Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for September, 2011

Apolist – september 2011

Posted by cris on September 30, 2011

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Bcl-2 family proteins
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2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma
Silvia Ramírez-Peinado, Fermín Alcázar-Limones, Laura Lagares-Tena, Nadia El Mjiyad, Alfredo Caro-Maldonado, Oscar M Tirado, and Cristina Muñoz-Pinedo
http://cancerres.aacrjournals.org/cgi/content/abstract/0008-5472.CAN-11-0759v1

Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy
Ryuji Yamaguchi, Edith Janssen, Guy Perkins, Mark Ellisman, Shinichi Kitada, John C. Reed
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024102

BH3 mimetics activate multiple pro-autophagic pathways
S A Malik, I Orhon, E Morselli, A Criollo, S Shen, G Mariño, A BenYounes, P Bénit, P Rustin, M C Maiuri and G Kroemer
http://www.nature.com/onc/journal/v30/n37/full/onc2011104a.html

Identification of a novel Mcl-1 binding motif
William J, Placzek, Mattia Sturlese, Bainan Wu, Jason F, Cellitti, Jun Wei, and Maurizio Pellecchia
http://www.jbc.org/cgi/content/abstract/M111.305326v1

An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737
Sayer Al-harbi, Brian T. Hill, Suparna Mazumder, Kamini Singh, Jennifer DeVecchio, Gaurav Choudhary, Lisa A. Rybicki, Matt Kalaycio, Jaroslaw P. Maciejewski, Janet A. Houghton, and Alexandru Almasan
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/118/13/3579

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
Emma C. Josefsson, Chloé James, Katya J. Henley, Marlyse A. Debrincat, Kelly L. Rogers, Mark R. Dowling, Michael J. White, Elizabeth A. Kruse, Rachael M. Lane, Sarah Ellis, Paquita Nurden, Kylie D. Mason, Lorraine A. O’Reilly, Andrew W. Roberts, Donald Metcalf, David C.S. Huang, and Benjamin T. Kile
Deletion of Bak and Bax, the effectors of mitochondrial apoptosis, does not affect platelet production, however, loss of prosurvival Bcl-xL results in megakaryocyte apoptosis and failure of platelet shedding.
http://jem.rupress.org/cgi/content/abstract/208/10/2017?etoc

BikDD Eliminates Breast Cancer Initiating Cells and Synergizes with Lapatinib for Breast Cancer Treatment
J.-Y. Lang, J.L. Hsu, F. Meric-Bernstam, C.-J. Chang, Q. Wang, Y. Bao, H. Yamaguchi, X. Xie, W.A. Woodward, D. Yu, G.N. Hortobagyi, and M.-C. Hung
http://www.cell.com/cancer-cell/abstract/S1535-6108%2811%2900267-4

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Death receptor pathway and IAPs
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The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion.
CD95 is a prototypic ‘death receptor’ that can also activate non-apoptotic signaling pathways, promoting tumour growth. The authors show that activated CD95 promotes tumor cell invasion by engaging a new signalling pathway that causes remodeling of the cellular architecture.
Ernst J A Steller, Laila Ritsma, Danielle A E Raats, Frederik J H Hoogwater, Benjamin L Emmink, Klaas M Govaert, Jamila Laoukili, Inne H M Borel Rinkes, Jacco van Rheenen and Onno Kranenburg
http://www.nature.com/embor/journal/v12/n9/full/embor2011129a.html

Tumor necrosis factor-α and interferon-  induce pancreatic β-cell apoptosis through STAT1-mediated Bim activation
Jenny Barthson, Carla M. Germano, Fabrice Moore, Adriano Maida, Daniel J. Drucker, Piero Marchetti, Conny Gysemans, Chantal Mathieu, Gabriel Nunez, Andrea Jurisicova, Decio L Eizirik, and Esteban N. Gurzov
http://www.jbc.org/cgi/content/abstract/M111.253591v2

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
Rong-Hua Tao, Zuzana Berkova, Jillian F. Wise, Abdol-Hossein Rezaeian, Urszula Daniluk, Xue Ao, David H. Hawke, Judith E. Karp, Hui-Kuan Lin, Jeffrey J. Molldrem, and Felipe Samaniego
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/118/11/3107

Celecoxib Promotes c-FLIP Degradation through Akt-Independent Inhibition of GSK3
Shuzhen Chen, Wei Cao, Ping Yue, Chunhai Hao, Fadlo R. Khuri, and Shi-Yong Sun
http://cancerres.aacrjournals.org/cgi/content/abstract/71/19/6270

TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation
Joo-Young Kim, Ju-Yeon Lee, Dong-Gun Kim, Gi-Bang Koo, Je-Wook Yu, You-Sun Kim
http://www.sciencedirect.com/science/article/pii/S001457931100398X

cIAP1/2 Are Direct E3 Ligases Conjugating Diverse Types of Ubiquitin Chains to Receptor Interacting Proteins Kinases 1 to 4 (RIP1–4)
Mathieu J. M. Bertrand, Saskia Lippens, An Staes, Barbara Gilbert, Ria Roelandt, Jelle De Medts, Kris Gevaert, Wim Declercq, Peter Vandenabeele
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022356

Arabidopsis IAP-like protein lacks a BIR domain and attenuates cell death in plant and animal systems
Woe Yeon Kim, Sun Yong Lee, Young Jun Jung, Ho Byoung Chae, Ganesh M. Nawkar, Mi Rim Shin, Sun Young Kim, Jin Ho Park, Chang Ho Kang, Yong Hoon Chi, Il Pyung Ahn, Dae Jin Yun, Kyun Oh Lee, Young-Myeong Kim, Min Gab Kim, and Sang Yeol Lee
http://www.jbc.org/cgi/content/abstract/M111.262204v1

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis ▶
Claudia Günther, Eva Martini, Nadine Wittkopf, Kerstin Amann, Benno Weigmann, Helmut Neumann,
Maximilian J. Waldner, Stephen M. Hedrick,  Stefan Tenzer, Markus F. Neurath & Christoph Becker
http://www.nature.com/nature/journal/v477/n7364/full/nature10400.html

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Caspases
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Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8
M A Laussmann, E Passante, H Düssmann, J A Rauen, M L Würstle, M E Delgado, M Devocelle, J H M Prehn and M Rehm
http://www.nature.com/cdd/journal/v18/n10/full/cdd201127a.html

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity
Jennifer V. Lu, Brian M. Weist, Bram J. van Raam, Brett S. Marro, Long V. Nguyen, Prathna Srinivas, Bryan D. Bell, Keith A. Luhrs, Thomas E. Lane, Guy S. Salvesen, and Craig M. Walsh
http://www.pnas.org/content/108/37/15312.abstract?etoc

A Biotin Switch-Based Proteomics Approach Identifies 14-3-3ζ as a Target of Sirt1 in the Metabolic Regulation of Caspase-2
J.L. Andersen, J.W. Thompson, K.R. Lindblom, E.S. Johnson, C.-S. Yang, L.R. Lilley, C.D. Freel, M.A. Moseley, and S. Kornbluth
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900629-0

Oncogenic ras-induced downregulation of a pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells
Byong Hoon Yoo, Yanfei Wang, Mete Erdogan, Takehiko Sasazuki, Senji Shirasawa, Laurent Corcos, Kanaga Sabapathy, and Kirill V. Rosen
http://www.jbc.org/cgi/content/abstract/M111.290692v1

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Miscellaneous
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Generation and characterization of antibodies specific for caspase-cleaved neo-epitopes: a novel approach
X Ai, B Butts, K Vora, W Li, C Tache-Talmadge, A Fridman and H Mehmet
http://www.nature.com/cddis/journal/v2/n9/full/cddis201191a.html

Intracellular K+ concentration decrease is not obligatory for apoptosis
Sara I. Borjesson, Ulrika H. Englund, Muhammad H. Asif, Magnus Willander, and Fredrik Elinder
http://www.jbc.org/cgi/content/abstract/M111.262725v1

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Reviews / comments
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Can the analysis of BH3-only protein knockout mice clarify the issue of ‘direct versus indirect’ activation of Bax and Bak?
A Villunger, V Labi, P Bouillet, J Adams and A Strasser
http://www.nature.com/cdd/journal/v18/n10/full/cdd2011100a.html

Targeting Bcl-2 in CLL: cui bono?
Anthony Letai
http://bloodjournal.hematologylibrary.org/cgi/content/full/118/13/3453

A yeast BH3-only protein for the rescue
A Gross
http://www.nature.com/cdd/journal/v18/n10/full/cdd201199a.html

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
For this New EMBO member’s review, three recognised experts joined forces to provide a comprehensive overview on the molecular control of apoptosis and to discuss prospects for therapies.
Andreas Strasser, Suzanne Cory and Jerry M Adams
http://www.nature.com/emboj/journal/v30/n18/full/emboj2011307a.html

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?
A Lemarie and S Grimm
http://www.nature.com/onc/journal/v30/n38/full/onc2011167a.html

Cell death: Linking metabolism to apoptotic sensitivity
BCL-XL suppresses acetyl CoA production to protect cells against apoptosis.
http://www.nature.com/nrm/journal/v12/n10/full/nrm3195.html

Akt, FoxO and regulation of apoptosis
Xinbo Zhang, Naimei Tang, Timothy J. Hadden, Arun K. Rishi
http://www.sciencedirect.com/science/article/pii/S0167488911000826

Cell death in disease: from 2010 onwards
R A Knight and G Melino
http://www.nature.com/cddis/journal/v2/n9/full/cddis201189a.html

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