Apolist – january 2009

Baxβ: A Constitutively Active Human Bax Isoform that Is under Tight Regulatory Control by the Proteasomal Degradation Mechanism
N.Y. Fu, S.K. Sukumaran, S.Y. Kerk, and V.C. Yu

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage
Ho-Chou Tu, Decheng Ren, Gary X. Wang, David Y. Chen, Todd D. Westergard, Hyungjin Kim, Satoru Sasagawa, James J.-D. Hsieh, and Emily H.-Y. Cheng

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim
T. Kaufmann, P.J. Jost, M. Pellegrini, H. Puthalakath, R. Gugasyan, S. Gerondakis, E. Cretney, M.J. Smyth, J. Silke, R. Hakem, P. Bouillet, T.W. Mak, V.M. Dixit, and A. Strasser

Induction of Hepatitis by JNK-Mediated Expression of TNF-α
M. Das, G. Sabio, F. Jiang, M. Rincón, R.A. Flavell, and R.J. Davis

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas
Vikas Anathy, Scott W. Aesif, Amy S. Guala, Marije Havermans, Niki L. Reynaert, Ye-Shih Ho, Ralph C. Budd, and Yvonne M.W. Janssen-Heininger

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms
Patricia Sancho, Esther Bertran, Laia Caja, Irene Carmona-Cuenca, Miguel M. Murillo, Isabel Fabregat

The isopeptidase inhibitor G5 triggers a caspase-independent necrotic death in cells resistant to apoptosis: A comparative study with the proteasome inhibitor bortezomib
Alessandra Fontanini, Carmen Foti, Harish Potu, Enrico Crivellato, Roberta Maestro, Paolo Bernardi, Francesca Demarchi, and Claudio Brancolini
J. Biol. Chem. published 12 January 2009, 10.1074/jbc.M806113200

Akt Regulates Drug-Induced Cell Death through Bcl-w Downregulation
Michela Garofalo1,2#, Cristina Quintavalle1,3#, Ciro Zanca1, Assunta De Rienzo5, Giulia Romano4, Mario Acunzo1,3, Loredana Puca1, Mariarosaria Incoronato4, Carlo M. Croce2, Gerolama Condorelli1,3,6*

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan–Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
Susan M. O’Brien, David F. Claxton, Michael Crump, Stefan Faderl, Thomas Kipps, Michael J. Keating, Jean Viallet, and Bruce D. Cheson

Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion
Franziska B. Mullauer, Jan H. Kessler, Jan Paul Medema

Protein phosphatase 2A inactivates Bcl2’s antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding
Xingming Deng, Fengqin Gao, and W. Stratford May

The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death
Kathleen A. Galindo, Wan-Jin Lu, Jae H. Park, and John M. Abrams

Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells
T R Wilson, M McEwan, K McLaughlin, C Le Clorennec, W L Allen, D A Fennell, P G Johnston & D B Longley

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice
Xin Wang, Raghavendra Pralhada Rao, Teresa Kosakowska-Cholody, M. Athar Masood, Eileen Southon, Helin Zhang, Cyril Berthet, Kunio Nagashim, Timothy K. Veenstra, Lino Tessarollo, Usha Acharya, and Jairaj K. Acharya

Apoptotic histone modification inhibits nuclear transport by regulating RCC1 pp36 – 45
Chi-Hang Wong, Hei Chan, Chin-Yee Ho, Soak-Kuan Lai, Kheng-Sze Chan, Cheng-Gee Koh and Hoi-Yeung Li

Mobilization of lysosomal calcium regulates the externalization of phosphatidylserine during apoptosis
Banafsheh Mirnikjoo, Krishnakumar Balasubramanian, and Alan J. Schroit

cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand
Alban Dupoux, Jessy Cartier, Séverine Cathelin, Rodolphe Filomenko, Eric Solary, and Laurence Dubrez-Daloz


The Jekyll and Hyde Functions of Caspases
C.H. Yi and J. Yuan

The enigma of caspase-2: the laymen’s view
G Krumschnabel, B Sohm, F Bock, C Manzl & A Villunger

Apoptotic cells let down their guard
Mitch Leslie

Deadly Splicing: Bax Becomes Almighty
H. Kim, J.J.-D. Hsieh, and E.H.-Y. Cheng