Apolist – october 2010

Caspases and execution phase

Pannexin 1 channels mediate ‘find-me’ signal release and membrane
permeability during apoptosis
Faraaz B. Chekeni,Michael R. Elliott,Joanna K. Sandilos,Scott F.
Walk,Jason M. Kinchen,Eduardo R. Lazarowski,Allison J.
Armstrong,Silvia Penuela,Dale W. Laird,Guy S. Salvesen,Brant E.
Isakson,Douglas A. Bayliss& Kodi S. Ravichandran

Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3
C. V. Srikanth,1,2,* Daniel M. Wall,1,3,* Ana Maldonado-Contreras,2
Hai Ning Shi,1 Daoguo Zhou,4 Zachary Demma,2 Karen L. Mumy,1,2 Beth A.

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I
Penghua Wang, Alvaro Arjona, Yue Zhang, Hameeda Sultana, Jianfeng Dai,
Long Yang, Philippe M LeBlanc, Karine Doiron, Maya Saleh and Erol

Activation of caspase-9, but not caspase-2 or caspase-8, is essential
for heat-induced apoptosis in jurkat cells
Shary N. Shelton, Cindy D. Dillard, and John D. Robertson

Crystal structures of human caspase 6 reveal a new mechanism for
intramolecular cleavage self-activation
Xiao-Jun Wang, Qin Cao, Xiang Liu, Kai-Tuo Wang, Wei Mi, Yan Zhang,
Lan-Fen Li, Andrea C LeBlanc and Xiao-Dong Su

Real-Time Dynamics of Ca2+, Caspase-3/7, and Morphological Changes in
Retinal Ganglion Cell Apoptosis under Elevated Pressure
Jae Kyoo Lee, Siyuan Lu, Anupam Madhukar

Characterization of a caspase-3-substrate kinome using an N- and
C-terminally tagged protein kinase library produced by a cell-free
D Tadokoro, S Takahama, K Shimizu, S Hayashi, Y Endo and T Sawasaki

Mutant nucleophosmin deregulates cell death and myeloid
differentiation through excessive caspase-6 and -8 inhibition
Sai Mun Leong, Ban Xiong Tan, Baidah Bte Ahmad, Tie Yan, Lai Yuen
Chee, Swee Tin Ang, Kian Ghee Tay, Liang Piu Koh, Allen Eng Juh Yeoh,
Evelyn Siew-Chuan Koay, Yu-Keung Mok, and Tit Meng Lim

Bcl-2 family proteins

BH3-only protein Bmf mediates apoptosis upon inhibition of
CAP-dependent protein synthesis
F Grespi, C Soratroi, G Krumschnabel, B Sohm, C Ploner, S Geley, L
Hengst, G Häcker and A Villunger

Parkin mono-ubiquitinates BCL-2 and regulates autophagy
Dong Chen, Feng Gao, Bin Li, Hongfeng Wang, Yuxia Xu, Cuiqing Zhu, and
Guanghui Wang

Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic
cell-to-cell variations in the mitochondrial pathway of cell death
Joanna Skommer, Tom Brittain & Subhadip Raychaudhuri

Mono- or Double-Site Phosphorylation Distinctly Regulates the
Proapoptotic Function of Bax
Qinhong Wang, Shi-Yong Sun, Fadlo Khuri, Walter J. Curran, Xingming Deng

The DNA damage response pathway regulates the alternative splicing of
the apoptotic mediator Bcl-x
Lulzim Shkreta, Laetitia Michelle, Johanne Toutant, Michel L.
Tremblay, and Benoit Chabot
J. Biol. Chem. published 27 October 2010, 10.1074/jbc.M110.162644

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of
hematopoietic stem/progenitor cells, and enhances drug resistance
Kirsteen J. Campbell, Mary L. Bath, Marian L. Turner, Cassandra J.
Vandenberg, Philippe Bouillet, Donald Metcalf, Clare L. Scott, and
Suzanne Cory

Death receptor pathway

Caspase-10-Dependent Cell Death in Fas/CD95 Signalling Is Not
Abrogated by Caspase Inhibitor zVAD-fmk
Elodie Lafont, Delphine Milhas, Justin Teissié, Nicole Therville,
Nathalie Andrieu-Abadie, Thierry Levade, Hervé Benoist, Bruno Ségui

