Apolist – august 2011

Bcl-2 family proteins
Bid can mediate a pro-apoptotic response to etoposide and ionizing radiation without cleavage in its unstructured loop and in the absence of p53
C Maas, E de Vries, S W G Tait and J Borst

Requirement of FADD, NEMO, and BAX/BAK for Aberrant Mitochondrial Function in Tumor Necrosis Factor Alpha-Induced Necrosis
Krishna M. Irrinki, Karthik Mallilankaraman, Roshan J. Thapa, Harish C. Chandramoorthy, Frank J. Smith, Neelakshi R. Jog, Rajesh Kumar Gandhirajan, Steven G. Kelsen, Steven R. Houser, Michael J. May, Siddharth Balachandran, and Muniswamy Madesh

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
C.H. Yi, H. Pan, J. Seebacher, I.-H. Jang, S.G. Hyberts, G.J. Heffron, M.G. Vander Heiden, R. Yang, F. Li, J.W. Locasale, H. Sharfi, B. Zhai, R. Rodriguez-Mias, H. Luithardt, L.C. Cantley, G.Q. Daley, J.M. Asara, S.P. Gygi, G. Wagner, C.-F. Liu, and J. Yuan

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress
L Dong, C C Jiang, R F Thorne, A Croft, F Yang, H Liu, C E de Bock, P Hersey and X D Zhang

Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells
Alejo A. Morales, Metin Kurtoglu, Shannon M. Matulis, Jiangxia Liu, David Siefker, Delia M. Gutman, Jonathan L. Kaufman, Kelvin P. Lee, Sagar Lonial, and Lawrence H. Boise

A Novel Tumor Antigen Derived from Enhanced Degradation of Bax Protein in Human Cancers
Cláudia Trindade Nunes, Kelly L. Miners, Garry Dolton, Chris Pepper, Chris Fegan, Malcolm D. Mason, and Stephen Man

Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) via induction of WW domain binding protein 1
Nobuhiro Morishima, Keiko Nakanishi, and Akihiko Nakano

Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL
Emmanuele Ambrosi, Stefano Capaldi, Michele Bovi, Gianmaria Saccomani, Massimiliano Perduca and Hugo L. Monaco

BH3-only protein Bim inhibits activity of antiapoptotic members of Bcl-2 family when expressed in yeast
Barbora Juhásová, Marek Mentel, Ingrid Bhatia-Kiššová, Igor Zeman, Jordan Kolarov, Michael Forte, Peter Polčic

Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL
Haigang Ren, Kai Fu, Dan Wang, Chenchen Mu, and Guanghui Wang
J. Biol. Chem. published 18 August 2011, 10.1074/jbc.M110.207134

Bcl-xL–inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets
Simone M. Schoenwaelder, Kate E. Jarman, Elizabeth E. Gardiner, My Hua, Jianlin Qiao, Michael J. White, Emma C. Josefsson, Imala Alwis, Akiko Ono, Abbey Willcox, Robert K. Andrews, Kylie D. Mason, Hatem H. Salem, David C. S. Huang, Benjamin T. Kile, Andrew W. Roberts, and Shaun P. Jackson

Death receptor pathway

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
Patrick-Simon Welz, Andy Wullaert,1 Katerina Vlantis,1 Vangelis Kondylis,1 Vanesa Fernández-Majada, Maria Ermolaeva,1 Petra Kirsch,2 Anja Sterner-Kock,3 Geert van Loo & Manolis Pasparaki

RIP1-Dependent and Independent Effects of Necrostatin-1 in Necrosis and T Cell Activation
YoungSik Cho, Thomas McQuade, Haibing Zhang, Jianke Zhang, Francis Ka-Ming Chan

Isolation of a TRAIL antagonist from the serum of HIV infected patients
David J. Schnepple, Brett Shepard, Gary D. Bren, Nathan W. Cummins, Sergey Trushin, Alicia Algeciras-Schimnich, Xue W. Meng, Amy M. Sainski, Stacey A. Rizza, Scott H. Kaufmann, and Andrew D. Badley

PEDF promotes tumor cell death by inducing macrophage membrane TRAIL
Tsung-Chuan Ho, Show-Li Chen, Shou-Chuan Shih, Shing-Jyh Chang, Su-Lin Yang, Jui-Wen Hsieh, Huey-Chuan Cheng, Lee-Jen Chen, and Yeou-Ping Tsao
J. Biol. Chem. published 16 August 2011, 10.1074/jbc.M111.266064

The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2
Yide Mei, Allison Alcivar Hahn, Shimin Hu, and Xiaolu Yang


Structural and enzymatic insights into caspase-2 substrate recognition and catalysis
Yinyan Tang, James A. Wells, and Michelle R. Arkin

Caspase-8-mediated cleavage inhibits IRF-3 by facilitating its proteasome-mediated degradation
Nathaniel Sears, Ganes C. Sen, George R. Stark, and Saurabh Chattopadhyay

Caspase-1 induces apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)-mediated necrosis independently of its catalytic activity
Kou Motani, Hiroko Kushiyama, Ryu Imamura, Takeshi Kinoshita, Takumi Nishiuchi, and Takashi Suda

Interaction patches of procaspase-1 CARD are differently involved in procaspase-1 activation and RIP2-dependent NF-KB signaling
Kristof Kersse, Mohammed Lamkanfi, Mathieu J.M. Bertrand, Tom Vanden Berghe, and Peter Vandenabeele
J. Biol. Chem. published 23 August 2011, 10.1074/jbc.M111.242321


Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging
Douglas R. Green, Lorenzo Galluzzi, Guido Kroemer

Special Issue on Nobel Symposium ‘The Cell Cycle and Apoptosis in Disease’
Volume 18, Issue 9 (September 2011)

News and views / Comments / Other

Oncogene-induced autophagy and the Goldilocks principle
Seamus J. Martin

The Ripoptosome: Death Decision in the Cytosol
M.J.M. Bertrand and P. Vandenabeele

BH3 mimetics reveal the network properties of autophagy-regulatory signaling cascades
Shoaib Ahmad Malik, Shensi Shen, Guillermo Mariño, Amena BenYounès, Maria Chiara Maiuri and Guido Kroemer

Death by Acetylation
Nancy R. Gough
Reduction in acetyl-CoA and protein N-acetylation is one mechanism by which Bcl-xL exerts its antiapoptotic effect.

A new platform for death
Identification of a signalling platform that can trigger apoptosis and necroptosis.

18th Euroconference on Apoptosis in Ghent, Belgium, 1–4 September 2010
W Declercq, P Agostinis and P Vandenabeele