——–
Death receptors and IAPs
————————————–

Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required
for Efficient Caspase-1 Activation by the Inflammasome
K. Labbé, C.R. McIntire, K. Doiron, P.M. Leblanc, and M.
Saleh
http://www.cell.com/immunity/abstract/S1074-7613%2811%2900506-1

Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin
kinase to induce reactive oxygen species-mediated apoptotic cell death
Kyung-Jin Park, Chang-Han Lee, Aeyung Kim, Ki Jun Jeong, Chul-Ho Kim,
and Yong-Sung Kim
http://www.jbc.org/cgi/content/abstract/M111.309021v1

SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to
Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent
Manner
Rachel M. Greer, Michael Peyton, Jill E. Larsen, Luc Girard, Yang Xie,
Adi F. Gazdar, Patrick Harran, Lai Wang, Rolf A. Brekken, Xiaodong
Wang, and John D. Minna
http://cancerres.aacrjournals.org/cgi/content/abstract/71/24/7640

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Caspases and downstream
—————————————-

A Quantitative Method for the Specific Assessment of Caspase-6
Activity in Cell Culture
Dagmar E. Ehrnhoefer, Niels H. Skotte, Jane Savill, Yen T. N. Nguyen,
Safia Ladha, Li-Ping Cao, Edie Dullaghan, Michael R. Hayden
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027680

Two-Step Engulfment of Apoptotic Cells
Satoshi Toda, Rikinari Hanayama, and Shigekazu Nagata
http://mcb.asm.org/cgi/content/abstract/32/1/118

Live imaging of apoptosis in a novel transgenic mouse highlights its
role in neural tube closure
Yoshifumi Yamaguchi, Naomi Shinotsuka, Keiko Nonomura, Kiwamu
Takemoto, Keisuke Kuida, Hiroki Yosida, and Masayuki Miura
http://jcb.rupress.org/cgi/content/abstract/195/6/1047?etoc

Apoptosis-dependent externalization and involvement in apoptotic cell
clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila
Ryo Okada, Kaz Nagaosa, Takayuki Kuraishi, Hiroshi Nakayama, Naoko
Yamamoto, Yukiko Nakagawa, Naoshi Dohmae, Akiko Shiratsuchi, and
Yoshinobu Nakanishi
http://www.jbc.org/cgi/content/abstract/M111.277921v1

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Miscellaneous
———————-

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory
Response SyndromeL. Duprez, N. Takahashi, F. Van Hauwermeiren, B.
Vandendriessche, V. Goossens, T. Vanden Berghe, W. Declercq, C.
Libert, A. Cauwels, and P. Vandenabeele
http://www.cell.com/immunity/abstract/S1074-7613%2811%2900508-5

Toll-like receptors activate programmed necrosis in macrophages
through a receptor-interacting kinase-3–mediated pathway
Sudan He, Yuqiong Liang, Feng Shao, and Xiaodong Wang
http://www.pnas.org/content/108/50/20054.full

Autophagy promotes T-cell survival through degradation of proteins of
the cell death machinery
J R Kovacs, C Li, Q Yang, G Li, I G Garcia, S Ju, D G Roodman, J J
Windle, X Zhang and B Lu
http://www.nature.com/cdd/journal/v19/n1/full/cdd201178a.html

The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic
reticulum stress  Kathryn Austgen, Emily T. Johnson, Tae-Ju Park, Tom
Curran and Scott A. Oakes
http://www.nature.com/ncb/journal/v14/n1/full/ncb2395.html

——————–
Reviews
——————–

Cell Death and Differentiation special issue – In memory of Jurg Tschopp

Editorial by J. Silke and JE. Vince
http://www.nature.com/cdd/journal/v19/n1/full/cdd2011166a.html

Reviews by everybody:
http://www.nature.com/cdd/journal/v19/n1/index.html#rv

The Emerging Role of Linear Ubiquitination in Cell Signaling
Christoph H. Emmerich, Anna C. Schmukle, Henning Walczak
Linear ubiquitin chains transmit signals that are induced by diverse
stimuli and regulate cell activation and death.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/204/re5

Programmed cell removal: a new obstacle in the road to developing cancer
Mark P. Chao, Ravindra Majeti & Irving L. Weissman
http://www.nature.com/nrc/journal/v12/n1/full/nrc3171.html

Metabolic Connections during Apoptotic Cell EngulfmentC.Z. Han and
K.S. Ravichandran
http://www.cell.com/abstract/S0092-8674%2811%2901505-4

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Comments – other
————————–

Who Put the ”A” in Atg12: Autophagy or Apoptosis?
T.N. Chonghaile and A. Letai
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900946-4

Necroptosis Turns TNF Lethal
L. Galluzzi and G. Kroemer
http://www.cell.com/immunity/abstract/S1074-7613%2811%2900513-9

Preventing Necrosis by Cleaving a Deubiquitinase
Wei Wong
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/203/ec344

Inducible Apoptosis Eliminates Patient-Transferred T Cells
http://cancerdiscovery.aacrjournals.org/cgi/content/full/1/7/549-a

Cell death helps give closure
Ben Short
http://jcb.rupress.org/cgi/content/full/195/6/922-b?etoc

Deleting Mcl-1 in mast cells: getting 2 birds with 1 stone
Booki Min
http://bloodjournal.hematologylibrary.org/cgi/content/full/118/26/6729

Conference: 1st international Cell Death In Cancer (CDIC)
http://www.celldeathincancer.com
Saint Malo in Brittany (France) from 13 to 16 May 2012.

———————————-
Death receptor pathway
———————————-

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation
Nadine Khadra, Laurence Bresson-Bepoldin, Aubin Penna, Benjamin Chaigne-Delalande, Bruno Ségui, Thierry Levade, Anne-Marie Vacher, Josy Reiffers, Thomas Ducret, Jean-François Moreau, Michael D. Cahalan, Pierre Vacher, and Patrick Legembre
http://www.pnas.org/content/108/47/19072.abstract?etoc

Cooperative Phosphorylation of FADD by Aur-A and Plk1 in Response to Taxol Triggers Both Apoptotic and Necrotic Cell Death
Moon-Sun Jang, Su-Jin Lee, Nam Sook Kang, and Eunhee Kim
http://cancerres.aacrjournals.org/cgi/content/abstract/71/23/7207

Oncogenic Ras and B-Raf positively regulates death receptor 5 expression through co-activation of ERK and JNK signaling
You-Take Oh, Ping Yue, Wei Zhou, Justin M. Balko, Esther P. Black, Taofeek K. Owonikoko, Fadlo R. Khuri, and Shi-Yong Sun
http://www.jbc.org/cgi/content/abstract/M111.304006v1

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Non-apoptotic cell death
————————————–

