Apolist – november 09

REVIEWS
.
Emerging Role for Members of the Bcl-2 Family in Mitochondrial Morphogenesis
A. Autret and S.J. Martin
http://dx.doi.org/10.1016/j.molcel.2009.10.011

.

Novel roles for GAPDH in cell death and carcinogenesis

A Colell, D R Green and J-E Ricci

http://www.nature.com/cdd/journal/v16/n12/abs/cdd2009137a.html

.

Cell Death
Richard S. Hotchkiss, M.D., Andreas Strasser, Ph.D., Jonathan E.
McDunn, Ph.D., and Paul E. Swanson, M.D.
http://content.nejm.org/cgi/content/full/361/16/1570

–
BH3

Bak Activation for Apoptosis Involves Oligomerization of Dimers via
Their α6 Helices
G. Dewson, T. Kratina, P. Czabotar, C.L. Day, J.M. Adams, and R.M. Kluck
http://www.cell.com/molecular-cell/abstract/S1097-2765(09)00821-1

Membrane promotes tBID interaction with BCL(XL).
García-Sáez AJ, Ries J, Orzáez M, Pérez-Payà E, Schwille P.
http://www.nature.com/nsmb/journal/v16/n11/abs/nsmb.1671.html

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates
Mitochondrial Apoptosis
H. Kim, H.-C. Tu, D. Ren, O. Takeuchi, J.R. Jeffers, G.P. Zambetti,
J.J.-D. Hsieh, and E.H.-Y. Cheng
http://www.cell.com/molecular-cell/abstract/S1097-2765(09)00690-X

Bax contains two functional mitochondrial targeting sequences and
translocates to mitochondria in a conformational change- and
homo-oligomerization-driven process
Nicholas M. George, Natalie Targy, Jacquelynn J. D. Evans, Liqiang
Zhang, and Xu Luo
http://www.jbc.org/cgi/content/abstract/M109.049924v1

Bim Upregulation by Histone Deacetylase Inhibitors Mediates
Interactions with the Bcl-2 Antagonist ABT-737: Evidence for Distinct
Roles for Bcl-2, Bcl-xL, and Mcl-1
Shuang Chen, Yun Dai, Xin-Yan Pei, and Steven Grant
http://mcb.asm.org/cgi/content/abstract/29/23/6149

The BH3-only protein Bim plays a critical role in leukemia cell death
triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2
pathways
Mohamed Rahmani, Anh Anderson, Joseph Reza Habibi, Timothy Ryan
Crabtree, Mandy Mayo, Hisashi Harada, Andrea Ferreira-Gonzalez, Paul
Dent, and Steven Grant
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/20/4507

From the Cover: Age-related hearing loss in C57BL/6J mice is mediated
by Bak-dependent mitochondrial apoptosis
Shinichi Someya, Jinze Xu, Kenji Kondo, Dalian Ding, Richard J. Salvi,
Tatsuya Yamasoba, Peter S. Rabinovitch, Richard Weindruch, Christiaan
Leeuwenburgh, Masaru Tanokura, and Tomas A. Prolla
http://www.pnas.org/content/106/46/19432.abstract?etoc

Facilitation of mitochondrial outer and inner membrane
permeabilization and cell death in oxidative stress by a novel BH3
domain protein
A. Szigeti, E. Hocsak, E. Rapolti, B. Racz, A. Boronkai, E. Pozsgai,
B. Debreceni, Z. Bognar, S. Bellyei, B. Sumegi, and F. Gallyas, Jr.
http://www.jbc.org/cgi/content/abstract/M109.015222v1

Dissimilar mechanisms of cytochrome c release induced by octyl
glucoside-activated BAX and by BAX activated with truncated BID
Tsyregma Li, Tatiana Brustovetsky, Bruno Antonsson, Nickolay Brustovetsky
http://dx.doi.org/10.1016/j.bbabio.2009.07.012

–
Miscellaneous

Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila
D. Denton, B. Shravage, R. Simin, K. Mills, D.L. Berry, E.H.
Baehrecke, and S. Kumar
http://dx.doi.org/10.1016/j.cub.2009.08.042

Determinism and divergence of apoptosis susceptibility in mammalian cells
Patrick D. Bhola and Sanford M. Simon
J Cell Sci 2009;122 4296-4302
http://jcs.biologists.org/cgi/content/abstract/122/23/4296

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER
Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis
R. Sano, I. Annunziata, A. Patterson, S. Moshiach, E. Gomero, J.
Opferman, M. Forte, and A. d’Azzo
http://www.cell.com/molecular-cell/abstract/S1097-2765(09)00786-2

Granzyme F induces a novel death pathway characterized by
Bid-independent cytochrome c release without caspase activation
LShi, L Wu, S Wang and Z Fan
http://www.nature.com/cdd/journal/v16/n12/abs/cdd2009101a.html

–
IAPs and death receptors

CD95 engagement mediates actin-independent and -dependent apoptotic signals
BChaigne-Delalande, W Mahfouf, S Daburon, J-F Moreau and P Legembre
http://www.nature.com/cdd/journal/v16/n12/abs/cdd2009111a.html

PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL
S Ueno, H Tatetsu, H Hata, T Iino, H Niiro, K Akashi, D G Tenen, H
Mitsuya and Y Okuno
http://www.nature.com/onc/journal/v28/n46/full/onc2009263a.html

A role for X-linked inhibitor of apoptosis protein upstream of
mitochondrial permeabilization
Thomas W. Owens, Fiona M. Foster, Anthony Valentijn, Andrew P.
Gilmore, and Charles H. Streuli
http://www.jbc.org/cgi/content/abstract/M109.072322v1

–
Caspases and downstream

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

Lata Mukundan, Justin I Odegaard, Christine R Morel, Jose E Heredia, Julia W Mwangi, Roberto R Ricardo-Gonzalez, Y P Sharon Goh, Alex Red Eagle, Shannon E Dunn, Jennifer U H Awakuni, Khoa D Nguyen, Lawrence Steinman, Sara A Michie and Ajay Chawl

http://www.nature.com/nm/journal/v15/n11/full/nm.2048.html

Recognition of apoptotic cells by epithelial cells: conserved versus
tissue-specific signaling responses
Vimal A. Patel, Daniel J. Lee, Lanfei Feng, Angelika Antoni, Wilfred
Lieberthal, John H. Schwartz, Joyce Rauch, David S. Ucker, and Jerrold
S. Levine
J. Biol. Chem. published 12 November 2009, 10.1074/jbc.M109.018440
http://www.jbc.org/cgi/content/abstract/M109.018440v1

Necrotic cells trigger a sterile inflammatory response through the
Nlrp3 inflammasome
Shankar S. Iyer, Wilco P. Pulskens, Jeffrey J. Sadler, Loes M. Butter,
Gwendoline J. Teske, Tyler K. Ulland, Stephanie C. Eisenbarth,
Sandrine Florquin, Richard A. Flavell, Jaklien C. Leemans, and Fayyaz
S. Sutterwala
http://www.pnas.org/content/106/48/20388.abstract?etoc

–
COMMENTS

BAX and BAK Caught in the Act
Y. Yao and F.M. Marassi
http://www.cell.com/molecular-cell/abstract/S1097-2765(09)00788-6

Apoptosis: the generation gap
http://jcs.biologists.org/cgi/content/full/122/23/e2302?etoc

Caspase 2 in apoptosis, the DNA damage response and tumour
suppression: enigma no more?
Sharad Kumar
http://www.nature.com/nrc/journal/v9/n12/full/nrc2745.html

Apolist – october 2009

Caspases and downstream
————————————–

Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development
Akiko Koto, Erina Kuranaga, and Masayuki Miura
http://jcb.rupress.org/cgi/content/abstract/187/2/219?etoc

Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2
Joshua L Andersen, Carrie E Johnson, Christopher D Freel, Amanda B Parrish, Jennifer L Day, Marisa R Buchakjian, Leta K Nutt, J Will Thompson, M Arthur Moseley and Sally Kornbluth
http://www.nature.com/emboj/journal/v28/n20/abs/emboj2009253a.html

Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7
Johnson Agniswamy, Bin Fang, Irene T. Weber
http://www.springerlink.com/content/37243830r711kw1u/

Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level
Young-wook Jun, Sassan Sheikholeslami, Daniel R. Hostetter, Cheryl Tajon, Charles S. Craik, and A. Paul Alivisatos
http://www.pnas.org/content/106/42/17735.abstract

ARTEMIS Nuclease Facilitates Apoptotic Chromatin Cleavage
Sébastien Britton, Philippe Frit, Denis Biard, Bernard Salles, and Patrick Calsou
Cancer Res 2009;69 8120-8126
http://cancerres.aacrjournals.org/cgi/content/abstract/69/20/8120

Autophagy is not universally required for phosphatidyl-serine exposure and
apoptotic cell engulfment during neural development
María A. Mellén, Enrique J. de la Rosa and Patricia Boya
http://www.landesbioscience.com/journals/autophagy/article/9292

 

Death receptor pathway
———————————-

FLIP-mediated autophagy regulation in cell death control
Jong-Soo Lee, Qinglin Li, June-Yong Lee, Sun-Hwa Lee, Joseph H. Jeong, Hye-Ra Lee, Heesoon Chang, Fu-Chun Zhou, Shou-Jiang Gao, Chengyu Liang and Jae U. Jung
http://www.nature.com/ncb/journal/v11/n11/full/ncb1980.html

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound
Herman H. Cheung, Douglas J. Mahoney, Eric C. LaCasse, and Robert G. Korneluk
http://cancerres.aacrjournals.org/cgi/content/abstract/69/19/7729

A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme
Amith Panner, Courtney A. Crane, Changjiang Weng, Alberto Feletti, Andrew T. Parsa, and Russell O. Pieper
http://cancerres.aacrjournals.org/cgi/content/abstract/69/20/7911

TRAF2 must bind to cIAPs for TNF to efficiently activate NF- B and to prevent TNF-induced apoptosis
James E. Vince, Delara Pantaki, Rebecca Feltham, Peter D. Mace, Stephanie M. Cordier, Anna C. Schmukle, Angelina J. Davidson, Bernard A. Callus, Wendy Wei-Lynn Wong, Ian E. Gentle, Holly Carter, Erinna F. Lee, Henning Walczak, Catherine L. Day, David L. Vaux, and John Silke
http://www.jbc.org/cgi/content/abstract/M109.072256v2

Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxygeldanamycin promotes TRAIL-induced apoptosis in breast tumor cells.
Palacios C, López-Pérez AI, López-Rivas A.
http://dx.doi.org/10.1016/j.canlet.2009.06.012

XIAP regulates cell death induction by pro-apoptotic receptor agonists
Eugene Varfolomeev, Bruno Alicke, J. Michael Elliott, Kerry Zobel, Kristina West, Harvey Wong, Justin M. Scheer, Avi Ashkenazi, Stephen E. Gould, Wayne J. Fairbrother, and Domagoj Vucic
http://www.jbc.org/cgi/content/abstract/M109.040139v1

Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients
Georg Stary, Irene Klein, Sabine Kohlhofer, Frieder Koszik, Thomas Scherzer, Leonhard Müllauer, Heribert Quendler, Norbert Kohrgruber, and Georg Stingl
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/18/3854

 

BH3
——-

Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid
Jun Peng, Jingzhen Ding, Chibing Tan, Bruce Baggenstoss, Zhi Zhang, Suzanne M. Lapolla, Jialing Lin
http://www.springerlink.com/content/u2g85655k10682j8/

MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts
Joslyn K. Brunelle, Jeremy Ryan, Derek Yecies, Joseph T. Opferman, and Anthony Letai
http://jcb.rupress.org/cgi/content/abstract/187/3/429?etoc

Bax activates endophilin B1 oligomerization and lipid membrane vesiculation
Tatiana K. Rostovtseva, Hacene Boukari, Antonella Antignani, Brian Shiu, Soojay Banerjee, Albert Neutzner, and Richard J. Youle
http://www.jbc.org/cgi/content/abstract/M109.021873v1

Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF-β–Induced Cell Death through Impairing Up-regulation of the NADPH Oxidase NOX4
Laia Caja, Patricia Sancho, Esther Bertran, Daniel Iglesias-Serret, Joan Gil, and Isabel Fabregat
http://cancerres.aacrjournals.org/cgi/content/abstract/69/19/7595

The anti-apoptotic molecule Bcl-2 regulates the differentiation, activation and survival of both osteoblasts and osteoclasts
Yuichi Nagase, Mitsuyasu Iwasawa, Toru Akiyama, Yuho Kadono, Masaki Nakamura, Yasushi Oshima, Tetsuro Yasui, Takumi Matsumoto, Jun Hirose, Hiroaki Nakamura, Takeshi Miyamoto, Philippe Bouillet, Kozo Nakamura, and Sakae Tanaka
http://www.jbc.org/cgi/content/abstract/M109.016915v1

Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK
TW Owens, AJ Valentijn, J-P Upton, J Keeble, L Zhang, J Lindsay, NK Zouq and AP Gilmore
http://www.nature.com/cdd/journal/v16/n11/full/cdd2009102a.html

The Cell Death–Inducing Activity of the Peptide Containing Noxa Mitochondrial-Targeting Domain Is Associated with Calcium Release
Young-Woo Seo, Ha-Na Woo, Sujan Piya, Ae Ran Moon, Jae-Wook Oh, Cheol-Won Yun, Kyung-Keun Kim, Ji-Young Min, Seon-Yong Jeong, Seyung Chung, Peter I. Song, Seong-Yun Jeong, Eun Kyung Choi, Dai-Wu Seol, and Tae-Hyoung Kim
http://cancerres.aacrjournals.org/cgi/content/abstract/69/21/8356

Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavage
B-ZYuan, J Chapman and S H Reynolds
http://www.nature.com/onc/journal/v28/n43/abs/onc2009240a.html

 

Other
——–

Spatial and temporal dynamics of mitochondrial membrane permeability waves during apoptosis.
Bhola PD, Mattheyses AL, Simon SM.
http://dx.doi.org/10.1016/j.bpj.2009.07.056

Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes
J Zhang, N Bahi, M Llovera, J X Comella and D Sanchis
http://www.nature.com/cdd/journal/v16/n11/full/cdd200987a.html

A novel membrane fusion-mediated plant immunity against bacterial pathogens
Noriyuki Hatsugai, Shinji Iwasaki, Kentaro Tamura, Maki Kondo, Kentaro Fuji, Kimi Ogasawara, Mikio Nishimura, and Ikuko Hara-Nishimura
http://genesdev.cshlp.org/cgi/content/abstract/23/21/2496

 

REVIEWS / COMMENTS
————————————–

Apoptosis: Calling Time on Apoptosome Activity
Colin Adrain and Seamus J. Martin
Caspase-9 autoprocessing displaces active caspase-9 bound to the apoptosome, thereby limiting proteolytic activity.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/91/pe62?etoc

Apoptosis: Watching caspase 2 get active
Katharine H. Wrighton
http://www.nature.com/nrm/journal/v10/n11/full/nrm2788.html

Walking a fine caspase line
Kendall Powell
http://jcb.rupress.org/cgi/content/full/187/2/150?etoc

HIV infection: TRAILing the killers
Andrea Cerutti
http://bloodjournal.hematologylibrary.org/cgi/content/full/114/18/3723

A kiss of death—proteasome-mediated membrane fusion and programmed cell death in plant defense against bacterial infection
Karolina Pajerowska-Mukhtar and Xinnian Dong
http://genesdev.cshlp.org/cgi/content/abstract/23/21/2449

Apolist – september 09

Caspases and downstream

Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity
L. Bouchier-Hayes, A. Oberst, G.P. McStay, S. Connell, S.W.G. Tait, C.P. Dillon, J.M. Flanagan, H.M. Beere, and D.R. Green
http://www.cell.com/molecular-cell/abstract/S1097-2765%2809%2900555-3

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
Andrew Kovalenko, Jin-Chul Kim, Tae-Bong Kang, Akhil Rajput, Konstantin Bogdanov, Oliver Dittrich-Breiholz, Michael Kracht, Ori Brenner, and David Wallach
http://jem.rupress.org/cgi/content/abstract/206/10/2161?etoc

Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53
Hyo-Jin Kim, Ho-June Lee, Joon-Il Jun, Yumin Oh, Seon-Guk Choi, Hyunjoo Kim, Chul-Woong Chung, In-Ki Kim, Il-Sun Park, Han-Jung Chae, Hyung-Ryong Kim, and Yong-Keun Jung
http://www.pnas.org/content/106/36/15326.abstract?etoc

Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3
Carlos H. Herrera-Mendez, Samira Becila, Xavier Blanchet, Patrick Pelissier, Didier Delourme, Gerald Coulis, Miguel A. Sentandreu, Abdelghani Boudjellal, Laure Bremaud, Ahmed Ouali
http://dx.doi.org/10.1016/j.febslet.2009.07.055

Caspase-2 Mediated Apoptotic and Necrotic Murine Macrophage Cell Death Induced by Rough Brucella abortus
Fang Chen, Yongqun He
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006830

The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor–1 in macrophages via sphingosine-1-phosphate and transforming growth factor-β
Barbara Herr, Jie Zhou, Christian Werno, Heidi Menrad, Dmitry Namgaladze, Andreas Weigert, Nathalie Dehne, and Bernhard Brüne
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/10/2140

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Michael R. Elliott1,2, Faraaz B. Chekeni1,3, Paul C. Trampont1,2, Eduardo R. Lazarowski7, Alexandra Kadl4, Scott F. Walk1,2, Daeho Park1,2, Robin I. Woodson5, Marina Ostankovich4, Poonam Sharma4, Jeffrey J. Lysiak5, T. Kendall Harden8, Norbert Leitinger3,4 & Kodi S. Ravichandran
http://www.nature.com/nature/journal/v461/n7261/full/nature08296.html

A new model for APAF-1’s transition from inactive monomer to caspase-activating apoptosome
Thomas F. Reubold, Sabine Wohlgemuth, and Susanne Eschenburg
J. Biol. Chem. published 30 September 2009, 10.1074/jbc.M109.014027
http://www.jbc.org/cgi/content/abstract/M109.014027v1

BH3

Identification of a Protein, G0S2, That Lacks Bcl-2 Homology Domains and Interacts with and Antagonizes Bcl-2
Christian Welch, Manas K. Santra, Wissal El-Assaad, Xiaochun Zhu, Wade E. Huber, Richard A. Keys, Jose G. Teodoro, and Michael R. Green
http://cancerres.aacrjournals.org/cgi/content/abstract/69/17/6782

Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77
Cristiano Ferlini, Lucia Cicchillitti, Giuseppina Raspaglio, Silvia Bartollino, Samanta Cimitan, Carlo Bertucci, Simona Mozzetti, Daniela Gallo, Marco Persico, Caterina Fattorusso, Giuseppe Campiani, and Giovanni Scambia
http://cancerres.aacrjournals.org/cgi/content/abstract/69/17/6906

Conformational changes in BCL-2 pro-survival proteins determine their capacity to bind ligands
Erinna F. Lee, Peter E. Czabotar, Hong Yang, Brad E. Sleebs, Guillaume Lessene, Peter M. Colman, Brian J. Smith, and Walter Douglas Fairlie
J. Biol. Chem. published 2 September 2009, 10.1074/jbc.M109.040725
http://www.jbc.org/cgi/content/abstract/M109.040725v1

Mcl-1 degradation during hepatocyte lipoapoptosis
Howard C. Masuoka, Justin Mott, Steven F. Bronk, Nathan W. Werneburg, Yuko Akazawa, Scott H. Kaufmann, and Gregory J. Gores
J. Biol. Chem. published 5 September 2009, 10.1074/jbc.M109.039545
http://www.jbc.org/cgi/content/abstract/M109.039545v1

MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death
Jae-Hong Kim, Se-Hoon Sim, Hye-Jeong Ha, Jeong-Jae Ko, Kangseok Lee, Jeehyeon Bae
http://dx.doi.org/10.1016/j.febslet.2009.08.006

Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax
Diana Hippe, Arnim Weber, Liying Zhou, Donald C. Chang, Georg Häcker, and Carsten G. K. Lüder
J Cell Sci 2009;122 3511-3521
http://jcs.biologists.org/cgi/content/abstract/122/19/3511

Carboxy-terminal residues regulate localization and function of the antiapoptotic protein Bfl-1
Gaelle Brien, Anne-Laure Debaud, Xavier Robert, Lisa Oliver, Marie-Claude Trescol-Biemont, Nicolas Cauquil, Olivier Geneste, Nushin Agahajari, Francois M. Vallette, Richard Haser, and Nathalie Bonnefoy-Berard
http://www.jbc.org/cgi/content/abstract/M109.040824v1

Novel BCL-2 homology (BH)-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival BCL 2 proteins
Erinna F. Lee, Anna Fedorova, Kerry Zobel, Michelle J. Boyle, Hong Yang, Matthew A. Perugini, Peter M. Colman, David C. S. Huang, Kurt Deshayes, and Walter Douglas Fairlie
http://www.jbc.org/cgi/content/abstract/M109.048009v1

p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2
Petra Obexer, Judith Hagenbuchner, Martina Rupp, Christina Salvador, Markus Holzner, Martin Deutsch, Verena Porto, Reinhard Kofler, Thomas Unterkirchner, and Michael J. Ausserlechner
J. Biol. Chem. published 8 September 2009, 10.1074/jbc.M109.051441
http://www.jbc.org/cgi/content/abstract/M109.051441v2

