ApoList – February 2013

Death receptors

Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells
Sean P. Cullen, Conor M. Henry, Conor J. Kearney, Susan E. Logue, Maria Feoktistova, Graham A. Tynan, Ed C. Lavelle, Martin Leverkus, Seamus J. Martin

Fas expression by tumor stroma is required for cancer eradication
Joanna J. Listopad, Thomas Kammertoens, Kathleen Anders, Bjoern Silkenstedt, Gerald Willimsky, Karin Schmidt, Anja A. Kuehl, Christoph Loddenkemper, and Thomas Blankenstein

Fas signaling promotes motility and metastasis through epithelial–mesenchymal transition in gastrointestinal cancer
H X Zheng, Y D Cai, Y D Wang, X B Cui, T T Xie, W J Li, L Peng, Y Zhang, Z Q Wang, J Wang and B Jiang

TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis
Syam Prakash Somasekharan, Michal Koc, Alexandre Morizot, Olivier Micheau, Poul H. B. Sorensen, Olivier Gaide, Ladislav Andera & Jean-Claude Martinou

Antagonism of Inhibitor of Apoptosis Proteins Increases Bone Metastasis via Unexpected Osteoclast Activation
Chang Yang, Jennifer L. Davis, Rong Zeng, Paras Vora, Xinming Su, Lynne I. Collins, Suwanna Vangveravong, Robert H. Mach, David Piwnica-Worms, Katherine N. Weilbaecher, Roberta Faccio, and Deborah Veis Novack

Bcl-2 family proteins

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Andrew J Souers, Joel D Leverson, Erwin R Boghaert, Scott L Ackler, Nathaniel D Catron, Jun Chen, Brian D Dayton, Hong Ding, Sari H Enschede, Wayne J Fairbrother, David C S Huang, Sarah G Hymowitz, Sha Jin, Seong Lin Khaw, Peter J Kovar, Lloyd T Lam, Jackie Lee, Heather L Maecker, Kennan C Marsh, Kylie D Mason, Michael J Mitten, Paul M Nimmer, Anatol Oleksijew, Chang H Park, Cheol-Min Park, Darren C Phillips, Andrew W Roberts, Deepak Sampath, John F Seymour, Morey L Smith, Gerard M Sullivan, Stephen K Tahir, Chris Tse, Michael D Wendt, Yu Xiao, John C Xue, Haichao Zhang, Rod A Humerickhouse, Saul H Rosenberg and Steven W Elmore

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Ariele Viacava Follis, Jerry E Chipuk, John C Fisher, Mi-Kyung Yun, Christy R Grace, Amanda Nourse, Katherine Baran, Li Ou, Lie Min, Stephen W White, Douglas R Green, Richard W Kriwacki

Mechanistic Differences in the Membrane Activity of Bax and Bcl-xL Correlate with Their Opposing Roles in Apoptosis
Stephanie Bleicken, Corinna Wagner, Ana J. García-Sáez

Bak apoptotic function is not directly regulated by phosphorylation
V H Tran, R Bartolo, D Westphal, A Alsop, G Dewson and R M Kluck

NF-κB activation fails to protect cells to TNFα-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w
Elisenda Casanelles, Raffaella Gozzelino, Fernando Marqués-Fernández, Victoria Iglesias-Guimarais, Mercè Garcia-Belinchón, María Sánchez-Osuna, Carme Solé, Rana S. Moubarak, Joan X. Comella, Victor J. Yuste

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease
Kylie D. Mason, Ann Lin, Lorraine Robb, Emma C. Josefsson, Katya J. Henley, Daniel H. D. Gray, Benjamin T. Kile, Andrew W. Roberts, Andreas Strasser, David C. S. Huang, Paul Waring, and Lorraine A. O’Reilly

Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Mohamed Rahmani, Mandy Mayo Aust, Elisa Attkisson, David C. Williams, Jr, Andrea Ferreira-Gonzalez, and Steven Grant

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
Eleni D. Lagadinou, Alexander Sach … Michael W. Becker, Craig T. Jordan

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cell Sensitive to Tyrosine Kinase Inhibition
Daniel J. Goff, Angela Court Recart … John C. Reed and Catriona H.M. Jamieson

