Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for June, 2012

Apolist – june 2012

Posted by cris on June 30, 2012

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Death receptor pathway
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A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death
Laura S. Dickens, Robert S. Boyd, Rebekah Jukes-Jones, Michelle A. Hughes, Gemma L. Robinson, Louise Fairall, John W.R. Schwabe, Kelvin Cain, and Marion MacFarlane
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900387-5

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model
Kolja Schleich, Uwe Warnken, Nicolai Fricker, Selcen Öztürk, Petra Richter, Kerstin Kammerer, Martina Schnölzer, Peter H. Krammer, and Inna N. Lavrik
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900389-9

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death
Ozlem Oral, Devrim Oz-Arslan, Zeynep Itah, Atabak Naghavi, Remziye Deveci, Sabire Karacali & Devrim Gozuacik
http://www.springerlink.com/content/x361246771151256/

A novel role for RIP1 kinase in mediating TNFα production
D E Christofferson, Y Li, J Hitomi, W Zhou, C Upperman, H Zhu, S A Gerber, S Gygi and J Yuan
http://www.nature.com/cddis/journal/v3/n6/abs/cddis201264a.html

NF-B directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression
Feiyan Liu, Kankana Bardhan, Dafeng Yang, Muthusamy Thangaraju, Vadivel Ganapathy, Georgia Liles, Jeffrey Lee, and Kebin Liu
http://www.jbc.org/cgi/content/abstract/M112.356279v1

A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency
M Chodorge, S Züger, C Stirnimann, C Briand, L Jermutus, M G Grütter and R R Minter
http://www.nature.com/cdd/journal/v19/n7/abs/cdd2011208a.html

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Caspases and downstream
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Survival Function of the FADD-CASPASE-8-cFLIPL Complex
Christopher P. Dillon, Andrew Oberst, Ricardo Weinlich, Laura J. Janke, Tae-Bong Kang, Tehila Ben-Moshe, Tak W. Mak, David Wallach, Douglas R. Green
http://www.cell.com/cell-reports/abstract/S2211-1247(12)00095-2

Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling
Annika Meinander, Christopher Runchel, Tencho Tenev, Li Chen, Chan-Hee Kim, Paulo S Ribeiro, Meike Broemer, Francois Leulier, Marketa Zvelebil, Neal Silverman and Pascal Meier
http://www.nature.com/emboj/journal/v31/n12/abs/emboj2012121a.html

zVAD-fmk upregulates caspase-9 cleavage and activity in etoposide-induced cell death of mouse embryonic fibroblasts
Aida Rodríguez-Enfedaque, Elisabeth Delmas, Arnaud Guillaume, Sébastien Gaumer, Bernard Mignotte, Jean-Luc Vayssière, Flore Renaud
http://www.sciencedirect.com/science/article/pii/S0167488912001292

Neuronal caspase 2 activity and function requires RAIDD, but not PIDD
Elena M. Ribe, Ying Y. Jean, Rebecca L. Goldstein, Claudia Manzl, Leonidas Stefanis, Andreas Villunger and Carol M. Troy
http://www.biochemj.org/bj/444/bj4440591.htm

The Core Apoptotic Executioner Proteins CED-3 and CED-4 Promote Initiation of Neuronal Regeneration in Caenorhabditis elegans
Berangere Pinan-Lucarre, Christopher V. Gabel, Christopher P. Reina, S. Elizabeth Hulme, Sergey S. Shevkoplyas, R. Daniel Slone, Jian Xue, Yujie Qiao, Sarah Weisberg, Kevin Roodhouse, Lin Sun, George M. Whitesides, Aravinthan Samuel, Monica Driscoll
http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001331

Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment
Yanyong Kang, Dongfeng Zhao, Huanhuan Liang, Bin Liu, Yan Zhang, Qinwen Liu, Xiaochen Wang, and Yingfang Liu
http://genesdev.cshlp.org/cgi/content/abstract/26/12/1339

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Bcl-2 family proteins
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Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules
Shouqing Luo, Moises Garcia-Arencibia, Rui Zhao, Claudia Puri, Pearl P.C. Toh, Oana Sadiq, and David C. Rubinsztein
http://www.sciencedirect.com/science/article/pii/S1097276512004856

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice
Eleonora Ottina, Francesca Grespi, Denise Tischner, Claudia Soratroi, Stephan Geley, Andreas Ploner, Holger M. Reichardt, Andreas Villunger, and Marco J. Herold
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/119/25/6032

Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
Delphine Mérino, Seong L. Khaw, Stefan P. Glaser, Daniel J. Anderson, Lisa D. Belmont, Chihunt Wong, Peng Yue, Mikara Robati, Belinda Phipson, Walter D. Fairlie, Erinna F. Lee, Kirsteen J. Campbell, Cassandra J. Vandenberg, Suzanne Cory, Andrew W. Roberts, Mary J. C. Ludlam, David C. S. Huang, and Philippe Bouillet
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/119/24/5807

2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines
O Zagorodna, S M Martin, D T Rutkowski, T Kuwana, D R Spitz and C M Knudson
http://www.nature.com/onc/journal/v31/n22/abs/onc2011454a.html

