Apolist – july 2009

Death receptors and IAPs

XIAP discriminates between type I and type II FAS-induced apoptosis
Philipp J. Jost, Stephanie Grabow1,2, Daniel Gray1, Mark D. McKenzie2,3, Ueli Nachbur4, David C. S. Huang1, Philippe Bouillet, Helen E. Thomas3, Christoph Borner, John Silke, Andreas Strasser & Thomas Kaufmann1
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08229.html#B19
PMID 19626005

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
D.-W. Zhang et al.
http://www.sciencemag.org/cgi/content/abstract/325/5938/332
PMID 19498109

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein
Nana Ueffing, Kusum K. Singh, Andrea Christians, Christoph Thorns, Alfred C. Feller, Florian Nagl, Falko Fend, Sebastian Heikaus, Alexander Marx, Rainer B. Zotz, Joachim Brade, Wolfgang A. Schulz, Klaus Schulze-Osthoff, Ingo Schmitz, and Christian Schwerk
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/3/572

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization
Céline Van Themsche, Valérie Leblanc, Sophie Parent, and Eric Asselin
http://www.jbc.org/cgi/content/abstract/284/31/20462

–
Caspases

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
Alexander U. Lüthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, Seamus J. Martin
http://www.cell.com/immunity/abstract/S1074-7613(09)00269-6

The Apaf-1-procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
Srinivas Malladi, Madhavi Challa-Malladi, Howard O Fearnhead and Shawn B Bratton
http://www.nature.com/emboj/journal/v28/n13/full/emboj2009152a.html

Dissecting an allosteric switch in caspase-7 using chemical and mutational probes
Jeanne A. Hardy and James A. Wells
http://www.jbc.org/cgi/content/abstract/M109.001826v1

Calpain-1 cleaves and activates caspase-7
Juliette Gafni, Xin Cong, Sylvia F. Chen, Bradford W. Gibson, and Lisa M. Ellerby
http://www.jbc.org/cgi/content/abstract/M109.038174v2

Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
Qing Lan, Lindsay M. Morton, Bruce Armstrong2, Patricia Hartge1, Idan Menashe1, Tongzhang Zheng3, Mark P. Purdue1, James R. Cerhan4, Yawei Zhang3, Andrew Grulich5, Wendy Cozen6, Meredith Yeager7, Theodore R. Holford3, Claire M. Vajdic8, Scott Davis9, Brian Leaderer3, Anne Kricker2, Maryjean Schenk10, Shelia H. Zahm1, Nilanjan Chatterjee1, Stephen J. Chanock1,7, Nathaniel Rothman1, and Sophia S. Wang
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/2/264?etoc

–
BH3

PUMA Promotes Bax Translocation by Both Directly Interacting with Bax and by Competitive Binding to Bcl-XL during UV-induced Apoptosis
Yingjie Zhang, Da Xing, and Lei Liu
http://www.molbiolcell.org/cgi/content/abstract/20/13/3077?etoc

Detergent activated BAX protein is a monomer
Olena Ivashyna, Ana J. Garcia-Saez, Jonas Ries, Eric T. Christenson, Petra Schwille, and Paul H. Schlesinger
http://www.jbc.org/cgi/content/abstract/M109.023853v1

PUMA- and Bax-induced autophagy contributes to apoptosis
K S Yee, S Wilkinson, J James, K M Ryan & K H Vousden
http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins
David Lam, David Dickens, Elizabeth B. Reid, Samantha H. Y. Loh, Nicoleta Moisoi, and L. Miguel Martins
http://www.pnas.org/content/106/29/11978.abstract?etoc

–
Other

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo, Simona Giglio, Igea D’Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta, Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu and Fabiola Moretti
http://www.nature.com/emboj/journal/v28/n13/full/emboj2009154a.html

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells
R Kar, P K Singha, M A Venkatachalam & P Saikumar
http://www.nature.com/onc/journal/v28/n28/full/onc2009118a.html

–
REVIEWS / COMMENTS

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
(plenty of authors)
http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

BCL2DB: moving ‘helix-bundled’ BCL-2 family members to their database
Stanislas Valentin Blaineau, Abdel Aouacheria
http://www.springerlink.com/content/j6×5l4117×50ph7m/

IL-33 Raises Alarm
M. Lamkanfi and V.M. Dixit
http://www.cell.com/immunity/abstract/S1074-7613(09)00284-2

Mitochondrial targeting of tBid/Bax: a role for the TOM complex?
M Ott, E Norberg, B Zhivotovsky & S Orrenius
http://www.nature.com/cdd/journal/v16/n8/full/cdd200961a.html

Caspase-8 for Outer Harmony
Gabriel Sollberger and Hans-Dietmar Beer
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/78/pe40?etoc

Caspase-2: controversial killer or checkpoint controller?
Tanja Kitevska, Damian M. S. Spencer, Christine J. Hawkins
http://www.springerlink.com/content/q88h871q37540753/