Death receptors

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
Lorraine A. O’ Reilly1, Lin Tai1, Lily Lee1, Elizabeth A. Kruse1,2, Stephanie Grabow1,2, W. Douglas Fairlie1, Nicole M. Haynes3, David M. Tarlinton1, Jian-Guo Zhang1, Gabrielle T. Belz1, Mark J. Smyth3, Philippe Bouillet1, Lorraine Robb1 & Andreas Strasser
http://www.nature.com/nature/journal/v461/n7264/full/nature08402.html

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions
M Reis-Sobreiro, C Gajate and F Mollinedo
http://www.nature.com/onc/journal/v28/n36/full/onc2009183a.html

Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing
T R Wilson, K M Redmond, K M McLaughlin, N Crawford, K Gately, K O’Byrne, C Le-Clorrenec, C Holohan, D A Fennell, P G Johnston and D B Longley
http://www.nature.com/cdd/journal/v16/n10/full/cdd200976a.html#bib11

Histone deacetylase inhibitors cooperate with IFN- to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8
S Häcker, A Dittrich, A Mohr, T Schweitzer, S Rutkowski, J Krauss, K-M Debatin and S Fulda
http://www.nature.com/onc/journal/v28/n35/full/onc2009161a.html

Caspase-9 activation by the apoptosome is not required for fas-mediated apoptosis in type II jurkat cells
Mary E. Shawgo, Shary N. Shelton, and John D. Robertson
http://www.jbc.org/cgi/content/abstract/M109.032359v1

Other

Expression, purification and use of recombinant annexin V for the detection of apoptotic cells
Susan E Logue, Mohamed Elgendy & Seamus J Martin
http://www.nature.com/nprot/journal/v4/n9/full/nprot.2009.143.html

c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol–Treated Ewing Sarcoma Cells
Séverine Lorin, Amélie Borges, Lisandra Ribeiro Dos Santos, Sylvie Souquère, Gérard Pierron, Kevin M. Ryan, Patrice Codogno, and Mojgan Djavaheri-Mergny
Cancer Res 2009;69 6924-6931
http://cancerres.aacrjournals.org/cgi/content/abstract/69/17/6924

Interfering with multimerization of netrin-1 receptors triggers tumor cell death
F Mille, F Llambi, C Guix, C Delloye-Bourgeois, C Guenebeaud, S Castro-Obregon, D E Bredesen, C Thibert and P Mehlen
http://www.nature.com/cdd/journal/v16/n10/full/cdd200975a.html

REVIEWS / COMMENTS

Caspase-2: killer, savior and safeguard—emerging versatile roles for an ill-defined caspase
G Krumschnabel, C Manzl and A Villunger
http://www.nature.com/onc/journal/v28/n35/full/onc2009173a.html

Caspases and Kinases in a Death Grip
Manabu Kurokawa, Sally Kornbluth
http://dx.doi.org/10.1016/j.cell.2009.08.021

Lots of reviews on autophagy (and autophagic cell death) in BBA-Molecular Cell Research:
http://www.sciencedirect.com/science/issue/4904-2009-982069990-1484090

A Cut Above the Other Caspases
J.L. Andersen and S. Kornbluth
http://www.cell.com/molecular-cell/abstract/S1097-2765%2809%2900629-7

Cell biology: Sent by the scent of death
Christopher Gregory
http://www.nature.com/nature/journal/v461/n7261/full/461181a.html

Apolist – august 09

This month we have a whole issue dedicated to reviews on BH3-only proteins in Oncogene:
http://www.nature.com/onc/journal/v27/n1s/index.html

And a whole issue of Apoptosis (the journal) dedicated to death in Drosophila
http://www.springerlink.com/content/r74684125h61/?p=c3a75d05149c4479a014c83ca0a4e1a9&pi=0

Death receptors

Reconstitution of the Death-Inducing Signaling Complex Reveals a Substrate Switch that Determines CD95-Mediated Death or Survival
M.A. Hughes, N. Harper, M. Butterworth, K. Cain, G.M. Cohen, and M. MacFarlane
http://www.cell.com/molecular-cell/abstract/S1097-2765(09)00423-7
PMID: 19683492

A New C-Terminal Cleavage Product of Procaspase-8, p30, Defines an Alternative Pathway of Procaspase-8 Activation
Julia C. Hoffmann, Alexander Pappa, Peter H. Krammer, and Inna N. Lavrik
http://mcb.asm.org/cgi/content/abstract/29/16/4431

AIMP2 promotes TNF-dependent apoptosis via ubiquitin-mediated degradation of TRAF2
Jin Woo Choi, Dae Gyu Kim, Min Chul Park, Jung Yeon Um, Jung Min Han, Sang Gyu Park, Eung-Chil Choi, and Sunghoon Kim
http://jcs.biologists.org/cgi/content/abstract/122/15/2710

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability
A Kaunisto, V Kochin, T Asaoka, A Mikhailov, M Poukkula, A Meinander & J E Eriksson
http://www.nature.com/cdd/journal/v16/n9/full/cdd200935a.html

The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis
Ravshan Burikhanov, Yanming Zhao, Anindya Goswami, Shirley Qiu, Steven R. Schwarze, Vivek M. Rangnekar
http://dx.doi.org/10.1016/j.cell.2009.05.022

The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases
R Audo, B Combe, B Coulet, J Morel & M Hahne
http://www.nature.com/cdd/journal/v16/n9/full/cdd200938a.html



BH3

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins
Delphine Mérino, Maybelline Giam, Peter D. Hughes, Owen M. Siggs, Klaus Heger, Lorraine A. O’Reilly, Jerry M. Adams, Andreas Strasser, Erinna F. Lee, Walter D. Fairlie, and Philippe Bouillet
http://jcb.rupress.org/cgi/content/abstract/186/3/355?etoc

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
Yi-Ping Rong, Geert Bultynck, Ademuyiwa S. Aromolaran, Fei Zhong, Jan B. Parys, Humbert De Smedt, Gregory A. Mignery, H. Llewelyn Roderick, Martin D. Bootman, and Clark W. Distelhorst
http://www.pnas.org/content/106/34/14397.abstract?etoc

Differentiation-Related Gene-1 Decreases Bim Stability by Proteasome-Mediated Degradation
Grazia Ambrosini, Sharon L. Seelman, and Gary K. Schwartz
http://cancerres.aacrjournals.org/cgi/content/abstract/69/15/6115

Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene
Akira Nakajima, Keishiro Nishimura, Yukana Nakaima, Tomohiko Oh, Shigeru Noguchi, Tadatsugu Taniguchi, and Tomohiko Tamura
http://www.pnas.org/content/106/30/12448.long

RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway
Angela M. Keuling, Kathleen E. A. Felton, Arabesque A. M. Parker, Majid Akbari, Susan E. Andrew, Victor A. Tron
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006651

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM
Roberto Alonso, Mónica López-Guerra, Ramanda Upshaw, Shanta Bantia, Caroline Smal, Françoise Bontemps, Chantal Manz, Thomas Mehrling, Neus Villamor, Elias Campo, Emili Montserrat, and Dolors Colomer
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/8/1563

Identification of novel in vivo phosphorylation sites of the human pro-apoptotic protein bad: pore-forming activity of bad is regulated by phosphorylation
Lisa Polzien, Angela Baljuls, Ulrike E. E. Rennefahrt, Andreas Fischer, Werner Schmitz, Rene P. Zahedi, Albert Sickmann, Renate Metz, Stefan Albert, Roland Benz, Mirko Hekman, and Ulf R. Rapp
http://www.jbc.org/cgi/content/abstract/M109.010702v1

JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis
Sophie C. Cazanave, Justin L. Mott, Nafisa A. Elmi, Steven F. Bronk, Nathan W. Werneburg, Yuko Akazawa, Alisan Kahraman, Sean P. Garrison, Gerard P. Zambetti, Michael R. Charlton, and Gregory J. Gores
http://www.jbc.org/cgi/content/abstract/M109.022491v1

The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion
Stéphane G. Rolland, Yun Lu, Charles N. David, and Barbara Conradt
http://jcb.rupress.org/cgi/content/abstract/186/4/525?etoc

PUMA is directly activated by NF-B and contributes to TNF–induced apoptosis
P Wang, W Qiu, C Dudgeon, H Liu, C Huang, G P Zambetti, J Yu & L Zhang
http://www.nature.com/cdd/journal/v16/n9/full/cdd200951a.html



IMMUNITY

The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
SandrineMarchetti, Parvati Gamas, Nathalie Belhacène, Sebastien Grosso, Ludivine A Pradelli, Pascal Colosetti, Claus Johansen, Lars Iversen, Marcel Deckert, Fréderic Luciano, Paul Hofman, Nicolas Ortonne, Abdallah Khemis, Bernard Mari, Jean-Paul Ortonne, Jean-Ehrland Ricci and Patrick Auberger
http://www.nature.com/emboj/journal/v28/n16/full/emboj2009183a.html

The VDAC2-BAK Rheostat Controls Thymocyte Survival
Decheng Ren, Hyungjin Kim, Ho-Chou Tu, Todd D. Westergard, Jill K. Fisher, Jeff A. Rubens, Stanley J. Korsmeyer, James J.-D. Hsieh, and Emily H.-Y. Cheng
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/85/ra48?etoc

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR
N. A-Gonzalez, S.J. Bensinger, C. Hong, S. Beceiro, M.N. Bradley, N. Zelcer, J. Deniz, C. Ramirez, M. D_iaz, G. Gallardo, C. Ruiz de Galarreta, J. Salazar, F. Lopez, P. Edwards, J. Parks, M. Andujar, P. Tontonoz, and A. Castrillo
http://www.cell.com/immunity/abstract/S1074-7613%2809%2900318-5

XIAP mediates NOD signaling via interaction with RIP2
Andreas Krieg, Ricardo G. Correa, Jason B. Garrison, Gaëlle Le Negrate, Kate Welsh, Ziwei Huang, Wolfram T. Knoefel, and John C. Reed
http://www.pnas.org/cgi/content/abstract/106/34/14524?etoc



Caspases and downstream

Suicidal Membrane Repair Regulates Phosphatidylserine Externalization during Apoptosis
Banafsheh Mirnikjoo, Krishnakumar Balasubramanian, and Alan J. Schroit
http://www.jbc.org/cgi/content/abstract/284/34/22512
PMID: 19561081

Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway
Lisa Trisciuoglio, Marco Emilio Bianchi
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006234

REVIEWS / COMMENTS

Live to dead cell imaging.
Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DR.
http://www.springerlink.com/content/v8wk3h734552v330/
PMID: 19609747

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis
Grant Dewson and Ruth M. Kluck
http://jcs.biologists.org/cgi/content/abstract/122/16/2801

Human Caspases: Activation, Specificity, and Regulation
Cristina Pop and Guy S. Salvesen
http://www.jbc.org/cgi/content/abstract/284/33/21777

Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?
Boris Turk and Vito Turk
http://www.jbc.org/cgi/content/full/284/33/21783

Bax activation by Bim?
P E Czabotar, P M Colman & D C S Huang
http://www.nature.com/cdd/journal/v16/n9/full/cdd200983a.html

Cell Death: A New Par-4 the TRAIL
Lori S. Hart, Wafik S. El-Deiry
http://dx.doi.org/10.1016/j.cell.2009.07.007

RIP Kinases at the Crossroads of Cell Death and Survival p229
Wim Declercq, Tom Vanden Berghe, Peter Vandenabeele
http://dx.doi.org/10.1016/j.cell.2009.07.006

SnapShot: BCL-2 Proteins
J. Marie Hardwick, Richard J. Youle
http://download.cell.com/pdf/PIIS0092867409008393.pdf

Mitochondrial calcium and the permeability transition in cell death
John J. Lemasters, Tom P. Theruvath, Zhi Zhong, Anna-Liisa Nieminen
http://dx.doi.org/10.1016/j.bbabio.2009.06.009

When Repair Is Suicide
Nancy R. Gough
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/85/ec283?etoc

Repairing to Destroy: Suicidal Membrane Repair Regulates Phosphatidylserine Externalization during Apoptosis
http://www.jbc.org/cgi/content/full/284/34/e99939

Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria
Maurizio Sorice, Valeria Manganelli, Paola Matarrese, Antonella Tinari, Roberta Misasi, Walter Malorni, Tina Garofalo
http://www.febsletters.org/article/S0014-5793(09)00545-6/abstract



Plenty of reviews in Oncogene and Apoptosis. Just a few samples:

BH3-only proteins in apoptosis and beyond: an overview
E Lomonosova & G Chinnadurai
http://www.nature.com/onc/journal/v27/n1s/full/onc200939a.html

Noxa: at the tip of the balance between life and death
C Ploner, R Kofler & A Villunger
http://www.nature.com/onc/journal/v27/n1s/full/onc200946a.html

Bim and Bmf in tissue homeostasis and malignant disease.
Piñon JD, Labi V, Egle A, Villunger A.
http://www.nature.com/onc/journal/v27/n1s/full/onc200942a.html
PMID: 19641506

Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death
Mariam Orme and Pascal Meier
http://www.springerlink.com/content/p021j271r1772362/fulltext.html



Other


Death on the slopes. Symposium on Cell Death Pathways
Christina K McPhee, Jahda H Hill & Mari Enoksson
http://www.nature.com/embor/journal/v10/n8/full/embor2009160.html
[about Keystone meeting in Whistler]

Latest Science/AAAS Webinar: Apoptotic Signaling in Normal and Cancer
Cell Biology, – September, 22 2009, at 12 noon Eastern Time (9 a.m.
Pacific, 4 p.m. GMT)
Register TODAY: www.sciencemag.org/webinar

Apolist – july 2009

Death receptors and IAPs

XIAP discriminates between type I and type II FAS-induced apoptosis
Philipp J. Jost, Stephanie Grabow1,2, Daniel Gray1, Mark D. McKenzie2,3, Ueli Nachbur4, David C. S. Huang1, Philippe Bouillet, Helen E. Thomas3, Christoph Borner, John Silke, Andreas Strasser & Thomas Kaufmann1
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08229.html#B19
PMID 19626005

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
D.-W. Zhang et al.
http://www.sciencemag.org/cgi/content/abstract/325/5938/332
PMID 19498109

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein
Nana Ueffing, Kusum K. Singh, Andrea Christians, Christoph Thorns, Alfred C. Feller, Florian Nagl, Falko Fend, Sebastian Heikaus, Alexander Marx, Rainer B. Zotz, Joachim Brade, Wolfgang A. Schulz, Klaus Schulze-Osthoff, Ingo Schmitz, and Christian Schwerk
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/3/572

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization
Céline Van Themsche, Valérie Leblanc, Sophie Parent, and Eric Asselin
http://www.jbc.org/cgi/content/abstract/284/31/20462

–
Caspases

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
Alexander U. Lüthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, Seamus J. Martin
http://www.cell.com/immunity/abstract/S1074-7613(09)00269-6

The Apaf-1-procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
Srinivas Malladi, Madhavi Challa-Malladi, Howard O Fearnhead and Shawn B Bratton
http://www.nature.com/emboj/journal/v28/n13/full/emboj2009152a.html

Dissecting an allosteric switch in caspase-7 using chemical and mutational probes
Jeanne A. Hardy and James A. Wells
http://www.jbc.org/cgi/content/abstract/M109.001826v1

Calpain-1 cleaves and activates caspase-7
Juliette Gafni, Xin Cong, Sylvia F. Chen, Bradford W. Gibson, and Lisa M. Ellerby
http://www.jbc.org/cgi/content/abstract/M109.038174v2

Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
Qing Lan, Lindsay M. Morton, Bruce Armstrong2, Patricia Hartge1, Idan Menashe1, Tongzhang Zheng3, Mark P. Purdue1, James R. Cerhan4, Yawei Zhang3, Andrew Grulich5, Wendy Cozen6, Meredith Yeager7, Theodore R. Holford3, Claire M. Vajdic8, Scott Davis9, Brian Leaderer3, Anne Kricker2, Maryjean Schenk10, Shelia H. Zahm1, Nilanjan Chatterjee1, Stephen J. Chanock1,7, Nathaniel Rothman1, and Sophia S. Wang
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/2/264?etoc

–
BH3

PUMA Promotes Bax Translocation by Both Directly Interacting with Bax and by Competitive Binding to Bcl-XL during UV-induced Apoptosis
Yingjie Zhang, Da Xing, and Lei Liu
http://www.molbiolcell.org/cgi/content/abstract/20/13/3077?etoc

Detergent activated BAX protein is a monomer
Olena Ivashyna, Ana J. Garcia-Saez, Jonas Ries, Eric T. Christenson, Petra Schwille, and Paul H. Schlesinger
http://www.jbc.org/cgi/content/abstract/M109.023853v1

PUMA- and Bax-induced autophagy contributes to apoptosis
K S Yee, S Wilkinson, J James, K M Ryan & K H Vousden
http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins
David Lam, David Dickens, Elizabeth B. Reid, Samantha H. Y. Loh, Nicoleta Moisoi, and L. Miguel Martins
http://www.pnas.org/content/106/29/11978.abstract?etoc

–
Other

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo, Simona Giglio, Igea D’Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta, Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu and Fabiola Moretti
http://www.nature.com/emboj/journal/v28/n13/full/emboj2009154a.html

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells
R Kar, P K Singha, M A Venkatachalam & P Saikumar
http://www.nature.com/onc/journal/v28/n28/full/onc2009118a.html

–
REVIEWS / COMMENTS

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
(plenty of authors)
http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

BCL2DB: moving ‘helix-bundled’ BCL-2 family members to their database
Stanislas Valentin Blaineau, Abdel Aouacheria
http://www.springerlink.com/content/j6×5l4117×50ph7m/

IL-33 Raises Alarm
M. Lamkanfi and V.M. Dixit
http://www.cell.com/immunity/abstract/S1074-7613(09)00284-2

Mitochondrial targeting of tBid/Bax: a role for the TOM complex?
M Ott, E Norberg, B Zhivotovsky & S Orrenius
http://www.nature.com/cdd/journal/v16/n8/full/cdd200961a.html

Caspase-8 for Outer Harmony
Gabriel Sollberger and Hans-Dietmar Beer
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/78/pe40?etoc

Caspase-2: controversial killer or checkpoint controller?
Tanja Kitevska, Damian M. S. Spencer, Christine J. Hawkins
http://www.springerlink.com/content/q88h871q37540753/

Death receptors and IAPs

XIAP discriminates between type I and type II FAS-induced apoptosis

Philipp J. Jost, Stephanie Grabow1,2, Daniel Gray1, Mark D. McKenzie2,3, Ueli Nachbur4, David C. S. Huang1, Philippe Bouillet, Helen E. Thomas3, Christoph Borner, John Silke, Andreas Strasser & Thomas Kaufmann1

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08229.html#B19

PMID 19626005

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

D.-W. Zhang et al.

http://www.sciencemag.org/cgi/content/abstract/325/5938/332

PMID 19498109

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein

Nana Ueffing, Kusum K. Singh, Andrea Christians, Christoph Thorns, Alfred C. Feller, Florian Nagl, Falko Fend, Sebastian Heikaus, Alexander Marx, Rainer B. Zotz, Joachim Brade, Wolfgang A. Schulz, Klaus Schulze-Osthoff, Ingo Schmitz, and Christian Schwerk

http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/3/572

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization

Céline Van Themsche, Valérie Leblanc, Sophie Parent, and Eric Asselin

http://www.jbc.org/cgi/content/abstract/284/31/20462

Caspases

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

Alexander U. Lüthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, Seamus J. Martin

http://www.cell.com/immunity/abstract/S1074-7613(09)00269-6

The Apaf-1-procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

Srinivas Malladi, Madhavi Challa-Malladi, Howard O Fearnhead and Shawn B Bratton

http://www.nature.com/emboj/journal/v28/n13/full/emboj2009152a.html

Dissecting an allosteric switch in caspase-7 using chemical and mutational probes

Jeanne A. Hardy and James A. Wells

http://www.jbc.org/cgi/content/abstract/M109.001826v1

Calpain-1 cleaves and activates caspase-7

Juliette Gafni, Xin Cong, Sylvia F. Chen, Bradford W. Gibson, and Lisa M. Ellerby

http://www.jbc.org/cgi/content/abstract/M109.038174v2

Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies

Qing Lan, Lindsay M. Morton, Bruce Armstrong2, Patricia Hartge1, Idan Menashe1, Tongzhang Zheng3, Mark P. Purdue1, James R. Cerhan4, Yawei Zhang3, Andrew Grulich5, Wendy Cozen6, Meredith Yeager7, Theodore R. Holford3, Claire M. Vajdic8, Scott Davis9, Brian Leaderer3, Anne Kricker2, Maryjean Schenk10, Shelia H. Zahm1, Nilanjan Chatterjee1, Stephen J. Chanock1,7, Nathaniel Rothman1, and Sophia S. Wang

http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/2/264?etoc

BH3

PUMA Promotes Bax Translocation by Both Directly Interacting with Bax and by Competitive Binding to Bcl-XL during UV-induced Apoptosis

Yingjie Zhang, Da Xing, and Lei Liu

http://www.molbiolcell.org/cgi/content/abstract/20/13/3077?etoc

Detergent activated BAX protein is a monomer

Olena Ivashyna, Ana J. Garcia-Saez, Jonas Ries, Eric T. Christenson, Petra Schwille, and Paul H. Schlesinger

http://www.jbc.org/cgi/content/abstract/M109.023853v1

PUMA- and Bax-induced autophagy contributes to apoptosis

K S Yee, S Wilkinson, J James, K M Ryan & K H Vousden

http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins

David Lam, David Dickens, Elizabeth B. Reid, Samantha H. Y. Loh, Nicoleta Moisoi, and L. Miguel Martins

http://www.pnas.org/content/106/29/11978.abstract?etoc

Other

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo, Simona Giglio, Igea D’Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta, Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu and Fabiola Moretti

http://www.nature.com/emboj/journal/v28/n13/full/emboj2009154a.html

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells

R Kar, P K Singha, M A Venkatachalam & P Saikumar

http://www.nature.com/onc/journal/v28/n28/full/onc2009118a.html

REVIEWS / COMMENTS

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(plenty of authors)

http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

BCL2DB: moving ‘helix-bundled’ BCL-2 family members to their database

Stanislas Valentin Blaineau, Abdel Aouacheria

http://www.springerlink.com/content/j6×5l4117×50ph7m/

IL-33 Raises Alarm

M. Lamkanfi and V.M. Dixit

http://www.cell.com/immunity/abstract/S1074-7613(09)00284-2

Mitochondrial targeting of tBid/Bax: a role for the TOM complex?

