Apolist – January 2012

Bcl-2 proteins

Cytosolic Bax: Does it require binding proteins to keep its pro-apoptotic activity in check?
Sandra Vogel, Nina Raulf, Stephanie Bregenhorn, Martin L. Biniossek, Ulrich Maurer, Peter Czabotar, and Christoph Borner

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl
G Monaco, E Decrock, H Akl, R Ponsaerts, T Vervliet, T Luyten, M De Maeyer, L Missiaen, C W Distelhorst, H De Smedt, J B Parys, L Leybaert and G Bultynck

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Stefan P. Glaser, Erinna F. Lee, Evelyn Trounson, Philippe Bouillet, Andrew Wei, W. Douglas Fairlie, David J. Izon, Johannes Zuber, Amy R. Rappaport, Marco J. Herold, Warren S. Alexander, Scott W. Lowe, Lorraine Robb, and Andreas Strasser

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Congcong He, 11 Michael C. Bassik,4, 12, 11 Viviana Moresi,5 Kai Sun,2, 6 Yongjie Wei,1, 2, 3 Zhongju Zou,1, 2, 3 Zhenyi An,1, 2 Joy Loh,7 Jill Fisher,4 Qihua Sun,1, 2 Stanley Korsmeyer,4, 13 Milton Packer,8 Herman I. May,2 Joseph A. Hill,2 Herbert W. Virgin,7 Christopher Gilpin,9 Guanghua Xiao,8 Rhonda Bassel-Duby,5 Philipp E. Scherer2, 6 & Beth Levine

The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast
Thibaud T. Renault, Xavier Grandier-Vazeille, Hubert Arokium, Gisèle Velours, Nadine Camougrand, Muriel Priault, Oscar Teijido, Laurent M. Dejean, Stéphen Manon

ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity
Y Shao and A E Aplin


Mitochondria – apoptosome

Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome
José M. García-Heredia, Irene Díaz-Moreno, Antonio Díaz-Quintana, Mar Orzáez, José A. Navarro, Manuel Hervás, Miguel A. De la Rosa

Label-free Raman observation of cytochrome c dynamics during apoptosis
Masaya Okada, Nicholas Isaac Smith, Almar Flotildes Palonpon, Hiromi Endo, Satoshi Kawata, Mikiko Sodeoka, and Katsumasa Fujita

Conformational properties of cardiolipin-bound cytochrome c
Jonas Hanske, Jason R. Toffey, Anna M. Morenz, Amber J. Bonilla, Katherine H. Schiavoni, and Ekaterina V. Pletneva

Multi-Parametric Analysis and Modeling of Relationships between Mitochondrial Morphology and Apoptosis
Yara Reis, Marti Bernardo-Faura, Daniela Richter, Thomas Wolf, Benedikt Brors, Anne Hamacher-Brady, Roland Eils, Nathan R. Brady


The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo
N Edison, D Zuri, I Maniv, B Bornstein, T Lev, Y Gottfried, S Kemeny, M Garcia-Fernandez, J Kagan and S Larisch

IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation
This study reveals targeting of the small GTPase Rac1 by the IAP family of E3 ligases. Functionally, this contributes to Rac1-dependent cellular migration in cancer cells and neuronal polarization in the developing zebrafish hindbrain.
Tripat Kaur Oberoi, Taner Dogan, Jennifer C Hocking, Rolf-Peter Scholz, Juliane Mooz, Carrie L Anderson, Christiaan Karreman, Dagmar Meyer zu Heringdorf, Gudula Schmidt, Mika Ruonala, Kazuhiko Namikawa, Gregory S Harms, Alejandro Carpy, Boris Macek, Reinhard W Köster and Krishnaraj Rajalingam

Death receptors

Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression
Monika C. Wolkers, Carmen Gerlach, Ramon Arens, Edith M. Janssen, Patrick Fitzgerald, Ton N. Schumacher, Jan Paul Medema, Douglas R. Green, and Stephen P. Schoenberger

Tumor necrosis factor receptor associated factor 7 (TRAF7) is required for Tumor Necrosis Factor (TNF) α-induced Jun NH2-terminal kinase (JNK) activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of cellular FLICE- inhibitory protein (c-FLIP)
Ivan Scudiero, Tiziana Zotti, Angela Ferravante, Mariangela Vessichelli, Carla Reale, Maria Chiara Masone, Antonio Leonardi, Pasquale Vito, and Romania Stilo


A Short Caspase-3 Isoform Inhibits Chemotherapy-Induced Apoptosis by Blocking Apoptosome Assembly
Frédérique Végran, Romain Boidot, Eric Solary, Sarab Lizard-Nacol

A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C
Robert Mintzer, Sreemathy Ramaswamy, Kinjalkumar Shah, Rami N. Hannoush, Christine D. Pozniak, Frederick Cohen, Xianrui Zhao, Emile Plise, Joseph W. Lewcock, Christopher E. Heise

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD
Victoria Iglesias-Guimarais, Estel Gil-Guinon, Gisela Gabernet, Merce Garcia-Belinchon, Maria Sanchez-Osuna, Elisenda Casanelles, Joan X. Comella, and Victor J. Yuste


Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy.
Hector S, Rehm M, Schmid J, Kehoe J, McCawley N, Dicker P, Murray F, McNamara D, Kay EW, Concannon CG, Huber HJ, Prehn JH.

TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis.
Rojas-Rivera D, Armisén R, Colombo A, Martínez G, Eguiguren AL, Díaz A, Kiviluoto S, Rodríguez D, Patron M, Rizzuto R, Bultynck G, Concha ML, Sierralta J, Stutzin A, Hetz C.

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
L. Sun, H. Wang, Z. Wang, S. He, S. Chen, D. Liao, L. Wang, J. Yan, W. Liu, X. Lei, and X. Wang

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways
Z. Wang, H. Jiang, S. Chen, F. Du, and X. Wang

BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation
L Cabon, P Galán-Malo, A Bouharrour, L Delavallée, M-N Brunelle-Navas, H K Lorenzo, A Gross and S A Susin

Reviews / Comments

TRAIL Signaling and Synergy Mechanisms Used in TRAIL-Based Combination Therapies.
Hellwig CT, Rehm M.

RIP3 Finds Partners in Crime
F.K.-M. Chan and E.H. Baehrecke

7th Tuscany Retreat on Cancer Research: Genetic profiling, resistance mechanism and novel treatment concepts in cancer
G Leprivier, A Rufini, A J García-Sáez, C Borner & B Rotblat

Prediction of response to anticancer treatment as simple as the resolution of ordinary differential equations?
Laurent-Puig P, Manceau G, Boige V, Blons H.