Caspase 8 inhibits programmed necrosis by processing CYLD.
O’Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT.
http://www.nature.com/ncb/journal/vaop/ncurrent/full/ncb2362.html

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members
N Vanlangenakker, M J M Bertrand, P Bogaert, P Vandenabeele and T Vanden Berghe
http://www.nature.com/cddis/journal/v2/n11/full/cddis2011111a.html

CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101
Margot Jak, Gregor G. W. van Bochove, Eric A. Reits, Wouter W. Kallemeijn, Jacqueline M. Tromp, Pablo Umana, Christian Klein, Rene A. W. van Lier, Marinus H. J. van Oers, and Eric Eldering
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/118/19/5178

Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death
Hiroshi Kanda, Tatsushi Igaki, Hideyuki Okano, and Masayuki Miura
http://www.pnas.org/content/108/47/18977.abstract?etoc

Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study
S Shen, O Kepp, M Michaud, I Martins, H Minoux, D Métivier, M C Maiuri, R T Kroemer and G Kroemer
http://www.nature.com/onc/journal/v30/n45/abs/onc2011168a.html

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes
Oliver Florey, Sung Eun Kim,1, 2 Cynthia P. Sandoval,3 Cole M. Haynes1, 2 & Michael Overholtzer
http://www.nature.com/ncb/journal/v13/n11/full/ncb2363.html

————————
Miscellaneous
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Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α
Inna S. Afonina, Graham A. Tynan, Susan E. Logue, Sean P. Cullen, Michael Bots, Alexander U. Lüthi, Emer P. Reeves, Noel G. McElvaney, Jan P. Medema, Ed C. Lavelle, Seamus J. Martin
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900717-9

Constitutive exposure of phosphatidylserine on viable cells
Katsumori Segawa, Jun Suzuki, and Shigekazu Nagata
http://www.pnas.org/content/108/48/19246.long

Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles
Rostyslav O. Bilyy, Tanya Shkandina, Andriy Tomin, Luis E. Munoz, Sandra Franz, Volodymyr Antonyuk, Yuriy Ya Kit, Matthias Zirngibl, Barbara G. Fuernrohr, Christina Janko, Kirsten Lauber, Martin Schiller, Georg Schett, Rostyslav S. Stoika, and Martin Herrmann
http://www.jbc.org/cgi/content/abstract/M111.273144v1

Polypeptide modulators of card-card-mediated protein-protein interactions
Yadira Palacios-Rodriguez, Guillermo Garcia-Lainez, Monica Sancho, Anna Gortat, Mar Orzaez, and Enrique Perez-Paya
http://www.jbc.org/cgi/content/abstract/M111.255364v1

BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C.
http://www.ncbi.nlm.nih.gov/pubmed/21926971

——————-
Reviews
——————-

Programmed Cell Death in Animal Development and Disease
Y. Fuchs and H. Steller
http://www.cell.com/abstract/S0092-8674%2811%2901283-9

Programmed necrosis: backup to and competitor with apoptosis in the immune system
Jiahuai Han, Chuan-Qi Zhong and Duan-Wu Zhang
http://www.nature.com/ni/journal/v12/n12/abs/ni.2159.html

Immunology: A heavyweight knocked out
Douglas R. Green
Caspase-1 is one of the main culprits behind sepsis, a form of systemic inflammation.
http://www.nature.com/nature/journal/v479/n7371/full/479048a.html

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore
Loren D. Walensky, Evripidis Gavathiotis
http://www.sciencedirect.com/science/article/pii/S0968000411001423

—————————————————–
Correspondence / Comments / other
—————————————————–

Staying Alive: Defensive Strategies in the BCL-2 Family Playbook
S.P. Cullen, C.M. Henry, and S.J. Martin
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900847-1

Priming Cancer Cells for Death
John C. Reed
http://www.sciencemag.org/content/334/6059/1075.full

Mcl-1 leves need not be lowered for ABT-263/737-induced apoptosis
R Yamaguchi and G Perkins
http://www.nature.com/cddis/journal/v2/n11/full/cddis2011109a.html

Finding a panacea among combination cancer therapies
by Ryuji Yamaguchi & Guy Perkins
http://cancerres.aacrjournals.org/content/early/2011/11/02/0008-5472.CAN-11-3091.abstract

Cell death: The single-membrane diet
Autophagy proteins function in a non-canonical single-membrane vesicle degradation pathway.
http://www.nature.com/nrm/journal/v12/n12/full/nrm3224.html

Primed for Death
Paula A. Kiberstis
The mitochondrial state of a tumor cell prior to chemotherapy may help determine how well it responds to drug treatment.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/201/ec335

Mcl-1 Reduction Due to Caspase-dependent Cleavage during Endoplasmic Reticulum Stress-induced Apoptosis
Jinsong Hu, Nana Dang, Tusheng Song, and Karin Vanderkerken
http://www.jbc.org/content/286/44/le24.long

Reply to Hu et al.: Mcl-1 Reduction Due to Caspase-dependent Cleavage during Endoplasmic Reticulum Stress-induced Apoptosis
Nobuhiro Morishima, Keiko Nakanishi, and Akihiko Nakano
http://www.jbc.org/content/286/44/le25.full

Profile of Tak Wah Mak
Jennifer Viegas
http://www.pnas.org/content/108/48/19124.full

Snapshot: Mitochondrial Quality Control
D.R. Green and B. van Houten
http://www.sciencedirect.com/science/article/pii/S0092867411012864

International EMBO Molecular Medicine Workshop 2011 on ‘Cell Death and Disease’
A Hague and L S Dickens
http://www.nature.com/cdd/journal/v18/n12/full/cdd2011108a.html

Cell picture show – cell death
http://www.cell.com/Cell_Picture_Show-celldeath

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————

————

 

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
Fabien Llambi, Tudor Moldoveanu, Stephen W.G. Tait, Lisa Bouchier-Hayes, Jamshid Temirov, Laura L. McCormick, Christopher P. Dillon, and Douglas R. Green
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900760-X

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase
Kambiz N. Alavian, Hongmei Li, Leon Collis, Laura Bonanni, Lu Zeng, Silvio Sacchetti, Emma Lazrove, Panah Nabili, Benjamin Flaherty, Morven Graham, Yingbei Chen, Shanta M. Messerli, Maria A. Mariggio, Christoph Rahner, Ewan McNay, Gordon C. Shore, Peter J. S. Smith, J. Marie Hardwick and Elizabeth A. Jonas
http://www.nature.com/ncb/journal/v13/n10/full/ncb2330.html

Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential
Ying-bei Chen, Miguel A. Aon, Yi-Te Hsu, Lucian Soane, Xinchen Teng, J. Michael McCaffery, Wen-Chih Cheng, Bing Qi, Hongmei Li, Kambiz N. Alavian, Margaret Dayhoff-Brannigan, Shifa Zou, Fernando J. Pineda, Brian O’Rourke, Young H. Ko, Peter L. Pedersen, Leonard K. Kaczmarek, Elizabeth A. Jonas, and J. Marie Hardwick
http://jcb.rupress.org/cgi/content/abstract/jcb.201108059v1?etoc

Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL
Angélica Ospina, Alfredo Lagunas-Martínez, Julián Pardo, José A. Carrodeguas
http://www.sciencedirect.com/science/article/pii/S0014579311006028

PNAS Plus: A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans
Yun Lu, Stéphane G. Rolland, and Barbara Conradt
http://www.pnas.org/content/108/41/E813.abstract?etoc

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins
S Torii, Y Goto, T Ishizawa, H Hoshi, K Goryo, K Yasumoto, H Fukumura and K Sogawa
http://www.nature.com/cdd/journal/v18/n11/abs/cdd201147a.html?WT.ec_id=CDD-201111

———————————-
Death receptor signaling
———————————

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
M.C. Bonnet, D. Preukschat, P.-S. Welz, G. van Loo, M.A. Ermolaeva, W. Bloch, I. Haase, and M. Pasparakis
http://www.cell.com/immunity/abstract/S1074-7613(11)00401-8?switch=standard

The Prevalence of TNFα-Induced Necrosis over Apoptosis Is Determined by TAK1-RIP1 Interplay
Seda Çöl Arslan, Claus Scheidereit
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026069

PNAS Plus: A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis
Nicholas Dompe, Celina Sanchez Rivers, Li Li, Shaun Cordes, Martin Schwickart, Elizabeth A. Punnoose, Lukas Amler, Somasekar Seshagiri, Jerry Tang, Zora Modrusan, and David P. Davis
http://www.pnas.org/content/108/43/E943.abstract?etoc

Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation
A M M Kober, S Legewie, C Pforr, N Fricker, R Eils, P H Krammer and I N Lavrik
http://www.nature.com/cddis/journal/v2/n10/abs/cddis201193a.html?WT.ec_id=CDDIS-201110

GMDS deficiency renders colon cancer cells resistant to TRAIL receptor- and CD95-mediated apoptosis by inhibiting complex II formation
Kenta Moriwaki, Shinichiro Shinzaki, and Eiji Miyoshi
http://www.jbc.org/cgi/content/abstract/M111.262741v1

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Caspases and IAPs
————————–

Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death
D.J. Mahoney, C. Lefebvre, K. Allan, J. Brun, C.A. Sanaei, S. Baird, N. Pearce, S. Grönberg, B. Wilson, M. Prakesh, A. Aman, M. Isaac, A. Mamai, D. Uehling, R. Al-Awar, T. Falls, T. Alain, and D.F. Stojdl
http://www.cell.com/cancer-cell/abstract/S1535-6108%2811%2900353-9

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice
Toshiyuki Bohgaki, Julien Mozo, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Miyuki Bohgaki, Otto Sanchez, Andreas Strasser, Anne Hakem, and Razqallah Hakem
http://jcb.rupress.org/cgi/content/abstract/195/2/277?etoc

Caspase deficiency alters the murine gut microbiome
B M Brinkman, F Hildebrand, M Kubica, D Goosens, J Del Favero, W Declercq, J Raes and P Vandenabeele
http://www.nature.com/cddis/journal/v2/n10/abs/cddis2011101a.html?WT.ec_id=CDDIS-201110

Drosophila IAP1-Mediated Ubiquitylation Controls Activation of the Initiator Caspase DRONC Independent of Protein Degradation
Tom V. Lee, Yun Fan, Shiuan Wang, Mayank Srivastava, Meike Broemer, Pascal Meier, Andreas Bergmann
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002261

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination
Erin C. Dueber, Allyn J. Schoeffler, Andreas Lingel, J. Michael Elliott,2 Anna V. Fedorova,1
Anthony M. Giannetti,3 Kerry Zobel,1 Brigitte Maurer,4 Eugene Varfolomeev, Ping Wu,4
Heidi J. A. Wallweber,4 Sarah G. Hymowitz,4 Kurt Deshayes,1 Domagoj Vucic, Wayne J. Fairbrother
http://www.sciencemag.org/cgi/content/summary/334/6054/376

The conservation and uniqueness of the caspase family in the basal chordate, amphioxus
Xu L, Yuan S, Li J, Huang S, Ruan J, Yang M, Huang H, Chen S, Ren Z, Xu A
http://www.biomedcentral.com/1741-7007/9/60/abstract

Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death
K K W Hui, A K Kanungo, A J Elia and J T Henderson
http://www.nature.com/cdd/journal/v18/n11/full/cdd201150a.html

Non-canonical inflammasome activation targets caspase-11.
Nobuhiko Kayagaki, Søren Warming,2 Mohamed Lamkanfi, Lieselotte Vande Walle,3, 4 Salina Louie,1 Jennifer Dong,1 Kim Newton,1 Yan Qu,1 Jinfeng Liu,5 Sherry Heldens,2 Juan Zhang,6 Wyne P. Lee,6 Merone Roose-Girma & Vishva M. Dixit
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10558.html?WT.ec_id=NATURE-20111020

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Miscellaneous
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Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
Jennifer Martinez, Johann Almendinger, Andrew Oberst, Rachel Ness, Christopher P. Dillon, Patrick Fitzgerald, Michael O. Hengartner, and Douglas R. Green
http://www.pnas.org/content/108/42/17396.long

Apaf1 plays a pro-survival role by regulating centrosome morphology and function
Elisabetta Ferraro, Maria Grazia Pesaresi, Daniela De Zio, Maria Teresa Cencioni, Anne Gortat, Mauro Cozzolino, Libera Berghella, Anna Maria Salvatore, Bjorn Oettinghaus, Luca Scorrano, Enrique Pérez-Payà, and Francesco Cecconi
http://jcs.biologists.org/cgi/content/abstract/124/20/3450

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA.
http://www.nature.com/nature/journal/v478/n7367/full/nature10490.html

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Reviews
—————–

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
Andrew Oberst & Douglas R. Green
http://www.nature.com/nrm/journal/v12/n11/full/nrm3214.html?WT.ec_id=NRM-201111

RIPK-Dependent Necrosis and Its Regulation by Caspases: A Mystery in Five Acts
D.R. Green, A. Oberst, C.P. Dillon, R. Weinlich, and G.S. Salvesen
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900714-3

Ripped to death
Ricardo Weinlich, Christopher P. Dillon, Douglas R. Green
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(11)00176-0

The End and After: How Dying Cells Impact the Living Organism
D.R. Green
http://www.cell.com/immunity/fulltext/S1074-7613(11)00407-9?large_figure=true

