Apolist – october 2009

Caspases and downstream

Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development
Akiko Koto, Erina Kuranaga, and Masayuki Miura

Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2
Joshua L Andersen, Carrie E Johnson, Christopher D Freel, Amanda B Parrish, Jennifer L Day, Marisa R Buchakjian, Leta K Nutt, J Will Thompson, M Arthur Moseley and Sally Kornbluth

Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7
Johnson Agniswamy, Bin Fang, Irene T. Weber

Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level
Young-wook Jun, Sassan Sheikholeslami, Daniel R. Hostetter, Cheryl Tajon, Charles S. Craik, and A. Paul Alivisatos

ARTEMIS Nuclease Facilitates Apoptotic Chromatin Cleavage
Sébastien Britton, Philippe Frit, Denis Biard, Bernard Salles, and Patrick Calsou
Cancer Res 2009;69 8120-8126

Autophagy is not universally required for phosphatidyl-serine exposure and
apoptotic cell engulfment during neural development
María A. Mellén, Enrique J. de la Rosa and Patricia Boya


Death receptor pathway

FLIP-mediated autophagy regulation in cell death control
Jong-Soo Lee, Qinglin Li, June-Yong Lee, Sun-Hwa Lee, Joseph H. Jeong, Hye-Ra Lee, Heesoon Chang, Fu-Chun Zhou, Shou-Jiang Gao, Chengyu Liang and Jae U. Jung

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound
Herman H. Cheung, Douglas J. Mahoney, Eric C. LaCasse, and Robert G. Korneluk

A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme
Amith Panner, Courtney A. Crane, Changjiang Weng, Alberto Feletti, Andrew T. Parsa, and Russell O. Pieper

TRAF2 must bind to cIAPs for TNF to efficiently activate NF- B and to prevent TNF-induced apoptosis
James E. Vince, Delara Pantaki, Rebecca Feltham, Peter D. Mace, Stephanie M. Cordier, Anna C. Schmukle, Angelina J. Davidson, Bernard A. Callus, Wendy Wei-Lynn Wong, Ian E. Gentle, Holly Carter, Erinna F. Lee, Henning Walczak, Catherine L. Day, David L. Vaux, and John Silke

Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxygeldanamycin promotes TRAIL-induced apoptosis in breast tumor cells.
Palacios C, López-Pérez AI, López-Rivas A.

XIAP regulates cell death induction by pro-apoptotic receptor agonists
Eugene Varfolomeev, Bruno Alicke, J. Michael Elliott, Kerry Zobel, Kristina West, Harvey Wong, Justin M. Scheer, Avi Ashkenazi, Stephen E. Gould, Wayne J. Fairbrother, and Domagoj Vucic

Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients
Georg Stary, Irene Klein, Sabine Kohlhofer, Frieder Koszik, Thomas Scherzer, Leonhard Müllauer, Heribert Quendler, Norbert Kohrgruber, and Georg Stingl



Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid
Jun Peng, Jingzhen Ding, Chibing Tan, Bruce Baggenstoss, Zhi Zhang, Suzanne M. Lapolla, Jialing Lin

MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts
Joslyn K. Brunelle, Jeremy Ryan, Derek Yecies, Joseph T. Opferman, and Anthony Letai

Bax activates endophilin B1 oligomerization and lipid membrane vesiculation
Tatiana K. Rostovtseva, Hacene Boukari, Antonella Antignani, Brian Shiu, Soojay Banerjee, Albert Neutzner, and Richard J. Youle

Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF-β–Induced Cell Death through Impairing Up-regulation of the NADPH Oxidase NOX4
Laia Caja, Patricia Sancho, Esther Bertran, Daniel Iglesias-Serret, Joan Gil, and Isabel Fabregat

The anti-apoptotic molecule Bcl-2 regulates the differentiation, activation and survival of both osteoblasts and osteoclasts
Yuichi Nagase, Mitsuyasu Iwasawa, Toru Akiyama, Yuho Kadono, Masaki Nakamura, Yasushi Oshima, Tetsuro Yasui, Takumi Matsumoto, Jun Hirose, Hiroaki Nakamura, Takeshi Miyamoto, Philippe Bouillet, Kozo Nakamura, and Sakae Tanaka

Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK
TW Owens, AJ Valentijn, J-P Upton, J Keeble, L Zhang, J Lindsay, NK Zouq and AP Gilmore

The Cell Death–Inducing Activity of the Peptide Containing Noxa Mitochondrial-Targeting Domain Is Associated with Calcium Release
Young-Woo Seo, Ha-Na Woo, Sujan Piya, Ae Ran Moon, Jae-Wook Oh, Cheol-Won Yun, Kyung-Keun Kim, Ji-Young Min, Seon-Yong Jeong, Seyung Chung, Peter I. Song, Seong-Yun Jeong, Eun Kyung Choi, Dai-Wu Seol, and Tae-Hyoung Kim

Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavage
B-ZYuan, J Chapman and S H Reynolds



Spatial and temporal dynamics of mitochondrial membrane permeability waves during apoptosis.
Bhola PD, Mattheyses AL, Simon SM.

Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes
J Zhang, N Bahi, M Llovera, J X Comella and D Sanchis

A novel membrane fusion-mediated plant immunity against bacterial pathogens
Noriyuki Hatsugai, Shinji Iwasaki, Kentaro Tamura, Maki Kondo, Kentaro Fuji, Kimi Ogasawara, Mikio Nishimura, and Ikuko Hara-Nishimura



Apoptosis: Calling Time on Apoptosome Activity
Colin Adrain and Seamus J. Martin
Caspase-9 autoprocessing displaces active caspase-9 bound to the apoptosome, thereby limiting proteolytic activity.

Apoptosis: Watching caspase 2 get active
Katharine H. Wrighton

Walking a fine caspase line
Kendall Powell

HIV infection: TRAILing the killers
Andrea Cerutti

A kiss of death—proteasome-mediated membrane fusion and programmed cell death in plant defense against bacterial infection
Karolina Pajerowska-Mukhtar and Xinnian Dong