Apoptosis and cell death

Apolist: monthly literature updates for researchers

Archive for June, 2011

Apolist – june 2011

Posted by cris on June 30, 2011

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Bcl-2 family proteins
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Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53
C. Charvet, M. Wissler, P. Brauns-Schubert, S.-J. Wang, Y. Tang, F.C. Sigloch, H. Mellert, M. Brandenburg, S.E. Lindner, B. Breit, D.R. Green, S.B. McMahon, C. Borner, W. Gu, and U. Maurer
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900343-1

Multiple BH3 mimetics antagonize anti-apoptotic MCL1 by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.
Albershardt TC, Salerni BL, Soderquist RS, Bates DJ, Pletnev AA, Kisselev AF, Eastman A.
http://www.jbc.org/content/early/2011/05/31/jbc.M111.255828.abstract

BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells
Martin Hausmann, Katharina Leucht, Christian Ploner, Stephan Kiessling, Andreas Villunger, Helen Becker, Claudia Hofmann, Werner Falk, Michaela Krebs, Silvia Kellermeier, Michael Fried, Jürgen Schölmerich, Florian Obermeier, and Gerhard Rogler
http://www.jbc.org/cgi/content/abstract/M111.265322v1

The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity
Rathiga Velaithan, Jia Kang, Jayshree L. Hirpara, Thomas Loh, Boon Cher Goh, Morgane Le Bras, Catherine Brenner, Marie-Veronique Clement, and Shazib Pervaiz
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/117/23/6214

Bcl-xL Blocks a Mitochondrial Inner Membrane Channel and Prevents Ca2+ Overload-Mediated Cell Death
Daniel Tornero, Inmaculada Posadas, Valentín Ceña
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020423

Repression of Puma by Scratch2 is required for neuronal survival during embryonic development
E Rodríguez-Aznar and M A Nieto
http://www.nature.com/cdd/journal/v18/n7/abs/cdd2010190a.html?WT.ec_id=CDD-201107

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation
Hyunmi Lee, Jimmy A. Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C. Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019783

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Death receptors
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Sam68 Is Required for Both NF-B Activation and Apoptosis Signaling by the TNF Receptor
Parameswaran Ramakrishnan and David Baltimore
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900339-X

A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2
S. Choksi, Y. Lin, Y. Pobezinskaya, L. Chen, C. Park, M. Morgan, T. Li, S. Jitkaew, X. Cao, Y.-S. Kim, H.-S. Kim, P. Levitt, G. Shih, M. Birre, C.-X. Deng, and Z.-g. Liu
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900335-2

A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils
Barbara Geering, Ursina Gurzeler, Elena Federzoni, Thomas Kaufmann, and Hans-Uwe Simon
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/117/22/5953

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes
R Alonso, C Mazzeo, M C Rodriguez, M Marsh, A Fraile-Ramos, V Calvo, A Avila-Flores, I Merida and M Izquierdo
http://www.nature.com/cdd/journal/v18/n7/full/cdd2010184a.html

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Miscellaneous
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The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans
A J Ross, M Li, B Yu, M X Gao and W B Derry
http://www.nature.com/cdd/journal/v18/n7/full/cdd2010180a.html

NF- B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis
Roshan J. Thapa, Suresh H. Basagoudanavar, Shoko Nogusa, Krishna Irrinki, Karthik Mallilankaraman, Michael J. Slifker, Amer A. Beg, Muniswamy Madesh, and Siddharth Balachandran
http://mcb.asm.org/cgi/content/abstract/31/14/2934

Squamous Cell Carcinoma Antigen 1 Promotes Caspase-8-Mediated Apoptosis in Response to Endoplasmic Reticulum Stress While Inhibiting Necrosis Induced by Lysosomal Injury
Erica Ullman, Ji-An Pan, and Wei-Xing Zong
http://mcb.asm.org/cgi/content/abstract/31/14/2902

Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling
Tatsuya Akagi, Kouhei Shimizu, Shoukichi Takahama, Takahiro Iwasaki, Kazuhiro Sakamaki, Yaeta Endo, Tatsuya Sawasaki
http://www.sciencedirect.com/science/article/pii/S001457931100278X

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Reviews
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Modulating stress responses by the UPRosome: A matter of life and death
Ute Woehlbier, Claudio Hetz
http://www.sciencedirect.com/science/article/pii/S0968000411000454

Caspase Substrates and Cellular Remodeling
Emily D. Crawford and James A. Wells
http://arjournals.annualreviews.org/doi/abs/10.1146/annurev-biochem-061809-121639

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
Domagoj Vucic, Vishva M. Dixit & Ingrid E. Wertz
http://www.nature.com/nrm/journal/v12/n7/full/nrm3143.html

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News and views
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GSK3 TIPping Off p53 to Unleash PUMA
F.J. Bock and A. Villunger
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900389-3

Making a Bid for Inflammation
John F. Foley
The proapoptotic protein Bid promotes innate immune responses in the intestine independently of its role in apoptosis.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/176/ec159?etoc

 

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