ApoList – July 2012

Bcl-2 family proteins

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax
F Wilfling, A Weber, S Potthoff, F-N Vögtle, C Meisinger, S A Paschen and G Häcker

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737
V R Sutton, K Sedelies, G Dewson, M E Christensen, P I Bird, R W Johnstone, R M Kluck9,11, J A Trapani and N J Waterhouse

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression
D Mérino, A Strasser and P Bouillet

Distinct roles of mitochondria- and ER-localized Bcl-xL in apoptosis resistance and Ca2+ homeostasis
Colins O. Eno, Emily F. Eckenrode, Kristen E. Olberding, Guoping Zhao, Carl White, and Chi Li

A Novel Role for Bcl-2 in Regulation of Cellular Calcium Extrusion
P.E. Ferdek, J.V. Gerasimenko, S. Peng, A.V. Tepikin, O.H. Petersen, and O.V. Gerasimenko

Death receptors, necroptosis

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis
Jixi Li, Thomas McQuade, Ansgar B. Siemer, Johanna Napetschnig, Kenta Moriwaki, Yu-Shan Hsiao, Ermelinda Damko, David Moquin, Thomas Walz, Ann McDermott, Francis Ka-Ming Chan, Hao Wu

Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth
Nicholas S. Wilson, Annie Yang, Becky Yang, Suzana Couto, Howard Stern, Alvin Gogineni, Robert Pitti, Scot Marsters, Robby M. Weimer, Mallika Singh, Avi Ashkenazi

Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fc receptor engagement
Fubin Li and Jeffrey V. Ravetch

Caspases and activating complexes

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling
Kiyohiro Ando, Jennifer L. Kernan, Peter H. Liu, Takaomi Sanda, Emmanuelle Logette, Jurg Tschopp, A. Thomas Look, Jianlong Wang, Lisa Bouchier-Hayes, and Samuel Sidi

Functional Interplay between Caspase Cleavage and Phosphorylation Sculpts the Apoptotic Proteome
Melissa M. Dix, Gabriel M. Simon, Chu Wang, Eric Okerberg, Matthew P. Patricelli, Benjamin F. Cravatt

A Class of Allosteric Caspase Inhibitors Identified by High-Throughput Screening
Taya Feldman, Venkataraman Kabaleeswaran, Se Bok Jang, Christophe Antczak, Hakim Djaballah, Hao Wu, and Xuejun Jiang

Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike
Magdalena Wejda, Francis Impens, Nozomi Takahashi, Petra Van Damme, Kris Gevaert, and Peter Vandenabeele

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability
L Dorstyn, J Puccini, C H Wilson, S Shalini, M Nicola, S Moore and S Kumar

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization
Anwari Akhter, Kyle Caution, Arwa Abu Khweek, Mia Tazi, Basant A. Abdulrahman, Dalia H.A. Abdelaziz, Oliver H. Voss, Andrea I. Doseff, Hoda Hassan, Abul K. Azad, Larry S. Schlesinger, Mark D. Wewers, Mikhail A. Gavrilin, Amal O. Amer


Antagonic activities of Trypanosoma cruzi metacaspases affect the balance between cell proliferation, death and differentiation
M Laverrière, J J Cazzulo and V E Alvarez

Crystal structure of the yeast metacaspase Yca1
Ada Hang-Heng Wong, Chuangye Yan, and Yigong Shi

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments
Konstantin I. Piatkov, Christopher S. Brower, and Alexander Varshavsky

Developmentally Programmed Nuclear Destruction during Yeast Gametogenesis
Michael D. Eastwood, Sally W.T. Cheung, Kwan Yin Lee, Jason Moffat, Marc D. Meneghini

Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis
Yanmei Qi, Xiaoxiang Tian, Jie Liu, Yaling Han, Alan M. Graham, M. Celeste Simon, Josef M. Penninger, Peter Carmeliet, and Shaohua Li

CED-1, CED-7, and TTR-52 Regulate Surface Phosphatidylserine Expression on Apoptotic and Phagocytic Cells
James Mapes, Yu-Zen Chen, Anna Kim, Shohei Mitani, Byung-Ho Kang, Ding Xue

Reviews / comments

Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’
Guy C. Brown, Jonas J. Neher

Caspase-1: is IL-1 just the tip of the ICEberg?
A Denes, G Lopez-Castejon and D Brough

Sporoptosis: Sowing the Seeds of Nuclear Destruction
Lior Aram, Eli Arama