M Ott, E Norberg, B Zhivotovsky & S Orrenius

http://www.nature.com/cdd/journal/v16/n8/full/cdd200961a.html

Caspase-8 for Outer Harmony

Gabriel Sollberger and Hans-Dietmar Beer

http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/78/pe40?etoc

Caspase-2: controversial killer or checkpoint controller?

Tanja Kitevska, Damian M. S. Spencer, Christine J. Hawkins

http://www.springerlink.com/content/q88h871q37540753/

Apolist – june 2009

Genome-wide silencing in Drosophila captures conserved apoptotic effectors
Su Kit Chew et al.
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08087.html

–
Death receptors and IAPs

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
S. He, L. Wang, L. Miao, T. Wang, F. Du, L. Zhao, and X. Wang
http://www.cell.com/abstract/S0092-8674%2809%2900578-9

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
Y.S. Cho, S. Challa, D. Moquin, R. Genga, T.D. Ray, M. Guildford, and F.K.-M. Chan
http://www.cell.com/abstract/S0092-8674%2809%2900642-4

Phenylarsine oxide interferes with the death inducing signaling complex and inhibits tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced apoptosis.
Sun XM, Canda-Sánchez A, Manjeri GR, Cohen GM, Pinkoski MJ.
http://dx.doi.org/10.1016/j.yexcr.2009.05.014

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
S Morioka, E Omori, T Kajino, R Kajino-Sakamoto, K Matsumoto & J Ninomiya-Tsuji
http://www.nature.com/onc/journal/v28/n23/full/onc2009110a.html

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling
Gudrun Strauss, Jonathan A. Lindquist, Nathalie Arhel, Edward Felder, Sabine Karl, Tobias L. Haas, Simone Fulda, Henning Walczak, Frank Kirchhoff, and Klaus-Michael Debatin
http://jem.rupress.org/cgi/content/abstract/206/6/1379?etoc

Cytotoxicity mediated by the FASL-activated apoptotic pathway in stem cells
Julia Mazar, Molly Thomas, Ludmila Bezrukov, Alexander Chanturia, Gulcin Pekkurnaz, Shurong Yin, Sergei A. Kuznetsov, Pamela Gehron Robey, and Joshua Zimmerberg
http://www.jbc.org/cgi/content/abstract/M109.032235v1

–
BH3

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak
Martina Klee, Kathrin Pallauf, Sonia Alcalá, Aarne Fleischer and Felipe X Pimentel-Muiños
http://www.nature.com/emboj/journal/v28/n12/abs/emboj200990a.html

KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model
Analisa DiFeo, Fei Huang, Jaya Sangodkar, Esteban A. Terzo, Devin Leake, Goutham Narla, and John A. Martignetti
http://cancerres.aacrjournals.org/cgi/content/abstract/69/11/4733

Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
Stephen M. Sykes, Timothy J. Stanek, Amanda Frank, Maureen E. Murphy, and Steven B. McMahon
http://www.jbc.org/cgi/content/abstract/M109.026096v1

BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis
Xianwang Wang, Da Xing, Lei Liu, Wei R. Chen
http://dx.doi.org/10.1016/j.febslet.2009.04.045

PUMA Suppresses Intestinal Tumorigenesis in Mice
Wei Qiu, Eleanor B. Carson-Walter, Shih Fan Kuan, Lin Zhang, and Jian Yu
http://cancerres.aacrjournals.org/cgi/content/abstract/69/12/4999

PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells
Q Sun, L Ming, S M Thomas, Y Wang, Z G Chen, R L Ferris, J R Grandis, L Zhang & J Yu
http://www.nature.com/onc/journal/v28/n24/full/onc2009108a.html

Different forms of cell death induced by putative BCL2 inhibitors
M Vogler, K Weber, D Dinsdale, I Schmitz, K Schulze-Osthoff, M J S Dyer & G M Cohen
http://www.nature.com/cdd/journal/v16/n7/full/cdd200948a.html

Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis
Caroline Morel, Scott M. Carlson, Forest M. White, and Roger J. Davis
http://mcb.asm.org/cgi/content/abstract/29/14/3845

Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery To Promote Apoptosis in Caenorhabditis elegans
Qinfang Shen, Fengsong Qin, Zhiyang Gao, Jie Cui, Hui Xiao, Zhiheng Xu, and Chonglin Yang
http://mcb.asm.org/cgi/content/abstract/29/14/3881

–
IAPs, caspases and downstream

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2
M.J.M. Bertrand, K. Doiron, K. Labb_e, R.G. Korneluk, P.A. Barker, and M. Saleh
http://dx.doi.org/10.1016/j.immuni.2009.04.011

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection
Garabet Yeretssian, Karine Doiron, Wei Shao, Blair R. Leavitt, Michael R. Hayden, Donald W. Nicholson, and Maya Saleh
http://www.pnas.org/cgi/content/abstract/106/22/9016?etoc

Enhanced cytoprotective effects of the IAP protein, c-IAP1, through stabilization with TRAF2
Rebecca A. Csomos, Graham F. Brady, and Colin S. Duckett
http://www.jbc.org/cgi/content/abstract/M109.029983v1

Critical Role for Caspase-8 in Epidermal Growth Factor Signaling
Darren Finlay, Amy Howes, and Kristiina Vuori
http://cancerres.aacrjournals.org/cgi/content/abstract/69/12/5023

Caspase-10-Mediated Heat Shock Protein 90β Cleavage Promotes UVB Irradiation-Induced Cell Apoptosis
Hehua Chen, Yan Xia, Dexing Fang, David Hawke, and Zhimin Lu
http://mcb.asm.org/cgi/content/abstract/29/13/3657

Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway
S Inoue, G Browne, G Melino & G M Cohen
http://www.nature.com/cdd/journal/v16/n7/full/cdd200929a.html

Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model
Edward M. Barnett, Xu Zhang, Dustin Maxwell, Qing Chang, and David Piwnica-Worms
http://www.pnas.org/content/106/23/9391.abstract?etoc

The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation
Patricia Rigou, Valeria Piddubnyak, Audrey Faye, Jean-Christophe Rain, Laurence Michel, Fabien Calvo and Jean-Luc Poyet
http://www.nature.com/emboj/journal/v28/n11/abs/emboj2009106a.html
–

REVIEWS / COMMENTS

A few reviews on autophagy in CDD: http://www.nature.com/cdd/journal/v16/n7/index.html

Caspase activation pathways: some recent progress
S P Cullen & S J Martin
http://www.nature.com/cdd/journal/v16/n7/full/cdd200959a.html

Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1
Ryuji Yamaguchi, Guy Perkins
http://dx.doi.org/10.1016/j.bbabio.2009.02.005

cIAP Proteins: Keystones in NOD Receptor Signal Transduction
C. Reardon and T.W. Mak
http://www.cell.com/immunity/abstract/S1074-7613%2809%2900243-X

Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor
Yi-Ping Rong, Paul Barr, Vivien C. Yee, Clark W. Distelhorst http://www.sciencedirect.com/science/journal/01674889

Letting go: modification of cell adhesion during apoptosis
Suzanne M, Steller H
http://jbiol.com/content/8/5/49

When separation means death: killing through the mitochondria, but starting from the endoplasmic reticulum
Violeta Lamarca and Luca Scorrano
http://www.nature.com/emboj/journal/v28/n12/full/emboj2009135a.html

Apoptosis: Death by ubiquitylation
http://www.nature.com/nrm/journal/v10/n7/full/nrm2714.html

Apoptosis and cancer: the genesis of a research field
Thomas G. Cotter
http://www.nature.com/nrc/journal/v9/n7/full/nrc2663.html

Supplemental Siberia I – into the cold
Mole
http://jcs.biologists.org/cgi/content/full/122/12/1931
Supplemental material: http://jcs.biologists.org/cgi/content/full/122/12/1931/DC1

Apolist – may 2009

Death receptors

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling
Z. Jin, Y. Li, R. Pitti, D. Lawrence, V.C. Pham, J.R. Lill, and A. Ashkenazi
http://dx.doi.org/10.1016/j.cell.2009.03.015

Mechanism of procaspase-8 activation by c-FLIPL
Jong W. Yu, Philip D. Jeffrey, and Yigong Shi
http://www.pnas.org/content/106/20/8169.full

Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo
Vladislava Juric, Chih-Chiun Chen, and Lester F. Lau
http://mcb.asm.org/cgi/content/abstract/29/12/3266

DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis
M Olsson, H Vakifahmetoglu, P M Abruzzo, K Högstrand, A Grandien & B Zhivotovsky
http://www.nature.com/onc/journal/v28/n18/full/onc200936a.html

Akt and 14-3-3 Control a PACS-2 Homeostatic Switch that Integrates Membrane Traffic with TRAIL-Induced Apoptosis
J.E. Aslan, H. You, D.M. Williamson, J. Endig, R.T. Youker, L. Thomas, H. Shu, Y. Du, R.L. Milewski, M.H. Brush, A. Possemato, K. Sprott, H. Fu, K.D. Greis, D.N. Runckel, A. Vogel, and G. Thomas
http://www.cell.com/molecular-cell/abstract/S1097-2765(09)00240-8

Modulation of Caspase Activity Regulates Skeletal Muscle Regeneration and Function in Response to Vasopressin and Tumor Necrosis Factor
Viviana Moresi, Gisela Garcia-Alvarez, Alessandro Pristerà, Emanuele Rizzuto, Maria C. Albertini, Marco Rocchi, Giovanna Marazzi, David Sassoon, Sergio Adamo, Dario Coletti
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005570