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways
K.S. Ravichandran
http://www.cell.com/immunity/fulltext/S1074-7613(11)00364-5

Cell Death in the Maintenance and Abrogation of Tolerance: The Five Ws of Dying Cells
T.S. Griffith and T.A. Ferguson
http://www.cell.com/immunity/fulltext/S1074-7613(11)00357-8

Tumor Promotion via Injury and Death-Induced Inflammation
A. Kuraishy, M. Karin, and S.I. Grivennikov
http://www.cell.com/immunity/fulltext/S1074-7613(11)00366-9

Dying to Replicate: The Orchestration of the Viral Life Cycle, Cell Death Pathways, and Immunity
N. Yatim and M.L. Albert
http://www.cell.com/immunity/fulltext/S1074-7613(11)00415-8

The executioners sing a new song: killer caspases activate microglia
J L Venero, M A Burguillos, P Brundin and B Joseph
http://www.nature.com/cdd/journal/v18/n11/abs/cdd2011107a.html?WT.ec_id=CDD-201111

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Comments
——————

Apaf1 balances life and death
http://jcs.biologists.org/cgi/content/full/124/20/e2005

Snapshot
Caspases
G.S. Salvesen and A. Ashkenazi
http://download.cell.com/pdf/PIIS009286741101141X.pdf

Allowing Apoptosis
Valda K. Vinson
Antagonist binding to an apoptosis inhibitor releases inhibition by promoting dimerization required for autoubiquitination.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/196/ec298

Evading Apoptosis to Promote Persistent Infection
Nancy R. Gough
By stimulating the production of an alternatively spliced antagonistic form of TRAIL, HIV-infected cells escape apoptotic death.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/195/ec293

Dual Face Apoptotic Machinery: From Initiator of Apoptosis to Guardian of Necroptosis
W. Declercq, N. Takahashi, and P. Vandenabeele
http://www.sciencedirect.com/science/article/pii/S1074761311004122

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Death receptor pathway and IAPs
——————————————–

The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion.
CD95 is a prototypic ‘death receptor’ that can also activate non-apoptotic signaling pathways, promoting tumour growth. The authors show that activated CD95 promotes tumor cell invasion by engaging a new signalling pathway that causes remodeling of the cellular architecture.
Ernst J A Steller, Laila Ritsma, Danielle A E Raats, Frederik J H Hoogwater, Benjamin L Emmink, Klaas M Govaert, Jamila Laoukili, Inne H M Borel Rinkes, Jacco van Rheenen and Onno Kranenburg
http://www.nature.com/embor/journal/v12/n9/full/embor2011129a.html

Tumor necrosis factor-α and interferon-  induce pancreatic β-cell apoptosis through STAT1-mediated Bim activation
Jenny Barthson, Carla M. Germano, Fabrice Moore, Adriano Maida, Daniel J. Drucker, Piero Marchetti, Conny Gysemans, Chantal Mathieu, Gabriel Nunez, Andrea Jurisicova, Decio L Eizirik, and Esteban N. Gurzov
http://www.jbc.org/cgi/content/abstract/M111.253591v2

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
Rong-Hua Tao, Zuzana Berkova, Jillian F. Wise, Abdol-Hossein Rezaeian, Urszula Daniluk, Xue Ao, David H. Hawke, Judith E. Karp, Hui-Kuan Lin, Jeffrey J. Molldrem, and Felipe Samaniego
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/118/11/3107

Celecoxib Promotes c-FLIP Degradation through Akt-Independent Inhibition of GSK3
Shuzhen Chen, Wei Cao, Ping Yue, Chunhai Hao, Fadlo R. Khuri, and Shi-Yong Sun
http://cancerres.aacrjournals.org/cgi/content/abstract/71/19/6270

TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation
Joo-Young Kim, Ju-Yeon Lee, Dong-Gun Kim, Gi-Bang Koo, Je-Wook Yu, You-Sun Kim
http://www.sciencedirect.com/science/article/pii/S001457931100398X

cIAP1/2 Are Direct E3 Ligases Conjugating Diverse Types of Ubiquitin Chains to Receptor Interacting Proteins Kinases 1 to 4 (RIP1–4)
Mathieu J. M. Bertrand, Saskia Lippens, An Staes, Barbara Gilbert, Ria Roelandt, Jelle De Medts, Kris Gevaert, Wim Declercq, Peter Vandenabeele
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022356

Arabidopsis IAP-like protein lacks a BIR domain and attenuates cell death in plant and animal systems
Woe Yeon Kim, Sun Yong Lee, Young Jun Jung, Ho Byoung Chae, Ganesh M. Nawkar, Mi Rim Shin, Sun Young Kim, Jin Ho Park, Chang Ho Kang, Yong Hoon Chi, Il Pyung Ahn, Dae Jin Yun, Kyun Oh Lee, Young-Myeong Kim, Min Gab Kim, and Sang Yeol Lee
http://www.jbc.org/cgi/content/abstract/M111.262204v1

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis ▶
Claudia Günther, Eva Martini, Nadine Wittkopf, Kerstin Amann, Benno Weigmann, Helmut Neumann,
Maximilian J. Waldner, Stephen M. Hedrick,  Stefan Tenzer, Markus F. Neurath & Christoph Becker
http://www.nature.com/nature/journal/v477/n7364/full/nature10400.html

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Caspases
—————-

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8
M A Laussmann, E Passante, H Düssmann, J A Rauen, M L Würstle, M E Delgado, M Devocelle, J H M Prehn and M Rehm
http://www.nature.com/cdd/journal/v18/n10/full/cdd201127a.html

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity
Jennifer V. Lu, Brian M. Weist, Bram J. van Raam, Brett S. Marro, Long V. Nguyen, Prathna Srinivas, Bryan D. Bell, Keith A. Luhrs, Thomas E. Lane, Guy S. Salvesen, and Craig M. Walsh
http://www.pnas.org/content/108/37/15312.abstract?etoc

A Biotin Switch-Based Proteomics Approach Identifies 14-3-3ζ as a Target of Sirt1 in the Metabolic Regulation of Caspase-2
J.L. Andersen, J.W. Thompson, K.R. Lindblom, E.S. Johnson, C.-S. Yang, L.R. Lilley, C.D. Freel, M.A. Moseley, and S. Kornbluth
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900629-0

Oncogenic ras-induced downregulation of a pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells
Byong Hoon Yoo, Yanfei Wang, Mete Erdogan, Takehiko Sasazuki, Senji Shirasawa, Laurent Corcos, Kanaga Sabapathy, and Kirill V. Rosen
http://www.jbc.org/cgi/content/abstract/M111.290692v1

