Apolist – may 2010

Resistance to Caspase-Independent Cell Death Requires Persistence of Intact Mitochondria
S.W.G. Tait, M.J. Parsons, F. Llambi, L. Bouchier-Hayes, S. Connell, C. Munoz-Pinedo, and D.R. Green


Bcl-2 proteins

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria
Yehudit Zaltsman, Liat Shachnai, Natalie Yivgi-Ohana, Michal Schwarz, Maria Maryanovich, Riekelt H. Houtkooper, Frédéric Maxime Vaz, Francesco De Leonardis, Giuseppe Fiermonte, Ferdinando Palmieri, Bernhard Gillissen, Peter T. Daniel, Erin Jimenez, Susan Walsh, Carla M. Koehler, Soumya Sinha Roy, Ludivine Walter, György Hajnóczky and Atan Gross

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
Panagiota A. Sotiropoulou, Aurélie Candi, Guilhem Mascré, Sarah De Clercq, Khalil Kass Youssef, Gaelle Lapouge, Ellen Dahl, Claudio Semeraro, Geertrui Denecker, Jean-Christophe Marine and Cédric Blanpain

Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding
Nathan P. Gomes and Joaquín M. Espinosa

MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1)
Ming Zhou, Zixing Liu, Yuhua Zhao, Yan Ding, Hao Liu, Yaguang Xi, Wei Xiong, Guiyuan Li, Jianrong Lu, Oystein Fodstad, Adam I Riker, and Ming Tan

From the Cover: Feature Article: Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy
Yun Chen, William Lewis, Abhinav Diwan, Emily H.-Y. Cheng, Scot J. Matkovich, and Gerald W. Dorn, II

Viral apoptosis is induced by IRF-3-mediated activation of Bax
Saurabh Chattopadhyay, Joao T Marques, Michifumi Yamashita, Kristi L Peters, Kevin Smith, Avanti Desai, Bryan R G Williams and Ganes C Sen

Ubiquitin-Independent Degradation of Antiapoptotic MCL-1
Daniel P. Stewart, Brian Koss, Madhavi Bathina, Rhonda M. Perciavalle, Kristen Bisanz, and Joseph T. Opferman

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
W J Placzek, J Wei, S Kitada, D Zhai, J C Reed and M Pellecchia

Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib
Siquan Chen, Jonathan L. Blank, Theodore Peters, Xiaozhen J. Liu, David M. Rappoli, Michael D. Pickard, Saurabh Menon, Jie Yu, Denise L. Driscoll, Trupti Lingaraj, Anne L. Burkhardt, Wei Chen, Khristofer Garcia, Darshan S. Sappal, Jesse Gray, Paul Hales, Patrick J. Leroy, John Ringeling, Claudia Rabino, James J. Spelman, Jay P. Morgenstern, and Eric S. Lightcap

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms
Thomas Landes, Laurent J Emorine, Delphine Courilleau, Manuel Rojo, Pascale Belenguer and Laetitia Arnauné-Pelloquin

Death receptors

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation
Christian T. Hellwig, Agnieszka H. Ludwig-Galezowska, Caoimhin G. Concannon, David W. Litchfield, Jochen H. M. Prehn, and Markus Rehm

CD95 promotes tumour growth
Lina Chen,Sun-Mi Park,Alexei V. Tumanov,Annika Hau,Kenjiro Sawada,Christine Feig,Jerrold R. Turner,Yang-Xin Fu,Iris L. Romero,Ernst Lengyel& Marcus E. Peter

Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1
L Bouchier-Hayes, S McBride, C M van Geelen, S Nance, L K Lewis, M J Pinkoski and H M Beere

miR-212 Increases Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Sensitivity in Non-Small Cell Lung Cancer by Targeting the Antiapoptotic Protein PED
Mariarosaria Incoronato, Michela Garofalo, Loredana Urso, Giulia Romano, Cristina Quintavalle, Ciro Zanca, Margherita Iaboni, Gerald Nuovo, Carlo Maria Croce, and Gerolama Condorelli

Caspases and demolition phase

Apaf-1-independent programmed cell death in mouse development
A Nagasaka, K Kawane, H Yoshida and S Nagata