BH3

Bcl-2 Proteins EGL-1 and CED-9 Do Not Regulate Mitochondrial Fission or Fusion in Caenorhabditis elegans
D.G. Breckenridge, B.-H. Kang, and D. Xue
http://www.cell.com/current-biology/abstract/S0960-9822%2809%2900825-2

BH3 Peptides Induce Mitochondrial Fission and Cell Death Independent of BAX/BAK
Emelyn H. Shroff, Colleen M. Snyder, G. R. Scott Budinger, Manu Jain, Teng-Leong Chew, Satya Khuon, Harris Perlman, Navdeep S. Chandel
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005646

Execution of Superoxide-Induced Cell Death by the Proapoptotic Bcl-2-Related Proteins Bid and Bak
Muniswamy Madesh, Wei-Xing Zong, Brian J. Hawkins, Subbiah Ramasamy, Thilagavathi Venkatachalam, Partha Mukhopadhyay, Patrick J. Doonan, Krishna M. Irrinki, Mohanraj Rajesh, Pál Pacher, and Craig B. Thompson
http://mcb.asm.org/cgi/content/abstract/29/11/3099

Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function
I A Ciechomska, G C Goemans, J N Skepper and A M Tolkovsky
http://www.nature.com/onc/journal/v28/n21/full/onc200960a.html

KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis
Chunyan Tian, Guichun Xing, Ping Xie, Kefeng Lu, Jing Nie, Jian Wang, Li Li, Mei Gao, Lingqiang Zhang and Fuchu He
http://www.nature.com/ncb/journal/v11/n5/full/ncb1864.html

Other

The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex
Frédéric Mille, Chantal Thibert, Joanna Fombonne, Nicolas Rama, Catherine Guix, Hideki Hayashi, Véronique Corset, John C. Reed and Patrick Mehlen
http://www.nature.com/ncb/journal/v11/n6/full/ncb1880.html

DeadEasy Caspase: Automatic Counting of Apoptotic Cells in Drosophila
Manuel G. Forero, Jenny A. Pennack, Anabel R. Learte, Alicia Hidalgo
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005441

Apoptosis is not required for mammalian neural tube closure
Valentina Massa, Dawn Savery, Patricia Ybot-Gonzalez, Elisabetta Ferraro, Anthony Rongvaux, Francesco Cecconi, Richard Flavell, Nicholas D. E. Greene, and Andrew J. Copp
http://www.pnas.org/content/106/20/8233.abstract?etoc

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins
Salah Abu-Hamad, Nir Arbel, Doron Calo, Laetitia Arzoine, Adrian Israelson, Nurit Keinan, Ronit Ben-Romano, Orr Friedman, and Varda Shoshan-Barmatz
http://jcs.biologists.org/cgi/content/abstract/122/11/1906

Stress-dependent chip/DAXX interaction suppresses the p53 apoptotic program
Holly McDonough, Peter C. Charles, Eleanor G. Hilliard, Shu-Bing Qian, Jin-na Min, Andrea L. Portbury, Douglas M. Cyr, and Cam Patterson
http://www.jbc.org/cgi/content/abstract/M109.011767v1

REVIEWS / COMMENTS

Cytoplasmic functions of the tumour suppressor p53
Douglas R. Green and Guido Kroemer
http://www.nature.com/nature/journal/v458/n7242/full/4581118a.html

The CULt of Caspase-8 Ubiquitination
M. Békés and G.S. Salvesen
http://dx.doi.org/10.1016/j.cell.2009.04.052

Of Elections and Cell-Death Decisions
P. Loriaux and A. Hoffmann
http://dx.doi.org/10.1016/j.molcel.2009.05.001

Immunogenic and tolerogenic cell death
Douglas R. Green, Thomas Ferguson, Laurence Zitvogel & Guido Kroemer
http://www.nature.com/nri/journal/v9/n5/abs/nri2545.html

Beclin 1: a BH3-only protein that fails to induce apoptosis
P Boya and G Kroemer
http://www.nature.com/onc/journal/v28/n21/full/onc200983a.html

Human caspases: Activation, specificity and regulation
Cristina Pop and Guy S Salvesen
http://www.jbc.org/cgi/content/abstract/R800084200v1

Hyung Don Ryoo: A healthy career in cellular death
Ruth Williams
http://jcb.rupress.org/cgi/content/full/185/5/758?etoc

Apolist – april 2009

APOLIST – APRIL 2009

Caspases

Caspase-2 activation in the absence of PIDDosome formation
Claudia Manzl, Gerhard Krumschnabel, Florian Bock, Benedicte Sohm,
Verena Labi, Florian Baumgartner, Emmanuelle Logette, Jürg Tschopp,
and Andreas Villunger
http://jcb.rupress.org/cgi/content/abstract/185/2/291?etoc

Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor
Cell Migration and Metastasis
Simone Barbero, Ainhoa Mielgo, Vicente Torres, Tal Teitz, David J.
Shields, David Mikolon, Matthew Bogyo, Daniela Barilà, Jill M. Lahti,
David Schlaepfer, and Dwayne G. Stupack
http://cancerres.aacrjournals.org/cgi/content/abstract/69/9/3755

Bicaudal Is a Conserved Substrate for Drosophila and Mammalian
Caspases and Is Essential for Cell Survival
Emma M. Creagh, Gabriela Brumatti, Clare Sheridan, Patrick J. Duriez,
Rebecca C. Taylor, Sean P. Cullen, Colin Adrain, Seamus J. Martin
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005055

BH3

Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated
Lipidic Pore Formation
Blanca Schafer, Joel Quispe, Vineet Choudhary, Jerry E. Chipuk, Teddy
G. Ajero, Han Du, Roger Schneiter, and Tomomi Kuwana
http://www.molbiolcell.org/cgi/content/abstract/20/8/2276?etoc

Bax activation by the BH3-only protein Puma promotes cell dependence
on antiapoptotic Bcl-2 family members
Tristan Gallenne, Fabien Gautier, Lisa Oliver, Eric Hervouet, Belinda
Noël, John A. Hickman, Olivier Geneste, Pierre-François Cartron,
François M. Vallette, Stephen Manon, and Philippe Juin
http://jcb.rupress.org/cgi/content/abstract/185/2/279?etoc

TOM-independent complex formation of Bax and Bak in mammalian
mitochondria during TNF-induced apoptosis
K Ross, T Rudel & V Kozjak-Pavlovic
http://www.nature.com/cdd/journal/v16/n5/full/cdd2008194a.html

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
E M Michalak, E S Jansen, L Happo, M S Cragg, L Tai, G K Smyth, A
Strasser, J M Adams & C L Scott
http://www.nature.com/cdd/journal/v16/n5/full/cdd2008195a.html

The Epstein–Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by
binding to a limited amount of Bim
Anthony L. Desbien, John W. Kappler, and Philippa Marrack
http://www.pnas.org/content/106/14/5663.abstract?etoc

The von Hippel-Lindau protein sensitizes renal carcinoma cells to
apoptotic stimuli through stabilization of BIMEL
Y Guo, M C Schoell & R S Freeman
http://www.nature.com/onc/journal/v28/n16/abs/onc200935a.html

Nucleophosmin blocks mitochondrial localization of p53 and apoptosis
Sanjit Kumar Dhar and Daret K. St. Clair
http://www.jbc.org/cgi/content/abstract/M109.005736v1

A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells
Jian Lin, Zhibin Zheng, Yanjun Li, Wenyu Yu, Wu Zhong, Songhai Tian,
Fang Zhao, Xiaobai Ren, Junhai Xiao, Nan Wang, Siyang Liu, Lili Wang,
Fugeng Sheng, Yingyu Chen, Changwen Jin, Song Li and Bin Xia
http://www.landesbioscience.com/journals/autophagy/article/7888

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor
Induction of BNIP3 and BNIP3L via Their BH3 Domains
Grégory Bellot, Raquel Garcia-Medina, Pierre Gounon, Johanna Chiche,
Danièle Roux, Jacques Pouysségur, and Nathalie M. Mazure
http://mcb.asm.org/cgi/content/abstract/29/10/2570

Death receptors

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Sabrina L. Spencer, Suzanne Gaudet, John G. Albeck, John M. Burke &
Peter K. Sorger
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08012.html

Notch1 signaling sensitizes TRAIL-induced apoptosis in human
hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53
degradation and up-regulating p53-dependent DR5 expression
Chunmei Wang, Runzi Qi, Nan Li, Zhengxin Wang, Huazhang An, Qinghua
Zhang, Yizhi Yu, and Xuetao Cao
http://www.jbc.org/cgi/content/abstract/M109.002105v1

IAPs

Regulation of XIAP Translation and Induction by MDM2 following Irradiation
L. Gu, N. Zhu, H. Zhang, D.L. Durden, Y. Feng, and M. Zhou
http://www.cell.com/cancer-cell/abstract/S1535-6108%2809%2900077-4

Skeletal Muscle Differentiation Evokes Endogenous XIAP to Restrict the
Apoptotic Pathway
Michelle I. Smith et al.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005097

Other

Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required
for Efficient Apoptosis
V.V. Grinkevich, F. Nikulenkov, Y. Shi, M. Enge, W. Bao, A. Maljukova,
A. Gluch, A. Kel, O. Sangfelt, and G. Selivanova
http://www.cell.com/cancer-cell/abstract/S1535-6108%2809%2900110-X

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
Peter J. Cook1,2,5, Bong Gun Ju1,3,5, Francesca Telese1, Xiangting
Wang1, Christopher K. Glass4 & Michael G. Rosenfeld
http://www.nature.com/nature/journal/v458/n7238/full/nature07849.html

Antimicrobial peptide-induced apoptotic death of Leishmania results
from calcium-dependent, caspase-independent mitochondrial toxicity
Manjusha M. Kulkarni, W. Robert McMaster, Wojciech Kamysz, and
Bradford S. McGwire
http://www.jbc.org/cgi/content/abstract/M809079200v1

The Early Apoptotic DNA Fragmentation Targets a Small Number of
Specific Open Chromatin Regions
Miriam Di Filippo, Giorgio Bernardi
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005010

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
Masafumi Nakayama, Hisaya Akiba, Kazuyoshi Takeda, Yuko Kojima,
Masaaki Hashiguchi, Miyuki Azuma, Hideo Yagita, and Ko Okumura
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/113/16/3821

REVIEWS / COMMENTS

April Fish
D R Green
Editor-in-Chief, Oncogene
http://www.nature.com/onc/journal/v28/n13/full/onc200928a.html

EMBO workshop on cytotoxicity, cell death and the immune system
A Anel, C Bleackley, C Borner, P Golstein, P H Krammer, A Müllbacher,
J Pardo, M M Simon & J A Trapani
http://www.nature.com/cdd/journal/v16/n5/full/cdd20094a.html

Is TRAIL the holy grail of cancer therapy?
Thomas Newsom-Davis, Silvia Prieske, Henning Walczak
http://www.springerlink.com/content/m4331mug22202113/fulltext.html

