ApoList – December 2012

Bcl-2 family and the mitochondrial pathway

Proliferative and Survival Effects of PUMA Promote Angiogenesis
Fan Zhang, Yang Li, Zhongshu Tang, Anil Kumar, Chunsik Lee, Liping Zhang, Chaoyong Zhu, Anne Klotzsche-von Ameln, Bin Wang, Zhiqin Gao, Shizhuang Zhang, Harald F. Langer, Xu Hou, Lasse Jensen, Wenxin Ma, Wai Wong, Triantafyllos Chavakis, Yizhi Liu, Yihai Cao, Xuri Li

Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens
R A Anvekar, J J Asciolla, E Lopez-Rivera, K V Floros, S Izadmehr, R Elkholi, G Belbin, A G Sikora and J E Chipuk

Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA
Junhe Ma, Frank Edlich, Guillermo A. Bermejo, Kristi L. Norris, Richard J. Youle, and Nico Tjandra

ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells
S Cristofanon and S Fulda

AMP-activated Protein Kinase (AMPK)-Induced Preconditioning in Primary Cortical Neurons Involves Activation of MCL-1.
Anilkumar U, Weisová P, Düssmann H, Concannon CG, König HG, Prehn JH.

Mitofilin regulates cytochrome c release during apoptosis by controlling mitochondrial cristae remodeling.
Yang RF, Zhao GW, Liang ST, Zhang Y, Sun LH, Chen HZ, Liu DP.

Death receptor pathway

Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL
G L Robinson, D Dinsdale, M MacFarlane and K Cain

TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer
Francois Gonzalvez, David Lawrence, Becky Yang, Sharon Yee, Robert Pitti, Scot Marsters, Victoria C. Pham, Jean-Philippe Stephan, Jennie Lill, Avi Ashkenazi

Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2- and RIPK1/RIP1-mediated MAPK8/JNK activation
Weiyang He, Qiong Wang, Jennings Xu, Xiuling Xu, Mabel T. Padilla, Guosheng Ren, Xin Gou and Yong Lin

Smad7 induces IRF1-dependent transcriptional activation of caspase 8 to restore TRAIL-mediated apoptosis
Suntaek Hong, Hye-Youn Kim, Jooyoung Kim, Huyen Trang Ha, Young-Mi Kim, Eunjin Bae, Tae Hyung Kim, Kang Choon Lee, and Seong-Jin Kim

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis
Xuehua Piao, Sachiko Komazawa-Sakon, Takashi Nishina, Masato Koike, Jiang-Hu Piao, Hanno Ehlken, Hidetake Kurihara, Mutsuko Hara, Nico Van Rooijen, Günther Schütz, Masaki Ohmuraya, Yasuo Uchiyama, Hideo Yagita, Ko Okumura, You-Wen He, and Hiroyasu Nakano

Caspases and phagocytosis

Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated DNASE and the PARP-regulated DNAS1L3, an ER-localized endonuclease that translocates to the nucleus during apoptosis
Youssef Errami, Amarjit S. Naura, Hogyoung Kim, Jihang Ju, Yasuhiro Suzuki, Ali H. El-Bahrawy, Mohamed A. Ghonim, Ramadan A. Hemeida, Moselhy S. Mansy, Jianhua Zhang, Ming Xu, Mark E. Smulson, Hassan Brim, and A. Hamid Boulares

Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm
S-H Lee, X W Meng, K S Flatten, D A Loegering and S H Kaufmann

Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6
B J van Raam, D E Ehrnhoefer, M R Hayden and G S Salvesen

Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells
Jon Iker Etchegaray, Allison K. Timmons, Adam P. Klein, Tracy L. Pritchett, Elaine Welch, Tracy L. Meehan, Christy Li, and Kimberly McCall

Non-apoptotic cell death

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
N Takahashi, L Duprez, S Grootjans, A Cauwels, W Nerinckx, J B DuHadaway, V Goossens, R Roelandt, F Van Hauwermeiren, C Libert, W Declercq, N Callewaert, G C Prendergast, A Degterev, J Yuan and P Vandenabeele

Jone López-Erauskin, Jorge Galino, Patrizia Bianchi, Stéphane Fourcade, Antoni L. Andreu, Isidre Ferrer, Cristina Muñoz-Pinedo, and Aurora Pujol
Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy


New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
J S Long and K M Ryan

Glucose-a sweet way to die Metabolic switching modulates tumor cell death
MacFarlane, M; Robinson, GL; Cain, K

Delving deeper: MCL-1’s contributions to normal and cancer biology
Rhonda M. Perciavalle, Joseph T. Opferman

Shedding Light on Apoptosis at Subcellular Membranes
Justin Kale, Qian Liu, Brian Leber, David W. Andrews

Special issue on apoptosis

Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release.
Monian P, Jiang X.

The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy
M.C. de Almagro, Vucic D.

Targeting the anti-apoptotic bcl-2 family members for the treatment of cancer
Weyhenmeyer B., Murphy A.C., Prehn J.H.M., Murphy B.M.

Comments – other

JOURNAL CLUB – The death and growth connection

Mitochondrial Apoptotic Priming Regulates Therapeutic Responses in AML

Compensatory proliferation and apoptosis-induced proliferation: a need for clarification
B Mollereau, A Perez-Garijo, A Bergmann, M Miura, O Gerlitz, H D Ryoo, H Steller and G Morata