Apolist – April 2011

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Bcl-2 family members
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Discovery and molecular characterization of a Bcl-2–regulated cell death pathway in schistosomes
Erinna F. Lee, Oliver B. Clarke, Marco Evangelista, Zhiping Feng, Terence P. Speed, Elissaveta B. Tchoubrieva, Andreas Strasser, Bernd H. Kalinna, Peter M. Colman, and W. Douglas Fairlie
http://www.pnas.org/content/108/17/6999.abstract?etoc

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways
L Zhang, H Lopez, N M George, X Liu, X Pang and X Luo
http://www.nature.com/cdd/journal/v18/n5/full/cdd2010152a.html

Investigation of the Bcl-2 multimerisation process: Structural and functional implications
Alessia, Camperchioli | Marisa, Mariani | Silvia, Bartollino | Lella, Petrella | Marco, Persico | Nausicaa, Orteca | Giovanni, Scambia | Shohreh, Shahabi | Cristiano, Ferlini | Caterina, Fattorusso
http://dx.doi.org/10.1016/j.bbamcr.2011.02.006

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol
F. Edlich, S. Banerjee, M. Suzuki, M.M. Cleland, D. Arnoult, C. Wang, A. Neutzner, N. Tjandra, and R.J. Youle
http://www.cell.com/abstract/S0092-8674%2811%2900186-3

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
FlavieStrappazzon, Matteo Vietri-Rudan, Silvia Campello, Francesca Nazio, Fulvio Florenzano, Gian Maria Fimia, Mauro Piacentini, Beth Levine and Francesco Cecconi
http://www.nature.com/emboj/journal/v30/n7/abs/emboj201149a.html

Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt
Jun-ichi Sakamaki, Hiroaki Daitoku, Katsuya Ueno, Ayano Hagiwara, Kazuyuki Yamagata, and Akiyoshi Fukamizu
http://www.pnas.org/content/108/15/6085.abstract?etoc

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
H Zhang, S Guttikonda, L Roberts, T Uziel, D Semizarov, S W Elmore, J D Leverson and L T Lam
http://www.nature.com/onc/journal/v30/n16/full/onc2010559a.html

The Anti-Apoptotic Bcl-xL Protein, a New Piece in the Puzzle of Cytochrome C Interactome
Ivano Bertini, Soizic Chevance, Rebecca Del Conte, Daniela Lalli, Paola Turano
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018329

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Death receptors and IAPs
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NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
S. Biton and A. Ashkenazi
http://www.cell.com/abstract/S0092-8674%2811%2900175-9

UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation
Yuefeng Huang, Liang Chen, Yi Zhou, Heng Liu, Jueqing Yang, Zhenggang Liu, and Chen Wang
http://www.molbiolcell.org/cgi/content/abstract/22/8/1389?etoc

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
Sandra Gardam, Vivian M. Turner, Holly Anderton, Sandhya Limaye, Antony Basten, Frank Koentgen, David L. Vaux, John Silke, and Robert Brink
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/117/15/4041

TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD) and caspase-8
Aminah Ikner and Avi Ashkenazi
http://www.jbc.org/cgi/content/abstract/M110.203745v1

Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain
Mar Orzáez, Anna Gortat, Mónica Sancho, Rodrigo J. Carbajo, Antonio Pineda-Lucena, Yadira Palacios-Rodríguez & Enrique Pérez-Payá
http://www.springerlink.com/content/xm45135052573643/

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Caspases and execution phase
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Concerted antigen processing of a short viral antigen by human caspases 5 and 10
Daniel López, Mercedes Jiménez, Margarita Garcia-Calvo, and Margarita Del Val
J. Biol. Chem. published 28 March 2011, 10.1074/jbc.M111.234658
http://www.jbc.org/cgi/content/abstract/M111.234658v1

Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria
Manuel Oropesa, Mario de la Mata, Juan Garrido Maraver, Mario D. Cordero, David Cotán, Ángeles Rodríguez-Hernández, Irene Domínguez-Moñino, Manuel de Miguel, Plácido Navas & José A. Sánchez-Alcázar
http://www.springerlink.com/content/47h1021vl35l1h77/

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
Mei He, Hiroshi Kubo, Konosuke Morimoto, Naoya Fujino, Takaya Suzuki, Toru Takahasi, Mitsuhiro Yamada, Mutsuo Yamaya, Tomoyuki Maekawa, Yasuhiko Yamamoto and Hiroshi Yamamoto
http://www.nature.com/embor/journal/v12/n4/full/embor201128a.html

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MISCELLANEOUS
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Mechanisms of necroptosis in T cells
Irene L. Ch’en, Jennifer S. Tsau, Jeffery D. Molkentin, Masaaki Komatsu, and Stephen M. Hedrick
In caspase 8-deficient mouse T cells, necroptosis occurs via a Ripk3- and Ripk1-dependent pathway independent of autophagy and programmed necrosis.
http://jem.rupress.org/cgi/content/abstract/208/4/633?etoc

