Apolist – december 2010


Means to an End: Apoptosis and Other Cell Death Mechanisms
Douglas R. Green


Opening the Cellular Poison Cabinet
Seamus J. Martin
The assembly and activation of a mitochondrial channel is triggered by direct interaction with signaling molecules that promote cell death.

Noxa: A Sweet Twist to Survival and More
A. Gimenez-Cassina and N.N. Danial

Divide and die another day
Frank Uhlmann, Guy Salvesen

Aspasing Out Metacaspases and Caspases: Proteases of Many Trades
Peter V. Bozhkov1, Andrei P. Smertenko, and Boris Zhivotovsky

Another Tier for Caspase Regulation: IAPs as NEDD8 E3 Ligases
S. Benjamin and H. Steller


The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose
X.H. Lowman, M.A. McDonnell, A. Kosloske, O.A. Odumade, C. Jenness, C.B. Karim, R. Jemmerson, and A. Kelekar

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program
D. Ren et al.
Proapoptotic proteins act directly on mitochondrial “gatekeeper” proteins to initiate apoptotic events during mouse development.

An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs
C Sheridan, G Brumatti, M Elgendy, M Brunet and S J Martin

AKT requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells
Jonathan L. Coloff, Emily F. Mason, Brian J. Altman, Valerie A. Gerriets, Tingyu Liu, Amanda N. Nichols, Yuxing Zhao, Jessica A. Wofford, Sarah R. Jacobs, Olga Ilkayeva, Sean P. Garrison, Gerard P. Zambetti, and Jeffrey C. Rathmell

A role for proapoptotic Bax and Bak in T-cell differentiation and transformation
Subhrajit Biswas, Qiong Shi, Lauren Matise, Susan Cleveland, Utpal Dave, and Sandra Zinkel
Blood 2010;116 5237-5246

The BH3 -helical mimic BH3-M6 disrupts BCL-XL, BCL-2 and MCL-1 protein-protein interactions with BAX, BAK, BAD or BIM and induces apoptosis in a BAX- and BIM-dependent manner
Aslamuzzaman Kazi, Jiazhi Sun, Kenichiro Doi, Shen-Shu Sung, Yoshinori Takahashi, Hang (Hubert) Yin, Johanna Rodriguez, Jorge Becerril, Norbert Berndt, Andrew D. Hamilton, Hong-Gang Wang, and Said M. Sebti

Amphipathic tail-anchoring peptide and BH3 peptides from BCL-2 family proteins induce apoptosis through different mechanisms
Jae-Kyun Ko, Kyoung-Han Choi, Jun Peng, Feng He, Zhi Zhang, Noah Weisleder, Jialing Lin, and Jianjie Ma
J. Biol. Chem. published 28 December 2010, 10.1074/jbc.M110.198457

Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
Lina Happo, Mark S. Cragg, Belinda Phipson, Jon M. Haga, Elisa S. Jansen, Marco J. Herold, Grant Dewson, Ewa M. Michalak, Cassandra J. Vandenberg, Gordon K. Smyth, Andreas Strasser, Suzanne Cory, and Clare L. Scott


Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8
Christopher Li, Samuel Lasse, Pedro Lee, Manando Nakasaki, Shih-Wei Chen, Kenshi Yamasaki, Richard L. Gallo, and Colin Jamora

Wnt11 Promotes Cardiomyocyte Development by Caspase-Mediated Suppression of Canonical Wnt Signals
Mohammad Abdul-Ghani, Daniel Dufort, Rebecca Stiles, Yves De Repentigny, Rashmi Kothary, and Lynn A. Megeney

Bax regulates production of superoxide in both apoptotic and nonapoptotic neurons: role of caspases.
Kirkland RA, Saavedra GM, Cummings BS, Franklin JL.

Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion
S Leverrier, G S Salvesen and C M Walsh

In vitro reconstitution of the interactions in the PIDDosome
Tae-ho Jang, Chao Zheng, Hao Wu, Ju-Hong Jeon & Hyun Ho Park


Arabidopsis Type I Metacaspases Control Cell Death
N. S. Coll et al.
An ancient link between cell death control and innate immune receptor function has been discovered in plants.

