Apolist – june 2010

Bcl-2 family proteins

Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones
F.M. Wensveen, K.P.J.M. van Gisbergen, I.A.M. Derks, C. Gerlach, T.N. Schumacher, R.A.W. van Lier, and E. Eldering

Growth factor stimulation induces cell survival by C-jun/ATF2-dependent activation of BCL-XL
Ahmad Salameh, Federico Galvagni, Francesca Anselmi, Caterina De Clemente, Maurizio Orlandini, and Salvatore Oliviero
J. Biol. Chem. published 27 May 2010, 10.1074/jbc.M109.087221

A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications
Zhi Sheng, Li Li, Lihua J Zhu, Thomas W Smith, Andrea Demers, Alonzo H Ross, Richard P Moser and Michael R Green

The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells
A Greenhough, C A Wallam, D J Hicks, M Moorghen, A C Williams and C Paraskeva

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation
Lijian Shao, Yan Sun, Zhonghui Zhang, Wei Feng, Yongxing Gao, Zailong Cai, Zack Z. Wang, A. Thomas Look, and Wen-Shu Wu
Blood 2010;115 4707-4714

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs
Emma M. Carrington, Ingela B. Vikstrom, Amanda Light, Robyn M. Sutherland, Sarah L. Londrigan, Kylie D. Mason, David C. S. Huang, Andrew M. Lew, and David M. Tarlinton

The BH3-mimetic gossypol induces both beclin 1-dependent and beclin 1-independent cytoprotective autophagy in cancer cells
Ping Gao, Chantal Bauvy, Sylvie Souquere, Giovanni Tonelli, Lei Liu, Yushan Zhu, Zhenzhen Qiao, Daniela Bakula, Tassula Proikas-Cezanne, Gerard Pierron, Patrice Codogno, Quan Chen, and Maryam Mehrpour
J. Biol. Chem. published 7 June 2010, 10.1074/jbc.M110.118125

BCL-2 and bax interact via the BH1-3 groove:BH3 motif interface and a novel interface involving the BH4 motif
Jingzhen Ding, Zhi Zhang, G. Jane Roberts, Mina Falcone, Yiwei Miao, Yuanlong Shao, Xuejun C. Zhang, David W. Andrews, and Jialing Lin
J. Biol. Chem. published 28 June 2010, 10.1074/jbc.M110.148361

High-Mobility Group A1 Proteins Regulate p53-Mediated Transcription of Bcl-2 Gene
Francesco Esposito, Mara Tornincasa, Paolo Chieffi, Ivana De Martino, Giovanna Maria Pierantoni, and Alfredo Fusco
Cancer Res 2010;70 5379-5388

Death receptors and IAPs

XIAP impairs Smac release from the mitochondria during apoptosis
L Flanagan, J Sebastià, L P Tuffy, A Spring, A Lichawska, M Devocelle, J H M Prehn and M Rehm

FADD-calmodulin interaction: A novel player in cell cycle regulation
Pages 898-911
Giuliana Papoff, Nadia Trivieri, Roberta Crielesi, Francesca Ruberti, Sonia Marsilio, Giovina Ruberti

Effective Blockage of Both the Extrinsic and Intrinsic Pathways of Apoptosis in Mice by TAT-crmA
Stefan Krautwald, Ekkehard Ziegler, Lars Rölver, Andreas Linkermann, Kirsten A. Keyser, Philip Steen, Kai C. Wollert, Mortimer Korf-Klingebiel, and Ulrich Kunzendorf

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
Sergio E. Alvarez, Kuzhuvelil B. Harikumar,Nitai C. Hait,Jeremy Allegood,Graham M. Strub,Eugene Y. Kim,Michael Maceyka,Hualiang Jiang, Cheng Luo, Tomasz Kordula, Sheldon Milstien & Sarah Spiegel

mir-200c Regulates Induction of Apoptosis through CD95 by Targeting FAP-1
R. Schickel, S.-M. Park, A.E. Murmann, and M.E. Peter

Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression
Sean L. Petersen, Michael Peyton, John D. Minna, and Xiaodong Wang


Activation of autophagy during cell death requires the engulfment receptor Draper
Christina K. McPhee, Mary A. Logan, Marc R. Freeman and Eric H. Baehrecke

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes
C Oberle, J Huai, T Reinheckel, M Tacke, M Rassner, P G Ekert, J Buellesbach and C Borner

Oncogene-Induced Sensitization to Chemotherapy-Induced Death Requires Induction as well as Deregulation of E2F1
G. Vignir Helgason, Jim O’Prey, and Kevin M. Ryan
Cancer Res 2010;70 4074-4080

Identification of functional regions defining different activity between caspase-3 and caspase-7 within cells
Hirokazu Nakatsumi and Shin Yonehara
J. Biol. Chem. published 21 June 2010, 10.1074/jbc.M110.126573


Bcl-2-regulated cell death signalling in the prevention of autoimmunity
D Tischner, C Woess, E Ottina and A Villunger

The role of caspase-2 in stress-induced apoptosis
Lisa Bouchier-Hayes

Neuronal caspase-3 signaling: not only cell death
M D’Amelio, V Cavallucci and F Cecconi

Clearance of apoptotic cells: implications in health and disease
Michael R. Elliott and Kodi S. Ravichandran

Only the Strong Survive
A. Villunger

Depressed About Caspases?
Elizabeth M. Adler
Sci. Signal. 3 (125), ec170. [DOI: 10.1126/scisignal.3125ec170]
Elements of the mitochondrial apoptosis pathway are used to mediate long-term depression of synaptic function.


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