Apolist – june 2011

Bcl-2 family proteins

Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53
C. Charvet, M. Wissler, P. Brauns-Schubert, S.-J. Wang, Y. Tang, F.C. Sigloch, H. Mellert, M. Brandenburg, S.E. Lindner, B. Breit, D.R. Green, S.B. McMahon, C. Borner, W. Gu, and U. Maurer

Multiple BH3 mimetics antagonize anti-apoptotic MCL1 by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.
Albershardt TC, Salerni BL, Soderquist RS, Bates DJ, Pletnev AA, Kisselev AF, Eastman A.

BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells
Martin Hausmann, Katharina Leucht, Christian Ploner, Stephan Kiessling, Andreas Villunger, Helen Becker, Claudia Hofmann, Werner Falk, Michaela Krebs, Silvia Kellermeier, Michael Fried, Jürgen Schölmerich, Florian Obermeier, and Gerhard Rogler

The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity
Rathiga Velaithan, Jia Kang, Jayshree L. Hirpara, Thomas Loh, Boon Cher Goh, Morgane Le Bras, Catherine Brenner, Marie-Veronique Clement, and Shazib Pervaiz

Bcl-xL Blocks a Mitochondrial Inner Membrane Channel and Prevents Ca2+ Overload-Mediated Cell Death
Daniel Tornero, Inmaculada Posadas, Valentín Ceña

Repression of Puma by Scratch2 is required for neuronal survival during embryonic development
E Rodríguez-Aznar and M A Nieto

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation
Hyunmi Lee, Jimmy A. Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C. Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick

Death receptors

Sam68 Is Required for Both NF-B Activation and Apoptosis Signaling by the TNF Receptor
Parameswaran Ramakrishnan and David Baltimore

A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2
S. Choksi, Y. Lin, Y. Pobezinskaya, L. Chen, C. Park, M. Morgan, T. Li, S. Jitkaew, X. Cao, Y.-S. Kim, H.-S. Kim, P. Levitt, G. Shih, M. Birre, C.-X. Deng, and Z.-g. Liu

A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils
Barbara Geering, Ursina Gurzeler, Elena Federzoni, Thomas Kaufmann, and Hans-Uwe Simon

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes
R Alonso, C Mazzeo, M C Rodriguez, M Marsh, A Fraile-Ramos, V Calvo, A Avila-Flores, I Merida and M Izquierdo


The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans
A J Ross, M Li, B Yu, M X Gao and W B Derry

NF- B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis
Roshan J. Thapa, Suresh H. Basagoudanavar, Shoko Nogusa, Krishna Irrinki, Karthik Mallilankaraman, Michael J. Slifker, Amer A. Beg, Muniswamy Madesh, and Siddharth Balachandran

Squamous Cell Carcinoma Antigen 1 Promotes Caspase-8-Mediated Apoptosis in Response to Endoplasmic Reticulum Stress While Inhibiting Necrosis Induced by Lysosomal Injury
Erica Ullman, Ji-An Pan, and Wei-Xing Zong

Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling
Tatsuya Akagi, Kouhei Shimizu, Shoukichi Takahama, Takahiro Iwasaki, Kazuhiro Sakamaki, Yaeta Endo, Tatsuya Sawasaki


Modulating stress responses by the UPRosome: A matter of life and death
Ute Woehlbier, Claudio Hetz

Caspase Substrates and Cellular Remodeling
Emily D. Crawford and James A. Wells

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
Domagoj Vucic, Vishva M. Dixit & Ingrid E. Wertz

News and views

GSK3 TIPping Off p53 to Unleash PUMA
F.J. Bock and A. Villunger

Making a Bid for Inflammation
John F. Foley
The proapoptotic protein Bid promotes innate immune responses in the intestine independently of its role in apoptosis.