Apolist – august 2010


Mitochondria and cell death: outer membrane permeabilization and beyond
Stephen W. G. Tait & Douglas R. Green

New insights into apoptosis signaling by Apo2L/TRAIL
F Gonzalvez and A Ashkenazi

The molecular regulation of programmed necrotic cell injury
David Moquin, Francis Ka-Ming Chan

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums
Kodi S. Ravichandran

FLIPping the kill switch
Ben Short
The amounts of different cFLIP isoforms help cells choose between life and death.

Local Caspase for Fertility, Not Death
Nancy R. Gough
Through gradients of inhibitors, fly spermatids control caspase activation to promote differentiation without death.


Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation
Verena Labi, Miriam Erlacher, Gerhard Krumschnabel, Claudia Manzl, Alexandar Tzankov, Josephina Pinon, Alexander Egle, and Andreas Villunger
Genes Dev. 2010;24 1602-1607

Apoptosis-promoted tumorigenesis: -irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death
Ewa M. Michalak, Cassandra J. Vandenberg, Alex R.D. Delbridge, Li Wu, Clare L. Scott, Jerry M. Adams, and Andreas Strasser
Genes Dev. 2010;24 1608-1613

AICAR induces apoptosis independently of AMPK and p53 through upregulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
Santidrián AF, González-Gironès DM, Iglesias-Serret D, Coll-Mulet L, Cosialls AM, de Frias M, Campàs C, González-Barca E, Alonso E, Labi V, Viollet B, Benito A, Pons G, Villunger A, Gil J.

Phosphorylation of Puma modulates its apoptotic function by regulating protein stability
M Fricker, J O’Prey, A M Tolkovsky and K M Ryan

Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria
O. Teijido, L. Dejean

The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity
Chi-Ruei Huang, Hsin-Fang Yang-Yen

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis
M.J. Moore, Q. Wang, C.J. Kennedy, and P.A. Silver

The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity
Clinton J. V. Campbell, Jung Bok Lee, Marilyne Levadoux-Martin, Tracy Wynder, Anargyros Xenocostas, Brian Leber, and Mickie Bhatia


Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease
D.C. Gray, S. Mahrus, and J.A. Wells

cIAP1 cooperatively inhibits procaspase-3 activation by the caspase-9 apoptosome
Stephen P. Burke, Lucinda Smith, and Jeffrey B. Smith
J. Biol. Chem. published 28 July 2010, 10.1074/jbc.M110.125955

Alternatively spliced caspase-6b isoform inhibits the activation of caspase-6a
Andrea W. Lee, Nathalie Champagne, Xiaojun Wang, Xiao-Dong Su, Cynthia G. Goodyer, and Andrea C. LeBlanc
J. Biol. Chem. published 3 August 2010, 10.1074/jbc.M110.152744

Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death
T. Nakamura, L. Wang, C.C.L. Wong, F.L. Scott, B.P. Eckelman, X. Han, C. Tzitzilonis, F. Meng, Z. Gu, E.A. Holland, A.T. Clemente, S.-i. Okamoto, G.S. Salvesen, R. Riek, J.R. Yates III, and S.A. Lipton

Metacaspase Yca1 is required for clearance of insoluble protein aggregates
Robin E. C. Lee, Steve Brunette, Lawrence G. Puente, and Lynn A. Megeney

Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
Shizue Ohsawa, Shun Hamada, Keisuke Kuida, Hiroki Yoshida, Tatsushi Igaki, and Masayuki Miura

The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins
Lasi, M; Pauly, B; Schmidt, N; Cikala, M; Stiening, B; Kasbauer, T; Zenner, G; Popp, T; Wagner, A; Knapp, RT; Huber, AH; Grunert, M; Soding, J; David, CN; Bottger, A

The caspase-8 dimerisation/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signalling
Maximilian L. Würstle, Maike A. Laussmann, and Markus Rehm

Death receptors

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL
Nicolai Fricker, Joel Beaudouin, Petra Richter, Roland Eils, Peter H. Krammer, and Inna N. Lavrik

T-cell receptor complex is essential for Fas signal transduction
Askar M. Akimzhanov, Xinmin Wang, Jiaren Sun, and Darren Boehning

Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis
Ting-Kuang Niu, Yan Cheng, Xingcong Ren, Jin-Ming Yang

Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation
M Ehrenschwender, D Siegmund, A Wicovsky, M Kracht, O Dittrich-Breiholz, V Spindler, J Waschke, H Kalthoff, A Trauzold and H Wajant


Knock-out of metacaspase and/or cytochrome c results in the activation of a ROS-independent acetic acid-induced programmed cell death pathway in yeast
Nicoletta Guaragnella, Salvatore Passarella, Ersilia Marra, Sergio Giannattasio

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
Ioannis P. Nezis, Bhupendra V. Shravage, Antonia P. Sagona, Trond Lamark, Geir Bjørkøy, Terje Johansen, Tor Erik Rusten, Andreas Brech, Eric H. Baehrecke, and Harald Stenmark

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death
L. Radoshevich, L. Murrow, N. Chen, E. Fernandez, S. Roy, C. Fung, and J. Debnath