Apolist – may 2011

Bcl-2 family proteins

Non-apoptotic role of BID in inflammation and innate immunity
Garabet Yeretssian, Ricardo G. Correa, Karine Doiron, Patrick Fitzgerald, Christopher P. Dillon, Douglas R. Green, John C. Reed & Maya Saleh

Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice
Karina Kaczmarek, Maja Studencka, Andreas Meinhardt, Krzysztof Wieczerzak, Sven Thoms, Wolfgang Engel, and Pawel Grzmil

Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1
Felix M. Wensveen, Nuno L. Alves, Ingrid A. M. Derks, Kris A. Reedquist and Eric Eldering

The Apoptotic Regulator Nrz Controls Cytoskeletal Dynamics via the Regulation of Ca2+ Trafficking in the Zebrafish Blastula
N. Popgeorgiev, B. Bonneau, K.F. Ferri, J. Prudent, J. Thibaut, and G. Gillet
[Nrz is BCL2L10, DIVA, BOO, BCL-B]

Bcl-2 Inhibits Nuclear Homologous Recombination by Localizing BRCA1 to the Endomembranes
Corentin Laulier, Aurélia Barascu, Josée Guirouilh-Barbat, Gaëlle Pennarun, Catherine Le Chalony, François Chevalier, Gaëlle Palierne, Pascale Bertrand, Jean Marc Verbavatz, and Bernard S. Lopez

Deciphering the Molecular Events Necessary for Synergistic Tumor Cell Apoptosis Mediated by the Histone Deacetylase Inhibitor Vorinostat and the BH3 Mimetic ABT-737
Adrian P. Wiegmans, Amber E. Alsop, Michael Bots, Leonie A. Cluse, Steven P. Williams, Kellie-Marie Banks, Rachael Ralli, Clare L. Scott, Anna Frenzel, Andreas Villunger, and Ricky W. Johnstone

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity
Rupesh Dash, Belal Azab, Bridget A. Quinn, Xuening Shen, Xiang-Yang Wang, Swadesh K. Das, Mohamed Rahmani, Jun Wei, Michael Hedvat, Paul Dent, Igor P. Dmitriev, David T. Curiel, Steven Grant, Bainan Wu, John L. Stebbins, Maurizio Pellecchia, John C. Reed, Devanand Sarkar, and Paul B. Fisher

Mitochondrial-dependent N-terminal processing of outer membrane Mcl-1 removes an essential mule/lasu1 binding site
Matthew R. Warr, John R. Mills, Mai Nguyen, Stephanie Lemaire-Ewing, Jason Baardsnes, Karen L.i W. Sun, Abba Malina, Jason C. Young, Danny V. Jeyaraju, Maureen O’Connor-McCourt, Luca Pellegrini, Jerry Pelletier, and Gordon C. Shore

Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells
D Trisciuoglio, C Gabellini, M Desideri, Y Ragazzoni, T De Luca, E Ziparo and D Del Bufalo

Death receptors and IAPs
CARD-Mediated Autoinhibition of cIAP1’s E3 Ligase Activity Suppresses Cell Proliferation and Migration
Juanita Lopez, Sidonie Wicky John, Tencho Tenev, Gilles J.P. Rautureau, Mark G. Hinds, Floriana Francalanci, Rebecca Wilson, Meike Broemer, Massimo M. Santoro, Catherine L. Day, and Pascal Meier

Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation
Olga M. Shatnyeva, Andriy V. Kubarenko, Claudia E. M. Weber, Alexander Pappa, Reinhard Schwartz-Albiez, Alexander N. R. Weber, Peter H. Krammer, Inna N. Lavrik

Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells.
Amanda F. Swindall and Susan L. Bellis

Survivin monomer plays an essential role in apoptosis regulation
Marat S. Pavlyukov, Nadezhda V. Antipova, Maria V. Balashova, Tatjana V. Vinogradova, Evgenij P. Kopantzev, and Mihail I. Shakhparonov

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT
Najoua Lalaoui, Aymeric Morlé, Delphine Mérino, Guillaume Jacquemin, Elisabetta Iessi, Alexandre Morizot, Sarah Shirley, Bruno Robert, Eric Solary, Carmen Garrido, Olivier Micheau


A Peptide-Based Target Screen Implicates the Protein Kinase CK2 in the Global Regulation of Caspase Signaling
James S. Duncan, Jacob P. Turowec, Kelly E. Duncan, Greg Vilk, Chenggang Wu, Bernhard Lüscher, Shawn S.-C. Li, Greg B. Gloor, and David W. Litchfield

Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8-Mediated Cleavage of Beclin 1
Hua Li, Peng Wang, Quanhong Sun, Wen-Xing Ding, Xiao-Ming Yin, Robert W. Sobol, Donna B. Stolz, Jian Yu, and Lin Zhang

Mechanism of a genetically-encoded dark-to-bright reporter for caspase activity
Samantha B. Nicholls, Jun Chu, Genevieve Abbruzzese, Kimberly D. Tremblay, and Jeanne Hardy

