Apolist – december 2011

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Bcl-2 family proteins
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The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family
Members to Promote Mitochondrial Apoptosis
A.D. Rubinstein, M. Eisenstein, Y. Ber, S. Bialik, and A. Kimchi
http://www.sciencedirect.com/science/article/pii/S1097276511008902

Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice
Priscilla N. Kelly, Stephanie Grabow, Alex R. D. Delbridge, Andreas
Strasser, and Jerry M. Adams
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/118/24/6380

MiR-125b and miR-155 contribute to BCL2 repression and proliferation
in response to CD40 ligand (CD154) in human leukemic B-cells.
Shaun Willimott and Simon D. Wagner
http://www.jbc.org/cgi/content/abstract/M111.285718v1

Human Embryonic Stem Cells Express Elevated Levels of Multiple
Pro-Apoptotic BCL-2 Family Members
David T. Madden, Diana Davila-Kruger, Simon Melov, Dale E. Bredesen
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028530

Reduced mast cell and basophil numbers and function in Cpa3-Cre;
Mcl-1fl/fl mice
Jennifer N. Lilla, Ching-Cheng Chen, Kaori Mukai, Maya J. BenBarak,
Christopher B. Franco, Janet Kalesnikoff, Mang Yu, Mindy Tsai, Adrian
M. Piliponsky, and Stephen J. Galli
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/118/26/6930

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Death receptors and IAPs
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Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required
for Efficient Caspase-1 Activation by the Inflammasome
K. Labbé, C.R. McIntire, K. Doiron, P.M. Leblanc, and M.
Saleh
http://www.cell.com/immunity/abstract/S1074-7613%2811%2900506-1

Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin
kinase to induce reactive oxygen species-mediated apoptotic cell death
Kyung-Jin Park, Chang-Han Lee, Aeyung Kim, Ki Jun Jeong, Chul-Ho Kim,
and Yong-Sung Kim
http://www.jbc.org/cgi/content/abstract/M111.309021v1

SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to
Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent
Manner
Rachel M. Greer, Michael Peyton, Jill E. Larsen, Luc Girard, Yang Xie,
Adi F. Gazdar, Patrick Harran, Lai Wang, Rolf A. Brekken, Xiaodong
Wang, and John D. Minna
http://cancerres.aacrjournals.org/cgi/content/abstract/71/24/7640

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Caspases and downstream
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A Quantitative Method for the Specific Assessment of Caspase-6
Activity in Cell Culture
Dagmar E. Ehrnhoefer, Niels H. Skotte, Jane Savill, Yen T. N. Nguyen,
Safia Ladha, Li-Ping Cao, Edie Dullaghan, Michael R. Hayden
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027680

Two-Step Engulfment of Apoptotic Cells
Satoshi Toda, Rikinari Hanayama, and Shigekazu Nagata
http://mcb.asm.org/cgi/content/abstract/32/1/118

Live imaging of apoptosis in a novel transgenic mouse highlights its
role in neural tube closure
Yoshifumi Yamaguchi, Naomi Shinotsuka, Keiko Nonomura, Kiwamu
Takemoto, Keisuke Kuida, Hiroki Yosida, and Masayuki Miura
http://jcb.rupress.org/cgi/content/abstract/195/6/1047?etoc

Apoptosis-dependent externalization and involvement in apoptotic cell
clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila
Ryo Okada, Kaz Nagaosa, Takayuki Kuraishi, Hiroshi Nakayama, Naoko
Yamamoto, Yukiko Nakagawa, Naoshi Dohmae, Akiko Shiratsuchi, and
Yoshinobu Nakanishi
http://www.jbc.org/cgi/content/abstract/M111.277921v1

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Miscellaneous
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RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory
Response SyndromeL. Duprez, N. Takahashi, F. Van Hauwermeiren, B.
Vandendriessche, V. Goossens, T. Vanden Berghe, W. Declercq, C.
Libert, A. Cauwels, and P. Vandenabeele
http://www.cell.com/immunity/abstract/S1074-7613%2811%2900508-5

Toll-like receptors activate programmed necrosis in macrophages
through a receptor-interacting kinase-3–mediated pathway
Sudan He, Yuqiong Liang, Feng Shao, and Xiaodong Wang
http://www.pnas.org/content/108/50/20054.full

Autophagy promotes T-cell survival through degradation of proteins of
the cell death machinery
J R Kovacs, C Li, Q Yang, G Li, I G Garcia, S Ju, D G Roodman, J J
Windle, X Zhang and B Lu
http://www.nature.com/cdd/journal/v19/n1/full/cdd201178a.html

The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic
reticulum stress  Kathryn Austgen, Emily T. Johnson, Tae-Ju Park, Tom
Curran and Scott A. Oakes
http://www.nature.com/ncb/journal/v14/n1/full/ncb2395.html

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Reviews
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Cell Death and Differentiation special issue – In memory of Jurg Tschopp

Editorial by J. Silke and JE. Vince
http://www.nature.com/cdd/journal/v19/n1/full/cdd2011166a.html

Reviews by everybody:
http://www.nature.com/cdd/journal/v19/n1/index.html#rv

The Emerging Role of Linear Ubiquitination in Cell Signaling
Christoph H. Emmerich, Anna C. Schmukle, Henning Walczak
Linear ubiquitin chains transmit signals that are induced by diverse
stimuli and regulate cell activation and death.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/204/re5

Programmed cell removal: a new obstacle in the road to developing cancer
Mark P. Chao, Ravindra Majeti & Irving L. Weissman
http://www.nature.com/nrc/journal/v12/n1/full/nrc3171.html

Metabolic Connections during Apoptotic Cell EngulfmentC.Z. Han and
K.S. Ravichandran
http://www.cell.com/abstract/S0092-8674%2811%2901505-4

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Comments – other
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Who Put the ”A” in Atg12: Autophagy or Apoptosis?
T.N. Chonghaile and A. Letai
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900946-4

Necroptosis Turns TNF Lethal
L. Galluzzi and G. Kroemer
http://www.cell.com/immunity/abstract/S1074-7613%2811%2900513-9

Preventing Necrosis by Cleaving a Deubiquitinase
Wei Wong
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/203/ec344

Inducible Apoptosis Eliminates Patient-Transferred T Cells
http://cancerdiscovery.aacrjournals.org/cgi/content/full/1/7/549-a

Cell death helps give closure
Ben Short
http://jcb.rupress.org/cgi/content/full/195/6/922-b?etoc

Deleting Mcl-1 in mast cells: getting 2 birds with 1 stone
Booki Min
http://bloodjournal.hematologylibrary.org/cgi/content/full/118/26/6729

Conference: 1st international Cell Death In Cancer (CDIC)
http://www.celldeathincancer.com
Saint Malo in Brittany (France) from 13 to 16 May 2012.