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features
T Vanden Berghe, N Vanlangenakker, E Parthoens, W Deckers, M Devos, N Festjens, C J Guerin, U T Brunk, W Declercq and P Vandenabeele

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization
Z. Li, J. Jo, J.-M. Jia, S.-C. Lo, D.J. Whitcomb, S. Jiao, K. Cho, and M. Sheng

Autophagic Cell Death in Dictyostelium Requires the Receptor Histidine Kinase DhkM
Corinne Giusti, Marie-Françoise Luciani, Sarina Ravens, Alexandre Gillet, and Pierre Golstein

The execution phase of autophagy associated PCD during insect metamorphosis
Caroline O. B. Facey & Richard A. Lockshin


AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX
Cédric Artus, Hanan Boujrad, Aïda Bouharrour, Marie-Noëlle Brunelle, Sylviane Hoos, Victor J Yuste, Pascal Lenormand, Jean-Claude Rousselle, Abdelkader Namane, Patrick England, Hans K Lorenzo and Santos A Susin

Nocodazole induces mitotic cell death with apoptotic-like features in Saccharomyces cerevisiae
Kingo Endo, Mayumi Mizuguchi, Aoi Harata, Go Itoh, Kozo Tanaka

Bre1p-mediated histone H2B ubiquitylation regulates apoptosis in Saccharomyces cerevisiae
David Walter, Anja Matter, and Birthe Fahrenkrog

Akt-phosphorylated MADD inhibits trail-induced apoptosis By blocking FADD association with death receptor-4
Peifeng Li, Shankar Jayarama, Lakshmy Ganesh, David Mordi, Ryan Carr, Prasad Kanteti, Nissim Hay, and Bellur S. Prabhakar

Dual roles of Drosophila p53 in cell death and cell differentiation
Y Fan, T V Lee, D Xu, Z Chen, A-F Lamblin, H Steller and A Bergmann

Autophagic Cell Death in Dictyostelium Requires the Receptor Histidine Kinase DhkM
Corinne Giusti, Marie-Françoise Luciani, Sarina Ravens, Alexandre Gillet, and Pierre Golstein


10 reviews on cell death in Cellular and Molecular Life Sciences,
including for instance:

– Non-caspase proteases: triggers or amplifiers of apoptosis?
Karen Schrader, Jisen Huai, Lars Jöckel, Carolin Oberle y Christoph Borner

– Bcl-2 family proteins and mitochondrial fission/fusion dynamics
Arnaud Autret y Seamus J. Martin

– Mitochondrial control of caspase-dependent and -independent cell death
Ludivine A. Pradelli, Marie Bénéteau y Jean-Ehrland Ricci

Regulation of ceramide channels by Bcl-2 family proteins
Vidyaramanan Ganesan, Marco Colombini

Contribution of voltage-gated potassium channels to the regulation of apoptosis
Ildikò Szabò, Mario Zoratti, Erich Gulbins

Life with or without AIF
Emilie Hangen, Klas Blomgren, Paule Bénit, Guido Kroemer, Nazanine Modjtahedi


Comments / Other

IRF-3 partners Bax in a viral-induced dance macarbre
James E Vince and Jurg Tschopp

No Transcription Required
Nancy R. Gough
Sci. Signal. 3 (124), ec161. [DOI: 10.1126/scisignal.3124ec161]
The transcription factor IRF-3 acts at the mitochondria to trigger apoptosis of virally infected cells.

Apoptosis: Which way will the Dicer roll?
An unexpected role for the RNase Dicer 1 as a DNase in apoptosis.

To H2B or not H2B: apoptosis regulation
J Cell Sci 2010;123 e1105

Signalling lessons from death receptors: the importance of cleavage
Vishva M. Dixit

A Deathly DNase Activity for Dicer
K. Okamura and E.C. Lai

For Synapses, It’s Depression Not Death
H.S. Bateup and B.L. Sabatini

Paradoxical Signaling
John F. Foley
Sci. Signal. 3 (124), ec162. [DOI: 10.1126/scisignal.3124ec162]
The death receptor CD95 (Fas) is required for the growth of tumor cells.