The Dependence Receptor UNC5H2/B Triggers Apoptosis via PP2A-Mediated Dephosphorylation of DAP Kinase
C. Guenebeaud, D. Goldschneider, M. Castets, C. Guix, G. Chazot, C. Delloye-Bourgeois, A. Eisenberg-Lerner, G. Shohat, M. Zhang, V. Laudet, A. Kimchi, A. Bernet, and P. Mehlen

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway
Y-T Wu, H-L Tan, Q Huang, X-J Sun, X Zhu and H-M Shen


Molecular cell death platforms and assemblies
Peter D Mace, Stefan J Riedl

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation
Annie Yang, Nicholas S Wilson, Avi Ashkenazi

Apoptosis: embedded in membranes
Christian Bogner, Brian Leber, David W Andrews

New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics
Stephane G Rolland, Barbara Conradt

Who gets cut during cell death ?
Francis Impens, Joël Vandekerckhove, Kris Gevaert

Life and death in the thymus—cell death signaling during T cell development
Jeniffer B Hernandez, Ryan H Newton, Craig M Walsh

To fight or die — inhibitor of apoptosis proteins at the crossroad of innate immunity and death
Juanita Lopez, Pascal Meier

Genetic control of necrosis—another type of programmed cell death
Kimberly McCall

Distinct death mechanisms in Drosophila development
Hyung Don Ryoo, Eric H Baehrecke


Apolist – november 2010

Conference announcement: “DEATH IN THE ALPS 3.0”


Bcl-2 family members

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
E. Gavathiotis, D.E. Reyna, M.L. Davis, G.H. Bird, and L.D. Walensky

BH3-domains other than Bim and Bid can directly activate BAX/BAK
Han Du, Jacob Wolf, Blanca Schafer, Tudor Moldoveanu, Jerry E. Chipuk, and Tomomi Kuwana
J. Biol. Chem. published 1 November 2010, 10.1074/jbc.M110.167148

Heterodimerization of BAK and MCL-1 activated by detergent micelles
Qian Liu and Kalle Gehring
J. Biol. Chem. published 29 October 2010, 10.1074/jbc.M110.144857

Characterization of Puma-Dependent and Puma-Independent Neuronal Cell Death Pathways following Prolonged Proteasomal Inhibition
Liam P. Tuffy, Caoimhín G. Concannon, Beatrice D’Orsi, Matthew A. King, Ina Woods, Heinrich J. Huber, Manus W. Ward, and Jochen H. M. Prehn
Mol. Cell. Biol. 2010;30 5484-5501

Tyrosine dephosphorylation is required for Bak activation in apoptosis
Joanna L Fox, Ferina Ismail, Abul Azad, Nicola Ternette, Sabrina Leverrier, Mariola J Edelmann, Benedikt M Kessler, Irene M Leigh, Sarah Jackson and Alan Storey

Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory
Ingela Vikstrom, Sebastian Carotta1, Katja Lüthje1, Victor Peperzak1, Philipp J. Jost1, Stefan Glaser1, Meinrad Busslinger2, Philippe Bouillet1,3, Andreas Strasser1,3, Stephen L. Nutt1,3 and David M. Tarlinton

Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18
Songhai Tian, Jian Lin, Jun Zhou, Xiaolong Wang, Yanjun Li, Xiaobai Ren, Wenyu Yu, Wu Zhong, Junhai Xiao, Fugeng Sheng, Yingyu Chen, Changwen Jin, Song Li, Zhibing Zheng and Bin Xia

Hypoxia Suppression of Bim and Bmf Blocks Anoikis and Luminal Clearing during Mammary Morphogenesis
Kelly A. Whelan, Sarah A. Caldwell, Kristina S. Shahriari, S. RaElle Jackson, Lisa D. Franchetti, Gregg J. Johannes, and Mauricio J. Reginato