Death receptors and IAPs

XIAP discriminates between type I and type II FAS-induced apoptosis

Philipp J. Jost, Stephanie Grabow1,2, Daniel Gray1, Mark D. McKenzie2,3, Ueli Nachbur4, David C. S. Huang1, Philippe Bouillet, Helen E. Thomas3, Christoph Borner, John Silke, Andreas Strasser & Thomas Kaufmann1

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08229.html#B19

PMID 19626005

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

D.-W. Zhang et al.

http://www.sciencemag.org/cgi/content/abstract/325/5938/332

PMID 19498109

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein

Nana Ueffing, Kusum K. Singh, Andrea Christians, Christoph Thorns, Alfred C. Feller, Florian Nagl, Falko Fend, Sebastian Heikaus, Alexander Marx, Rainer B. Zotz, Joachim Brade, Wolfgang A. Schulz, Klaus Schulze-Osthoff, Ingo Schmitz, and Christian Schwerk

http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/3/572

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization

Céline Van Themsche, Valérie Leblanc, Sophie Parent, and Eric Asselin

http://www.jbc.org/cgi/content/abstract/284/31/20462

Caspases

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

Alexander U. Lüthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, Seamus J. Martin

http://www.cell.com/immunity/abstract/S1074-7613(09)00269-6

The Apaf-1-procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

Srinivas Malladi, Madhavi Challa-Malladi, Howard O Fearnhead and Shawn B Bratton

http://www.nature.com/emboj/journal/v28/n13/full/emboj2009152a.html

Dissecting an allosteric switch in caspase-7 using chemical and mutational probes

Jeanne A. Hardy and James A. Wells

http://www.jbc.org/cgi/content/abstract/M109.001826v1

Calpain-1 cleaves and activates caspase-7

Juliette Gafni, Xin Cong, Sylvia F. Chen, Bradford W. Gibson, and Lisa M. Ellerby

http://www.jbc.org/cgi/content/abstract/M109.038174v2

Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies

Qing Lan, Lindsay M. Morton, Bruce Armstrong2, Patricia Hartge1, Idan Menashe1, Tongzhang Zheng3, Mark P. Purdue1, James R. Cerhan4, Yawei Zhang3, Andrew Grulich5, Wendy Cozen6, Meredith Yeager7, Theodore R. Holford3, Claire M. Vajdic8, Scott Davis9, Brian Leaderer3, Anne Kricker2, Maryjean Schenk10, Shelia H. Zahm1, Nilanjan Chatterjee1, Stephen J. Chanock1,7, Nathaniel Rothman1, and Sophia S. Wang

http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/2/264?etoc

BH3

PUMA Promotes Bax Translocation by Both Directly Interacting with Bax and by Competitive Binding to Bcl-XL during UV-induced Apoptosis

Yingjie Zhang, Da Xing, and Lei Liu

http://www.molbiolcell.org/cgi/content/abstract/20/13/3077?etoc

Detergent activated BAX protein is a monomer

Olena Ivashyna, Ana J. Garcia-Saez, Jonas Ries, Eric T. Christenson, Petra Schwille, and Paul H. Schlesinger

http://www.jbc.org/cgi/content/abstract/M109.023853v1

PUMA- and Bax-induced autophagy contributes to apoptosis

K S Yee, S Wilkinson, J James, K M Ryan & K H Vousden

http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins

David Lam, David Dickens, Elizabeth B. Reid, Samantha H. Y. Loh, Nicoleta Moisoi, and L. Miguel Martins

http://www.pnas.org/content/106/29/11978.abstract?etoc

Other

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo, Simona Giglio, Igea D’Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta, Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu and Fabiola Moretti

http://www.nature.com/emboj/journal/v28/n13/full/emboj2009154a.html

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells

R Kar, P K Singha, M A Venkatachalam & P Saikumar

http://www.nature.com/onc/journal/v28/n28/full/onc2009118a.html

REVIEWS / COMMENTS

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(plenty of authors)

http://www.nature.com/cdd/journal/v16/n8/full/cdd200944a.html

BCL2DB: moving ‘helix-bundled’ BCL-2 family members to their database

Stanislas Valentin Blaineau, Abdel Aouacheria

http://www.springerlink.com/content/j6×5l4117×50ph7m/

IL-33 Raises Alarm

M. Lamkanfi and V.M. Dixit

http://www.cell.com/immunity/abstract/S1074-7613(09)00284-2

Mitochondrial targeting of tBid/Bax: a role for the TOM complex?

M Ott, E Norberg, B Zhivotovsky & S Orrenius

http://www.nature.com/cdd/journal/v16/n8/full/cdd200961a.html

Caspase-8 for Outer Harmony

Gabriel Sollberger and Hans-Dietmar Beer

http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/78/pe40?etoc

Caspase-2: controversial killer or checkpoint controller?

Tanja Kitevska, Damian M. S. Spencer, Christine J. Hawkins

http://www.springerlink.com/content/q88h871q37540753/