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
Marlyse A. Debrincat, Emma C. Josefsson, Chloé James, Katya J. Henley, Sarah Ellis, Marion Lebois, Kelly L. Betterman, Rachael M. Lane, Kelly L. Rogers, Michael J. White, Andrew W. Roberts, Natasha L. Harvey, Donald Metcalf, and Benjamin T. Kile
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/119/24/5850

Mcl-1 Phosphorylation Defines ABT-737 Resistance That Can Be Overcome by Increased NOXA Expression in Leukemic B cells
Suparna Mazumder, Gaurav S. Choudhary, Sayer Al-harbi, and Alexandru Almasan
http://cancerres.aacrjournals.org/cgi/content/abstract/72/12/3069

Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1’s inhibitory effect on Bak
C Wang and R J Youle
http://www.nature.com/onc/journal/v31/n26/abs/onc2011497a.html

Bax and Bcl-xL exert their regulation on different sites of the ceramide channel
Meenu N. Perera, Shang H. Lin, Yuri K. Peterson, Alicja Bielawska, Zdzislaw M. Szulc, Robert Bittman and Marco Colombini
http://www.biochemj.org/bj/445/bj4450081.htm

Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation
Crina-Maria Ionescu1,2, Radka Svobodová Vařeková1,2, Jochen H. M. Prehn3,4, Heinrich J. Huber3,4, Jaroslav Koča
http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002565

µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis
Juan García Valero, Aurélie Cornut-Thibaut, Romain Jugé, Anne-Laure Debaud, Diana Giménez, Germain Gillet, Nathalie Bonnefoy-Bérard, Jesús Salgado, Gilles Salles, Abdel Aouacheria, Jérôme Kucharczak
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0038620

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death
Guillaume Robert, Cecile Gastaldi, Alexandre Puissant, Amine Hamouda, Arnaud Jacquel, Maeva Dufies, Nathalie Belhacene, Pascal Colosetti, John C. Reed, Patrick Auberger and Fréderic Luciano
http://dx.doi.org/10.4161/auto.19084

Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis
[Bim]
S Gupta, D E Read, A Deepti, K Cawley, A Gupta, D Oommen, T Verfaillie, S Matus, M A Smith, J L Mott, P Agostinis, C Hetz and A Samali
http://www.nature.com/cddis/journal/v3/n6/abs/cddis201274a.html

Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation
Crina-Maria Ionescu, Radka Svobodová Vařeková, Jochen H. M. Prehn, Heinrich J. Huber, Jaroslav Koča
http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002565

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Mitochondria and cell death
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A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway
Sebastián Zamorano, Diego Rojas-Rivera, Fernanda Lisbona, Valentina Parra, Felipe A. Court, Rosario Villegas, Emily H. Cheng, Stanley J. Korsmeyer, Sergio Lavandero, Claudio Hetz
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037782

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis
Angelina V. Vaseva, Natalie D. Marchenko, Kyungmin Ji, Stella E. Tsirka, Sonja Holzmann, Ute M. Moll
http://www.cell.com/abstract/S0092-8674(12)00593-4

Structure-based analysis of VDAC1: N-terminus location, translocation, channel gating and association with anti-apoptotic proteins
Shay Geula, Danya Ben Hail and Varda Shoshan Barmatz
http://www.biochemj.org/bj/444/bj4440475.htm

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Reviews / Comments / Previews
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The flick of a switch: which death program to choose?
P Vandenabeele and G Melino
http://www.nature.com/cdd/journal/v19/n7/full/cdd201265a.html

Caspase-3 and prostaglandins signal for tumor regrowth in cancer therapy
L Galluzzi, O Kepp and G Kroemer
http://www.nature.com/onc/journal/v31/n23/full/onc2011459a.html

Innate immunity: regulation of caspases by IAP-dependent ubiquitylation
DIAP2-mediated ubiquitylation of the pro-apoptotic initiator caspase Dredd converts it to an activator of the NfκB pathway required for innate immune signalling in Drosophila.
Christina Falschlehner and Michael Boutros
http://www.nature.com/emboj/journal/v31/n12/full/emboj2012148a.html

When Death Was Young: An Ancestral Apoptotic Network in Bacteria
D. Carmona-Gutierrez, G. Kroemer, and F. Madeo
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900448-0

Stemming Danger with Golgified BAX
L.D. Walensky
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900450-9

Death regulates platelet birth and life
Karin M. Hoffmeister
http://bloodjournal.hematologylibrary.org/cgi/content/full/119/24/5617

Cancer drug’s survivin suppression called into question
David Holmes
http://www.nature.com/nm/journal/v18/n6/full/nm0612-842b.html

Channeling Death
Nancy R. Gough
Caspase-mediated cleavage of the channel TRPM7 enhances its activity and promotes Fas-mediated cell death.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/229/ec171

p53 Opens the Gates to Necrosis
Ernesto Andrianantoandro
p53 induces necrosis in response to oxidative stress by opening the mitochondrial permeability transition pore.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/230/ec175

Cell death: 1+1≠2
Michael Yaffe and colleagues show that pretreatment with one targeted drug for a specific period of time can increase the sensitivity of triple-negative breast cancer cells to standard chemotherapy.
http://www.nature.com/nrc/journal/v12/n7/full/nrc3301.html

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