Phosphorylation of caspase-7 by P21-activated protein kinase (PAK)2 inhibits chemotherapeutic drugs-induced apoptosis of breast cancer cell lines
Xiang Li, Weihong Wen, Kangdong Liu, Feng Zhu, Margarita Malakhova, Cong Peng, Tingting Li, Hong-Gyum Kim, Weiya Ma, Yong Yeon Cho, Ann M. Bode, Ziming Dong, and Zigang Dong


Atg1 allows second-signaled autophagic cell death in Dictyostelium
Marie-Françoise Luciani, Corinne Giusti, Birthe Harms, Yoshiteru Oshima, Haruhisa Kikuchi, Yuzuru Kubohara and Pierre Golstein

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia
Philippe Pasdois, Joanne E. Parker, Elinor J. Griffiths and Andrew P. Halestrap

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway
Yapeng Gu, Tetyana Forostyan, Roger Sabbadini, and Jody Rosenblatt

Defining the Origins of the NOD-Like Receptor System at the Base of Animal Evolution.
Lange C, Hemmrich G, Klostermeier UC, López-Quintero JA, Miller DJ, Rahn T, Weiss Y, Bosch TC, Rosenstiel P.


Mitochondrial involvement in cell death of non-mammalian eukaryotes.
Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM, White K.

News and views / other

Autophagic cell death: Loch Ness monster or endangered species?
Han-Ming Shen and Patrice Codogno

I think autophagy controls the death of my cells: What do I do to get my paper published?
Andrew Thorburn

Cell death: A killer puts a stop on necroptosis
FADD-caspase 8-mediated apoptosis inhibits necroptosis during development.

Autophagy and apoptosis are redundantly required for C. elegans embryogenesis
Éva Borsos, Péter Erdélyi and Tibor Vellai

MCL-1 regulates the balance between autophagy and apoptosis
Marc Germain and Ruth S. Slack

There Is More to Life than Death: A Moonlighting Function of a Bcl-2 Member
L. Ravid and E. Arama

Protein Kinases Curb Cell Death
Odile Filhol and Claude Cochet
Phosphorylation of procaspases and their substrates by protein kinase CK2 puts the brakes on cell death.

Sphingolipid puts the squeeze on apoptotic cells
Ben Short

Aha! … apoptosis: means to an end
R A Knight and G Melino

Jürg Tschopp (1951-2011)
Luke A. O’Neill
A scientist’s basic research into cell death and inflammation will continue to have a clinical impact.

Jürg Tschopp 1951-2011
R.A. Flavell

Jürg Tschopp-1951-2011-an immortal contribution.
Kroemer G, Martinon F, Lippens S, Green DR, Knight R, Vandenabeele P, Piacentini M, Nagata S, Borner C, Simon HU, Krammer P, Melino G.


Apolist – April 2011


Bcl-2 family members

Discovery and molecular characterization of a Bcl-2–regulated cell death pathway in schistosomes
Erinna F. Lee, Oliver B. Clarke, Marco Evangelista, Zhiping Feng, Terence P. Speed, Elissaveta B. Tchoubrieva, Andreas Strasser, Bernd H. Kalinna, Peter M. Colman, and W. Douglas Fairlie

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways
L Zhang, H Lopez, N M George, X Liu, X Pang and X Luo

Investigation of the Bcl-2 multimerisation process: Structural and functional implications
Alessia, Camperchioli | Marisa, Mariani | Silvia, Bartollino | Lella, Petrella | Marco, Persico | Nausicaa, Orteca | Giovanni, Scambia | Shohreh, Shahabi | Cristiano, Ferlini | Caterina, Fattorusso

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol
F. Edlich, S. Banerjee, M. Suzuki, M.M. Cleland, D. Arnoult, C. Wang, A. Neutzner, N. Tjandra, and R.J. Youle

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
FlavieStrappazzon, Matteo Vietri-Rudan, Silvia Campello, Francesca Nazio, Fulvio Florenzano, Gian Maria Fimia, Mauro Piacentini, Beth Levine and Francesco Cecconi

Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt
Jun-ichi Sakamaki, Hiroaki Daitoku, Katsuya Ueno, Ayano Hagiwara, Kazuyuki Yamagata, and Akiyoshi Fukamizu

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
H Zhang, S Guttikonda, L Roberts, T Uziel, D Semizarov, S W Elmore, J D Leverson and L T Lam

The Anti-Apoptotic Bcl-xL Protein, a New Piece in the Puzzle of Cytochrome C Interactome
Ivano Bertini, Soizic Chevance, Rebecca Del Conte, Daniela Lalli, Paola Turano

Death receptors and IAPs

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
S. Biton and A. Ashkenazi

UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation
Yuefeng Huang, Liang Chen, Yi Zhou, Heng Liu, Jueqing Yang, Zhenggang Liu, and Chen Wang

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
Sandra Gardam, Vivian M. Turner, Holly Anderton, Sandhya Limaye, Antony Basten, Frank Koentgen, David L. Vaux, John Silke, and Robert Brink

TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD) and caspase-8
Aminah Ikner and Avi Ashkenazi

Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain
Mar Orzáez, Anna Gortat, Mónica Sancho, Rodrigo J. Carbajo, Antonio Pineda-Lucena, Yadira Palacios-Rodríguez & Enrique Pérez-Payá

Caspases and execution phase

Concerted antigen processing of a short viral antigen by human caspases 5 and 10
Daniel López, Mercedes Jiménez, Margarita Garcia-Calvo, and Margarita Del Val
J. Biol. Chem. published 28 March 2011, 10.1074/jbc.M111.234658

Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria
Manuel Oropesa, Mario de la Mata, Juan Garrido Maraver, Mario D. Cordero, David Cotán, Ángeles Rodríguez-Hernández, Irene Domínguez-Moñino, Manuel de Miguel, Plácido Navas & José A. Sánchez-Alcázar

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
Mei He, Hiroshi Kubo, Konosuke Morimoto, Naoya Fujino, Takaya Suzuki, Toru Takahasi, Mitsuhiro Yamada, Mutsuo Yamaya, Tomoyuki Maekawa, Yasuhiko Yamamoto and Hiroshi Yamamoto


Mechanisms of necroptosis in T cells
Irene L. Ch’en, Jennifer S. Tsau, Jeffery D. Molkentin, Masaaki Komatsu, and Stephen M. Hedrick
In caspase 8-deficient mouse T cells, necroptosis occurs via a Ripk3- and Ripk1-dependent pathway independent of autophagy and programmed necrosis.

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)
Yingfei Wang, No Soo Kim, Jean-Francois Haince, Ho Chul Kang, Karen K. David, Shaida A. Andrabi, Guy G. Poirier, Valina L. Dawson, and Ted M. Dawson

Activation of p53 by Nutlin-3a Induces Apoptosis and Cellular Senescence in Human Glioblastoma Multiforme
Ruth Villalonga-Planells, Llorenç Coll-Mulet, Fina Martínez-Soler, Esther Castaño, Juan-Jose Acebes, Pepita Giménez-Bonafé, Joan Gil, Avelina Tortosa

Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization
Lorna Flanagan, Jordi Sebastia, Maria Eugenia Delgado, Jennifer C. Lennon, Markus Rehm


The Open Cell Signaling Journal special issue:
“Life and death: A cell signaling prospective”

– Editorial
John Silke

– Interplay of Bcl-2 Proteins Decides the Life or Death Fate
Grant Dewson

– A Prickly Subject: Apoptotic Regulation by Hedgehog Morphogens
Mark Ditzel

– Cytokine Deprivation and Cell Death
Paul G. Ekert and Anissa M. Jabbour

– Dual Philosophy in Death Receptor Signalling
Chahrazade Kantari and Henning Walczak

– Scorched Earth or Viral Birth?
Ian Gentle and Ueli Nachbur

– Dying for Something to Eat: How Cells Respond to Starvation
Alfredo Caro-Maldonado and Cristina Muñoz-Pinedo

Armed response: how dying cells influence T-cell functions
Ferguson, Thomas A.; Choi, Jayoung; Green, Douglas R.

Signaling cell death from the endoplasmic reticulum stress response
Gordon C Shore, Feroz R Papa, Scott A Oakes

Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl 2
Shefali Krishna, Ivan Cherh Chiet Low and Shazib Pervaiz

Apoptosis promotes early tumorigenesis
D Tang, M T Lotze, R Kang and H J Zeh

Programmed Necrosis, Not Apoptosis, in the Heart
Kung, Gloria; Konstantinidis, Klitos; Kitsis, Richard N.

News and views / other

Retraction Notice to: DNA-PKcs-PIDDosome: A Nuclear Caspase-2-Activating Complex with Role in G2/M Checkpoint Maintenance
M. Shi, C.J. Vivian, K.-J. Lee, C. Ge, K. Morotomi-Yano, C. Manzl, F. Bock, S. Sato, C. Tomomori-Sato, R. Zhu, J.S. Haug, S.K. Swanson, M.P. Washburn, D.J. Chen, B.P.C. Chen, A. Villunger, L. Florens, and C. Du

Autophagy in Ras-Induced Malignant Transformation: Fatal or Vital?
G. Mariño, I. Martins, and G. Kroemer

Traveling Bax and Forth from Mitochondria to Control Apoptosis
M.E. Soriano and L. Scorrano

MCL1 meets its end during mitotic arrest
Scott E Millman and Michele Pagano

Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2
Sharon ATooze and Patrice Codogno

Activated by Caspases
Wei Wong
Caspase activity in microglia does not trigger cell death, but rather induces proinflammatory responses.

Jurg Tschopp 1951-2011
Ralph C Budd, Pascal Schneider, Fabienne Mackay and Andreas Strasser

Jürg Tschopp (1951–2011) ▶
Immunologist whose discoveries transformed patients’ lives.

Jürg Tschopp (1951-2011)
J. Browning and C. Ware