Apolist – january 10


Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
Martin Schwickart et al.

Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-xL
L Lindenboim, E Blacher, C Borner and R Stein

The Antiapoptotic Protein BCL2L1/BCL-XL is Neutralized by Proapoptotic PMAIP1/Noxa in Neuroblastoma Thereby Determining Bortezomib-Sensitivity Independent of Prosurvival MCL1 Expression
Judith Hagenbuchner, Michael J. Ausserlechner, Verena Porto, Reinhard David, Bernhard Meister, Martin Bodner, Andreas Villunger, Kathrin Geiger, and Petra Obexer
J. Biol. Chem. published 5 January 2010, 10.1074/jbc.M109.038331

Rheb GTPase controls apoptosis by regulating the interaction of FKBP38 with Bcl-2 and Bcl-XL
Dongzhu Ma, Xiaochun Bai, Huafei Zou, Yumei Lai, and Yu Jiang
J. Biol. Chem. published 4 January 2010, 10.1074/jbc.M109.092353

The Bax carboxy-terminal hydrophobic helix does not determine organelle-specific targeting but is essential for maintaining Bax in an inactive state and for stable mitochondrial membrane insertion
Stephanie E. Brock, Chi Li & Binks W. Wattenberg

Mcl-1128–350 fragment induces apoptosis through direct interaction with Bax
Emmanuelle Ménoret, Patricia Gomez-Bougie, Sylvanie Surget, Valérie Trichet, Lisa Oliver, Catherine Pellat-Deceunynck, Martine Amiot

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
Anissa M. Jabbour, Carmel P. Daunt, Benjamin D. Green, Sandra Vogel, Lavinia Gordon, Rachel S. Lee, Natasha Silke, Richard B. Pearson, Cassandra J. Vandenberg, Priscilla N. Kelly, Stephen L. Nutt, Andreas Strasser, Christoph Borner, and Paul G. Ekert
Blood 2010;115 344-352

Interleukin-7 Regulates Bim Proapoptotic Activity in Peripheral T-Cell Survival
Wen Qing Li, Tad Guszczynski, Julie A. Hixon, and Scott K. Durum
Mol. Cell. Biol. 2010;30 590-600

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis
David T. Terrano, Meenakshi Upreti, and Timothy C. Chambers
Mol. Cell. Biol. 2010;30 640-656

Differential Dependence on Beclin 1 for the Regulation of Pro-Survival Autophagy by Bcl-2 and Bcl-xL in HCT116 Colorectal Cancer Cells
Muriel Priault, Erika Hue, Fanny Marhuenda, Paul Pilet, Lisa Oliver, François M. Vallette

Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species
J -J Lee, J -H Lee, Y -G Ko, S I Hong and J -S Lee


Death receptors and IAPs

Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling
N. Paquette, M. Broemer, K. Aggarwal, L. Chen, M. Husson, D. Ertürk-Hasdemir, J.-M. Reichhart, P. Meier, and N. Silverman

TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL
Josep Maria Lluis, Ulrich Nachbur, Wendy Diane Cook, Ian Edward Gentle, Donia Moujalled, Maryline Moulin, Wendy Wei-Lynn Wong, Nufail Khan, Diep Chau, Bernard Andrew Callus, James Edward Vince, John Silke, David Lawrence Vaux

Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein
M R Abedini, E J Muller, R Bergeron, D A Gray and B K Tsang

Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation
E Borbone, M T Berlingieri, F De Bellis, A Nebbioso, G Chiappetta, A Mai, L Altucci and A Fusco

Avicin D, a Plant Triterpenoid, Induces Cell Apoptosis by Recruitment of Fas and Downstream Signaling Molecules into Lipid Rafts
Zhi-Xiang Xu, Tian Ding, Valsala Haridas, Fiona Connolly, Jordan U. Gutterman

IAP Regulation of Metastasis
S. Mehrotra, L.R. Languino, C.M. Raskett, A.M. Mercurio, T. Dohi, and D.C. Altieri

Targeting a novel N-terminal epitope of death receptor 5 triggers tumor cell death
Peng Zhang, Yong Zheng, Juan Shi, Yaxi Zhang, Shilian Liu, Yanxin Liu, and Dexian Zheng
J. Biol. Chem. published 27 January 2010, 10.1074/jbc.M109.070680

Multivalent DR5 Peptides Activate the TRAIL Death Pathway and Exert Tumoricidal Activity
Valeria Pavet, Julien Beyrath, Christophe Pardin, Alexandre Morizot, Marie-Charlotte Lechner, Jean-Paul Briand, Miriam Wendland, Wolfgang Maison, Sylvie Fournel, Olivier Micheau, Gilles Guichard, and Hinrich Gronemeyer
Cancer Res 2010;70 1101-1110

Tumor necrosis factor–related apoptosis-inducing ligand 1 (TRAIL1) enhances the transition of red blood cells from the larval to adult type during metamorphosis in Xenopus
Kei Tamura, Shuuji Mawaribuchi, Shin Yoshimoto, Tadayoshi Shiba, Nobuhiko Takamatsu, and Michihiko Ito
Blood 2010;115 850-859


Apoptotic process

Inhibition of a protein kinase Akt1 by apoptosis signal-regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory volume increase
Muthangi Subramanyam, Nobuyuki Takahashi, Yuichi Hasegawa, Tatsuma Mohri, and Yasunobu Okada
J. Biol. Chem. published 4 January 2010, 10.1074/jbc.M109.072785

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
S Luo and D C Rubinsztein

Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration pp67 – 73
Yujin E Kim, Jeannie Chen, Jonah R Chan and Ralf Langen



Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila
Yakup Batlevi, Damali N. Martin, Udai Bhan Pandey, Claudio R. Simon, Christine M. Powers, J. Paul Taylor, and Eric H. Baehrecke

Rab5 Mediates Caspase-8–promoted Cell Motility and Metastasis
Vicente A. Torres, Ainhoa Mielgo, Simone Barbero, Ruth Hsiao, John A. Wilkins, and Dwayne G. Stupack

The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma
Di Pietro, C; Ragusa, M; Barbagallo, D; Duro, LR; Guglielmino, MR; Majorana, A; Angelica, R; Scalia, M; Statello, L; Salito, L; Tomasello, L; Pernagallo, S; Valenti, S; D’Agostino, V; Triberio, P; Tandurella, I; Palumbo, GA; La Cava, P; Cafiso, V; Bertuccio, T; Santagati, M; Destri, GL; Lanzafame, S; Di Raimondo, F; Stefani, S; Mishra, B; Purrello, M

Positive selection on apoptosis related genes
Rute R. da Fonseca, Carolin Kosiol, Tomáš Vinař, Adam Siepel, Rasmus Nielsen

Coupling of the cell cycle and apoptotic machineries in developing T cells
Ling Xue, Yuefang Sun, Leslie Chiang, Bo He, Chulho Kang, Hector Nolla, and Astar Winoto
J. Biol. Chem. published 12 January 2010, 10.1074/jbc.M109.035535

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis
D. G. Kirsch et al.


Several reviews on microRNAs and cell death/cancer in CDD:
MicroRNAs meet cell death
G Melino and R A Knight

Cellular and nuclear degradation during apoptosis
Pages 900-912
Bin He, Nan Lu, Zheng Zhou

Modulation of apoptosis by early human papillomavirus proteins in cervical cancer
A. Lagunas-Martínez, V. Madrid-Marina, P. Gariglio

Transcription-independent p53 apoptosis: an alternative route to death
Daniel Speidel