Apolist – december 2011

Bcl-2 family proteins

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family
Members to Promote Mitochondrial Apoptosis
A.D. Rubinstein, M. Eisenstein, Y. Ber, S. Bialik, and A. Kimchi

Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice
Priscilla N. Kelly, Stephanie Grabow, Alex R. D. Delbridge, Andreas
Strasser, and Jerry M. Adams

MiR-125b and miR-155 contribute to BCL2 repression and proliferation
in response to CD40 ligand (CD154) in human leukemic B-cells.
Shaun Willimott and Simon D. Wagner

Human Embryonic Stem Cells Express Elevated Levels of Multiple
Pro-Apoptotic BCL-2 Family Members
David T. Madden, Diana Davila-Kruger, Simon Melov, Dale E. Bredesen

Reduced mast cell and basophil numbers and function in Cpa3-Cre;
Mcl-1fl/fl mice
Jennifer N. Lilla, Ching-Cheng Chen, Kaori Mukai, Maya J. BenBarak,
Christopher B. Franco, Janet Kalesnikoff, Mang Yu, Mindy Tsai, Adrian
M. Piliponsky, and Stephen J. Galli


Death receptors and IAPs

Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required
for Efficient Caspase-1 Activation by the Inflammasome
K. Labbé, C.R. McIntire, K. Doiron, P.M. Leblanc, and M.

Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin
kinase to induce reactive oxygen species-mediated apoptotic cell death
Kyung-Jin Park, Chang-Han Lee, Aeyung Kim, Ki Jun Jeong, Chul-Ho Kim,
and Yong-Sung Kim

SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to
Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent
Rachel M. Greer, Michael Peyton, Jill E. Larsen, Luc Girard, Yang Xie,
Adi F. Gazdar, Patrick Harran, Lai Wang, Rolf A. Brekken, Xiaodong
Wang, and John D. Minna

Caspases and downstream

A Quantitative Method for the Specific Assessment of Caspase-6
Activity in Cell Culture
Dagmar E. Ehrnhoefer, Niels H. Skotte, Jane Savill, Yen T. N. Nguyen,
Safia Ladha, Li-Ping Cao, Edie Dullaghan, Michael R. Hayden

Two-Step Engulfment of Apoptotic Cells
Satoshi Toda, Rikinari Hanayama, and Shigekazu Nagata

Live imaging of apoptosis in a novel transgenic mouse highlights its
role in neural tube closure
Yoshifumi Yamaguchi, Naomi Shinotsuka, Keiko Nonomura, Kiwamu
Takemoto, Keisuke Kuida, Hiroki Yosida, and Masayuki Miura

Apoptosis-dependent externalization and involvement in apoptotic cell
clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila
Ryo Okada, Kaz Nagaosa, Takayuki Kuraishi, Hiroshi Nakayama, Naoko
Yamamoto, Yukiko Nakagawa, Naoshi Dohmae, Akiko Shiratsuchi, and
Yoshinobu Nakanishi


RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory
Response SyndromeL. Duprez, N. Takahashi, F. Van Hauwermeiren, B.
Vandendriessche, V. Goossens, T. Vanden Berghe, W. Declercq, C.
Libert, A. Cauwels, and P. Vandenabeele

Toll-like receptors activate programmed necrosis in macrophages
through a receptor-interacting kinase-3–mediated pathway
Sudan He, Yuqiong Liang, Feng Shao, and Xiaodong Wang

Autophagy promotes T-cell survival through degradation of proteins of
the cell death machinery
J R Kovacs, C Li, Q Yang, G Li, I G Garcia, S Ju, D G Roodman, J J
Windle, X Zhang and B Lu

The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic
reticulum stress  Kathryn Austgen, Emily T. Johnson, Tae-Ju Park, Tom
Curran and Scott A. Oakes


Cell Death and Differentiation special issue – In memory of Jurg Tschopp

Editorial by J. Silke and JE. Vince

Reviews by everybody:

The Emerging Role of Linear Ubiquitination in Cell Signaling
Christoph H. Emmerich, Anna C. Schmukle, Henning Walczak
Linear ubiquitin chains transmit signals that are induced by diverse
stimuli and regulate cell activation and death.