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Miscellaneous
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Generation and characterization of antibodies specific for caspase-cleaved neo-epitopes: a novel approach
X Ai, B Butts, K Vora, W Li, C Tache-Talmadge, A Fridman and H Mehmet
http://www.nature.com/cddis/journal/v2/n9/full/cddis201191a.html

Intracellular K+ concentration decrease is not obligatory for apoptosis
Sara I. Borjesson, Ulrika H. Englund, Muhammad H. Asif, Magnus Willander, and Fredrik Elinder
http://www.jbc.org/cgi/content/abstract/M111.262725v1

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Reviews / comments
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Can the analysis of BH3-only protein knockout mice clarify the issue of ‘direct versus indirect’ activation of Bax and Bak?
A Villunger, V Labi, P Bouillet, J Adams and A Strasser
http://www.nature.com/cdd/journal/v18/n10/full/cdd2011100a.html

Targeting Bcl-2 in CLL: cui bono?
Anthony Letai
http://bloodjournal.hematologylibrary.org/cgi/content/full/118/13/3453

A yeast BH3-only protein for the rescue
A Gross
http://www.nature.com/cdd/journal/v18/n10/full/cdd201199a.html

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
For this New EMBO member’s review, three recognised experts joined forces to provide a comprehensive overview on the molecular control of apoptosis and to discuss prospects for therapies.
Andreas Strasser, Suzanne Cory and Jerry M Adams
http://www.nature.com/emboj/journal/v30/n18/full/emboj2011307a.html

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?
A Lemarie and S Grimm
http://www.nature.com/onc/journal/v30/n38/full/onc2011167a.html

Cell death: Linking metabolism to apoptotic sensitivity
BCL-XL suppresses acetyl CoA production to protect cells against apoptosis.
http://www.nature.com/nrm/journal/v12/n10/full/nrm3195.html

Akt, FoxO and regulation of apoptosis
Xinbo Zhang, Naimei Tang, Timothy J. Hadden, Arun K. Rishi
http://www.sciencedirect.com/science/article/pii/S0167488911000826

Cell death in disease: from 2010 onwards
R A Knight and G Melino
http://www.nature.com/cddis/journal/v2/n9/full/cddis201189a.html

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Bcl-2 family proteins

——————————–Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
Haiming Dai, Alyson Smith, X. Wei Meng, Paula A. Schneider, Yuan-Ping Pang, and Scott H. Kaufmann
http://jcb.rupress.org/cgi/content/abstract/194/1/39?etoc

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation
Meike Vogler, Hassan A. Hamali, Xiao-Ming Sun, Edward T. W. Bampton, David Dinsdale, Roger T. Snowden, Martin J. S. Dyer, Alison H. Goodall, and Gerald M. Cohen
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/117/26/7145

Intrinsic Order and Disorder in the Bcl-2 Member Harakiri: Insights into Its Proapoptotic Activity
Susana Barrera-Vilarmau, Patricia Obregón, Eva de Alba
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021413

UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation
Xiaocheng Yin, Lizhi Cao, Rui Kang, Minghua Yang, Zhuo Wang, Yanhui Peng, Yanfang Tan, Liying Liu, Min Xie, Yiming Zhao, Kristen M Livesey and Daolin Tang
http://www.nature.com/embor/journal/v12/n7/full/embor201179a.html

A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma
Elena Beltran, Vicente Fresquet, Javier Martinez-Useros, Jose A. Richter-Larrea, Ainara Sagardoy, Izaskun Sesma, Luciana L. Almada, Santiago Montes-Moreno, Reiner Siebert, Stefan Gesk, Maria J. Calasanz, Raquel Malumbres, Melissa Rieger, Felipe Prosper, Izidore S. Lossos, Miguel Angel Piris, Martin E. Fernandez-Zapico, and Jose A. Martinez-Climent
http://www.pnas.org/content/108/30/12461.long

A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis
Sabrina Büttner, Doris Ruli, F-Nora Vögtle, Lorenzo Galluzzi, Barbara Moitzi, Tobias Eisenberg, Oliver Kepp, Lukas Habernig, Didac Carmona-Gutierrez, Patrick Rockenfeller, Peter Laun, Michael Breitenbach, Chamel Khoury, Kai-Uwe Fröhlich, Gerald Rechberger, Chris Meisinger, Guido Kroemer and Frank Madeo
http://www.nature.com/emboj/journal/v30/n14/full/emboj2011197a.html

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Death receptors and IAPs
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TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation
Joo-Young Kim, Ju-Yeon Lee, Dong-Gun Kim, Gi-Bang Koo, Je-Wook Yu, You-Sun Kim
http://www.sciencedirect.com/science/article/pii/S001457931100398X

Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination
Xuan-Hung Nguyen, Philipp A. Lang, Karl S. Lang, Dieter Adam, Gulnar Fattakhova, Niko Föger, Mohammad Azhar Kamal, Patricia Prilla, Sabine Mathieu, Christina Wagner, Tak Mak, Andrew C. Chan, and Kyeong-Hee Lee
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/118/3/598

The acquisition of resistance to TNFα in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray
Etienne Moussay, Tony Kaoma, Joanna Baginska, Arnaud Muller, Kris Van Moer, Nathalie Nicot, Petr V. Nazarov, Laurent Vallar, Salem Chouaib, Guy Berchem and Bassam Janji
http://www.landesbioscience.com/journals/autophagy/article/15454/

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
M Darding, R Feltham, T Tenev, K Bianchi, C Benetatos, J Silke and P Meier
http://www.nature.com/cdd/journal/v18/n8/full/cdd201110a.html

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Caspases
——————–

Caspase-1 promiscuity is counterbalanced by rapid inactivation of the processed enzyme
John G. Walsh, Susan E. Logue, Alexander U. Luthi, and Seamus J. Martin
J. Biol. Chem. published 11 July 2011, 10.1074/jbc.M111.225862
http://www.jbc.org/cgi/content/abstract/M111.225862v1

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop
T.G. Oliver, E. Meylan, G.P. Chang, W. Xue, J.R. Burke, T.J. Humpton, D. Hubbard, A. Bhutkar, and T. Jacks
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900453-9

Structural determinants of caspase-9 inhibition by the vaccinia virus protein, F1L
Eric Yu, Dayong Zhai, Motti Gerlic, Chaofang Jin, John C. Reed, and Robert Liddington
http://www.jbc.org/cgi/content/abstract/M111.280149v1

Inhibition of Protein Degradation Induces Apoptosis through a Microtubule-Associated Protein 1 Light Chain 3-Mediated Activation of Caspase-8 at Intracellular Membranes
Ji-An Pan, Erica Ullman, Zhixun Dou, and Wei-Xing Zong
http://mcb.asm.org/cgi/content/abstract/31/15/3158

Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells
Kyunghee Lee, Alison E. Kenny, and Conly L. Rieder
http://www.molbiolcell.org/cgi/content/abstract/22/14/2470?etoc

miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia
Chad Siegel, Jun Li, Fudong Liu, Sharon E. Benashski, and Louise D. McCullough
http://www.pnas.org/content/108/28/11662.abstract?etoc

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Miscellaneous
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Resveratrol Induces p53-Independent, XIAP-Mediated Bax Oligomerization on Mitochondria to Initiate Cytochrome c Release and Caspase Activation
Raghu Gogada, Varun Prabhu, Michael Amadori, Rachael Scott, Sana Hashmi, and Dhyan Chandra
http://www.jbc.org/cgi/content/abstract/M110.202440v1

Apoptosis-inducing factor is a target gene of C/EBPα and participates in adipocyte differentiation
Shao-Ming Shen, Yun Yu, Zhao-Xia Wu, Ying Zheng, Guo-Qiang Chen, Li-Shun Wang
http://www.sciencedirect.com/science/article/pii/S0014579311004388

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation
D V Krysko, A Kaczmarek, O Krysko, L Heyndrickx, J Woznicki, P Bogaert, A Cauwels, N Takahashi, S Magez, C Bachert and P Vandenabeele
http://www.nature.com/cdd/journal/v18/n8/full/cdd20114a.html

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Reviews
——————–

CDD Special Issue: Programmed Cell Death in Plants
Green death: revealing programmed cell death in plants
P V Bozhkov and E Lam
http://www.nature.com/cdd/journal/v18/n8/index.html

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
Jean-Claude Martinou, Richard J. Youle
http://www.cell.com/developmental-cell/abstract/S1534-5807(11)00251-6

Autophagy and apoptosis: what is the connection?
Jacob M. Gump, Andrew Thorburn
http://www.sciencedirect.com/science/article/pii/S0962892411000493

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction
Esteban N. Gurzov, Decio L. Eizirik
http://www.nature.com/cdd/journal/v18/n2/full/cdd2010105a.html

Utilizing mitochondrial events as biomarkers for imaging apoptosis
N Yivgi-Ohana, M Eifer, Y Addadi, M Neeman and A Gross
http://www.nature.com/cddis/journal/v2/n6/full/cddis201147a.html

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News and views
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Tonight, the same old, deadly programme: BH3-only proteins, mitochondria and yeast
Bjorn Oettinghaus, Stephan Frank and Luca Scorrano
http://www.nature.com/emboj/journal/v30/n14/full/emboj2011220a.html

Does N-terminal Processing of Mcl-1 Occur at Mitochondrial Outer Membrane or Matrix?
Hsin-Fang Yang-Yen
J. Biol. Chem. 2011;286 le15
http://www.jbc.org/cgi/content/full/286/30/le15

Response to Yang-Yen: Does N-terminal Processing of Mcl-1 Occur at Mitochondrial Outer Membrane or Matrix?
Matthew R. Warr, Mai Nguyen, and Gordon C. Shore
J. Biol. Chem. 2011;286 le16
http://www.jbc.org/cgi/content/full/286/30/le16

Sam68 Guest STARs in TNF-α Signaling
G.T. Kunkel and X. Wang
http://www.sciencedirect.com/science/article/pii/S1097276511004953

Mitochondrial regulation of cell death in the Drosophila ovary
Elizabeth A. Tanner and Kim McCall
http://www.landesbioscience.com/journals/autophagy/article/15695/

Evading Death
Wei Wong
Sialylation of Fas may enable colon carcinoma cells to evade apoptosis.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/180/ec184?etoc

Bak activators get in the groove
Mitch Leslie
http://jcb.rupress.org/cgi/content/full/194/1/2-a?etoc

Bnip3-mediated defects in oxidative phosphorylation promote mitophagy
Robert L. Thomas, Dieter A. Kubli and Åsa B. Gustafsson
http://www.landesbioscience.com/journals/autophagy/article/15536/

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Death receptors and IAPs
————————————–

CARD-Mediated Autoinhibition of cIAP1′s E3 Ligase Activity Suppresses Cell Proliferation and Migration
Juanita Lopez, Sidonie Wicky John, Tencho Tenev, Gilles J.P. Rautureau, Mark G. Hinds, Floriana Francalanci, Rebecca Wilson, Meike Broemer, Massimo M. Santoro, Catherine L. Day, and Pascal Meier
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900289-9

Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation
Olga M. Shatnyeva, Andriy V. Kubarenko, Claudia E. M. Weber, Alexander Pappa, Reinhard Schwartz-Albiez, Alexander N. R. Weber, Peter H. Krammer, Inna N. Lavrik
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019927

Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells.
Amanda F. Swindall and Susan L. Bellis
http://www.jbc.org/cgi/content/abstract/M110.211375v1

Survivin monomer plays an essential role in apoptosis regulation
Marat S. Pavlyukov, Nadezhda V. Antipova, Maria V. Balashova, Tatjana V. Vinogradova, Evgenij P. Kopantzev, and Mihail I. Shakhparonov
http://www.jbc.org/cgi/content/abstract/M111.237586v1

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT
Najoua Lalaoui, Aymeric Morlé, Delphine Mérino, Guillaume Jacquemin, Elisabetta Iessi, Alexandre Morizot, Sarah Shirley, Bruno Robert, Eric Solary, Carmen Garrido, Olivier Micheau
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019679

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Caspases
—————–

A Peptide-Based Target Screen Implicates the Protein Kinase CK2 in the Global Regulation of Caspase Signaling
James S. Duncan, Jacob P. Turowec, Kelly E. Duncan, Greg Vilk, Chenggang Wu, Bernhard Lüscher, Shawn S.-C. Li, Greg B. Gloor, and David W. Litchfield
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/172/ra30?etoc

Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8-Mediated Cleavage of Beclin 1
Hua Li, Peng Wang, Quanhong Sun, Wen-Xing Ding, Xiao-Ming Yin, Robert W. Sobol, Donna B. Stolz, Jian Yu, and Lin Zhang
http://cancerres.aacrjournals.org/cgi/content/abstract/71/10/3625

Mechanism of a genetically-encoded dark-to-bright reporter for caspase activity
Samantha B. Nicholls, Jun Chu, Genevieve Abbruzzese, Kimberly D. Tremblay, and Jeanne Hardy
http://www.jbc.org/cgi/content/abstract/M111.221648v1

Phosphorylation of caspase-7 by P21-activated protein kinase (PAK)2 inhibits chemotherapeutic drugs-induced apoptosis of breast cancer cell lines
Xiang Li, Weihong Wen, Kangdong Liu, Feng Zhu, Margarita Malakhova, Cong Peng, Tingting Li, Hong-Gyum Kim, Weiya Ma, Yong Yeon Cho, Ann M. Bode, Ziming Dong, and Zigang Dong
http://www.jbc.org/cgi/content/abstract/M111.236596v1

