Apolist – february 2009

DNA-PKcs-PIDDosome: A Nuclear Caspase-2-Activating Complex with Role in G2/M Checkpoint Maintenance
M. Shi, C.J. Vivian, K.-J. Lee, C. Ge, K. Morotomi-Yano, C. Manzl, F. Bock, S. Sato, C. Tomomori-Sato, R. Zhu, J.S. Haug, S.K. Swanson, M.P. Washburn, D.J. Chen, B.P.C. Chen, A. Villunger, L. Florens, and C. Du

Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells
Luiz C. Godoy, Cristina Muñoz-Pinedo, Laura Castro, Simone Cardaci, Christopher M. Schonhoff, Michael King, Verónica Tórtora, Mónica Marín, Qian Miao, Jian Fei Jiang, Alexandr Kapralov, Ronald Jemmerson, Gary G. Silkstone, Jinal N. Patel, James E. Evans, Michael T. Wilson, Douglas R. Green, Valerian E. Kagan, Rafael Radi, and Joan B. Mannick

The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation.Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS.

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Anatoly Nikolaev, Todd McLaughlin, Dennis D. M. O’Leary and Marc Tessier-Lavigne

p53 isoform  113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish
Jun Chen, Sok Meng Ng, Changqing Chang, Zhenhai Zhang, Jean-Christophe Bourdon, David P. Lane, and Jinrong Peng
Genes Dev. 2009;23 278-290

BCL-xL is a target gene regulated by hypoxia-inducible factor-1-alpha
Ni Chen, Xueqin Chen, Rui Huang, Hao Zeng, Jing Gong, Wentong Meng, Yiping Lu, Fang Zhao, Lin Wang, and Qiao Zhou
J. Biol. Chem. published 10 February 2009, 10.1074/jbc.M805997200

Prep1 Directly Regulates the Intrinsic Apoptotic Pathway by Controlling Bcl-XL Levels
Nicola Micali, Carmelo Ferrai, Luis C. Fernandez-Diaz, Francesco Blasi, and Massimo P. Crippa

Cyclophilin D interacts with BCL2 and exerts an anti-apoptotic effect
Roman A. Eliseev, Jonathan Malecki, Tobias Lester, Yu Zhang, John Humpfrey, and Thomas E. Gunter

Bad Targets the Permeability Transition Pore Independent of Bax or Bak to Switch between Ca2+-Dependent Cell Survival and Death
S.S. Roy, M. Madesh, E. Davies, B. Antonsson, N. Danial, and G. Hajnóczky

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
Qiuyan Wang, Helena Mora-Jensen, Marc A. Weniger, Patricia Perez-Galan, Chris Wolford, Tsonwin Hai, David Ron, Weiping Chen, William Trenkle, Adrian Wiestner, and Yihong Ye

PERK-dependent regulation of IAP translation during ER stress
R B Hamanaka, E Bobrovnikova-Marjon, X Ji, S A Liebhaber & J A Diehl

The Fas–FADD death domain complex structure unravels signalling by receptor clustering
Fiona L. Scott, Boguslaw Stec1, Cristina Pop1, Magorzata K. Dobaczewska1, JeongEun J. Lee1, Edward Monosov1, Howard Robinson2, Guy S. Salvesen1, Robert Schwarzenbacher3 & Stefan J. Riedl

The death domain of FADD is essential for embryogenesis, lymphocyte development and proliferation
Hongxia Z. Imtiyaz, Xiaohui Zhou, Haibing Zhang, Dehua Chen, Taishan Hu, and Jianke Z. Zhang
J. Biol. Chem. published 10 February 2009, 10.1074/jbc.M900249200

PTEN Loss Promotes Mitochondrially Dependent Type II Fas-Induced Apoptosis via PEA-15
James W. Peacock, Jodie Palmer, Dieter Fink, Stephen Ip, Eric M. Pietras, Alice L.-F. Mui, Stephen W. Chung, Martin E. Gleave, Michael E. Cox, Ramon Parsons, Marcus E. Peter, and Christopher J. Ong

A non-apoptotic role for Fas/FasL in erythropoiesis
Graeme W. Carlile, Deborah H. Smith, Martin Wiedmann

Potential Prognostic Significance of Decreased Serum Levels of TRAIL after Acute Myocardial Infarction
Paola Secchiero et al.

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2–mediated resistance
Melanie Fakler, Sandra Loeder, Meike Vogler, Katja Schneider, Irmela Jeremias, Klaus-Michael Debatin, and Simone Fulda

TNFα-induced macrophage death via caspase-dependent and independent pathways
Tri M. Tran, Vladislav Temkin, Bo Shi, Lisa Pagliari, Soizic Daniel, Christiane Ferran, Richard M. Pope

Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase
David K. Moss, Andrew Wilde, and Jon D. Lane
J Cell Sci 2009;122 644-655

Absence of caspase-3 protects pancreatic  -cells from c-Myc-induced apoptosis without leading to tumor formation
Anna Radziszewska, Stephanie A. Schroer, Diana Choi, Panteha Tajmir, Nikolina Radulovich, James C. Ho, Linyuan Wang, Nicole Liadis, Razqallah Hakem, Ming-Sound Tsao, Linda Z. Penn, Gerard I. Evan, and Minna Woo

Shift from apoptotic to necrotic cell death during HPV-induced transformation of keratinocytes
Nataly Kravchenko-Balasha, Sarit Mizrachy-Schwartz, Shoshana Klein, and Alexander Levitzki

A prion of yeast metacaspase homolog (Mca1p) detected by a genetic screen
Julie Nemecek, Toru Nakayashiki, and Reed B. Wickner

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
David Sancho, Olivier P. Joffre1,4, Anna M. Keller1, Neil C. Rogers1, Dolores Martínez2, Patricia Hernanz-Falcón1, Ian Rosewell3 & Caetano Reis e Sousa

Monitoring of tumor response to chemotherapy in vivo by a novel small-molecule detector of apoptosis
Hagit Grimberg, Galit Levin, Anat Shirvan, Avi Cohen, Merav Yogev-Falach, Ayelet Reshef, Ilan Ziv


Control of mitochondrial apoptosis by the Bcl-2 family
Joslyn K. Brunelle and Anthony Letai
J Cell Sci 2009;122 437-441

The Many Roles of FAS Receptor Signaling in the Immune System
A. Strasser, P.J. Jost, and S. Nagata

The insect caspases
Dawn M. Cooper, David J. Granville, Carl Lowenberger

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy
M Vogler, D Dinsdale, M J S Dyer & G M Cohen

Tumour cell survival signalling by the ERK1/2 pathway
K Balmanno & S J Cook

Neuroscience: Good and bad cell death
Donald W. Nicholson

Coordinate regulation of autophagy and apoptosis in T cells by death
effectors: FADD or foundation
Bryan D. Bell and Craig M. Walsh