Bcl2 family proteins in carcinogenesis and the treatment of cancer
Anna Frenzel, Francesca Grespi, Waldemar Chmelewskij, Andreas Villunger
http://www.springerlink.com/content/e80363n402846317/fulltext.html

Inflammasomes in infection and inflammation
Christian R. McIntire, Garabet Yeretssian, Maya Saleh
http://www.springerlink.com/content/68t4252214270158/

Puma strikes Bax
Anthony Letai
http://jcb.rupress.org/cgi/content/abstract/185/2/189?etoc

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
Mark S. Cragg, Claire Harris, Andreas Strasser & Clare L. Scott
http://www.nature.com/nrc/journal/v9/n5/full/nrc2615.html

Tumour necrosis factor and cancer
Frances Balkwill
http://www.nature.com/nrc/journal/v9/n5/full/nrc2628.html

Compilated by Cristina Muñoz-Pinedo

Apolist march 2009

APOLIST – MARCH 2009
© Cristina Muñoz-Pinedo

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells
Griselda Herrero-Martín, Maria Høyer-Hansen, Celina García-García, Claudia Fumarola, Thomas Farkas, Abelardo López-Rivas and Marja Jäättelä
http://www.nature.com/emboj/journal/v28/n6/full/emboj20098a.html

Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila
T. Igaki, J.C. Pastor-Pareja, H. Aonuma, M. Miura, and T. Xu
http://www.cell.com/developmental-cell/abstract/S1534-5807%2809%2900030-6

BH3 / mitochondria

Dynamics of outer mitochondrial membrane permeabilization during apoptosis
M Rehm, H J Huber, C T Hellwig, S Anguissola, H Dussmann & J H M Prehn
http://www.nature.com/cdd/journal/v16/n4/full/cdd2008187a.html

Bcl-xL increases mitochondrial fission, fusion, and biomass in neurons
Sarah B. Berman, Ying-bei Chen, Bing Qi, J. Michael McCaffery, Edmund B. Rucker, III, Sandra Goebbels, Klaus-Armin Nave, Beth A. Arnold, Elizabeth A. Jonas, Fernando J. Pineda, and J. Marie Hardwick
http://jcb.rupress.org/cgi/content/abstract/184/5/707?etoc

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim
A M Jabbour, J E Heraud, C P Daunt, T Kaufmann, J Sandow, L A O’Reilly, B A Callus, A Lopez, A Strasser, D L Vaux & P G Ekert
http://www.nature.com/cdd/journal/v16/n4/full/cdd2008179a.html

Role of BNIP3 in TNF-induced cell death — TNF upregulates BNIP3 expression
Saeid Ghavami, Mehdi Eshraghi, Kamran Kadkhoda, Mark M. Mutawe, Subbareddy Maddika, Graham H. Bay, Sebastian Wesselborg, Andrew J. Halayko, Thomas Klonisch, Marek Los
http://dx.doi.org/10.1016/j.bbamcr.2009.01.002

Mitogen-Activated Protein Kinase Inhibition Induces Translocation of Bmf to Promote Apoptosis in Melanoma
Matthew W. VanBrocklin, Monique Verhaegen, Maria S. Soengas, and Sheri L. Holmen
Cancer Res 2009;69 1985-1994
http://cancerres.aacrjournals.org/cgi/content/abstract/69/5/1985

Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization
Benjamin Faustin, Ya Chen, Dayong Zhai, Gaelle Le Negrate, Lydia Lartigue, Arnold Satterthwait, and John C. Reed
http://www.pnas.org/content/106/10/3935.abstract?etoc

Molecular basis for BH3 domain recognition in the BCL-2 protein family:Identification of conserved hot-spot interactions
Gautier Moroy, Elyette Martin, Annick Dejaegere, and Roland H. Stote
http://www.jbc.org/cgi/content/abstract/M805542200v1

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
Desiree A. Steimer, Kelli Boyd, Osamu Takeuchi, Jill K. Fisher, Gerard P. Zambetti, and Joseph T. Opferman
Blood 2009;113 2805-2815
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/113/12/2805

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family
L J Beverly & H E Varmus
http://www.nature.com/onc/journal/v28/n9/full/onc2008466a.html

P53 acetylation is crucial for its transcription-independent proapoptotic functions
Hirohito Yamaguchi, Nicholas T. Woods, Landon G. Piluso, Heng-Huan Lee, Jiandong Chen, Kapil N. Bhalla, Alvaro Monteiro, Xuan Liu, Mien-Chie Hung, and Hong-Gang Wang
http://www.jbc.org/cgi/content/abstract/M809268200v1

BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor–induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3
Amanda Nordigården, Maria Kraft, Pernilla Eliasson, Verena Labi, Eric W.-F. Lam, Andreas Villunger, and Jan-Ingvar Jönsson
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/113/10/2302

BCL-2 expression and p38MAPK activity in cells infected with influenza a virus: Impact on virally induced apoptosis and viral replication
Lucia Nencioni, Giovanna De Chiara, Rossella Sgarbanti, Donatella Amatore, Katia Aquilano, Maria E. Marcocci, Annalucia Serafino, Maria Torcia, Federico Cozzolino, Maria R. Ciriolo, Enrico Garaci, and Anna T. Palamara
http://www.jbc.org/cgi/content/abstract/M900146200v1

Assembly of the mitochondrial apoptosis-induced channel, MAC
Sonia Martinez-Caballero, Laurent M. Dejean, Michael S. Kinnally, Kyoung Joon Oh, Carmen A. Mannella, and Kathleen W. Kinnally
http://www.jbc.org/cgi/content/abstract/M806610200v1

CICD

Modulation of Caspase-Independent Cell Death Leads to Resensitization of Imatinib Mesylate–Resistant Cells
Vanessa J. Lavallard, Ludivine A. Pradelli, Audrey Paul, Marie Bénéteau, Arnaud Jacquel, Patrick Auberger, and Jean-Ehrland Ricci
Cancer Res 2009;69 3013-3020
http://cancerres.aacrjournals.org/cgi/content/abstract/69/7/3013

Copper-dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death
Irmgard Paris, Carolina Perez-Pastene, Eduardo Couve, Pablo Caviedes, Susan LeDoux, and Juan Segura-Aguilar
http://www.jbc.org/cgi/content/abstract/M900323200v1

Death receptors

HIV Induces TRAIL Sensitivity in Hepatocytes
Challagundla K. Babu1, Kanitta Suwansrinon1, Gary D. Bren1, Andrew D. Badley1,2, Stacey A. Rizza
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0004623

Oxaliplatin enhances TRAIL-induced apoptosis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts
Pages 943-948
Ling Xu, Xiujuan Qu, Ye Zhang, Xuejun Hu, Xianghong Yang, Kezuo Hou, Yuee Teng, Jingdong Zhang, Kiyonao Sada, Yunpeng Liu
http://dx.doi.org/10.1016/j.febslet.2009.02.014

IAPs

S-nitrosylation of XIAP compromises neuronal survival in Parkinson’s disease
Anthony H. K. Tsang, Yun-IL Lee, Han Seok Ko, Joseph M. Savitt, Olga Pletnikova, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson, and Kenny K. K. Chung
http://www.pnas.org/content/106/12/4900.abstract?etoc

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma
Meike Vogler, Henning Walczak, Dominic Stadel, Tobias L. Haas, Felicitas Genze, Marjana Jovanovic, Umesh Bhanot, Cornelia Hasel, Peter Möller, Jürgen E. Gschwend, Thomas Simmet, Klaus-Michael Debatin, and Simone Fulda
Cancer Res 2009;69 2425-2434
http://cancerres.aacrjournals.org/cgi/content/abstract/69/6/2425

The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspases-3 and -7 via unique mechanisms at distinct steps in their processing
Young Eun Choi, Michael Butterworth, Srinivas Malladi, Colin S. Duckett, Gerald M. Cohen, and Shawn B. Bratton
J. Biol. Chem. published 3 March 2009, 10.1074/jbc.M807550200
http://www.jbc.org/cgi/content/abstract/M807550200v1

cIAP1, cIAP2, and XIAP Act Cooperatively via Nonredundant Pathways to Regulate Genotoxic Stress–Induced Nuclear Factor- B Activation
Hyung-Seung Jin, Dong-Hee Lee, Dong-Hwan Kim, Ji-Hye Chung, Seul-Ji Lee, and Tae H. Lee
Cancer Res 2009;69 1782-1791
http://cancerres.aacrjournals.org/cgi/content/abstract/69/5/1782

Caspases

Dynamic expression of epidermal caspase 8 simulates a wound healing response
Pedro Lee1, Dai-Jen Lee1, Carol Chan1, Shih-Wei Chen1, Irene Ch’en2 & Colin Jamora
http://www.nature.com/nature/journal/v458/n7237/full/nature07687.html

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells
Pages 592-601
Guy Klaiman, Nathalie Champagne, Andréa C. LeBlanc
http://dx.doi.org/10.1016/j.bbamcr.2008.12.004

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival
Mohamed Lamkanfi, Lilian O. Moreira, Patrudu Makena, Diana C. J. Spierings, Kelli Boyd, Peter J. Murray, Douglas R. Green, and Thirumala-Devi Kanneganti
Blood 2009;113 2742-2745
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/113/12/2742

A Breast Cancer Risk Haplotype in the Caspase-8 Gene
Neil Duncan Shephard, Ryan Abo, Sushila Harkisandas Rigas, Bernd Frank, Wei-Yu Lin, Ian Wallace Brock, Adam Shippen, Sabapathy Prakash Balasubramanian, Malcolm Walter Ronald Reed, Claus Rainer Bartram, Alfons Meindl, Rita Katharina Schmutzler, Christoph Engel, Barbara Burwinkel, Lisa Anne Cannon-Albright, Kristina Allen-Brady, Nicola Jane Camp, and Angela Cox
Cancer Res 2009;69 2724-2728
http://cancerres.aacrjournals.org/cgi/content/abstract/69/7/2724

Immunity

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing
M R Jenkins, N L La Gruta, P C Doherty, J A Trapani, S J Turner & N J Waterhouse
http://www.nature.com/cdd/journal/v16/n4/full/cdd2008176a.html

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation
Miriam Beer Torchinsky, Johan Garaude, Andrea P. Martin and J. Magarian Blander
http://www.nature.com/nature/journal/v458/n7234/full/nature07781.html

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death
Theocharis Panaretakis, Oliver Kepp, Ulf Brockmeier, Antoine Tesniere, Ann-Charlotte Bjorklund, Daniel C Chapman, Michael Durchschlag, Nicholas Joza, Gérard Pierron, Peter van Endert, Junying Yuan, Laurence Zitvogel, Frank Madeo, David B Williams and Guido Kroemer
http://www.nature.com/emboj/journal/v28/n5/abs/emboj20091a.html