Mcl-1 is essential for the survival of plasma cells
Victor Peperzak, Ingela Vikström, Jennifer Walker, Stefan P Glaser, Melanie LePage, Christine M Coquery, Loren D Erickson, Kirsten Fairfax, Fabienne Mackay, Andreas Strasser, Stephen L Nutt and David M Tarlinton

Caspases and downstream

MerCASBA: an updated and refined database of caspase substrates
Arthur Fridman, Irene Pak, Brent D. Butts, Maarten Hoek, Donald W. Nicholson & Huseyin Mehmet

Specific Inhibition of Caspase-3 by a Competitive DARPin: Molecular Mimicry between Native and Designed Inhibitors
Thilo Schroeder, Jonas Barandun, Andreas Flütsch, Christophe Briand, Peer R.E. Mittl, Markus G. Grütter

Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion
Vivek A Rudrapatna, Erdem Bangi and Ross L Cagan

Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3
Debajyoti Datta, Christopher L. McClendon, Matthew P. Jacobson, and James A. Wells

Caspase-8 Binding to Cardiolipin in Giant Unilamellar Vesicles Provides a Functional Docking Platform for Bid
Olivier Jalmar, Liberty François-Moutal, Ana-Jesus García-Sáez, Mark Perry, Thierry Granjon, François Gonzalvez, Eyal Gottlieb, Jesus Ayala-Sanmartin, Beate Klösgen, Petra Schwille, Patrice X. Petit

Caspase 14 does not influence intestinal epithelial cell differentiation
J Benedict Seidelin, J Sträter and O Haagen Nielsen

Metabolic regulation of CaMKII and caspases in Xenopus laevis egg extracts
Francis McCoy, Rashid Darbandi, Si-Ing Chen, Laura Eckard, Keela Dodd, Kelly Jones, Anthony J. Baucum, III, Jennifer A. Gibbons, Sue-Hwa Lin, Roger J. Colbran, and Leta K. Nutt

hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L
Ngoc T. Vu, Margaret A. Park, Jacqueline C. Shultz, Rachel W. Goehe, L. Alexis Hoeferlin, Michael D. Shultz, Sarah A. Smith, Krysten W. Lynch, and Charles E. Chalfant

Caspase-11 Protects Against Bacteria That Escape the Vacuole
Youssef Aachoui, Irina A. Lea, Jon A. Hagar, Mary F. Fontana, Cristine G. Campos, Daniel E. Zak, Michael H. Tan, Peggy A. Cotter, Russell E. Vance, Alan Aderem, Edward A. Miao

Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development
Shuyi Huang, Kailiang Jia, Ying Wang, Zheng Zhou and Beth Levine

Non-apoptotic cell death

Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia
Michael Fricker, Anna Vilalta, Aviva M. Tolkovsky, and Guy C. Brown

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
D M Moujalled, W D Cook, T Okamoto, J Murphy, K E Lawlor, J E Vince and D L Vaux


Evolution of Bcl-2 homology motifs: homology versus homoplasy
Abdel Aouacheria, Valentine Rech de Laval, Christophe Combet, J. Marie Hardwick

Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis
Assaf D. Rubinstein and Adi Kimchi

The Tangled Circuitry of Metabolism and Apoptosis
Joshua L. Andersen, Sally Kornbluth

Non-apoptotic roles of Bcl-2 family: The calcium connection
Benjamin Bonneau, Julien Prudent, Nikolay Popgeorgiev, Germain Gillet

Regulation of cell death in cancer-possible implications for immunotherapy
Simone Fulda

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
Agnieszka Kaczmarek, Peter Vandenabeele, Dmitri V. Krysko

Comments / Other

Apoptosis therapy: driving cancers down the road to ruin
Douglas R. Green and Henning Walczak

ABT-199: Taking Dead Aim at BCL-2
Matthew S. Davids, Anthony Letai

Death takes a holiday—non-apoptotic role for caspases in cell migration and invasion
Marta Portela and Helena E Richardson

Caspase-2 at a glance
Luca L. Fava, Florian J. Bock, Stephan Geley, and Andreas Villunger

Conference announcement: “cancer cell death and resistance”, Toulouse, France, on May 6 and 7, 2013