, Jennifer Walker, Stefan P Glaser, Melanie LePage, Christine M Coquery, Loren D Erickson, Kirsten Fairfax, Fabienne Mackay, Andreas Strasser, Stephen L Nutt and David M Tarlinton
http://www.nature.com/ni/journal/v14/n3/full/ni.2527.html

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Caspases and downstream
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MerCASBA: an updated and refined database of caspase substrates
Arthur Fridman, Irene Pak, Brent D. Butts, Maarten Hoek, Donald W. Nicholson & Huseyin Mehmet
http://link.springer.com/article/10.1007/s10495-012-0789-z
http://link.springer.com/content/esm/art:10.1007/s10495-012-0789-z/file/MediaObjects/10495_2012_789_MOESM1_ESM.xls

Specific Inhibition of Caspase-3 by a Competitive DARPin: Molecular Mimicry between Native and Designed Inhibitors
Thilo Schroeder, Jonas Barandun, Andreas Flütsch, Christophe Briand, Peer R.E. Mittl, Markus G. Grütter
http://www.cell.com/structure/abstract/S0969-2126(12)00466-2

Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion
Vivek A Rudrapatna, Erdem Bangi and Ross L Cagan
http://www.nature.com/embor/journal/v14/n2/abs/embor2012217a.html

Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3
Debajyoti Datta, Christopher L. McClendon, Matthew P. Jacobson, and James A. Wells
http://www.jbc.org/cgi/content/abstract/M112.426460v1

Caspase-8 Binding to Cardiolipin in Giant Unilamellar Vesicles Provides a Functional Docking Platform for Bid
Olivier Jalmar, Liberty François-Moutal, Ana-Jesus García-Sáez, Mark Perry, Thierry Granjon, François Gonzalvez, Eyal Gottlieb, Jesus Ayala-Sanmartin, Beate Klösgen, Petra Schwille, Patrice X. Petit
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055250

Caspase 14 does not influence intestinal epithelial cell differentiation
J Benedict Seidelin, J Sträter and O Haagen Nielsen
http://www.nature.com/cdd/journal/v20/n3/full/cdd2012164a.html

Metabolic regulation of CaMKII and caspases in Xenopus laevis egg extracts
Francis McCoy, Rashid Darbandi, Si-Ing Chen, Laura Eckard, Keela Dodd, Kelly Jones, Anthony J. Baucum, III, Jennifer A. Gibbons, Sue-Hwa Lin, Roger J. Colbran, and Leta K. Nutt
http://www.jbc.org/cgi/content/abstract/M112.437186v1

hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L
Ngoc T. Vu, Margaret A. Park, Jacqueline C. Shultz, Rachel W. Goehe, L. Alexis Hoeferlin, Michael D. Shultz, Sarah A. Smith, Krysten W. Lynch, and Charles E. Chalfant
http://www.jbc.org/cgi/content/abstract/M112.443333v1

Caspase-11 Protects Against Bacteria That Escape the Vacuole
Youssef Aachoui, Irina A. Lea, Jon A. Hagar, Mary F. Fontana, Cristine G. Campos, Daniel E. Zak, Michael H. Tan, Peggy A. Cotter, Russell E. Vance, Alan Aderem, Edward A. Miao
http://www.sciencemag.org/content/339/6122/975.abstract

Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development
Shuyi Huang, Kailiang Jia, Ying Wang, Zheng Zhou and Beth Levine
http://dx.doi.org/10.4161/auto.22352

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Non-apoptotic cell death
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Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia
Michael Fricker, Anna Vilalta, Aviva M. Tolkovsky, and Guy C. Brown
http://www.jbc.org/cgi/content/abstract/M112.427880v1

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
D M Moujalled, W D Cook, T Okamoto, J Murphy, K E Lawlor, J E Vince and D L Vaux
http://www.nature.com/cddis/journal/v4/n1/abs/cddis2012201a.html

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Reviews
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Evolution of Bcl-2 homology motifs: homology versus homoplasy
Abdel Aouacheria, Valentine Rech de Laval, Christophe Combet, J. Marie Hardwick
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(12)00202-4

Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis
Assaf D. Rubinstein and Adi Kimchi
http://jcs.biologists.org/content/125/22/5259.abstract.html

The Tangled Circuitry of Metabolism and Apoptosis
Joshua L. Andersen, Sally Kornbluth
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00051-8

Non-apoptotic roles of Bcl-2 family: The calcium connection
Benjamin Bonneau, Julien Prudent, Nikolay Popgeorgiev, Germain Gillet
http://www.sciencedirect.com/science/article/pii/S0167488913000360

Regulation of cell death in cancer-possible implications for immunotherapy
Simone Fulda
http://www.frontiersin.org/Pediatric_Oncology/10.3389/fonc.2013.00029/full

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
Agnieszka Kaczmarek, Peter Vandenabeele, Dmitri V. Krysko
http://www.cell.com/immunity/abstract/S1074-7613(13)00058-7

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Comments / Other
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Apoptosis therapy: driving cancers down the road to ruin
Douglas R. Green and Henning Walczak
http://www.nature.com/nm/journal/v19/n2/full/nm.3076.html

ABT-199: Taking Dead Aim at BCL-2
Matthew S. Davids, Anthony Letai
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00039-1

Death takes a holiday—non-apoptotic role for caspases in cell migration and invasion
Marta Portela and Helena E Richardson
http://www.nature.com/embor/journal/v14/n2/full/embor2012224a.html

Caspase-2 at a glance
Luca L. Fava, Florian J. Bock, Stephan Geley, and Andreas Villunger
http://jcs.biologists.org/content/125/24/5911.full.html

Conference announcement: “cancer cell death and resistance”, Toulouse, France, on May 6 and 7, 2013
http://kcelldeath.sciencesconf.org

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