Other

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α
F. Lisbona, D. Rojas-Rivera, P. Thielen, S. Zamorano, D. Todd, F. Martinon, A. Glavic, C. Kress, J.H. Lin, P. Walter, J.C. Reed, L.H. Glimcher, and C. Hetz
http://www.cell.com/molecular-cell/abstract/S1097-2765%2809%2900133-6

Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae
Pages 561-571
Patricia Lisa-Santamaría, Aaron M. Neiman, Álvaro Cuesta-Marbán, Faustino Mollinedo, José L. Revuelta, Alberto Jiménez
http://dx.doi.org/10.1016/j.bbamcr.2008.12.016

Vacuolar functions determine the mode of cell death
[in yeast]
Alexandra Schauer, Heide Knauer, Christoph Ruckenstuhl, Heike Fussi, Michael Durchschlag, Ulrike Potocnik, Kai-Uwe Fröhlich
http://dx.doi.org/10.1016/j.bbamcr.2008.11.006

REVIEWS / COMMENTS

Many reviews on cell death and disease in Apoptosis (the journal)
http://www.springerlink.com/content/x0k422557704/?p=9f68203c1a2445c6b90444d85acbb875&pi=0

Ubiquitin-mediated regulation of apoptosis
Meike Broemer, Pascal Meier
http://dx.doi.org/10.1016/j.tcb.2009.01.004

Immunology: Cause of death matters
Brigitta Stockinger
http://www.nature.com/nature/journal/v458/n7234/full/458044a.html

Lysosomal involvement in cell death and cancer
Thomas Kirkegaard, Marja Jäättelä
http://dx.doi.org/10.1016/j.bbamcr.2008.09.008

A caspase homolog keeps CED-3 in check
Graham F. Brady, Colin S. Duckett
http://dx.doi.org/10.1016/j.tibs.2008.11.003

Intricate Links between ER Stress and Apoptosis
F. Madeo and G. Kroemer
http://dx.doi.org/10.1016/j.molcel.2009.03.002

The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death
T R Burton & S B Gibson
http://www.nature.com/cdd/journal/v16/n4/full/cdd2008185a.html

Apolist – february 2009

DNA-PKcs-PIDDosome: A Nuclear Caspase-2-Activating Complex with Role in G2/M Checkpoint Maintenance
M. Shi, C.J. Vivian, K.-J. Lee, C. Ge, K. Morotomi-Yano, C. Manzl, F. Bock, S. Sato, C. Tomomori-Sato, R. Zhu, J.S. Haug, S.K. Swanson, M.P. Washburn, D.J. Chen, B.P.C. Chen, A. Villunger, L. Florens, and C. Du
http://www.cell.com/abstract/S0092-8674%2808%2901609-7

Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells
Luiz C. Godoy, Cristina Muñoz-Pinedo, Laura Castro, Simone Cardaci, Christopher M. Schonhoff, Michael King, Verónica Tórtora, Mónica Marín, Qian Miao, Jian Fei Jiang, Alexandr Kapralov, Ronald Jemmerson, Gary G. Silkstone, Jinal N. Patel, James E. Evans, Michael T. Wilson, Douglas R. Green, Valerian E. Kagan, Rafael Radi, and Joan B. Mannick
http://www.pnas.org/content/106/8/2653.abstract?etoc

The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation.Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS.
http://www.nature.com/ni/journal/v10/n3/abs/ni.1697.html

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Anatoly Nikolaev, Todd McLaughlin, Dennis D. M. O’Leary and Marc Tessier-Lavigne
http://www.nature.com/nature/journal/v457/n7232/full/nature07767.html

p53 isoform  113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish
Jun Chen, Sok Meng Ng, Changqing Chang, Zhenhai Zhang, Jean-Christophe Bourdon, David P. Lane, and Jinrong Peng
Genes Dev. 2009;23 278-290
http://genesdev.cshlp.org/cgi/content/abstract/23/3/278

BCL-xL is a target gene regulated by hypoxia-inducible factor-1-alpha
Ni Chen, Xueqin Chen, Rui Huang, Hao Zeng, Jing Gong, Wentong Meng, Yiping Lu, Fang Zhao, Lin Wang, and Qiao Zhou
J. Biol. Chem. published 10 February 2009, 10.1074/jbc.M805997200
http://www.jbc.org/cgi/content/abstract/M805997200v1

Prep1 Directly Regulates the Intrinsic Apoptotic Pathway by Controlling Bcl-XL Levels
Nicola Micali, Carmelo Ferrai, Luis C. Fernandez-Diaz, Francesco Blasi, and Massimo P. Crippa
http://mcb.asm.org/cgi/content/abstract/29/5/1143

Cyclophilin D interacts with BCL2 and exerts an anti-apoptotic effect
Roman A. Eliseev, Jonathan Malecki, Tobias Lester, Yu Zhang, John Humpfrey, and Thomas E. Gunter
http://www.jbc.org/cgi/content/abstract/M808750200v1

Bad Targets the Permeability Transition Pore Independent of Bax or Bak to Switch between Ca2+-Dependent Cell Survival and Death
S.S. Roy, M. Madesh, E. Davies, B. Antonsson, N. Danial, and G. Hajnóczky
http://www.cell.com/molecular-cell/abstract/S1097-2765%2809%2900062-8

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
Qiuyan Wang, Helena Mora-Jensen, Marc A. Weniger, Patricia Perez-Galan, Chris Wolford, Tsonwin Hai, David Ron, Weiping Chen, William Trenkle, Adrian Wiestner, and Yihong Ye
http://www.pnas.org/content/106/7/2200.abstract?etoc

PERK-dependent regulation of IAP translation during ER stress
R B Hamanaka, E Bobrovnikova-Marjon, X Ji, S A Liebhaber & J A Diehl
http://www.nature.com/onc/journal/v28/n6/abs/onc2008428a.html

The Fas–FADD death domain complex structure unravels signalling by receptor clustering
Fiona L. Scott, Boguslaw Stec1, Cristina Pop1, Magorzata K. Dobaczewska1, JeongEun J. Lee1, Edward Monosov1, Howard Robinson2, Guy S. Salvesen1, Robert Schwarzenbacher3 & Stefan J. Riedl
http://www.nature.com/nature/journal/v457/n7232/full/nature07606.html

The death domain of FADD is essential for embryogenesis, lymphocyte development and proliferation
Hongxia Z. Imtiyaz, Xiaohui Zhou, Haibing Zhang, Dehua Chen, Taishan Hu, and Jianke Z. Zhang
J. Biol. Chem. published 10 February 2009, 10.1074/jbc.M900249200
http://www.jbc.org/cgi/content/abstract/M900249200v2

PTEN Loss Promotes Mitochondrially Dependent Type II Fas-Induced Apoptosis via PEA-15
James W. Peacock, Jodie Palmer, Dieter Fink, Stephen Ip, Eric M. Pietras, Alice L.-F. Mui, Stephen W. Chung, Martin E. Gleave, Michael E. Cox, Ramon Parsons, Marcus E. Peter, and Christopher J. Ong
http://mcb.asm.org/cgi/content/abstract/29/5/1222

A non-apoptotic role for Fas/FasL in erythropoiesis
Graeme W. Carlile, Deborah H. Smith, Martin Wiedmann
http://dx.doi.org/10.1016/j.febslet.2009.01.047

Potential Prognostic Significance of Decreased Serum Levels of TRAIL after Acute Myocardial Infarction
Paola Secchiero et al.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0004442

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2–mediated resistance
Melanie Fakler, Sandra Loeder, Meike Vogler, Katja Schneider, Irmela Jeremias, Klaus-Michael Debatin, and Simone Fulda
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/113/8/1710

TNFα-induced macrophage death via caspase-dependent and independent pathways
Tri M. Tran, Vladislav Temkin, Bo Shi, Lisa Pagliari, Soizic Daniel, Christiane Ferran, Richard M. Pope
http://www.springerlink.com/content/l70g1338r515067u/

Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase
David K. Moss, Andrew Wilde, and Jon D. Lane
J Cell Sci 2009;122 644-655
http://jcs.biologists.org/cgi/content/abstract/122/5/644

Absence of caspase-3 protects pancreatic  -cells from c-Myc-induced apoptosis without leading to tumor formation
Anna Radziszewska, Stephanie A. Schroer, Diana Choi, Panteha Tajmir, Nikolina Radulovich, James C. Ho, Linyuan Wang, Nicole Liadis, Razqallah Hakem, Ming-Sound Tsao, Linda Z. Penn, Gerard I. Evan, and Minna Woo
http://www.jbc.org/cgi/content/abstract/M806960200v1

Shift from apoptotic to necrotic cell death during HPV-induced transformation of keratinocytes
Nataly Kravchenko-Balasha, Sarit Mizrachy-Schwartz, Shoshana Klein, and Alexander Levitzki
http://www.jbc.org/cgi/content/abstract/M900217200v1

A prion of yeast metacaspase homolog (Mca1p) detected by a genetic screen
Julie Nemecek, Toru Nakayashiki, and Reed B. Wickner
http://www.pnas.org/content/106/6/1892.abstract?etoc

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
David Sancho, Olivier P. Joffre1,4, Anna M. Keller1, Neil C. Rogers1, Dolores Martínez2, Patricia Hernanz-Falcón1, Ian Rosewell3 & Caetano Reis e Sousa
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature07750.html

Monitoring of tumor response to chemotherapy in vivo by a novel small-molecule detector of apoptosis
Hagit Grimberg, Galit Levin, Anat Shirvan, Avi Cohen, Merav Yogev-Falach, Ayelet Reshef, Ilan Ziv
http://www.springerlink.com/content/t316766g13176764/

REVIEWS

Control of mitochondrial apoptosis by the Bcl-2 family
Joslyn K. Brunelle and Anthony Letai
J Cell Sci 2009;122 437-441
http://jcs.biologists.org/cgi/content/full/122/4/437

The Many Roles of FAS Receptor Signaling in the Immune System
A. Strasser, P.J. Jost, and S. Nagata
http://www.cell.com/immunity/abstract/S1074-7613%2809%2900069-7

The insect caspases
Dawn M. Cooper, David J. Granville, Carl Lowenberger
http://www.springerlink.com/content/j723411607k8tk26/

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy
M Vogler, D Dinsdale, M J S Dyer & G M Cohen
http://www.nature.com/cdd/journal/v16/n3/full/cdd2008137a.html

Tumour cell survival signalling by the ERK1/2 pathway
K Balmanno & S J Cook
http://www.nature.com/cdd/journal/v16/n3/full/cdd2008148a.html

Neuroscience: Good and bad cell death
Donald W. Nicholson
http://www.nature.com/nature/journal/v457/n7232/full/457970a.html

Coordinate regulation of autophagy and apoptosis in T cells by death
effectors: FADD or foundation
Bryan D. Bell and Craig M. Walsh
http://www.landesbioscience.com/journals/autophagy/article/7512