Apolist – november 09

Emerging Role for Members of the Bcl-2 Family in Mitochondrial Morphogenesis
A. Autret and S.J. Martin

Novel roles for GAPDH in cell death and carcinogenesis

A Colell, D R Green and J-E Ricci


Cell Death
Richard S. Hotchkiss, M.D., Andreas Strasser, Ph.D., Jonathan E.
McDunn, Ph.D., and Paul E. Swanson, M.D.


Bak Activation for Apoptosis Involves Oligomerization of Dimers via
Their α6 Helices
G. Dewson, T. Kratina, P. Czabotar, C.L. Day, J.M. Adams, and R.M. Kluck

Membrane promotes tBID interaction with BCL(XL).
García-Sáez AJ, Ries J, Orzáez M, Pérez-Payà E, Schwille P.

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates
Mitochondrial Apoptosis
H. Kim, H.-C. Tu, D. Ren, O. Takeuchi, J.R. Jeffers, G.P. Zambetti,
J.J.-D. Hsieh, and E.H.-Y. Cheng

Bax contains two functional mitochondrial targeting sequences and
translocates to mitochondria in a conformational change- and
homo-oligomerization-driven process
Nicholas M. George, Natalie Targy, Jacquelynn J. D. Evans, Liqiang
Zhang, and Xu Luo

Bim Upregulation by Histone Deacetylase Inhibitors Mediates
Interactions with the Bcl-2 Antagonist ABT-737: Evidence for Distinct
Roles for Bcl-2, Bcl-xL, and Mcl-1
Shuang Chen, Yun Dai, Xin-Yan Pei, and Steven Grant

The BH3-only protein Bim plays a critical role in leukemia cell death
triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2
Mohamed Rahmani, Anh Anderson, Joseph Reza Habibi, Timothy Ryan
Crabtree, Mandy Mayo, Hisashi Harada, Andrea Ferreira-Gonzalez, Paul
Dent, and Steven Grant

From the Cover: Age-related hearing loss in C57BL/6J mice is mediated
by Bak-dependent mitochondrial apoptosis
Shinichi Someya, Jinze Xu, Kenji Kondo, Dalian Ding, Richard J. Salvi,
Tatsuya Yamasoba, Peter S. Rabinovitch, Richard Weindruch, Christiaan
Leeuwenburgh, Masaru Tanokura, and Tomas A. Prolla

Facilitation of mitochondrial outer and inner membrane
permeabilization and cell death in oxidative stress by a novel BH3
domain protein
A. Szigeti, E. Hocsak, E. Rapolti, B. Racz, A. Boronkai, E. Pozsgai,
B. Debreceni, Z. Bognar, S. Bellyei, B. Sumegi, and F. Gallyas, Jr.

Dissimilar mechanisms of cytochrome c release induced by octyl
glucoside-activated BAX and by BAX activated with truncated BID
Tsyregma Li, Tatiana Brustovetsky, Bruno Antonsson, Nickolay Brustovetsky


Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila
D. Denton, B. Shravage, R. Simin, K. Mills, D.L. Berry, E.H.
Baehrecke, and S. Kumar

Determinism and divergence of apoptosis susceptibility in mammalian cells
Patrick D. Bhola and Sanford M. Simon
J Cell Sci 2009;122 4296-4302

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER
Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis
R. Sano, I. Annunziata, A. Patterson, S. Moshiach, E. Gomero, J.
Opferman, M. Forte, and A. d’Azzo

Granzyme F induces a novel death pathway characterized by
Bid-independent cytochrome c release without caspase activation
LShi, L Wu, S Wang and Z Fan

IAPs and death receptors

CD95 engagement mediates actin-independent and -dependent apoptotic signals
BChaigne-Delalande, W Mahfouf, S Daburon, J-F Moreau and P Legembre

PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL
S Ueno, H Tatetsu, H Hata, T Iino, H Niiro, K Akashi, D G Tenen, H
Mitsuya and Y Okuno

A role for X-linked inhibitor of apoptosis protein upstream of
mitochondrial permeabilization
Thomas W. Owens, Fiona M. Foster, Anthony Valentijn, Andrew P.
Gilmore, and Charles H. Streuli

Caspases and downstream

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

Lata Mukundan, Justin I Odegaard, Christine R Morel, Jose E Heredia, Julia W Mwangi, Roberto R Ricardo-Gonzalez, Y P Sharon Goh, Alex Red Eagle, Shannon E Dunn, Jennifer U H Awakuni, Khoa D Nguyen, Lawrence Steinman, Sara A Michie and Ajay Chawl


Recognition of apoptotic cells by epithelial cells: conserved versus
tissue-specific signaling responses
Vimal A. Patel, Daniel J. Lee, Lanfei Feng, Angelika Antoni, Wilfred
Lieberthal, John H. Schwartz, Joyce Rauch, David S. Ucker, and Jerrold
S. Levine
J. Biol. Chem. published 12 November 2009, 10.1074/jbc.M109.018440

Necrotic cells trigger a sterile inflammatory response through the
Nlrp3 inflammasome
Shankar S. Iyer, Wilco P. Pulskens, Jeffrey J. Sadler, Loes M. Butter,
Gwendoline J. Teske, Tyler K. Ulland, Stephanie C. Eisenbarth,
Sandrine Florquin, Richard A. Flavell, Jaklien C. Leemans, and Fayyaz
S. Sutterwala


BAX and BAK Caught in the Act
Y. Yao and F.M. Marassi

Apoptosis: the generation gap

Caspase 2 in apoptosis, the DNA damage response and tumour
suppression: enigma no more?
Sharad Kumar