Programmed cell removal: a new obstacle in the road to developing cancer
Mark P. Chao, Ravindra Majeti & Irving L. Weissman

Metabolic Connections during Apoptotic Cell EngulfmentC.Z. Han and
K.S. Ravichandran

Comments – other

Who Put the ”A” in Atg12: Autophagy or Apoptosis?
T.N. Chonghaile and A. Letai

Necroptosis Turns TNF Lethal
L. Galluzzi and G. Kroemer

Preventing Necrosis by Cleaving a Deubiquitinase
Wei Wong

Inducible Apoptosis Eliminates Patient-Transferred T Cells

Cell death helps give closure
Ben Short

Deleting Mcl-1 in mast cells: getting 2 birds with 1 stone
Booki Min

Conference: 1st international Cell Death In Cancer (CDIC)
Saint Malo in Brittany (France) from 13 to 16 May 2012.


Apolist – november 2011

Bcl-2 family

Glycolysis inhibition targets Mcl-1 to restore sensitivity of lymphoma cells to ABT-737-induced apoptosis
O Meynet, M Bénéteau, M A Jacquin, L A Pradelli, A Cornille, M Carles and J-E Ricci

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy
Triona Ni Chonghaile, Kristopher A. Sarosiek, Thanh-Trang Vo, Jeremy A. Ryan, Anupama Tammareddi, Victoria Del Gaizo Moore, Jing Deng, Kenneth C. Anderson, Paul Richardson, Yu-Tzu Tai, Constantine S. Mitsiades, Ursula A. Matulonis, Ronny Drapkin, Richard Stone, Daniel J. DeAngelo, David J. McConkey, Stephen E. Sallan, Lewis Silverman, Michelle S. Hirsch, Daniel Ruben Carrasco, and Anthony Letai

Active Bax and Bak are functional holins
Xiaming Pang, Samir H. Moussa, Natalie M. Targy, Jeffrey L. Bose, Nicholas M. George, Casey Gries, Hernando Lopez, Liqiang Zhang, Kenneth W. Bayles, Ry Young, and Xu Luo

A natural compound elevates expression of Bim that interacts with Bcl-2 converting the anti-apoptotic protein to a pro-apoptotic Bax-like molecule
Lixia Zhao, Feng He, Haiyang Liu, Yushan Zhu, Weili Tian, Ping Gao, Hongping He, Wen Yue, Xiaobo Lei, Biyun Ni, Xiaohui Wang, Haijing Jin, Xiaojiang Hao, Jialing Lin, and Quan Chen

Inhibitor of Nrf2 (INrf2 or Keap1) degrades Bcl-xL via Phosphoglycerate mutase 5 and controls cellular apoptosis
Suryakant K. Niture and Anil K. Jaiswal

Death receptor pathway
CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation
Nadine Khadra, Laurence Bresson-Bepoldin, Aubin Penna, Benjamin Chaigne-Delalande, Bruno Ségui, Thierry Levade, Anne-Marie Vacher, Josy Reiffers, Thomas Ducret, Jean-François Moreau, Michael D. Cahalan, Pierre Vacher, and Patrick Legembre

Cooperative Phosphorylation of FADD by Aur-A and Plk1 in Response to Taxol Triggers Both Apoptotic and Necrotic Cell Death
Moon-Sun Jang, Su-Jin Lee, Nam Sook Kang, and Eunhee Kim

Oncogenic Ras and B-Raf positively regulates death receptor 5 expression through co-activation of ERK and JNK signaling
You-Take Oh, Ping Yue, Wei Zhou, Justin M. Balko, Esther P. Black, Taofeek K. Owonikoko, Fadlo R. Khuri, and Shi-Yong Sun

Non-apoptotic cell death

Caspase 8 inhibits programmed necrosis by processing CYLD.
O’Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT.