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)
Yingfei Wang, No Soo Kim, Jean-Francois Haince, Ho Chul Kang, Karen K. David, Shaida A. Andrabi, Guy G. Poirier, Valina L. Dawson, and Ted M. Dawson
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/ra20?etoc

Activation of p53 by Nutlin-3a Induces Apoptosis and Cellular Senescence in Human Glioblastoma Multiforme
Ruth Villalonga-Planells, Llorenç Coll-Mulet, Fina Martínez-Soler, Esther Castaño, Juan-Jose Acebes, Pepita Giménez-Bonafé, Joan Gil, Avelina Tortosa
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018588

Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization
Lorna Flanagan, Jordi Sebastia, Maria Eugenia Delgado, Jennifer C. Lennon, Markus Rehm
http://dx.doi.org/10.1016/j.bbamcr.2011.02.011

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Reviews
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The Open Cell Signaling Journal special issue:
“Life and death: A cell signaling prospective”

– Editorial
John Silke
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/1TOCELLSJ.pdf

– Interplay of Bcl-2 Proteins Decides the Life or Death Fate
Grant Dewson
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/3TOCELLSJ.htm

– A Prickly Subject: Apoptotic Regulation by Hedgehog Morphogens
Mark Ditzel
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/9TOCELLSJ.htm

– Cytokine Deprivation and Cell Death
Paul G. Ekert and Anissa M. Jabbour
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/20TOCELLSJ.htm

– Dual Philosophy in Death Receptor Signalling
Chahrazade Kantari and Henning Walczak
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/27TOCELLSJ.htm

– Scorched Earth or Viral Birth?
Ian Gentle and Ueli Nachbur
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/35TOCELLSJ.htm

– Dying for Something to Eat: How Cells Respond to Starvation
Alfredo Caro-Maldonado and Cristina Muñoz-Pinedo
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/42TOCELLSJ.htm

Armed response: how dying cells influence T-cell functions
Ferguson, Thomas A.; Choi, Jayoung; Green, Douglas R.
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.2011.01006.x/abstract

Signaling cell death from the endoplasmic reticulum stress response
Gordon C Shore, Feroz R Papa, Scott A Oakes
http://dx.doi.org/10.1016/j.ceb.2010.11.003

Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl 2
Shefali Krishna, Ivan Cherh Chiet Low and Shazib Pervaiz
http://www.biochemj.org/bj/435/bj4350545.htm

Apoptosis promotes early tumorigenesis
D Tang, M T Lotze, R Kang and H J Zeh
http://www.nature.com/onc/journal/v30/n16/full/onc2010573a.html

Programmed Necrosis, Not Apoptosis, in the Heart
Kung, Gloria; Konstantinidis, Klitos; Kitsis, Richard N.
http://circres.ahajournals.org/cgi/pmidlookup?view=long&pmid=21493924

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News and views / other
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Retraction
Retraction Notice to: DNA-PKcs-PIDDosome: A Nuclear Caspase-2-Activating Complex with Role in G2/M Checkpoint Maintenance
M. Shi, C.J. Vivian, K.-J. Lee, C. Ge, K. Morotomi-Yano, C. Manzl, F. Bock, S. Sato, C. Tomomori-Sato, R. Zhu, J.S. Haug, S.K. Swanson, M.P. Washburn, D.J. Chen, B.P.C. Chen, A. Villunger, L. Florens, and C. Du
http://www.cell.com/fulltext/S0092-8674%2811%2900292-3

Autophagy in Ras-Induced Malignant Transformation: Fatal or Vital?
G. Mariño, I. Martins, and G. Kroemer
http://dx.doi.org/10.1016/j.molcel.2011.03.003

Traveling Bax and Forth from Mitochondria to Control Apoptosis
M.E. Soriano and L. Scorrano
http://www.cell.com/abstract/S0092-8674%2811%2900302-3

MCL1 meets its end during mitotic arrest
Scott E Millman and Michele Pagano
http://www.nature.com/embor/journal/v12/n5/full/embor201162a.html

Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2
Sharon ATooze and Patrice Codogno
http://www.nature.com/emboj/journal/v30/n7/abs/emboj201175a.html

Activated by Caspases
Wei Wong
Caspase activity in microglia does not trigger cell death, but rather induces proinflammatory responses.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/170/ec115?etoc

Jurg Tschopp 1951-2011
Ralph C Budd, Pascal Schneider, Fabienne Mackay and Andreas Strasser
http://www.nature.com/ni/journal/v12/n5/full/ni0511-367.html?WT.ec_id=NI-201105

Jürg Tschopp (1951–2011) ▶
Immunologist whose discoveries transformed patients’ lives.
http://www.nature.com/nature/journal/v472/n7343/full/472296a.html

Jürg Tschopp (1951-2011)
J. Browning and C. Ware
http://www.cell.com/immunity/fulltext/S1074-7613%2811%2900135-X

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