Apolist – august 09

This month we have a whole issue dedicated to reviews on BH3-only proteins in Oncogene:

And a whole issue of Apoptosis (the journal) dedicated to death in Drosophila

Death receptors

Reconstitution of the Death-Inducing Signaling Complex Reveals a Substrate Switch that Determines CD95-Mediated Death or Survival
M.A. Hughes, N. Harper, M. Butterworth, K. Cain, G.M. Cohen, and M. MacFarlane
PMID: 19683492

A New C-Terminal Cleavage Product of Procaspase-8, p30, Defines an Alternative Pathway of Procaspase-8 Activation
Julia C. Hoffmann, Alexander Pappa, Peter H. Krammer, and Inna N. Lavrik

AIMP2 promotes TNF-dependent apoptosis via ubiquitin-mediated degradation of TRAF2
Jin Woo Choi, Dae Gyu Kim, Min Chul Park, Jung Yeon Um, Jung Min Han, Sang Gyu Park, Eung-Chil Choi, and Sunghoon Kim

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability
A Kaunisto, V Kochin, T Asaoka, A Mikhailov, M Poukkula, A Meinander & J E Eriksson

The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis
Ravshan Burikhanov, Yanming Zhao, Anindya Goswami, Shirley Qiu, Steven R. Schwarze, Vivek M. Rangnekar

The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases
R Audo, B Combe, B Coulet, J Morel & M Hahne


The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins
Delphine Mérino, Maybelline Giam, Peter D. Hughes, Owen M. Siggs, Klaus Heger, Lorraine A. O’Reilly, Jerry M. Adams, Andreas Strasser, Erinna F. Lee, Walter D. Fairlie, and Philippe Bouillet

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
Yi-Ping Rong, Geert Bultynck, Ademuyiwa S. Aromolaran, Fei Zhong, Jan B. Parys, Humbert De Smedt, Gregory A. Mignery, H. Llewelyn Roderick, Martin D. Bootman, and Clark W. Distelhorst

Differentiation-Related Gene-1 Decreases Bim Stability by Proteasome-Mediated Degradation
Grazia Ambrosini, Sharon L. Seelman, and Gary K. Schwartz

Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene
Akira Nakajima, Keishiro Nishimura, Yukana Nakaima, Tomohiko Oh, Shigeru Noguchi, Tadatsugu Taniguchi, and Tomohiko Tamura

RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway
Angela M. Keuling, Kathleen E. A. Felton, Arabesque A. M. Parker, Majid Akbari, Susan E. Andrew, Victor A. Tron

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM
Roberto Alonso, Mónica López-Guerra, Ramanda Upshaw, Shanta Bantia, Caroline Smal, Françoise Bontemps, Chantal Manz, Thomas Mehrling, Neus Villamor, Elias Campo, Emili Montserrat, and Dolors Colomer

Identification of novel in vivo phosphorylation sites of the human pro-apoptotic protein bad: pore-forming activity of bad is regulated by phosphorylation
Lisa Polzien, Angela Baljuls, Ulrike E. E. Rennefahrt, Andreas Fischer, Werner Schmitz, Rene P. Zahedi, Albert Sickmann, Renate Metz, Stefan Albert, Roland Benz, Mirko Hekman, and Ulf R. Rapp

JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis
Sophie C. Cazanave, Justin L. Mott, Nafisa A. Elmi, Steven F. Bronk, Nathan W. Werneburg, Yuko Akazawa, Alisan Kahraman, Sean P. Garrison, Gerard P. Zambetti, Michael R. Charlton, and Gregory J. Gores

The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion
Stéphane G. Rolland, Yun Lu, Charles N. David, and Barbara Conradt

PUMA is directly activated by NF-B and contributes to TNF–induced apoptosis
P Wang, W Qiu, C Dudgeon, H Liu, C Huang, G P Zambetti, J Yu & L Zhang


The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
SandrineMarchetti, Parvati Gamas, Nathalie Belhacène, Sebastien Grosso, Ludivine A Pradelli, Pascal Colosetti, Claus Johansen, Lars Iversen, Marcel Deckert, Fréderic Luciano, Paul Hofman, Nicolas Ortonne, Abdallah Khemis, Bernard Mari, Jean-Paul Ortonne, Jean-Ehrland Ricci and Patrick Auberger

The VDAC2-BAK Rheostat Controls Thymocyte Survival
Decheng Ren, Hyungjin Kim, Ho-Chou Tu, Todd D. Westergard, Jill K. Fisher, Jeff A. Rubens, Stanley J. Korsmeyer, James J.-D. Hsieh, and Emily H.-Y. Cheng

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR
N. A-Gonzalez, S.J. Bensinger, C. Hong, S. Beceiro, M.N. Bradley, N. Zelcer, J. Deniz, C. Ramirez, M. D_iaz, G. Gallardo, C. Ruiz de Galarreta, J. Salazar, F. Lopez, P. Edwards, J. Parks, M. Andujar, P. Tontonoz, and A. Castrillo

XIAP mediates NOD signaling via interaction with RIP2
Andreas Krieg, Ricardo G. Correa, Jason B. Garrison, Gaëlle Le Negrate, Kate Welsh, Ziwei Huang, Wolfram T. Knoefel, and John C. Reed

Caspases and downstream

Suicidal Membrane Repair Regulates Phosphatidylserine Externalization during Apoptosis
Banafsheh Mirnikjoo, Krishnakumar Balasubramanian, and Alan J. Schroit
PMID: 19561081

Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway
Lisa Trisciuoglio, Marco Emilio Bianchi


Live to dead cell imaging.
Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DR.
PMID: 19609747

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis
Grant Dewson and Ruth M. Kluck

Human Caspases: Activation, Specificity, and Regulation
Cristina Pop and Guy S. Salvesen

Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?
Boris Turk and Vito Turk

Bax activation by Bim?
P E Czabotar, P M Colman & D C S Huang

Cell Death: A New Par-4 the TRAIL
Lori S. Hart, Wafik S. El-Deiry

RIP Kinases at the Crossroads of Cell Death and Survival p229
Wim Declercq, Tom Vanden Berghe, Peter Vandenabeele

SnapShot: BCL-2 Proteins
J. Marie Hardwick, Richard J. Youle

Mitochondrial calcium and the permeability transition in cell death
John J. Lemasters, Tom P. Theruvath, Zhi Zhong, Anna-Liisa Nieminen

When Repair Is Suicide
Nancy R. Gough

Repairing to Destroy: Suicidal Membrane Repair Regulates Phosphatidylserine Externalization during Apoptosis

Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria
Maurizio Sorice, Valeria Manganelli, Paola Matarrese, Antonella Tinari, Roberta Misasi, Walter Malorni, Tina Garofalo

Plenty of reviews in Oncogene and Apoptosis. Just a few samples:

BH3-only proteins in apoptosis and beyond: an overview
E Lomonosova & G Chinnadurai

Noxa: at the tip of the balance between life and death
C Ploner, R Kofler & A Villunger

Bim and Bmf in tissue homeostasis and malignant disease.
Piñon JD, Labi V, Egle A, Villunger A.
PMID: 19641506

Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death
Mariam Orme and Pascal Meier


Death on the slopes. Symposium on Cell Death Pathways
Christina K McPhee, Jahda H Hill & Mari Enoksson
[about Keystone meeting in Whistler]

Latest Science/AAAS Webinar: Apoptotic Signaling in Normal and Cancer
Cell Biology, – September, 22 2009, at 12 noon Eastern Time (9 a.m.
Pacific, 4 p.m. GMT)
Register TODAY: www.sciencemag.org/webinar