The Fas–FADD death domain complex structure reveals the basis of DISC
assembly and disease mutations
Liwei Wang,Jin Kuk Yang,Venkataraman Kabaleeswaran,Amanda J
Rice,Anthony C Cruz,Ah Young Park,Qian Yin,Ermelinda Damko,Se Bok
Jang,Stefan Raunser,Carol V Robinson,Richard M Siegel,Thomas Walz& Hao

The inhibition of Bid expression by Akt leads to resistance to
TRAIL-induced apoptosis in ovarian cancer cells
N Goncharenko-Khaider, D Lane, I Matte, C Rancourt and A Piché

HDAC inhibitors with different gene regulation activities depend on
the mitochondrial pathway for the sensitization of leukemic T cells to
TRAIL-induced apoptosis
Morales, JC; Ruiz-Magana, MJ; Carranza, D; Ortiz-Ferron, G; Ruiz-Ruiz, C

Novel HTS Strategy Identifies TRAIL-Sensitizing Compounds Acting
Specifically Through the Caspase-8 Apoptotic Axis
Darren Finlay, Robyn D. Richardson, Lisa K. Landberg, Amy L. Howes,
Kristiina Vuori

Caspase cleavage of the Golgi stacking factor GRASP65 is required for
Fas/CD95-mediated apoptosis
J P X Cheng, V M S Betin, H Weir, G M A Shelmani, D K Moss and J D Lane


A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage
Signaling to Ubiquitin-Mediated NF-κB Activation
M. Hinz, M. Stilmann, S.Ç. Arslan, K.K. Khanna, G. Dittmar, and C. Scheidereit

Monomerization of Cytosolic Mature Smac Attenuates Interaction with
IAPs and Potentiation of Caspase Activation
Stephen P. Burke, Jeffrey B. Smith

Smac mimetic compounds potentiate interleukin-1 beta-mediated cell death
Herman H. Cheung, Shawn T. Beug, Martine St. Jean, Audrey Brewster, N.
Lynn Kelly, Shaomeng Wang, and Robert G. Korneluk
J. Biol. Chem. published 18 October 2010, 10.1074/jbc.M110.183616

Mitochondrial fission leads to Smac/DIABLO release quenched by ARC
Jincheng Li, Yanrui Li, Danian Qin, Ruediger von Harsdorf & Peifeng Li


NF- B inhibits T-cell activation-induced, p73-dependent cell death by
induction of MDM2
Valere Busuttil, Nathalie Droin, Laura McCormick, Francesca
Bernassola, Eleonora Candi, Gerry Melino, and Douglas R. Green

Sphingolipid-mediated inhibition of apoptotic cell clearance by
alveolar macrophages
Daniela N. Petrusca, Yuan Gu, Jeremy J. Adamowicz, Natalia I. Rush,
Walter C. Hubbard, Patricia A. Smith, Evgeny V. Berdyshev, Konstantin
G. Birukov, Chao-Hung Lee, Rubin M. Tuder, Homer L. Twigg IIIrd, R.
William Vandivier, and Irina Petrache

REVIEWS / Comments

Sugar-free approaches to cancer cell killing.
Nadia El Mjiyad, Alfredo Caro-Maldonado, Silvia Ramírez-Peinado, Cristina Muñoz-Pinedo

Molecular mechanisms of necroptosis: an ordered cellular explosion
Peter Vandenabeele, Lorenzo Galluzzi, Tom Vanden Berghe & Guido Kroemer

Systems biology analysis of programmed cell death
Shani Bialik, Einat Zalckvar, Yaara Ber, Assaf D. Rubinstein, Adi Kimchi

Apoptotic volume decrease as a geometric determinant for cell
dismantling into apoptotic bodies
R Núñez, S M Sancho-Martínez, J M L Novoa and F J López-Hernández

Apoptosis, Stem Cells, and Tissue Regeneration
Andreas Bergmann and Hermann Steller

The engine driving the ship: metabolic steering of cell proliferation and death
Marisa R. Buchakjian & Sally Kornbluth

Channeling Death
Wei Wong
Apoptotic cells release ATP and UTP through pannexin 1 to recruit
phagocytes that clear them.