Death receptors

Inhibition of NF-κB induces a switch from CD95L-dependent to CD95L-independent and JNK-mediated apoptosis in T cells
Michael K. Kießling, Björn Linke, Markus Brechmann, Dorothee Süss, Peter H. Krammer, Karsten Gülow

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
Zhi-Hua Chen, Hilaire C. Lam, Yang Jin, Hong-Pyo Kim, Jiaofei Cao, Seon-Jin Lee, Emeka Ifedigbo, Harikrishnan Parameswaran, Stefan W. Ryter, and Augustine M. K. Choi

The Adaptor Protein TRIP6 Antagonizes Fas-Induced Apoptosis but Promotes Its Effect on Cell Migration
Yun-Ju Lai, Victor T. G. Lin, Ying Zheng, Etty N. Benveniste, and Fang-Tsyr Lin
Mol. Cell. Biol. 2010;30 5582-5596

Solution of the Structure of the TNF-TNFR2 Complex
Yohei Mukai, Teruya Nakamura, Mai Yoshikawa, Yasuo Yoshioka, Shin-ichi Tsunoda, Shinsaku Nakagawa, Yuriko Yamagata, and Yasuo Tsutsumi

Cdk1/Cyclin B1 Controls Fas-Mediated Apoptosis by Regulating Caspase-8 Activity
Yves Matthess, Monika Raab, Mourad Sanhaji, Inna N. Lavrik, and Klaus Strebhardt

c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity
C Quintavalle, M Incoronato, L Puca, M Acunzo, C Zanca, G Romano, M Garofalo, M Iaboni, C M Croce and G Condorelli

FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis
Qi-Quan Huang, Harris Perlman, Zan Huang, Robert Birkett, Lixin Kan, Hemant Agrawal, Alexander Misharin, Sandeep Gurbuxani, John D. Crispino, and Richard M. Pope


Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
Edward A Miao, Irina A Leaf, Piper M Treuting, Dat P Mao, Monica Dors, Anasuya Sarkar, Sarah E Warren, Mark D Wewers and Alan Aderem

The in vitro cleavage of the hAtg proteins by cell death proteases
Joanna M. Norman, Gerald M. Cohen and Edward T.W. Bampton

Alternative Splicing of Caspase 9 Is Modulated by the Phosphoinositide 3-Kinase/Akt Pathway via Phosphorylation of SRp30a
Jacqueline C. Shultz, Rachel W. Goehe, D. Shanaka Wijesinghe, Charuta Murudkar, Amy J. Hawkins, Jerry W. Shay, John D. Minna, and Charles E. Chalfant

Autophagic degradation of active caspase-8: A crosstalk mechanism between autophagy and apoptosis
Wen Hou, Jie Han, Caisheng Lu, Leslie A. Goldstein and Hannah Rabinowich


Secondary necrosis: The natural outcome of the complete apoptotic program
Manuel T. Silva

The engulfment receptor Draper is required for autophagy during cell death
Christina K. McPhee and Eric H. Baehrecke

“Apoptosis in the aging brain”, special issue of Apoptosis

Mitochondrial fusion and fission in cell life and death
Benedikt Westermann

Mechanisms of HIV-associated lymphocyte apoptosis: 2010
N W Cummins and A D Badley

Alternative cell death mechanisms in development and beyond
Junying Yuan and Guido Kroemer


Autophagy as a trigger for cell death: Autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila
Ioannis P. Nezis, Bhupendra V. Shravage, Antonia P. Sagona, Terje Johansen, Eric H. Baehrecke and Harald Stenmark

Dephosphorylation to Die For
L. Bryan Ray

Cyclophilin A release as a biomarker of necrotic cell death
D E Christofferson and J Yuan

Chapter from the book “Self and non-self”
SIGNALING PATHWAYS THAT REGULATE LIFE AND CELL DEATH. Evolution of Apoptosis in the Context of Self Defense
Cristina Muñoz-Pinedo
http://www.landesbioscience.com/curie/chapter/4923/ or