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Miscellaneous
————————

Atg1 allows second-signaled autophagic cell death in Dictyostelium
Marie-Françoise Luciani, Corinne Giusti, Birthe Harms, Yoshiteru Oshima, Haruhisa Kikuchi, Yuzuru Kubohara and Pierre Golstein
http://www.landesbioscience.com/journals/autophagy/article/14957/

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia
Philippe Pasdois, Joanne E. Parker, Elinor J. Griffiths and Andrew P. Halestrap
http://www.biochemj.org/bj/436/bj4360493.htm

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway
Yapeng Gu, Tetyana Forostyan, Roger Sabbadini, and Jody Rosenblatt
http://jcb.rupress.org/cgi/content/abstract/193/4/667?etoc

Defining the Origins of the NOD-Like Receptor System at the Base of Animal Evolution.
Lange C, Hemmrich G, Klostermeier UC, López-Quintero JA, Miller DJ, Rahn T, Weiss Y, Bosch TC, Rosenstiel P.
http://mbe.oxfordjournals.org/content/28/5/1687.abstract

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Reviews
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Mitochondrial involvement in cell death of non-mammalian eukaryotes.
Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM, White K.
http://dx.doi.org/10.1016/j.bbamcr.2010.10.008

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News and views / other
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Autophagic cell death: Loch Ness monster or endangered species?
Han-Ming Shen and Patrice Codogno
http://www.landesbioscience.com/journals/autophagy/ShenAUTO7-5.pdf

I think autophagy controls the death of my cells: What do I do to get my paper published?
Andrew Thorburn
http://www.landesbioscience.com/journals/autophagy/article/14797/

Cell death: A killer puts a stop on necroptosis
FADD-caspase 8-mediated apoptosis inhibits necroptosis during development.
http://www.nature.com/nrm/journal/v12/n5/full/nrm3101.html?WT.ec_id=NRM-201105

Autophagy and apoptosis are redundantly required for C. elegans embryogenesis
Éva Borsos, Péter Erdélyi and Tibor Vellai
http://www.landesbioscience.com/journals/autophagy/article/14685/

MCL-1 regulates the balance between autophagy and apoptosis
Marc Germain and Ruth S. Slack
http://www.landesbioscience.com/journals/autophagy/article/15098/

There Is More to Life than Death: A Moonlighting Function of a Bcl-2 Member
L. Ravid and E. Arama
http://www.cell.com/developmental-cell/abstract/S1534-5807%2811%2900167-5

Protein Kinases Curb Cell Death
Odile Filhol and Claude Cochet
Phosphorylation of procaspases and their substrates by protein kinase CK2 puts the brakes on cell death.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/172/pe26?etoc

Sphingolipid puts the squeeze on apoptotic cells
Ben Short
http://jcb.rupress.org/cgi/content/full/193/4/596-a?etoc

–
Aha! … apoptosis: means to an end
R A Knight and G Melino
http://www.nature.com/cdd/journal/v18/n6/full/cdd201125a.html
–

Jürg Tschopp (1951-2011)
Luke A. O’Neill
A scientist’s basic research into cell death and inflammation will continue to have a clinical impact.
http://www.sciencemag.org/cgi/content/summary/332/6030/679

Jürg Tschopp 1951-2011
R.A. Flavell
http://www.sciencedirect.com/science/article/pii/S0092867411004855

Jürg Tschopp-1951-2011-an immortal contribution.
Kroemer G, Martinon F, Lippens S, Green DR, Knight R, Vandenabeele P, Piacentini M, Nagata S, Borner C, Simon HU, Krammer P, Melino G.
http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd201146a.html

–

Bcl-2 family members
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Discovery and molecular characterization of a Bcl-2–regulated cell death pathway in schistosomes
Erinna F. Lee, Oliver B. Clarke, Marco Evangelista, Zhiping Feng, Terence P. Speed, Elissaveta B. Tchoubrieva, Andreas Strasser, Bernd H. Kalinna, Peter M. Colman, and W. Douglas Fairlie
http://www.pnas.org/content/108/17/6999.abstract?etoc

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways
L Zhang, H Lopez, N M George, X Liu, X Pang and X Luo
http://www.nature.com/cdd/journal/v18/n5/full/cdd2010152a.html

Investigation of the Bcl-2 multimerisation process: Structural and functional implications
Alessia, Camperchioli | Marisa, Mariani | Silvia, Bartollino | Lella, Petrella | Marco, Persico | Nausicaa, Orteca | Giovanni, Scambia | Shohreh, Shahabi | Cristiano, Ferlini | Caterina, Fattorusso
http://dx.doi.org/10.1016/j.bbamcr.2011.02.006

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol
F. Edlich, S. Banerjee, M. Suzuki, M.M. Cleland, D. Arnoult, C. Wang, A. Neutzner, N. Tjandra, and R.J. Youle
http://www.cell.com/abstract/S0092-8674%2811%2900186-3

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
FlavieStrappazzon, Matteo Vietri-Rudan, Silvia Campello, Francesca Nazio, Fulvio Florenzano, Gian Maria Fimia, Mauro Piacentini, Beth Levine and Francesco Cecconi
http://www.nature.com/emboj/journal/v30/n7/abs/emboj201149a.html

Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt
Jun-ichi Sakamaki, Hiroaki Daitoku, Katsuya Ueno, Ayano Hagiwara, Kazuyuki Yamagata, and Akiyoshi Fukamizu
http://www.pnas.org/content/108/15/6085.abstract?etoc

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
H Zhang, S Guttikonda, L Roberts, T Uziel, D Semizarov, S W Elmore, J D Leverson and L T Lam
http://www.nature.com/onc/journal/v30/n16/full/onc2010559a.html

The Anti-Apoptotic Bcl-xL Protein, a New Piece in the Puzzle of Cytochrome C Interactome
Ivano Bertini, Soizic Chevance, Rebecca Del Conte, Daniela Lalli, Paola Turano
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018329

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Death receptors and IAPs
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NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
S. Biton and A. Ashkenazi
http://www.cell.com/abstract/S0092-8674%2811%2900175-9

UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation
Yuefeng Huang, Liang Chen, Yi Zhou, Heng Liu, Jueqing Yang, Zhenggang Liu, and Chen Wang
http://www.molbiolcell.org/cgi/content/abstract/22/8/1389?etoc

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
Sandra Gardam, Vivian M. Turner, Holly Anderton, Sandhya Limaye, Antony Basten, Frank Koentgen, David L. Vaux, John Silke, and Robert Brink
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/117/15/4041

TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD) and caspase-8
Aminah Ikner and Avi Ashkenazi
http://www.jbc.org/cgi/content/abstract/M110.203745v1

Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain
Mar Orzáez, Anna Gortat, Mónica Sancho, Rodrigo J. Carbajo, Antonio Pineda-Lucena, Yadira Palacios-Rodríguez & Enrique Pérez-Payá
http://www.springerlink.com/content/xm45135052573643/

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Caspases and execution phase
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Concerted antigen processing of a short viral antigen by human caspases 5 and 10
Daniel López, Mercedes Jiménez, Margarita Garcia-Calvo, and Margarita Del Val
J. Biol. Chem. published 28 March 2011, 10.1074/jbc.M111.234658
http://www.jbc.org/cgi/content/abstract/M111.234658v1

Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria
Manuel Oropesa, Mario de la Mata, Juan Garrido Maraver, Mario D. Cordero, David Cotán, Ángeles Rodríguez-Hernández, Irene Domínguez-Moñino, Manuel de Miguel, Plácido Navas & José A. Sánchez-Alcázar
http://www.springerlink.com/content/47h1021vl35l1h77/

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
Mei He, Hiroshi Kubo, Konosuke Morimoto, Naoya Fujino, Takaya Suzuki, Toru Takahasi, Mitsuhiro Yamada, Mutsuo Yamaya, Tomoyuki Maekawa, Yasuhiko Yamamoto and Hiroshi Yamamoto
http://www.nature.com/embor/journal/v12/n4/full/embor201128a.html

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MISCELLANEOUS
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Mechanisms of necroptosis in T cells
Irene L. Ch’en, Jennifer S. Tsau, Jeffery D. Molkentin, Masaaki Komatsu, and Stephen M. Hedrick
In caspase 8-deficient mouse T cells, necroptosis occurs via a Ripk3- and Ripk1-dependent pathway independent of autophagy and programmed necrosis.
http://jem.rupress.org/cgi/content/abstract/208/4/633?etoc

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)
Yingfei Wang, No Soo Kim, Jean-Francois Haince, Ho Chul Kang, Karen K. David, Shaida A. Andrabi, Guy G. Poirier, Valina L. Dawson, and Ted M. Dawson
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/ra20?etoc

Activation of p53 by Nutlin-3a Induces Apoptosis and Cellular Senescence in Human Glioblastoma Multiforme
Ruth Villalonga-Planells, Llorenç Coll-Mulet, Fina Martínez-Soler, Esther Castaño, Juan-Jose Acebes, Pepita Giménez-Bonafé, Joan Gil, Avelina Tortosa
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018588

Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization
Lorna Flanagan, Jordi Sebastia, Maria Eugenia Delgado, Jennifer C. Lennon, Markus Rehm
http://dx.doi.org/10.1016/j.bbamcr.2011.02.011

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Reviews
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The Open Cell Signaling Journal special issue:
“Life and death: A cell signaling prospective”

- Editorial
John Silke
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/1TOCELLSJ.pdf

- Interplay of Bcl-2 Proteins Decides the Life or Death Fate
Grant Dewson
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/3TOCELLSJ.htm

- A Prickly Subject: Apoptotic Regulation by Hedgehog Morphogens
Mark Ditzel
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/9TOCELLSJ.htm

- Cytokine Deprivation and Cell Death
Paul G. Ekert and Anissa M. Jabbour
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/20TOCELLSJ.htm

- Dual Philosophy in Death Receptor Signalling
Chahrazade Kantari and Henning Walczak
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/27TOCELLSJ.htm

- Scorched Earth or Viral Birth?
Ian Gentle and Ueli Nachbur
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/35TOCELLSJ.htm

- Dying for Something to Eat: How Cells Respond to Starvation
Alfredo Caro-Maldonado and Cristina Muñoz-Pinedo
http://www.benthamscience.com/open/tocellsj/articles/V003/SI0001TOCELLSJ/42TOCELLSJ.htm

Armed response: how dying cells influence T-cell functions
Ferguson, Thomas A.; Choi, Jayoung; Green, Douglas R.
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.2011.01006.x/abstract

Signaling cell death from the endoplasmic reticulum stress response
Gordon C Shore, Feroz R Papa, Scott A Oakes
http://dx.doi.org/10.1016/j.ceb.2010.11.003

Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl 2
Shefali Krishna, Ivan Cherh Chiet Low and Shazib Pervaiz
http://www.biochemj.org/bj/435/bj4350545.htm

Apoptosis promotes early tumorigenesis
D Tang, M T Lotze, R Kang and H J Zeh
http://www.nature.com/onc/journal/v30/n16/full/onc2010573a.html

Programmed Necrosis, Not Apoptosis, in the Heart
Kung, Gloria; Konstantinidis, Klitos; Kitsis, Richard N.
http://circres.ahajournals.org/cgi/pmidlookup?view=long&pmid=21493924

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News and views / other
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Retraction
Retraction Notice to: DNA-PKcs-PIDDosome: A Nuclear Caspase-2-Activating Complex with Role in G2/M Checkpoint Maintenance
M. Shi, C.J. Vivian, K.-J. Lee, C. Ge, K. Morotomi-Yano, C. Manzl, F. Bock, S. Sato, C. Tomomori-Sato, R. Zhu, J.S. Haug, S.K. Swanson, M.P. Washburn, D.J. Chen, B.P.C. Chen, A. Villunger, L. Florens, and C. Du
http://www.cell.com/fulltext/S0092-8674%2811%2900292-3

Autophagy in Ras-Induced Malignant Transformation: Fatal or Vital?
G. Mariño, I. Martins, and G. Kroemer
http://dx.doi.org/10.1016/j.molcel.2011.03.003

Traveling Bax and Forth from Mitochondria to Control Apoptosis
M.E. Soriano and L. Scorrano
http://www.cell.com/abstract/S0092-8674%2811%2900302-3

MCL1 meets its end during mitotic arrest
Scott E Millman and Michele Pagano
http://www.nature.com/embor/journal/v12/n5/full/embor201162a.html

Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2
Sharon ATooze and Patrice Codogno
http://www.nature.com/emboj/journal/v30/n7/abs/emboj201175a.html

Activated by Caspases
Wei Wong
Caspase activity in microglia does not trigger cell death, but rather induces proinflammatory responses.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/170/ec115?etoc

Jurg Tschopp 1951-2011
Ralph C Budd, Pascal Schneider, Fabienne Mackay and Andreas Strasser
http://www.nature.com/ni/journal/v12/n5/full/ni0511-367.html?WT.ec_id=NI-201105

Jürg Tschopp (1951–2011) ▶
Immunologist whose discoveries transformed patients’ lives.
http://www.nature.com/nature/journal/v472/n7343/full/472296a.html

Jürg Tschopp (1951-2011)
J. Browning and C. Ware
http://www.cell.com/immunity/fulltext/S1074-7613%2811%2900135-X