ApoList – May 2012


A Perspective on Mammalian Caspases as Positive and Negative Regulators of Inflammation
S.J. Martin, C.M. Henry, and S.P. Cullen

Multipolar functions of BCL-2 proteins link energetics to apoptosis
J. Marie Hardwick, Ying-bei Chen, Elizabeth A. Jonas

CD95 signaling in colorectal cancer
Frederik J.H. Hoogwater, Ernst J.A. Steller, B. Florien Westendorp, Inne H.M. Borel Rinkes, Onno Kranenburg

Killing a cancer: what are the alternatives?
Peter Kreuzaler & Christine J. Watson

Comments / previews

In epilepsy, BAD is not really bad.
E. Ziviani, L. Scorrano

Mcl-1 rescues a glitch in the matrix
Joshua L. Andersen and Sally Kornbluth

Death-defying apoptotic caspases in thrombopoiesis
Alan B. Cantor

Intrinsic TKI Resistance Is Associated with a BIM Polymorphism
Cancer Discovery May 2012;2:389

Oxygenated Lipids: A Mode to WiPE Out Inflammation?
Amelia E. Hochreiter-Hufford, Kodi S. Ravichandran

Ironing Out Cell Death Mechanisms
J.C. Reed and M. Pellecchia

A BAD Metabolic Choice  – Wei Wong
Preventing the phosphorylation of BAD switches the primary fuel source of neurons from glucose to ketone bodies.

Bcl-2 family proteins

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
Rhonda M. Perciavalle, Daniel P. Stewart, Brian Koss, John Lynch, Sandra Milasta, Madhavi Bathina, Jamshid Temirov, Megan M. Cleland, Stéphane Pelletier, John D. Schuetz, Richard J. Youle, Douglas R. Green and Joseph T. Opferman

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice
F Ke, A Voss, J B Kerr, L A O’Reilly, L Tai, N Echeverry, P Bouillet, A Strasser and T Kaufmann

A. Giménez-Cassina, J. R. Martínez-François, J. K. Fisher, B. Szlyk, K. Polak, J. Wiwczar, G. R. Tanner, A. Lutas, G. Yellen, N. N. Danial
BAD-dependent regulation of fuel metabolism and KATP channel activity confers resistance to epileptic seizures.

The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells
Maria Maryanovich, Galia Oberkovitz, Hagit Niv, Lidiya Vorobiyov, Yehudit Zaltsman, Ori Brenner, Tsvee Lapidot, Steffen Jung and Atan Gross

The MUC1-C Oncoprotein Binds to the BH3 Domain of the Proapoptotic BAX Protein and Blocks BAX Function
Rehan Ahmad, Maroof Alam, Hasan Rajabi, and Donald Kufe

Mitochondrial Bcl-2 Family Dynamics Define Therapy Response and Resistance in Neuroblastoma
Kelly C. Goldsmith, Michelle Gross, Susan Peirce, Dema Luyindula, Xueyuan Liu, Annette Vu, Michael Sliozberg, Rong Guo, Huaqing Zhao, C. Patrick Reynolds, and Michael D. Hogarty

MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal Inhibitors
Mikael Lerner, Moritz Haneklaus, Masako Harada, Dan Grandér

Mediation of the anti-apoptotic activity of BCL-XL upon interaction with VDAC1
Nir Arbel, Danya Ben-Hail, and Varda Shoshan-Barmatz

Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis
Raluca Dumitru, Vivian Gama, B. Matthew Fagan, Jacquelyn J. Bower, Vijay Swahari, Larysa H. Pevny, and Mohanish Deshmukh

Correspondence: Bcl-xL–inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores
Matthew T. Harper and Alastair W. Poole

IAPs and death receptors

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity
Rune Busk Damgaard, Ueli Nachbur, Monica Yabal, Wendy Wei-Lynn Wong, Berthe Katrine Fiil, Mischa Kastirr, Eva Rieser, James Arthur Rickard, Aleksandra Bankovacki, Christian Peschel, Juergen Ruland, Simon Bekker-Jensen, Niels Mailand, Thomas Kaufmann, Andreas Strasser, Henning Walczak, John Silke, Philipp J. Jost, and Mads Gyrd-Hansen

X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8–E3 ligase for caspase-7
Taiki Nagano, Toshiaki Hashimoto, Akio Nakashima, Ushio Kikkawa, Shinji Kamada

Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis
Georg Eschenburg, Angelika Eggert, Alexander Schramm, Holger N. Lode, and Patrick Hundsdoerfer

Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL
Catarina Castro Alves, Nadia Terziyska, Michaela Grunert, Sibylle Gündisch, Ulrike Graubner, Leticia Quintanilla-Martinez, and Irmela Jeremias

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2)
Nathan W. Werneburg, Steve F. Bronk, Maria Eugenia Guicciardi, Laurel Thomas, Jimmy D. Dikeakos, Gary Thomas, and Gregory J. Gores

Signaling active CD95 molecules trigger co-translocation of inactive CD95 molecules into lipid rafts
Isabell Lang, Andrea Fick, Viktoria Schaefer, Tina Giner, Daniela Siegmund, and Harald Wajant

Regulation of PKC Inactivation by FADD
Wei Cheng, Lu Wang, Rong Zhang, Pan Du, Bingya Yang, Hongqin Zhuang, Bo Tang, Chun Yao, Mei Yu, Yuxuan Wang, Jing Zhang, Wu Yin, Jiahuang Li, Weijuan Zheng, Min Lu, and Zichun Hua


Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function
Michael J. White, Simone M. Schoenwaelder, Emma C. Josefsson, Kate E. Jarman, Katya J. Henley, Chloé James, Marlyse A. Debrincat, Shaun P. Jackson, David C. S. Huang, and Benjamin T. Kile

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis
Gergely Imre, Jan Heering, Armelle-Natsuo Takeda, Matthias Husmann, Bernd Thiede, Dagmar Meyer zu Heringdorf, Douglas R Green, F Gisou van der Goot, Bhanu Sinha, Volker Dötsch and Krishnaraj Rajalingam

Crystal structure of a Trypanosoma brucei metacaspase
Karen McLuskey, Jana Rudolf, William R. Proto, Neil W. Isaacs, Graham H. Coombs, Catherine X. Moss, and Jeremy C. Mottram

The Loss of Functional Caspase-12 in Europe Is a Pre-Neolithic Event
Montserrat Hervella, Theo S. Plantinga, Santos Alonso, Bart Ferwerda, Neskuts Izagirre, Lara Fontecha, Rosa Fregel, Jos W. M. van der Meer, Concepcion de-la-Rúa, Mihai G. Netea

FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma
Kathrin Geiger, Judith Hagenbuchner, Martina Rupp, Heidi Fiegl, Consolato Sergi, Bernhard Meister, Ursula Kiechl-Kohlendorfer, Thomas Müller, Michael J. Ausserlechner, and Petra Obexer

A Meta-Analysis of Caspase 9 Polymorphisms in Promoter and Exon Sequence on Cancer Susceptibility
Wei Xu, Shengqiang Jiang, Yuanyuan Xu, Bo Chen, Yan Li, Feng Zong, Weihong Zhao, Jianqing Wu


12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance
Stefan Uderhardt, Martin Herrmann, Olga V. Oskolkova, Susanne Aschermann, Wolfgang Bicker, Natacha Ipseiz, Kerstin Sarter, Benjamin Frey, Tobias Rothe, Reinhard Voll, Falk Nimmerjahn, Valery N. Bochkov, Georg Schett, Gerhard Krönke

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
S.J. Dixon, K.M. Lemberg, M.R. Lamprecht, R. Skouta, E.M. Zaitsev, C.E. Gleason, D.N. Patel, A.J. Bauer, A.M. Cantley, W.S. Yang, B. Morrison III, and B.R. Stockwell

Antibiotic-Induced Bacterial Cell Death Exhibits Physiological and Biochemical Hallmarks of Apoptosis
Daniel J. Dwyer, Diogo M. Camacho, Michael A. Kohanski, Jarred M. Callura, and James J. Collins

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks
M.J. Lee, A.S. Ye, A.K. Gardino, A.M. Heijink, P.K. Sorger, G. MacBeath, and M.B. Yaffe

Alterations in RNA processing during immune-mediated programmed cell death
Danielle K. Rajani, Michael Walch, Denis Martinvalet, Marshall P. Thomas, and Judy Lieberman


Cell death research, on an island girt by sea
Meeting report: 1st Australian Workshop, on cell Death: Death on the Reef
M E Christensen, W W-L Wong, M Waibel, R W Johnstone and N J Waterhouse

Postdoctoral research associate position available at Innsbruck Medical University
Contact Prof. Andreas Villunger, PhD