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members
N Vanlangenakker, M J M Bertrand, P Bogaert, P Vandenabeele and T Vanden Berghe

CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101
Margot Jak, Gregor G. W. van Bochove, Eric A. Reits, Wouter W. Kallemeijn, Jacqueline M. Tromp, Pablo Umana, Christian Klein, Rene A. W. van Lier, Marinus H. J. van Oers, and Eric Eldering

Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death
Hiroshi Kanda, Tatsushi Igaki, Hideyuki Okano, and Masayuki Miura

Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study
S Shen, O Kepp, M Michaud, I Martins, H Minoux, D Métivier, M C Maiuri, R T Kroemer and G Kroemer

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes
Oliver Florey, Sung Eun Kim,1, 2 Cynthia P. Sandoval,3 Cole M. Haynes1, 2 & Michael Overholtzer


Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α
Inna S. Afonina, Graham A. Tynan, Susan E. Logue, Sean P. Cullen, Michael Bots, Alexander U. Lüthi, Emer P. Reeves, Noel G. McElvaney, Jan P. Medema, Ed C. Lavelle, Seamus J. Martin

Constitutive exposure of phosphatidylserine on viable cells
Katsumori Segawa, Jun Suzuki, and Shigekazu Nagata

Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles
Rostyslav O. Bilyy, Tanya Shkandina, Andriy Tomin, Luis E. Munoz, Sandra Franz, Volodymyr Antonyuk, Yuriy Ya Kit, Matthias Zirngibl, Barbara G. Fuernrohr, Christina Janko, Kirsten Lauber, Martin Schiller, Georg Schett, Rostyslav S. Stoika, and Martin Herrmann

Polypeptide modulators of card-card-mediated protein-protein interactions
Yadira Palacios-Rodriguez, Guillermo Garcia-Lainez, Monica Sancho, Anna Gortat, Mar Orzaez, and Enrique Perez-Paya

BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C.


Programmed Cell Death in Animal Development and Disease
Y. Fuchs and H. Steller

Programmed necrosis: backup to and competitor with apoptosis in the immune system
Jiahuai Han, Chuan-Qi Zhong and Duan-Wu Zhang

Immunology: A heavyweight knocked out
Douglas R. Green
Caspase-1 is one of the main culprits behind sepsis, a form of systemic inflammation.

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore
Loren D. Walensky, Evripidis Gavathiotis

Correspondence / Comments / other

Staying Alive: Defensive Strategies in the BCL-2 Family Playbook
S.P. Cullen, C.M. Henry, and S.J. Martin

Priming Cancer Cells for Death
John C. Reed

Mcl-1 leves need not be lowered for ABT-263/737-induced apoptosis
R Yamaguchi and G Perkins

Finding a panacea among combination cancer therapies
by Ryuji Yamaguchi & Guy Perkins

Cell death: The single-membrane diet
Autophagy proteins function in a non-canonical single-membrane vesicle degradation pathway.

Primed for Death
Paula A. Kiberstis
The mitochondrial state of a tumor cell prior to chemotherapy may help determine how well it responds to drug treatment.

Mcl-1 Reduction Due to Caspase-dependent Cleavage during Endoplasmic Reticulum Stress-induced Apoptosis
Jinsong Hu, Nana Dang, Tusheng Song, and Karin Vanderkerken

Reply to Hu et al.: Mcl-1 Reduction Due to Caspase-dependent Cleavage during Endoplasmic Reticulum Stress-induced Apoptosis
Nobuhiro Morishima, Keiko Nakanishi, and Akihiko Nakano

Profile of Tak Wah Mak
Jennifer Viegas

Snapshot: Mitochondrial Quality Control
D.R. Green and B. van Houten

International EMBO Molecular Medicine Workshop 2011 on ‘Cell Death and Disease’
A Hague and L S Dickens

Cell picture show – cell death