Apolist – october 2011

Bcl-2 family proteins

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
Fabien Llambi, Tudor Moldoveanu, Stephen W.G. Tait, Lisa Bouchier-Hayes, Jamshid Temirov, Laura L. McCormick, Christopher P. Dillon, and Douglas R. Green

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase
Kambiz N. Alavian, Hongmei Li, Leon Collis, Laura Bonanni, Lu Zeng, Silvio Sacchetti, Emma Lazrove, Panah Nabili, Benjamin Flaherty, Morven Graham, Yingbei Chen, Shanta M. Messerli, Maria A. Mariggio, Christoph Rahner, Ewan McNay, Gordon C. Shore, Peter J. S. Smith, J. Marie Hardwick and Elizabeth A. Jonas

Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential
Ying-bei Chen, Miguel A. Aon, Yi-Te Hsu, Lucian Soane, Xinchen Teng, J. Michael McCaffery, Wen-Chih Cheng, Bing Qi, Hongmei Li, Kambiz N. Alavian, Margaret Dayhoff-Brannigan, Shifa Zou, Fernando J. Pineda, Brian O’Rourke, Young H. Ko, Peter L. Pedersen, Leonard K. Kaczmarek, Elizabeth A. Jonas, and J. Marie Hardwick

Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL
Angélica Ospina, Alfredo Lagunas-Martínez, Julián Pardo, José A. Carrodeguas

PNAS Plus: A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans
Yun Lu, Stéphane G. Rolland, and Barbara Conradt

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins
S Torii, Y Goto, T Ishizawa, H Hoshi, K Goryo, K Yasumoto, H Fukumura and K Sogawa

Death receptor signaling

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
M.C. Bonnet, D. Preukschat, P.-S. Welz, G. van Loo, M.A. Ermolaeva, W. Bloch, I. Haase, and M. Pasparakis

The Prevalence of TNFα-Induced Necrosis over Apoptosis Is Determined by TAK1-RIP1 Interplay
Seda Çöl Arslan, Claus Scheidereit

PNAS Plus: A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis
Nicholas Dompe, Celina Sanchez Rivers, Li Li, Shaun Cordes, Martin Schwickart, Elizabeth A. Punnoose, Lukas Amler, Somasekar Seshagiri, Jerry Tang, Zora Modrusan, and David P. Davis

Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation
A M M Kober, S Legewie, C Pforr, N Fricker, R Eils, P H Krammer and I N Lavrik

GMDS deficiency renders colon cancer cells resistant to TRAIL receptor- and CD95-mediated apoptosis by inhibiting complex II formation
Kenta Moriwaki, Shinichiro Shinzaki, and Eiji Miyoshi

Caspases and IAPs

Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death
D.J. Mahoney, C. Lefebvre, K. Allan, J. Brun, C.A. Sanaei, S. Baird, N. Pearce, S. Grönberg, B. Wilson, M. Prakesh, A. Aman, M. Isaac, A. Mamai, D. Uehling, R. Al-Awar, T. Falls, T. Alain, and D.F. Stojdl

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice
Toshiyuki Bohgaki, Julien Mozo, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Miyuki Bohgaki, Otto Sanchez, Andreas Strasser, Anne Hakem, and Razqallah Hakem

Caspase deficiency alters the murine gut microbiome
B M Brinkman, F Hildebrand, M Kubica, D Goosens, J Del Favero, W Declercq, J Raes and P Vandenabeele

Drosophila IAP1-Mediated Ubiquitylation Controls Activation of the Initiator Caspase DRONC Independent of Protein Degradation
Tom V. Lee, Yun Fan, Shiuan Wang, Mayank Srivastava, Meike Broemer, Pascal Meier, Andreas Bergmann

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination
Erin C. Dueber, Allyn J. Schoeffler, Andreas Lingel, J. Michael Elliott,2 Anna V. Fedorova,1
Anthony M. Giannetti,3 Kerry Zobel,1 Brigitte Maurer,4 Eugene Varfolomeev, Ping Wu,4
Heidi J. A. Wallweber,4 Sarah G. Hymowitz,4 Kurt Deshayes,1 Domagoj Vucic, Wayne J. Fairbrother

The conservation and uniqueness of the caspase family in the basal chordate, amphioxus
Xu L, Yuan S, Li J, Huang S, Ruan J, Yang M, Huang H, Chen S, Ren Z, Xu A

Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death
K K W Hui, A K Kanungo, A J Elia and J T Henderson

Non-canonical inflammasome activation targets caspase-11.
Nobuhiko Kayagaki, Søren Warming,2 Mohamed Lamkanfi, Lieselotte Vande Walle,3, 4 Salina Louie,1 Jennifer Dong,1 Kim Newton,1 Yan Qu,1 Jinfeng Liu,5 Sherry Heldens,2 Juan Zhang,6 Wyne P. Lee,6 Merone Roose-Girma & Vishva M. Dixit


Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
Jennifer Martinez, Johann Almendinger, Andrew Oberst, Rachel Ness, Christopher P. Dillon, Patrick Fitzgerald, Michael O. Hengartner, and Douglas R. Green

Apaf1 plays a pro-survival role by regulating centrosome morphology and function
Elisabetta Ferraro, Maria Grazia Pesaresi, Daniela De Zio, Maria Teresa Cencioni, Anne Gortat, Mauro Cozzolino, Libera Berghella, Anna Maria Salvatore, Bjorn Oettinghaus, Luca Scorrano, Enrique Pérez-Payà, and Francesco Cecconi

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA.


It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
Andrew Oberst & Douglas R. Green

RIPK-Dependent Necrosis and Its Regulation by Caspases: A Mystery in Five Acts
D.R. Green, A. Oberst, C.P. Dillon, R. Weinlich, and G.S. Salvesen

Ripped to death
Ricardo Weinlich, Christopher P. Dillon, Douglas R. Green

The End and After: How Dying Cells Impact the Living Organism
D.R. Green

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways
K.S. Ravichandran

Cell Death in the Maintenance and Abrogation of Tolerance: The Five Ws of Dying Cells
T.S. Griffith and T.A. Ferguson

Tumor Promotion via Injury and Death-Induced Inflammation
A. Kuraishy, M. Karin, and S.I. Grivennikov

Dying to Replicate: The Orchestration of the Viral Life Cycle, Cell Death Pathways, and Immunity
N. Yatim and M.L. Albert

The executioners sing a new song: killer caspases activate microglia
J L Venero, M A Burguillos, P Brundin and B Joseph


Apaf1 balances life and death

G.S. Salvesen and A. Ashkenazi

Allowing Apoptosis
Valda K. Vinson
Antagonist binding to an apoptosis inhibitor releases inhibition by promoting dimerization required for autoubiquitination.

Evading Apoptosis to Promote Persistent Infection
Nancy R. Gough
By stimulating the production of an alternatively spliced antagonistic form of TRAIL, HIV-infected cells escape apoptotic death.

Dual Face Apoptotic Machinery: From Initiator of Apoptosis to Guardian of Necroptosis
W. Declercq, N. Takahashi, and P. Vandenabeele