ApoList – January 2013

Bcl-2 family proteins

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
Peter E. Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W. Douglas Fairlie, Erinna F. Lee, Shenggen Yao, Adeline Y. Robin, Brian J. Smith, David C.S. Huang, Ruth M. Kluck, Jerry M. Adams, Peter M. Colman

Direct interaction of Bax and Bak with Bcl-2 Homology domain-3 (BH3)-only proteins in living cells revealed by fluorescence complementation
Laura Vela, Oscar Gonzalo, Javier Naval, and Isabel Marzo

Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy
Andreas U. Lindner, Caoimhín G. Concannon, Gerhardt J. Boukes, Mary D. Cannon, Fabien Llambi, Deborah Ryan, Karen Boland, Joan Kehoe, Deborah A. McNamara, Frank Murray, Elaine W. Kay, Suzanne Hector, Douglas R. Green, Heinrich J. Huber, and Jochen H.M. Prehn

Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
F Baumgartner, C Woess, V Pedit, A Tzankov, V Labi and A Villunger

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
G J P Rautureau, M Yabal, H Yang, D C S Huang, M Kvansakul and M G Hinds

Dual-site interactions of p53 transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways
Ji-Hyang Ha, Jae-Sun Shin, Mi-Kyung Yoon, Min-Sung Lee, Fahu He, Kwang-Hee Bae, Ho Sup Yoon, Chong-Kil Lee, Sung Goo Park, Yutaka Muto, and Seung-Wook Chi

Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons
M M Magiera, S Mora, B Mojsa, I Robbins, I Lassot and S Desagher

The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria
F Todt, Z Cakir, F Reichenbach, R J Youle and F Edlich

The stress protein BAG3 stabilizes Mcl-1 and promotes survival of cancer cells and resistance to ABT-737
Mariana Boiani, Cristina Daniel, Xueyuan Liu, Michael D. Hogarty, and Lawrence J. Marnett

Death receptors and IAPs

IAPs and their Antagonists Regulate Spontaneous and TNF-Induced Pro-Inflammatory Cytokine and Chemokine production
Conor J. Kearney, Clare Sheridan, Sean P. Cullen, Graham A. Tynan, Susan E. Logue, Inna S. Afonina, Domagoj Vucic, Ed C. Lavelle, and Seamus J. Martin

Inactivation of BAD by IKK Inhibits TNFα-Induced Apoptosis Independently of NF-κB Activation
Jie Yan, Jialing Xiang, Yutin Lin, Jingui Ma, Jiyan Zhang, Hao Zhang, Jisheng Sun, Nika N. Danial, Jing Liu, Anning Lin

Ubiquitination by the membrane-associated RING-CH-8 (MARCH-8) ligase controls steady-state cell surface expression of the death receptor TRAIL-R1
Bert van de Kooij, Inge Verbrugge, Evert de Vries, Merel Gijsen, Veronica Montserrat, Chiel Maas, Jacques Neefjes, and Jannie Borst

Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions
Natalie Hartmann, Joanna J. Messmann, Frank Leithäuser, Maxi Weiswange, Michael Kluge, Harald Fricke, Klaus-Michael Debatin, and Gudrun Strauss

Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling
Marjorie Poggi, Imène Kara, Jean-Michel Brunel, Jean-François Landrier, Roland Govers, Bernadette Bonardo, Regina Fluhrer, Christian Haass, Marie-Christine Alessi, Franck Peiretti

Non-apoptotic cell death

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models
P Vandenabeele, S Grootjans, N Callewaert and N Takahashi

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase
A Degterev, J L Maki and J Yuan

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development
Juan Lin, Hanjie Li, Min Yang, Junming Ren, Zhe Huang, Felicia Han, Jian Huang, Jianhui Ma, Duanwu Zhang, Zhirong Zhang, Jianfeng Wu, Deli Huang, Muzhen Qiao, Guanghui Jin, Qiao Wu, Yinghui Huang, Jie Du, Jiahuai Han

A role for c-FLIPL in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes
M-X He and Y-W He

Identification of factors that function in Drosophila salivary gland cell death during development using proteomics
C K McPhee, B M Balgley, C Nelson, J H Hill, Y Batlevi, X Fang, C S Lee and E H Baehrecke


Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome
Tae-Bong Kang, Seung-Hoon Yang, Beata Toth, Andrew Kovalenko, David Wallach

Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer
I Paul, A D Chacko, I Stasik, S Busacca, N Crawford, F McCoy, N McTavish, B Wilson, M Barr, K J O’Byrne, D B Longley and D A Fennell

Type I Interferons Induce Apoptosis by Balancing cFLIP and Caspase-8 Independent of Death Ligands
Amir Apelbaum, Ganit Yarden, Shira Warszawski, Daniel Harari, and Gideon Schreiber

Apaf-1- and Caspase-8-independent apoptosis
T Imao and S Nagata

Equilibria and stability of a class of positive feedback loops : Mathematical analysis and its application to caspase-dependent apoptosis.
López-Caamal F, Middleton RH, Huber HJ.

Comments / reviews

The FLIP Side of Life
John Silke and Andreas Strasser
The protein c-FLIP plays a role in preventing cell death by both apoptosis and necroptosis.

Unlatched BAX Pairs for Death
Heather M. Lamb, J. Marie Hardwick

IAP proteins: regulators of cell migration and development
Niall S Kenneth, Colin S Duckett

BCL2L11/BIM: A novel molecular link between autophagy and apoptosis
Shouqing Luo and David C. Rubinsztein

Activation and Inactivation of Caspase-8 by Ubiquitylation

The IKK complex targets the proapoptotic protein BAD to inhibit TNF-induced apoptosis independently of nuclear factor κB signaling.