Apolist – september 09

Caspases and downstream

Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity
L. Bouchier-Hayes, A. Oberst, G.P. McStay, S. Connell, S.W.G. Tait, C.P. Dillon, J.M. Flanagan, H.M. Beere, and D.R. Green

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
Andrew Kovalenko, Jin-Chul Kim, Tae-Bong Kang, Akhil Rajput, Konstantin Bogdanov, Oliver Dittrich-Breiholz, Michael Kracht, Ori Brenner, and David Wallach

Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53
Hyo-Jin Kim, Ho-June Lee, Joon-Il Jun, Yumin Oh, Seon-Guk Choi, Hyunjoo Kim, Chul-Woong Chung, In-Ki Kim, Il-Sun Park, Han-Jung Chae, Hyung-Ryong Kim, and Yong-Keun Jung

Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3
Carlos H. Herrera-Mendez, Samira Becila, Xavier Blanchet, Patrick Pelissier, Didier Delourme, Gerald Coulis, Miguel A. Sentandreu, Abdelghani Boudjellal, Laure Bremaud, Ahmed Ouali

Caspase-2 Mediated Apoptotic and Necrotic Murine Macrophage Cell Death Induced by Rough Brucella abortus
Fang Chen, Yongqun He

The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor–1 in macrophages via sphingosine-1-phosphate and transforming growth factor-β
Barbara Herr, Jie Zhou, Christian Werno, Heidi Menrad, Dmitry Namgaladze, Andreas Weigert, Nathalie Dehne, and Bernhard Brüne

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Michael R. Elliott1,2, Faraaz B. Chekeni1,3, Paul C. Trampont1,2, Eduardo R. Lazarowski7, Alexandra Kadl4, Scott F. Walk1,2, Daeho Park1,2, Robin I. Woodson5, Marina Ostankovich4, Poonam Sharma4, Jeffrey J. Lysiak5, T. Kendall Harden8, Norbert Leitinger3,4 & Kodi S. Ravichandran

A new model for APAF-1’s transition from inactive monomer to caspase-activating apoptosome
Thomas F. Reubold, Sabine Wohlgemuth, and Susanne Eschenburg
J. Biol. Chem. published 30 September 2009, 10.1074/jbc.M109.014027


Identification of a Protein, G0S2, That Lacks Bcl-2 Homology Domains and Interacts with and Antagonizes Bcl-2
Christian Welch, Manas K. Santra, Wissal El-Assaad, Xiaochun Zhu, Wade E. Huber, Richard A. Keys, Jose G. Teodoro, and Michael R. Green

Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77
Cristiano Ferlini, Lucia Cicchillitti, Giuseppina Raspaglio, Silvia Bartollino, Samanta Cimitan, Carlo Bertucci, Simona Mozzetti, Daniela Gallo, Marco Persico, Caterina Fattorusso, Giuseppe Campiani, and Giovanni Scambia

Conformational changes in BCL-2 pro-survival proteins determine their capacity to bind ligands
Erinna F. Lee, Peter E. Czabotar, Hong Yang, Brad E. Sleebs, Guillaume Lessene, Peter M. Colman, Brian J. Smith, and Walter Douglas Fairlie
J. Biol. Chem. published 2 September 2009, 10.1074/jbc.M109.040725

Mcl-1 degradation during hepatocyte lipoapoptosis
Howard C. Masuoka, Justin Mott, Steven F. Bronk, Nathan W. Werneburg, Yuko Akazawa, Scott H. Kaufmann, and Gregory J. Gores
J. Biol. Chem. published 5 September 2009, 10.1074/jbc.M109.039545

MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death
Jae-Hong Kim, Se-Hoon Sim, Hye-Jeong Ha, Jeong-Jae Ko, Kangseok Lee, Jeehyeon Bae

Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax
Diana Hippe, Arnim Weber, Liying Zhou, Donald C. Chang, Georg Häcker, and Carsten G. K. Lüder
J Cell Sci 2009;122 3511-3521

Carboxy-terminal residues regulate localization and function of the antiapoptotic protein Bfl-1
Gaelle Brien, Anne-Laure Debaud, Xavier Robert, Lisa Oliver, Marie-Claude Trescol-Biemont, Nicolas Cauquil, Olivier Geneste, Nushin Agahajari, Francois M. Vallette, Richard Haser, and Nathalie Bonnefoy-Berard

Novel BCL-2 homology (BH)-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival BCL 2 proteins
Erinna F. Lee, Anna Fedorova, Kerry Zobel, Michelle J. Boyle, Hong Yang, Matthew A. Perugini, Peter M. Colman, David C. S. Huang, Kurt Deshayes, and Walter Douglas Fairlie

p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2
Petra Obexer, Judith Hagenbuchner, Martina Rupp, Christina Salvador, Markus Holzner, Martin Deutsch, Verena Porto, Reinhard Kofler, Thomas Unterkirchner, and Michael J. Ausserlechner
J. Biol. Chem. published 8 September 2009, 10.1074/jbc.M109.051441

Death receptors

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
Lorraine A. O’ Reilly1, Lin Tai1, Lily Lee1, Elizabeth A. Kruse1,2, Stephanie Grabow1,2, W. Douglas Fairlie1, Nicole M. Haynes3, David M. Tarlinton1, Jian-Guo Zhang1, Gabrielle T. Belz1, Mark J. Smyth3, Philippe Bouillet1, Lorraine Robb1 & Andreas Strasser

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions
M Reis-Sobreiro, C Gajate and F Mollinedo

Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing
T R Wilson, K M Redmond, K M McLaughlin, N Crawford, K Gately, K O’Byrne, C Le-Clorrenec, C Holohan, D A Fennell, P G Johnston and D B Longley

Histone deacetylase inhibitors cooperate with IFN- to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8
S Häcker, A Dittrich, A Mohr, T Schweitzer, S Rutkowski, J Krauss, K-M Debatin and S Fulda

Caspase-9 activation by the apoptosome is not required for fas-mediated apoptosis in type II jurkat cells
Mary E. Shawgo, Shary N. Shelton, and John D. Robertson


Expression, purification and use of recombinant annexin V for the detection of apoptotic cells
Susan E Logue, Mohamed Elgendy & Seamus J Martin

c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol–Treated Ewing Sarcoma Cells
Séverine Lorin, Amélie Borges, Lisandra Ribeiro Dos Santos, Sylvie Souquère, Gérard Pierron, Kevin M. Ryan, Patrice Codogno, and Mojgan Djavaheri-Mergny
Cancer Res 2009;69 6924-6931

Interfering with multimerization of netrin-1 receptors triggers tumor cell death
F Mille, F Llambi, C Guix, C Delloye-Bourgeois, C Guenebeaud, S Castro-Obregon, D E Bredesen, C Thibert and P Mehlen


Caspase-2: killer, savior and safeguard—emerging versatile roles for an ill-defined caspase
G Krumschnabel, C Manzl and A Villunger

Caspases and Kinases in a Death Grip
Manabu Kurokawa, Sally Kornbluth

Lots of reviews on autophagy (and autophagic cell death) in BBA-Molecular Cell Research:

A Cut Above the Other Caspases
J.L. Andersen and S. Kornbluth

Cell biology: Sent by the scent of death
Christopher Gregory